103 Matching Annotations
  1. Jun 2024
  2. link.springer.com link.springer.com
    ATG16L1 induces the formation of phagophore-like membrane cups
    1
    1. scibot 06 Jun 2024
      RRID:AB_11178668

      DOI: 10.1038/s41594-024-01300-y

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    link.springer.com/article/10.1038/s41594-024-01300-y
  3. May 2024
  4. www.sciencedirect.com www.sciencedirect.com
    TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery
    1
    1. scibot 30 May 2024
      RRID:AB_11178668

      DOI: 10.1016/j.celrep.2024.114294

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    sciencedirect.com/science/article/pii/S2211124724006223
  5. www.sciencedirect.com www.sciencedirect.com
    Leucyl-tRNA synthetase contributes to muscle weakness through mTORC1 activation and autophagy suppression in a mouse model of Duchenne Muscular Dystrophy
    1
    1. scibot 17 May 2024
      RRID:AB_11178668

      DOI: 10.1016/j.ajpath.2024.04.006

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    sciencedirect.com/science/article/pii/S0002944024001743
  6. Apr 2024
  7. www.sciencedirect.com www.sciencedirect.com
    An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade
    1
    1. scibot 02 Apr 2024
      Cell Signaling Technology8054S

      DOI: 10.1016/j.celrep.2024.114020

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    sciencedirect.com/science/article/pii/S2211124724003486
  8. Feb 2024
  9. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 16 Feb 2024
      RRID:AB_11178668

      DOI: 10.1111/bph.16283

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16283
  10. 52.53.155.43 52.53.155.43
    mTOR regulates mineralocorticoid receptor transcriptional activity by ULK1- dependent and independent mechanisms
    1
    1. scibot 15 Feb 2024
      AB_11178668

      DOI: 10.1210/endocr/bqae015

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    52.53.155.43/6951e0010ae4c14df11b3315f954e81c6a9c88a4/bqae015-html.html
  11. www.sciencedirect.com www.sciencedirect.com
    Proline restores mitochondrial function and reverses aging hallmarks in senescent cells
    1
    1. scibot 14 Feb 2024
      RRID:AB_11178668

      DOI: 10.1016/j.celrep.2024.113738

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    sciencedirect.com/science/article/pii/S2211124724000664
  12. Jan 2024
  13. www.sciencedirect.com www.sciencedirect.com
    Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression
    1
    1. scibot 11 Jan 2024
      RRID:AB_11178668

      DOI: 10.1016/j.celrep.2023.113575

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    sciencedirect.com/science/article/pii/S2211124723015875
  14. Dec 2023
  15. www.sciencedirect.com www.sciencedirect.com
    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
    1
    1. scibot 16 Dec 2023
      RRID:AB_11178668

      DOI: 10.1016/j.molcel.2023.11.023

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    sciencedirect.com/science/article/pii/S1097276523009681
  16. www.sciencedirect.com www.sciencedirect.com
    Nutrient-regulated control of lysosome function by signaling lipid conversion
    1
    1. scibot 02 Dec 2023
      RRID:AB_11178668

      DOI: 10.1016/j.cell.2023.09.027

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    sciencedirect.com/science/article/pii/S0092867423010814
  17. Nov 2023
  18. www.sciencedirect.com www.sciencedirect.com
    Macrophage AMPK β1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice
    1
    1. scibot 29 Nov 2023
      RRID:AB_11178668

      DOI: 10.1016/j.isci.2023.108269

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    sciencedirect.com/science/article/pii/S2589004223023465
  19. www.sciencedirect.com www.sciencedirect.com
    An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant
    1
    1. scibot 28 Nov 2023
      RRID:AB_11178668

      DOI: 10.1016/j.celrep.2023.113484

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    sciencedirect.com/science/article/pii/S2211124723014961
  20. Oct 2023
  21. 52.53.155.43 52.53.155.43
    s41586-023-06657-6_reference-html.html
    1
    1. scibot 06 Oct 2023
      RRID:AB_11178668

