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Vesicle-mediated mitochondrial clearance presents an actionable metabolic vulnerability in triple-negative breast cancer

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sciencedirect.com:5037/science/article/pii/S2666379125005518
Dec 2025
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Inhibition of glycolysis and stimulation of mitochondrial biogenesis lead to increased ROS levels and cell death in HNF-1ß positive clear cell carcinoma

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pmc.ncbi.nlm.nih.gov/articles/PMC12669797/
Sep 2025
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Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress

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1. scibot 07 Sep 2025
  
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  DOI: 10.1126/sciadv.ady0240
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12383277/
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Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress

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science.org/doi/10.1126/sciadv.ady0240
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Impaired MAPT/tau-secretory lysosomes are linked to cognitive vulnerability in Alzheimer patients

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tandfonline.com/doi/full/10.1080/15548627.2025.2552905
Jul 2025
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RFX2-BNIP3 axis-driven adaptive mitophagy promotes resistance to ACK1-targeted therapy in non-small cell lung cancer

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PINK1 Loss of Function Selectively Alters the Mitochondrial‐Derived Vesicle Pathway

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pmc.ncbi.nlm.nih.gov/articles/PMC12242855/
Jun 2025
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PLK1-mediated PDHA1 phosphorylation drives mitochondrial dysfunction, mitophagy, and cancer progression in Cr(VI)-associated lung cancer

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sciencedirect.com/science/article/pii/S0021925825022562
Apr 2025
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BPS Publications

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  DOI: 10.1111/bph.70022
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70022
Mar 2025
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Screening of patient-derived organoids identifies mitophagy as a cell-intrinsic vulnerability in colorectal cancer during statin treatment

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sciencedirect.com/science/article/pii/S2666379125001120
Dec 2024
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Phosphorylation of Optineurin by protein kinase D regulates Parkin-dependent mitophagy

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1. scibot 14 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111384
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11634986/
Nov 2024
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AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection

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  DOI: 10.1016/j.celrep.2024.115001
  
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sciencedirect.com/science/article/pii/S2211124724013524
Sep 2024
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Resistance Training Diminishes Mitochondrial Adaptations to Subsequent Endurance Training in Healthy Untrained Men

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  DOI: 10.1113/JP284822
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11062412/
Feb 2024
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Trichinella spiralis inhibits myoblast differentiation by targeting SQSTM1/p62 with a secreted E3 ubiquitin ligase

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sciencedirect.com/science/article/pii/S2589004224003237
Jan 2024
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Interaction of PINK1 with nucleotides and kinetin

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  DOI: 10.1126/sciadv.adj7408
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10798554/
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Maintaining Toll signaling in Drosophila brain is required to sustain autophagy for dopamine neuron survival

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  DOI: 10.1016/j.isci.2024.108795
  
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sciencedirect.com/science/article/pii/S2589004224000166
Oct 2023
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Sex Differences in the Skeletal Muscle Response to a High Fat, High Sucrose Diet in Rats

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1. scibot 27 Oct 2023
  
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  DOI: 10.3390/nu15204438
  
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mdpi.com/2072-6643/15/20/4438
Aug 2023
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E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response

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1. scibot 18 Aug 2023
  
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  DOI: 10.1016/j.molcel.2023.07.021
  
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sciencedirect.com/science/article/pii/S1097276523005634
Jun 2023
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Targeting extracellular CIRP with an X-aptamer shows therapeutic potential in acute pancreatitis

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sciencedirect.com/science/article/pii/S2589004223011203
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A mitochondrial iron-responsive pathway regulated by DELE1

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  DOI: 10.1016/j.molcel.2023.05.031
  
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sciencedirect.com/science/article/pii/S1097276523004136
May 2023
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TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria

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  DOI: 10.1016/j.celrep.2023.112454
  
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sciencedirect.com/science/article/pii/S2211124723004655
Apr 2023
www.biorxiv.org www.biorxiv.org

Resistance Training Diminishes Mitochondrial Adaptations to Subsequent Endurance Training

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  DOI: 10.1101/2023.04.06.535919
  
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biorxiv.org/content/10.1101/2023.04.06.535919v1
Dec 2022
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Effects of aging and long‐term physical activity on mitochondrial physiology and redox state of the cortex and cerebellum of female rats

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  DOI: 10.14814/phy2.15542
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9771693/
Nov 2022
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LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus

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  DOI: 10.15252/embj.2022112006
  
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embopress.org/doi/10.15252/embj.2022112006
Jun 2022
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Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease

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  DOI: 10.1016/j.neuron.2022.05.009
  
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Dec 2021
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Mechanism of PINK1 activation by autophosphorylation and insights into assembly on the TOM complex

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Nov 2021
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TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis

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cell.com/cell-reports/fulltext/S2211-1247(21)01456-X
Oct 2021
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TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson’s disease

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  DOI: 10.1016/j.neuron.2021.09.031
  
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Sep 2021
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Overexpression of α-synuclein inhibits mitochondrial Ca2+ trafficking between the endoplasmic reticulum and mitochondria through MAMs by altering the GRP75–IP3R interaction

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  DOI: 10.1002/jnr.24952
  
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onlinelibrary.wiley.com/doi/10.1002/jnr.24952
Jul 2021
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Lifelong Ulk1-Mediated Autophagy Deficiency in Muscle Induces Mitochondrial Dysfunction and Contractile Weakness

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1. scibot 19 Jul 2021
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7919824/
Jun 2021
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High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol

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nature.com/articles/s41419-021-03830-5
May 2021
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Paradoxical Mitophagy Regulation by PINK1 and TUFm

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  DOI: 10.1016/j.molcel.2020.10.007
  
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NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

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1. scibot 06 May 2021
  
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  DOI: 10.1016/j.devcel.2020.11.016
  
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sciencedirect.com/science/article/pii/S1534580720309254
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Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications

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  DOI: 10.1016/j.devcel.2020.11.007
  
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sciencedirect.com/science/article/pii/S1534580720308832
Feb 2021
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Metabolism, Oxidative Stress and Cell Signaling: Mitochondrial-specific autophagy linked to mitochondrial dysfunction following traumatic freeze injury in mice

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  DOI: 10.1152/ajpcell.00123.2019
  
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Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults

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PPEF2 Opposes PINK1-Mediated Mitochondrial Quality Control by Dephosphorylating Ubiquitin

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  DOI: 10.1016/j.celrep.2019.10.130
  
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PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis

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Untitled document

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AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells

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Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells

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The Matrix Protein of Human Parainfluenza Virus Type 3 Induces Mitophagy that Suppresses Interferon Responses

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Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy

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