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Inhibiting KRAS with CD47 and immune checkpoint overcomes intrinsic resistance to combined KRAS and immune checkpoint inhibitor therapy

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1. scibot 30 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102317
  
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sciencedirect.com/science/article/pii/S2666379125003908
Aug 2025
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Nrf2 drives activation-driven expansion of CD4+T cells by modulating glucose and glutamine metabolism

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116177
  
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sciencedirect.com/science/article/pii/S2211124725009489
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2025.08.13.669552v1.full-html.html

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1. scibot 22 Aug 2025
  
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  DOI: 10.1101/2025.08.13.669552
  
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52.53.155.43/cbef6d49734833e21d46745b8a2764b4c745ed76/2025.08.13.669552v1.full-html.html
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USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment

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1. scibot 05 Aug 2025
  
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  DOI: 10.1158/2326-6066.CIR-24-1194
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12314529/
Jul 2025
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Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102251
  
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sciencedirect.com/science/article/pii/S2666379125003246
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Alistipes finegoldii augments the efficacy of immunotherapy against solid tumors

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1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.ccell.2025.07.002
  
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sciencedirect.com/science/article/pii/S1535610825002739
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Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity

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1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.ccell.2025.07.001
  
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sciencedirect.com/science/article/pii/S1535610825002727
Jun 2025
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Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation

1
1. scibot 17 Jun 2025
  
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  DOI: 10.1016/j.molcel.2025.05.029
  
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sciencedirect.com/science/article/pii/S109727652500468X
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PDF-html.html

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1. scibot 13 Jun 2025
  
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2. scibot 12 Jun 2025
  
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52.53.155.43/a7ee3b12d468dfb2dd9f5d25a6280eb2adf38466/PDF-html.html
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KMT2D coordinates antiviral CD4+ T cell responses through opposing effects on T follicular helper and cytotoxic gene expression

1
1. scibot 03 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115775
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12302258/
Apr 2025
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Ultrastable and versatile multimeric ensembles of FoxP3 on microsatellites

1
1. scibot 03 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.03.005
  
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sciencedirect.com/science/article/pii/S1097276525001984
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CD4+ T cell–innate immune crosstalk is critical during Staphylococcus aureus craniotomy infection

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1. scibot 02 Apr 2025
  
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  RRID:AB_11149115
  
  DOI: 10.1172/jci.insight.183327
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11949042/
Mar 2025
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Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy

1
1. scibot 11 Mar 2025
  
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  RRID:AB_11149115
  
  DOI: 10.1016/j.ccell.2025.02.014
  
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sciencedirect.com/science/article/pii/S1535610825000662
Feb 2025
jneuroinflammation.biomedcentral.com jneuroinflammation.biomedcentral.com

Interferon-gamma receptor signaling regulates innate immunity during Staphylococcus aureus craniotomy infection

1
1. scibot 25 Feb 2025
  
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  RRID:AB_11149115
  
  DOI: 10.1186/s12974-025-03376-9
  
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jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-025-03376-9
Dec 2024
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Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function

1
1. scibot 13 Dec 2024
  
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  RRID:AB_11149115
  
  DOI: 10.1007/s00125-024-06329-8
  
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link.springer.com/article/10.1007/s00125-024-06329-8
Sep 2024
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Immune isolation-enabled nanoencapsulation of donor T cells: a promising strategy for mitigating GVHD and treating AML in preclinical models

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1. scibot 12 Sep 2024
  
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  RRID:AB_11149115
  
  DOI: 10.1136/jitc-2023-008663
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11381671/
Aug 2024
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PD-1 signaling limits expression of phospholipid phosphatase 1 and promotes intratumoral CD8+ T cell ferroptosis

1
1. scibot 29 Aug 2024
  
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  RRID:AB_11149115
  
  DOI: 10.1016/j.immuni.2024.08.003
  
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sciencedirect.com/science/article/pii/S1074761324003765
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LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity

1
1. scibot 20 Aug 2024
  
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  RRID:AB_11149115
  
  DOI: 10.1016/j.cell.2024.07.016
  
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sciencedirect.com/science/article/pii/S0092867424007761
Jul 2024
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Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor

1
1. scibot 30 Jul 2024
  
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  DOI: 10.1016/j.chom.2024.06.010
  
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cell.com/cell-host-microbe/abstract/S1931-3128(24)00228-2
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Inhibition of CD226 Co-Stimulation Suppresses Diabetes Development in the NOD Mouse by Augmenting Tregs and Diminishing Effector T Cell Function

