131 Matching Annotations
  1. Aug 2025
  2. 52.53.155.43 52.53.155.43
    A lipid transfer-dependent feedback loop activates ATG9A compartments in autophagy initiation
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  3. Jul 2025
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    Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling
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    science.org/doi/10.1126/science.adm9805
  6. Jun 2025
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    EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
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    sciencedirect.com/science/article/pii/S2589004225010119
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    The Effect of FPR2 on the Regulation of Trophoblast Autophagy via the PI3K/AKT/mTOR Signaling Pathway in Preeclampsia
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202402938RR
  10. May 2025
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    Inhibition of histone deacetylase 6 activity mitigates neurological impairment and post-hemorrhagic hydrocephalus after intraventricular hemorrhage by modulating pyroptosis and autophagy pathways
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    link.springer.com/article/10.1186/s12987-025-00658-5
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    m6A alters ribosome dynamics to initiate mRNA degradation
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    cell.com/cell/abstract/S0092-8674(25)00455-6
  13. Mar 2025
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    Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression
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  15. Feb 2025
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    Yeast TIA1 coordinates with Npl3 to promote ATG1 translation during starvation
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    ERK inhibits osteoclast differentiation in RAW 264.7 cells through the osteoprotegerin-mediated autophagy
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  20. Jan 2025
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    Ca2+/calmodulin-dependent protein kinase II β decodes ER Ca2+ transients to trigger autophagosome formation
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  22. Dec 2024
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    DEP-1 is a brain insulin receptor phosphatase that prevents the simultaneous activation of counteracting metabolic pathways
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  24. Nov 2024
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    Opposing roles for AMPK in regulating distinct mitophagy pathways
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  26. Oct 2024
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux
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    ncbi.nlm.nih.gov/pmc/articles/PMC11426993/
  28. Sep 2024
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    The ULK1 effector BAG2 regulates autophagy initiation by modulating AMBRA1 localization
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    Activating mTOR mutations are detrimental in nutrient-poor conditions
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    aacrjournals.org/cancerres/article/82/18/3263/709030/Activating-mTOR-Mutations-Are-Detrimental-in
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    Starvation-induced phosphorylation activates gasdermin A to initiate pyroptosis
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  32. Aug 2024
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    Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions
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    Adiponectin inhibits the progression of obesity-associated papillary thyroid carcinoma through autophagy
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    M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival
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    RIPK1 Promotes Energy Sensing by the mTORC1 Pathway
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  37. Jul 2024
  38. www.sciencedirect.com www.sciencedirect.com
    Cell-specific Nav1.6 knockdown reduced astrocyte-derived Aβ by reverse Na+-Ca2+ transporter-mediated autophagy in alzheimer-like mice
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    Pro-survival signaling regulates lipophagy essential for multiple myeloma resistance to stress-induced death
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    Increased regional activity of a pro-autophagy pathway in schizophrenia as a contributor to sex differences in the disease pathology
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    Novel autophagy inducers by accelerating lysosomal clustering against Parkinson’s disease
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  42. Jun 2024
  43. link.springer.com link.springer.com
    ATG16L1 induces the formation of phagophore-like membrane cups
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    link.springer.com/article/10.1038/s41594-024-01300-y
  44. May 2024
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    TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery
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    Leucyl-tRNA synthetase contributes to muscle weakness through mTORC1 activation and autophagy suppression in a mouse model of Duchenne Muscular Dystrophy
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  47. Apr 2024
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    An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade
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  49. Feb 2024
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  51. 52.53.155.43 52.53.155.43
    mTOR regulates mineralocorticoid receptor transcriptional activity by ULK1- dependent and independent mechanisms
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    Proline restores mitochondrial function and reverses aging hallmarks in senescent cells
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  53. Jan 2024
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    Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression
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  55. Dec 2023
  56. www.sciencedirect.com www.sciencedirect.com
    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
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    Nutrient-regulated control of lysosome function by signaling lipid conversion
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  58. Nov 2023
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    Macrophage AMPK β1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice
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    An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant
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  61. Oct 2023