      DOI: 10.1038/s41586-023-06657-6

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    52.53.155.43/0f3eb7b8d15ef36be47b7c18ecdf1d19ad34ca1a/s41586-023-06657-6_reference-html.html
  22. Sep 2023
  23. www.biorxiv.org www.biorxiv.org
    Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD
    1
    1. scibot 30 Sep 2023
      RRID:AB_11178668

      DOI: 10.1101/2023.09.25.559255

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    biorxiv.org/content/10.1101/2023.09.25.559255v1
  24. Aug 2023
  25. 52.53.155.43 52.53.155.43
    PIIS2589004223017029-html.html
    1
    1. scibot 18 Aug 2023
      RRID:AB_11178668

      DOI: 10.1016/j.isci.2023.107625

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    52.53.155.43/258d74bd1c79cf4d725c254c0f9188b69c056c90/PIIS2589004223017029-html.html
  26. Jul 2023
  27. www.sciencedirect.com www.sciencedirect.com
    Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machinery
    1
    1. scibot 15 Jul 2023
      RRID:AB_11178668

      DOI: 10.1016/j.celrep.2023.112807

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    sciencedirect.com/science/article/pii/S2211124723008185
  28. Jun 2023
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Restored autophagy is protective against PAK3-induced cardiac dysfunction
    1
    1. scibot 17 Jun 2023
      RRID:AB_11178668

      DOI: 10.1016/j.isci.2023.106970

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    ncbi.nlm.nih.gov/pmc/articles/PMC10265534/
  30. www.embopress.org www.embopress.org
    Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response
    1
    1. scibot 15 Jun 2023
      RRID:AB_11178668

      DOI: 10.15252/embj.2022113349

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    embopress.org/doi/10.15252/embj.2022113349
  31. aacrjournals.org aacrjournals.org
    Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer
    1
    1. scibot 03 Jun 2023
      RRID:AB_11178668

      DOI: 10.1158/0008-5472.CAN-22-2525

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    aacrjournals.org/cancerres/article/83/8/1280/725099/Dysregulation-of-Mitochondrial-Translation-Caused
  32. aacrjournals.org aacrjournals.org
    Targeting CHAF1B enhances Interferon activity against Myeloproliferative Neoplasm cells
    1
    1. scibot 02 Jun 2023
      RRID:AB_11178668

      DOI: 10.1158/2767-9764.CRC-23-0010

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    aacrjournals.org/cancerrescommun/article/3/5/943/727012/Targeting-CHAF1B-Enhances-IFN-Activity-against
  33. May 2023
  34. www.sciencedirect.com www.sciencedirect.com
    Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
    1
    1. scibot 27 May 2023
      RRID:AB_11178668

      DOI: 10.1016/j.ccell.2023.04.016

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    sciencedirect.com/science/article/pii/S1535610823001423
  35. www.sciencedirect.com www.sciencedirect.com
    Metamorphic proteins at the basis of human autophagy initiation and lipid transfer
    1
    1. scibot 20 May 2023
      RRID:AB_11178668

      DOI: 10.1016/j.molcel.2023.04.026

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    sciencedirect.com/science/article/pii/S1097276523003210
  36. www.sciencedirect.com www.sciencedirect.com
    Unconventional initiation of PINK1/Parkin mitophagy by Optineurin
    1
    1. scibot 19 May 2023
      RRID:AB_11178668

      DOI: 10.1016/j.molcel.2023.04.021

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    sciencedirect.com/science/article/pii/S1097276523002927
  37. Apr 2023
  38. europepmc.org europepmc.org
    A Novel Method for Visualizing In-Vivo Rates of Protein Degradation Provides Insight into how TRIM28 Regulates Muscle Size
    1
    1. scibot 20 Apr 2023
      RRID:AB_11178668

      DOI: 10.1016/j.isci.2023.106526

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    europepmc.org/article/pmc/pmc10105291
  39. www.sciencedirect.com www.sciencedirect.com
    CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth
    1
    1. scibot 06 Apr 2023
      RRID:AB_11178668