1
1. scibot 23 Jul 2024
  
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  DOI: 10.1101/2024.07.16.603756
  
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biorxiv.org/content/10.1101/2024.07.16.603756v1
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PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies

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1. scibot 17 Jul 2024
  
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  DOI: 10.1016/j.xcrm.2024.101649
  
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A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation

1
1. scibot 12 Jul 2024
  
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  DOI: 10.1016/j.cmet.2024.06.010
  
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sciencedirect.com/science/article/pii/S1550413124002353
Jun 2024
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Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss

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1. scibot 05 Jun 2024
  
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  DOI: 10.1016/j.cell.2024.05.003
  
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May 2024
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Metabolic coordination between skin epithelium and type 17 immunity sustains chronic skin inflammation

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1. scibot 21 May 2024
  
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  DOI: 10.1016/j.immuni.2024.04.022
  
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sciencedirect.com/science/article/pii/S1074761324002279
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Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity

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1. scibot 17 May 2024
  
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  DOI: 10.1016/j.chembiol.2024.04.005
  
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sciencedirect.com/science/article/pii/S2451945624001673
Apr 2024
aacrjournals.org aacrjournals.org

Spatial and temporal mapping of breast cancer lung metastases identify TREM2 macrophages as regulators of the metastatic boundary

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1. scibot 19 Apr 2024
  
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  DOI: 10.1158/2159-8290.CD-23-0299
  
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aacrjournals.org/cancerdiscovery/article/13/12/2610/731625/Spatial-and-Temporal-Mapping-of-Breast-Cancer-Lung
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IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

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1. scibot 11 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114088
  
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sciencedirect.com/science/article/pii/S2211124724004169
Feb 2024
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UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity

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1. scibot 28 Feb 2024
  
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  DOI: 10.1016/j.molcel.2024.01.024
  
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sciencedirect.com/science/article/pii/S1097276524000911
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An anti-CD19/CTLA-4 switch improves efficacy and selectivity of CAR T cells targeting CD80/86-upregulated DLBCL

1
1. scibot 14 Feb 2024
  
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  DOI: 10.1016/j.xcrm.2024.101421
  
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sciencedirect.com/science/article/pii/S2666379124000442
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Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells

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1. scibot 06 Feb 2024
  
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  DOI: 10.1016/j.cmet.2024.01.005
  
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sciencedirect.com/science/article/pii/S1550413124000068
Dec 2023
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Machine learning analysis of the T cell receptor repertoire identifies sequence features of self-reactivity

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1. scibot 20 Dec 2023
  
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  RRID:AB_11149115
  
  DOI: 10.1016/j.cels.2023.11.004
  
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sciencedirect.com/science/article/pii/S2405471223003277
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MHC class II regulation of CD8+ T cell tolerance and implications in autoimmunity and cancer immunotherapy

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1. scibot 01 Dec 2023
  
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  DOI: 10.1016/j.celrep.2023.113452
  
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sciencedirect.com/science/article/pii/S221112472301464X
52.53.155.43 52.53.155.43

cd-23-0299-html.html

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1. scibot 01 Dec 2023
  
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  DOI: 10.1158/2159-8290.cd-23-0299
  
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52.53.155.43/2b6c279d82b7a0e0d491057f5790a1189e93077e/cd-23-0299-html.html
Nov 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Five Inhibitory Receptors Display Distinct Vesicular Distributions in Murine T Cells

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1. scibot 18 Nov 2023
  
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  RRID:AB_11149115
  
  DOI: 10.3390/cells12212558
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10649679/
Oct 2023
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Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells

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  DOI: 10.1016/j.celrep.2023.113180
  
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Sep 2023
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Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity

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Aug 2023
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Five inhibitory receptors display distinct vesicular distributions in T cells

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  DOI: 10.1101/2023.07.21.550019
  
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Jul 2023
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QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations

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Jun 2023
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The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells

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Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow

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May 2023
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Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity

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  DOI: 10.1016/j.ccell.2023.04.016
  
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Asymmetric cell division safeguards memory CD8 T cell development

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  DOI: 10.1016/j.celrep.2023.112468
  
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cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity

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1. scibot 11 May 2023
  
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Mar 2023
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Galectin-3 expression in donor T cells reduces GvHD severity and lethality after allogeneic hematopoietic cell transplantation