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  63. Sep 2023
  64. www.biorxiv.org www.biorxiv.org
    Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD
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    biorxiv.org/content/10.1101/2023.09.25.559255v1
  65. Aug 2023
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  67. Jul 2023
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    Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machinery
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  69. Jun 2023
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Restored autophagy is protective against PAK3-induced cardiac dysfunction
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    ncbi.nlm.nih.gov/pmc/articles/PMC10265534/
  71. www.embopress.org www.embopress.org
    Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response
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    embopress.org/doi/10.15252/embj.2022113349
  72. aacrjournals.org aacrjournals.org
    Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer
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    aacrjournals.org/cancerres/article/83/8/1280/725099/Dysregulation-of-Mitochondrial-Translation-Caused
  73. aacrjournals.org aacrjournals.org
    Targeting CHAF1B enhances Interferon activity against Myeloproliferative Neoplasm cells
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    aacrjournals.org/cancerrescommun/article/3/5/943/727012/Targeting-CHAF1B-Enhances-IFN-Activity-against
  74. May 2023
  75. www.sciencedirect.com www.sciencedirect.com
    Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
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    Metamorphic proteins at the basis of human autophagy initiation and lipid transfer
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    Unconventional initiation of PINK1/Parkin mitophagy by Optineurin
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  78. Apr 2023
  79. europepmc.org europepmc.org
    A Novel Method for Visualizing In-Vivo Rates of Protein Degradation Provides Insight into how TRIM28 Regulates Muscle Size
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    CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth
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  81. Feb 2023
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    An affinity-directed phosphatase, AdPhosphatase, system for targeted protein dephosphorylation
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  83. Dec 2022
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    Lysine crotonylation regulates leucine-deprivation-induced autophagy by a 14-3-3ε-PPM1B axis
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    Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis
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    USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction
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  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The κ-opioid receptor-induced autophagy is implicated in stress-driven synaptic alterations
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    ncbi.nlm.nih.gov/pmc/articles/PMC9709411/
  88. Nov 2022
  89. www.sciencedirect.com www.sciencedirect.com
    AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity
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  90. Oct 2022
  91. www.nature.com www.nature.com
    Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D
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    Estrogen receptor β activation inhibits colitis by promoting NLRP6-mediated autophagy
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  93. Aug 2022
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    Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia
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  96. Jul 2022
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    Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy
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  98. academic.oup.com academic.oup.com
    T cells mediate kidney tubular injury via impaired PDHA1 and Autophagy in type 1 diabetes
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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac378/6613175
  99. Jun 2022
  100. academic.oup.com academic.oup.com
    Deficiency of C1QL1 reduced murine ovarian follicle reserve through intraovarian and endocrine control
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    academic.oup.com/endo/article/163/6/bqac048/6569208
  101. Apr 2022
  102. www.sciencedirect.com www.sciencedirect.com
    Cholesterol suppresses GOLM1-dependent selective autophagy of RTKs in hepatocellular carcinoma
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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron  depletion
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    ncbi.nlm.nih.gov/pmc/articles/PMC9108618/
  104. Mar 2022
  105. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    DRAM-4 and DRAM-5 are compensatory regulators of autophagy and cell survival in nutrient-deprived conditions
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.16365
  106. Feb 2022
  107. journals.plos.org journals.plos.org
    A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring
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  108. Jan 2022
  109. www.sciencedirect.com www.sciencedirect.com
    MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells
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    Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism
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  111. Sep 2021
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    PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis
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    Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
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  114. Aug 2021
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    Protocol to study starvation-induced autophagy in developing rat neurons
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  119. Jul 2021
  120. stemcellsjournals.onlinelibrary.wiley.com stemcellsjournals.onlinelibrary.wiley.com
    Mitochondrial phosphoenolpyruvate carboxykinase (PCK2) regulates osteogenic differentiation by modulating AMPK/ULK1‐dependent autophagy
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    stemcellsjournals.onlinelibrary.wiley.com/doi/10.1002/stem.3091
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    Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins
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  124. www.nature.com www.nature.com
    FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates
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