      DOI: 10.1016/j.celrep.2023.112316

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    sciencedirect.com/science/article/pii/S2211124723003273
  40. Feb 2023
  41. www.sciencedirect.com www.sciencedirect.com
    An affinity-directed phosphatase, AdPhosphatase, system for targeted protein dephosphorylation
    1
    1. scibot 02 Feb 2023
      RRID:AB_11178668

      DOI: 10.1016/j.chembiol.2023.01.003

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    sciencedirect.com/science/article/pii/S2451945623000260
  42. Dec 2022
  43. www.sciencedirect.com www.sciencedirect.com
    Lysine crotonylation regulates leucine-deprivation-induced autophagy by a 14-3-3ε-PPM1B axis
    1
    1. scibot 24 Dec 2022
      RRID:AB_11178668

      DOI: 10.1016/j.celrep.2022.111850

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    sciencedirect.com/science/article/pii/S2211124722017429
  44. www.sciencedirect.com www.sciencedirect.com
    Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis
    1
    1. scibot 24 Dec 2022
      RRID:AB_11178668

      DOI: 10.1016/j.celrep.2022.111834

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    sciencedirect.com/science/article/pii/S2211124722017260
  45. www.sciencedirect.com www.sciencedirect.com
    USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction
    1
    1. scibot 08 Dec 2022
      RRID:AB_11178668

      DOI: 10.1016/j.celrep.2022.111653

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    sciencedirect.com/science/article/pii/S2211124722015248
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The κ-opioid receptor-induced autophagy is implicated in stress-driven synaptic alterations
    1
    1. scibot 02 Dec 2022
      RRID:AB_11178668

      DOI: 10.3389/fnmol.2022.1039135

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    ncbi.nlm.nih.gov/pmc/articles/PMC9709411/
  47. Nov 2022
  48. www.sciencedirect.com www.sciencedirect.com
    AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity
    1
    1. scibot 17 Nov 2022
      RRID:AB_11178668

      DOI: 10.1016/j.molcel.2022.10.026

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    sciencedirect.com/science/article/pii/S1097276522010541
  49. Oct 2022
  50. www.nature.com www.nature.com
    Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D
    1
    1. scibot 16 Oct 2022
      RRID:AB_11178668

      DOI: 10.1038/s41467-022-33749-0

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    nature.com/articles/s41467-022-33749-0
  51. www.sciencedirect.com www.sciencedirect.com
    Estrogen receptor β activation inhibits colitis by promoting NLRP6-mediated autophagy
    1
    1. scibot 13 Oct 2022
      RRID:AB_11178668

      DOI: 10.1016/j.celrep.2022.111454

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    sciencedirect.com/science/article/pii/S2211124722012955
  52. Aug 2022
  53. 52.53.155.43 52.53.155.43
    can-22-0121-html.html
    1
    1. scibot 27 Aug 2022
      RRID:AB_11178668

      DOI: 10.1158/0008-5472.can-22-0121

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    52.53.155.43/e39c6cee634d068d1d0118b99a8c3dfd324cbcce/can-22-0121-html.html
  54. www.sciencedirect.com www.sciencedirect.com
    Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia
    1
    1. scibot 27 Aug 2022
      RRID:AB_11178668

      DOI: 10.1016/j.heliyon.2022.e10371

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    sciencedirect.com/science/article/pii/S2405844022016590
  55. Jul 2022
  56. www.sciencedirect.com www.sciencedirect.com
    Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy
    1
    1. scibot 27 Jul 2022
      RRID:AB_11178668

      DOI: 10.1016/j.celrep.2022.111124

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    sciencedirect.com/science/article/pii/S2211124722009305
  57. academic.oup.com academic.oup.com
    T cells mediate kidney tubular injury via impaired PDHA1 and Autophagy in type 1 diabetes
    1
    1. scibot 14 Jul 2022
      RRID:AB_11178668

