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An IL-12 partial agonist sustains intratumoral lymphocyte activation and detoxifies systemic IL-12 therapy

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  DOI: 10.1016/j.celrep.2025.116757
  
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sciencedirect.com:5037/science/article/pii/S2211124725015293
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Lymphodepleting chemotherapy potentiates neoantigen-directed T cell therapy by enhancing antigen presentation

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  DOI: 10.1016/j.xcrm.2025.102506
  
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sciencedirect.com:5037/science/article/pii/S2666379125005798
Nov 2025
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Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.cell.2025.10.030
  
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sciencedirect.com/science/article/pii/S0092867425012358
Sep 2025
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Monocyte/macrophage-derived interleukin-15 mediates the pro-inflammatory phenotype of CD226+ B cells in type 1 diabetes

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sciencedirect.com/science/article/pii/S2352396425003901
Aug 2025
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Engineered T cells stimulate dendritic cell recruitment and antigen spreading for potent anti-tumor immunity

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102307
  
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Enhanced formation of tertiary lymphoid structures shapes the anti-tumor microenvironment in hepatocellular carcinoma after FOLFOX-HAIC therapy

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Succinate preserves CD8+ T cell fitness to augment antitumor immunity

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  DOI: 10.1016/j.immuni.2025.07.017
  
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sciencedirect.com/science/article/pii/S1074761325003267
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Potassium channels mediate the inhibitory effect of exosomes on anti-tumor immunity in head and neck cancer

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1. scibot 01 Aug 2025
  
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  DOI: 10.1101/2025.07.25.666838
  
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biorxiv.org/content/10.1101/2025.07.25.666838v1
May 2025
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Immunosequencing identifies signatures of T cell responses for early detection of nasopharyngeal carcinoma

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.ccell.2025.04.009
  
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sciencedirect.com/science/article/pii/S1535610825001680
Mar 2025
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Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells

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  DOI: 10.1016/j.immuni.2025.02.007
  
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sciencedirect.com/science/article/pii/S107476132500072X
Dec 2024
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Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity

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1. scibot 06 Dec 2024
  
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  DOI: 10.1016/j.ccell.2024.11.003
  
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sciencedirect.com/science/article/pii/S1535610824004380
Oct 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

MerTK+ macrophages promote melanoma progression and immunotherapy resistance through AhR-ALKAL1 activation

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1. scibot 08 Oct 2024
  
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  DOI: 10.1126/sciadv.ado8366
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11451552/
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NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs

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1. scibot 08 Oct 2024
  
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  RRID:AB_11150592
  
  DOI: 10.1158/2326-6066.CIR-24-0061
  
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aacrjournals.org/cancerimmunolres/article/12/10/1421/748722/NK-Receptor-Signaling-Lowers-TCR-Activation
Sep 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Induction of immortal-like and functional CAR T cells by defined factors

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1. scibot 27 Sep 2024
  
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  DOI: 10.1084/jem.20232368
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10965394/
Jul 2024
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IRF4 impedes human CD8 T cell function and promotes cell proliferation and PD-1 expression

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1. scibot 23 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114401
  
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sciencedirect.com/science/article/pii/S2211124724007290
Apr 2024
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Protocol for isolation of tumor-derived extracellular vesicles and functional studies on human T cell subsets

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1. scibot 19 Apr 2024
  
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  DOI: 10.1016/j.xpro.2024.103011
  
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sciencedirect.com/science/article/pii/S266616672400176X
Mar 2024
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The guanine nucleotide exchange factor Rin-like controls Tfh cell differentiation via CD28 signaling

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1. scibot 16 Mar 2024
  
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  DOI: 10.1084/jem.20221466
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10499045/
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Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer

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1. scibot 15 Mar 2024
  
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  DOI: 10.1016/j.cell.2024.02.022
  
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cell.com/cell/fulltext/S0092-8674(24)00224-1
Feb 2024
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Suppression of the METTL3-m6A-integrin β1 axis by extracellular acidification impairs T cell infiltration and antitumor activity

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1. scibot 21 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113796
  
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FPFT-2216, a novel anti-lymphoma compound, induces simultaneous degradation of IKZF1/3 and CK1α to activate p53 and inhibit NF-κB signaling

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1. scibot 08 Feb 2024
  
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  DOI: 10.1158/2767-9764.CRC-23-0264
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10846380/
Jan 2024
52.53.155.43 52.53.155.43

Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors

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1. scibot 10 Jan 2024
  
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  DOI: 10.1126/sciimmunol.abq2424
  
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52.53.155.43/93ebbe5a83b6a28b0d01edad42fa81f437079176/sciimmunol.abq2424_sm-html.html
Dec 2023
www.science.org www.science.org

T cell responses to SARS-CoV-2 infection and vaccination are elevated in B cell deficiency and reduce risk of severe COVID-19

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1. scibot 02 Dec 2023
  
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  DOI: 10.1126/scitranslmed.adh4529
  
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science.org/doi/10.1126/scitranslmed.adh4529
Nov 2023
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Induction of immortal-like and functional CAR-T cells by defined factors

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1. scibot 17 Nov 2023
  
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  RRID:AB_11150592
  
  DOI: 10.1101/2023.11.06.565785
  
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biorxiv.org/content/10.1101/2023.11.06.565785v1
Aug 2023
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Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects

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1. scibot 16 Aug 2023
  
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  DOI: 10.1016/j.xcrm.2023.101157
  
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sciencedirect.com/science/article/pii/S2666379123003105
Jul 2023
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Extracellular vesicles in COVID-19 convalescence can regulate T cell metabolism and function

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1. scibot 15 Jul 2023
  
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  DOI: 10.1016/j.isci.2023.107280
  
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sciencedirect.com/science/article/pii/S2589004223013573
May 2023
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Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity

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1. scibot 25 May 2023
  
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  DOI: 10.1016/j.cmet.2023.05.001
  
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sciencedirect.com/science/article/pii/S155041312300178X
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cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity

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1. scibot 11 May 2023
  
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  DOI: 10.1016/j.immuni.2023.04.005
  
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sciencedirect.com/science/article/pii/S1074761323001735
Apr 2023
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CD8+ T cells promote HIV latency by remodeling CD4+ T cell metabolism to enhance their survival, quiescence, and stemness

1
1. scibot 08 Apr 2023
  
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  DOI: 10.1016/j.immuni.2023.03.010
  
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sciencedirect.com/science/article/pii/S1074761323001309
www.nature.com www.nature.com

Membrane phase separation drives responsive assembly of receptor signaling domains

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1. scibot 05 Apr 2023
  
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  DOI: 10.1038/s41589-023-01268-8
  
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nature.com/articles/s41589-023-01268-8
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses

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1. scibot 04 Apr 2023
  
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  RRID:AB_11150592
  
  DOI: 10.7554/eLife.81577
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10065793/
Mar 2023
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Galectin-3 expression in donor T cells reduces GvHD severity and lethality after allogeneic hematopoietic cell transplantation

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1. scibot 16 Mar 2023
  
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  DOI: 10.1016/j.celrep.2023.112250
  
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sciencedirect.com/science/article/pii/S2211124723002619
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Cytotoxic CD161−CD8+ TEMRA cells contribute to the pathogenesis of systemic lupus erythematosus

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1. scibot 09 Mar 2023
  
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  DOI: 10.1016/j.ebiom.2023.104507
  
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sciencedirect.com/science/article/pii/S2352396423000725
Jan 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Development of CAR-T cells specifically targeting cancer stem cell antigen DNAJB8 against solid tumours

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1. scibot 12 Jan 2023
  
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  DOI: 10.1038/s41416-022-02100-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9977765/
Nov 2022
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Protocol for evaluating antitumor activity of KIR3DL3 blockade in an NK cell-based xenogeneic lung tumor model

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1. scibot 05 Nov 2022
  
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  RRID:AB_11150592
  
  DOI: 10.1016/j.xpro.2022.101818
  
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sciencedirect.com/science/article/pii/S2666166722006980
Oct 2022
www.sciencedirect.com www.sciencedirect.com

High-throughput T cell receptor engineering by functional screening identifies candidates with enhanced potency and specificity

1
1. scibot 05 Oct 2022
  
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  RRID:AB_11150592
  
  DOI: 10.1016/j.immuni.2022.09.004
  
  Resource: (BioLegend Cat# 317326, RRID:AB_11150592)
  
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sciencedirect.com/science/article/pii/S1074761322004988
Jun 2022
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TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8+ memory T cells

