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    Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication
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  3. Mar 2024
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
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    INX-315, a selective CDK2 inhibitor, induces cell cycle arrest and senescence in solid tumors
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  6. Feb 2024
  7. 52.53.155.43 52.53.155.43
    cd-23-0954-html.html
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    Proteogenomic characterization of primary colorectal cancer and metastatic progression identifies proteome-based subtypes and signatures
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    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
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  10. Dec 2023
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    Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives
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  12. Nov 2023
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    Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest
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    sciencedirect.com/science/article/abs/pii/S2451945623003720
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    Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest
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    cell.com/molecular-cell/fulltext/S1097-2765(23)00857-2
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    Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition
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    p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP
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    Antitumor effects of PRMT5 inhibition in sarcomas
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  18. aacrjournals.org aacrjournals.org
    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
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    aacrjournals.org/cancerdiscovery/article/13/11/2412/729848/MRTX1719-Is-an-MTA-Cooperative-PRMT5-Inhibitor
  19. Oct 2023
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    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
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    Typhoid toxin hijacks Wnt5a to establish host senescence and Salmonella infection
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  22. Aug 2023
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    FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth
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  24. Jul 2023
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    British J Pharmacology - 2023 - Cheng - Pharmacological targeting of Axin2 suppresses cell growth and metastasis in-html.html
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    52.53.155.43/51180316abfac9593501c4c683749a3ad6cad477/British J Pharmacology - 2023 - Cheng - Pharmacological targeting of Axin2 suppresses cell growth and metastasis in-html.html
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    Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer
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  27. Jun 2023
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    Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity
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  29. May 2023
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    Protocol to determine the subcellular localization of protein interactions in murine keratinocytes
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  31. Mar 2023
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    Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction
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    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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  34. Jan 2023
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    Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling
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    The human placenta shapes the phenotype of decidual macrophages
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  37. Dec 2022
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    p53/p21 pathway activation contributes to the ependymal fate decision downstream of GemC1
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  39. Oct 2022
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    Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein
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  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human cutaneous interfollicular melanocytes differentiate temporarily under genotoxic stress
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  42. Sep 2022
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    Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors
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  44. Aug 2022
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    Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression
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    sciencedirect.com/science/article/pii/S1097276522007109
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    Alterations of serine racemase expression determine proliferation and differentiation of neuroblastoma cells
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      DOI: 10.1096/fj.202200394RRR

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202200394RRR
  47. May 2022
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    Stromal cell senescence contributes to impaired endometrial decidualization and defective interaction with trophoblast cells
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    academic.oup.com/humrep/advance-article/doi/10.1093/humrep/deac112/6590738
  49. Apr 2022
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    BPS Publications
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      DOI: 10.1111/bph.15763

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15763
  51. Mar 2022
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    The KRAS-G12D mutation induces Metabolic Vulnerability in B-cell Acute Lymphoblastic Leukemia
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    sciencedirect.com/science/article/pii/S2589004222001511
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    CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities
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    sciencedirect.com/science/article/pii/S2211124722001759
  54. Jan 2022
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
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      DOI: 10.1038/s41408-021-00603-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC8752621/
  56. Dec 2021
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2
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      DOI: 10.7554/eLife.70691

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    ncbi.nlm.nih.gov/pmc/articles/PMC8670743/
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    Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways
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      DOI: 10.3389/fcell.2021.773048

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    ncbi.nlm.nih.gov/pmc/articles/PMC8652204/
  59. Nov 2021
  60. 52.53.155.43 52.53.155.43
    ajpheart.00125.2021-html.html
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  61. Oct 2021
  62. mct.aacrjournals.org mct.aacrjournals.org
    Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma
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  63. Sep 2021
  64. www.sciencedirect.com www.sciencedirect.com
    Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor
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    Rack1 is essential for corticogenesis by preventing p21-dependent senescence in neural stem cells
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  66. Aug 2021
  67. www.nature.com www.nature.com
    Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system
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      DOI: 10.1038/s41467-021-24821-2

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  68. www.sciencedirect.com www.sciencedirect.com
    Molecular control of cell density-mediated exit to quiescence
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  69. europepmc.org europepmc.org
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  71. Jul 2021
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    RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway
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      P-Rb

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    MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer
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    An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors
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    CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells
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  76. May 2021
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    Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK
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    Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer
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    Transient Primary Cilia Mediate Robust Hedgehog Pathway-Dependent Cell Cycle Control
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    Transient phases of OXPHOS inhibitor resistance reveal underlying metabolic heterogeneity in single cells
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    Deciphering the signaling network of breast cancer improves drug sensitivity prediction
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  82. Apr 2021
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    Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells
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    Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG
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    Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors
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      DOI: 10.1016/j.celrep.2021.108944

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  86. Dec 2020
  87. www.cell.com www.cell.com
    Neuropeptides Modulate Local Astrocytes to Regulate Adult Hippocampal Neural Stem Cells
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  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen identifies noncanonical NF-κB signaling as a regulator of density-dependent proliferation
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  89. Sep 2020
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single cell analysis reveals multiple requirements for zinc in the mammalian cell cycle
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      RRID:AB_11178658

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    Disentangling Pro-mitotic Signaling during Cell Cycle Progression using Time-Resolved Single-Cell Imaging
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      RRID:AB_11178658

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    GATA-4, a potential novel therapeutic target for high-grade meningioma, regulates miR-497, a potential novel circulating biomarker for high-grade meningioma
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      anti-pRb

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  93. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    RABL6A is an essential driver of MPNSTs that negatively regulates the RB1 pathway and sensitizes tumor cells to CDK4/6 inhibitors
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      p-RB1-S807/811

      DOI: 10.1158/1078-0432.CCR-19-2706

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  94. Jan 2020
  95. www.sciencedirect.com www.sciencedirect.com
    Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements
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      RRID:AB_11178658

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    Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells
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    Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1
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    Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy
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      DOI: 10.1016/j.cell.2019.05.041

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    MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer
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      RRID:AB_11178658

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  105. Nov 2018
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    Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib
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