      DOI: 10.1210/clinem/dgac378

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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac378/6613175
  58. Jun 2022
  59. academic.oup.com academic.oup.com
    Deficiency of C1QL1 reduced murine ovarian follicle reserve through intraovarian and endocrine control
    1
    1. scibot 02 Jun 2022
      AB_11178668

      DOI: 10.1210/endocr/bqac048

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    academic.oup.com/endo/article/163/6/bqac048/6569208
  60. Apr 2022
  61. www.sciencedirect.com www.sciencedirect.com
    Cholesterol suppresses GOLM1-dependent selective autophagy of RTKs in hepatocellular carcinoma
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    1. scibot 21 Apr 2022
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    DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron  depletion
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  63. Mar 2022
  64. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    DRAM-4 and DRAM-5 are compensatory regulators of autophagy and cell survival in nutrient-deprived conditions
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  65. Feb 2022
  66. journals.plos.org journals.plos.org
    A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring
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  67. Jan 2022
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    MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells
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    Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism
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  70. Sep 2021
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    PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis
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    Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
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  73. Aug 2021
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  78. Jul 2021
  79. stemcellsjournals.onlinelibrary.wiley.com stemcellsjournals.onlinelibrary.wiley.com
    Mitochondrial phosphoenolpyruvate carboxykinase (PCK2) regulates osteogenic differentiation by modulating AMPK/ULK1‐dependent autophagy
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  80. www.sciencedirect.com www.sciencedirect.com
    Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins
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      Rabbit monoclonal Anti-ULK1

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  83. www.nature.com www.nature.com
    FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates
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    SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice
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  85. Jun 2021
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    High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol
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  87. May 2021
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    Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities
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    ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system
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    Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity
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  93. Apr 2021
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    Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis
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  95. Mar 2021
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    Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling
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    Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis
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    Lifelong Ulk1-Mediated Autophagy Deficiency in Muscle Induces Mitochondrial Dysfunction and Contractile Weakness
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    Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy
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  100. Feb 2021
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    Metabolism, Oxidative Stress and Cell Signaling: Mitochondrial-specific autophagy linked to mitochondrial dysfunction following traumatic freeze injury in mice
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  102. Jan 2021
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    ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation
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  104. Dec 2020
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    Role of VAMP7-Dependent Secretion of Reticulon 3 in Neurite Growth
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  106. Oct 2020
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    Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis
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  108. Sep 2020
  109. www.cell.com www.cell.com
    A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation
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    AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
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  112. onlinelibrary.wiley.com onlinelibrary.wiley.com
    H63D variant of the homeostatic iron regulator (HFE) gene alters α‐synuclein expression, aggregation, and toxicity
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    The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death
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    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
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      ULK1

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  115. Jan 2020
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    RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres
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  117. www.nature.com www.nature.com
    ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12–ATG5-ATG16L1 complex assembly and autophagy
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  118. elifesciences.org elifesciences.org
    Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons
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  119. www.sciencedirect.com www.sciencedirect.com
    The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1
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  120. www.mdpi.com www.mdpi.com
    Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1
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  121. www.sciencedirect.com www.sciencedirect.com
    Lysosome Positioning Influences mTORC2 and AKT Signaling
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  122. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
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  123. www.sciencedirect.com www.sciencedirect.com
    Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy
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    Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models
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  128. Nov 2018
  129. www.sciencedirect.com www.sciencedirect.com
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    Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma
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  132. www.sciencedirect.com www.sciencedirect.com
    Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1
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    The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis
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  134. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  135. www.sciencedirect.com www.sciencedirect.com
    CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis
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  136. Nov 2017
  137. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Tumor necrosis factor receptor‐associated factor 6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress
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      Curator: @patriciaelyse_

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  138. www.sciencedirect.com www.sciencedirect.com
    The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation
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  139. www.sciencedirect.com www.sciencedirect.com
    Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy
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      AB_11178668

      Curator: @chewbeccax

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  140. www.sciencedirect.com www.sciencedirect.com
    DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy
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  141. elifesciences.org elifesciences.org
    Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator
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  142. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding
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