1
1. scibot 29 Jun 2022
  
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  RRID:AB_11150592
  
  DOI: 10.1016/j.molcel.2022.06.002
  
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sciencedirect.com/science/article/pii/S109727652200538X
www.frontiersin.org www.frontiersin.org

Human CD4+CD25+CD226- Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4+CD25+CD127lo/- Tregs for Adoptive Cell Therapy

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1. scibot 11 Jun 2022
  
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  RRID:AB_11150592
  
  DOI: 10.3389/fimmu.2022.873560
  
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frontiersin.org/article/10.3389/fimmu.2022.873560/full
Apr 2022
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HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells

1
1. scibot 14 Apr 2022
  
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  RRID:AB_11150592
  
  DOI: 10.1016/j.celrep.2022.110650
  
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sciencedirect.com/science/article/pii/S2211124722004028
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Transcriptomic profiles of neoantigen-reactive T cells in human gastrointestinal cancers

1
1. scibot 13 Apr 2022
  
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  RRID:AB_11150592
  
  DOI: 10.1016/j.ccell.2022.03.005
  
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sciencedirect.com/science/article/pii/S1535610822001209
Mar 2022
www.cell.com www.cell.com

Facile discovery of surrogate cytokine agonists

1
1. scibot 31 Mar 2022
  
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  RRID:AB_11150592
  
  DOI: 10.1016/j.cell.2022.02.025
  
  Resource: (BioLegend Cat# 317326, RRID:AB_11150592)
  
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cell.com/cell/fulltext/S0092-8674(22)00247-1
Nov 2021
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The cell-surface 5′-nucleotidase CD73 defines a functional T memory cell subset that declines with age

1
1. scibot 10 Nov 2021
  
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  RRID:AB_11150592
  
  DOI: 10.1016/j.celrep.2021.109981
  
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sciencedirect.com/science/article/pii/S2211124721014601
Sep 2021
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Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia

1
1. scibot 08 Sep 2021
  
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  RRID:AB_11150592
  
  DOI: 10.1016/j.immuni.2021.08.007
  
  Resource: (BioLegend Cat# 317326, RRID:AB_11150592)
  
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sciencedirect.com/science/article/pii/S107476132100337X
May 2021
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HIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responses

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1. scibot 07 May 2021
  
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  RRID:_AB_11150592
  
  DOI: 10.1016/j.chom.2021.01.006
  
  Resource: (BioLegend Cat# 317326, RRID:AB_11150592)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_11150592
  
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  RRIDCUR:Unresolved RRID:AB_11150592 RRIDCUR:SyntaxError
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sciencedirect.com/science/article/pii/S1931312821000366
Apr 2021
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HIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responses

1
1. scibot 29 Apr 2021
  
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  RRID:AB_11150592
  
  DOI: 10.1016/j.chom.2021.01.006
  
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sciencedirect.com/science/article/pii/S1931312821000366
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Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells

1
1. scibot 24 Apr 2021
  
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  RRID:AB_11150592
  
  DOI: 10.1016/j.cell.2021.01.018
  
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sciencedirect.com/science/article/pii/S0092867421000611
Feb 2021
www.cell.com www.cell.com

Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies

1
1. scibot 27 Feb 2021
  
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  RRID:AB_11150592
  
  DOI: 10.1016/j.ccell.2020.08.001
  
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cell.com/cancer-cell/abstract/S1535-6108(20)30375-5
Dec 2020
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Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis

1
1. scibot 07 Dec 2020
  
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  RRID:AB_11150592
  
  DOI: 10.1016/j.immuni.2020.11.001
  
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sciencedirect.com/science/article/pii/S1074761320304660
Oct 2020
www.cell.com www.cell.com

Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19

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1. scibot 31 Oct 2020
  
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  RRID:AB_11150592
  
  DOI: 10.1016/j.cell.2020.08.017
  
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  Curator: @evieth
  
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  RRIDCUR:Validated RRID:AB_11150592
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cell.com/cell/abstract/S0092-8674(20)31008-4
Sep 2020
onlinelibrary.wiley.com onlinelibrary.wiley.com

Heparin affects the induction of regulatory T cells independent of anticoagulant activity and suppresses the allogeneic immune responses

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1. scibot 08 Sep 2020
  
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  RRID:AB_11150592
  
  DOI: 10.1111/cei.13480
  
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onlinelibrary.wiley.com/doi/10.1111/cei.13480