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  DOI: 10.1016/j.celrep.2023.112250
  
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Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions

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Jan 2023
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Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy

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  DOI: 10.1158/2159-8290.CD-21-0003
  
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Nov 2022
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CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation

1
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Chronic type I interferon signaling promotes lipid-peroxidation-driven terminal CD8+ T cell exhaustion and curtails anti-PD-1 efficacy

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  DOI: 10.1016/j.celrep.2022.111647
  
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Aug 2022
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Succinate uptake by T cells suppresses their effector function via inhibition of mitochondrial glucose oxidation

1
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  DOI: 10.1016/j.celrep.2022.111193
  
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Faecalibaculum rodentium remodels retinoic acid signaling to govern eosinophil-dependent intestinal epithelial homeostasis

1
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  DOI: 10.1016/j.chom.2022.07.015
  
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Jun 2022
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Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

1
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  DOI: 10.1016/j.ccell.2022.06.001
  
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May 2022
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Immune-mediated neurodegenerative trait provoked by multimodal derepression of long-interspersed nuclear element-1

1
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  DOI: 10.1016/j.isci.2022.104278
  
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Apr 2022
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Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity

1
1. scibot 13 Apr 2022
  
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  DOI: 10.1016/j.immuni.2022.03.013
  
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Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer

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Mar 2022
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A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy

1
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  DOI: 10.1016/j.cmet.2022.02.009
  
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Dec 2021
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Pre-existing chromatin accessibility and gene expression differences among naive CD4+ T cells influence effector potential

1
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  DOI: 10.1016/j.celrep.2021.110064
  
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Nov 2021
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6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function

1
1. scibot 05 Nov 2021
  
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  DOI: 10.7554/eLife.67476
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8553335/
Sep 2021
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A Cre-driven allele-conditioning line to interrogate CD4+ conventional T cells

1
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  DOI: 10.1016/j.immuni.2021.08.029
  
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May 2021
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Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist

1
1. scibot 21 May 2021
  
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  Anti-mouse CD3ε (145–2 c11) Armenian hamster monoclonal
  
  DOI: 10.7554/eLife.65777
  
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Apr 2021
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Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells

1
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  DOI: 10.1016/j.cell.2021.01.018
  
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UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability

1
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  DOI: 10.1016/j.celrep.2021.108966
  
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Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity

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  DOI: 10.1016/j.cmet.2021.03.002
  
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cell.com/cell-metabolism/fulltext/S1550-4131(21)00109-1
Mar 2021
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Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function

1
1. scibot 10 Mar 2021
  
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  DOI: 10.1016/j.celrep.2021.108831
  
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Feb 2021
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Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy

1
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  RRID:AB_11149115
  
  DOI: 10.1016/j.celrep.2021.108706
  
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Sep 2020
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Landscape of Exhausted Virus-Specific CD8 T Cells in Chronic LCMV Infection

1
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  RRID:AB_11149115
  
  DOI: 10.1016/j.celrep.2020.108078
  
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Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function

1
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  DOI: 10.1016/j.cmet.2020.03.004
  
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A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling

1
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  DOI: 10.1016/j.celrep.2020.03.030
  
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Jan 2020
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Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells

1
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  RRID:AB_11149115
  
  DOI: 10.1016/j.cell.2019.07.044
  
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TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases

1
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  RRID:AB_11149115
  
  DOI: 10.1016/j.celrep.2019.05.061
  
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sciencedirect.com/science/article/pii/S2211124719306904
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_11149115
  
  DOI: 10.1016/j.cels.2019.01.004
  
  Resource: (BioLegend Cat# 100340, RRID:AB_11149115)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_11149115
  
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  RRID:AB_11149115 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2405471219300328
Nov 2018
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Untitled document

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1. scibot 05 Nov 2018
  
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  RRID:AB_11149115
  
  Resource used:
  
  (BioLegend Cat# 100340, RRID:AB_11149115)
  
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sciencedirect.com/science/article/pii/S2211124718310854
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CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells

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1. scibot 05 Nov 2018
  
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  RRID:AB_11149115
  
  Curator: @evieth
  
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  RRID:AB_11149115 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC5728720/
Nov 2017
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Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells

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1. scibot 08 Nov 2017
  
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  RRID:AB_11149115
  
  Curator: @Jmenke
  
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  RRID:AB_11149115 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1074761317303151

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