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Jun 2025
www.nature.com www.nature.com

DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation

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1. scibot 18 Jun 2025
  
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  DOI: 10.1038/s41594-025-01581-x
  
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nature.com/articles/s41594-025-01581-x
elifesciences.org elifesciences.org

Small-molecule Activation of TFEB Alleviates Niemann-Pick Disease Type C via Promoting Lysosomal Exocytosis and Biogenesis

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1. scibot 11 Jun 2025
  
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  Cell Signaling Technology, 4240
  
  DOI: 10.7554/eLife.103137.2
  
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elifesciences.org/reviewed-preprints/103137v2
Dec 2024
www.cell.com www.cell.com

TFEB triggers a matrix degradation and invasion program in triple-negative breast cancer cells upon mTORC1 repression

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1. scibot 29 Dec 2024
  
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  DOI: 10.1016/j.devcel.2024.12.005
  
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cell.com/developmental-cell/fulltext/S1534-5807(24)00727-5
52.53.155.43 52.53.155.43

Functional specialization of MITF, TFEB and TFE3 drives radically distinct adaptive gene expression programs in melanoma

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1. scibot 27 Dec 2024
  
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  DOI: 10.1101/2024.12.23.629393
  
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52.53.155.43/e70ff79afc559a11e17818daacbae0950eb62f01/PDF-html.html
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The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance

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1. scibot 17 Dec 2024
  
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  DOI: 10.1016/j.immuni.2024.11.017
  
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sciencedirect.com/science/article/pii/S1074761324005326
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread

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ncbi.nlm.nih.gov/pmc/articles/PMC11316253/
Jun 2024
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Identifying FUS amyotrophic lateral sclerosis disease signatures in patient dermal fibroblasts

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  DOI: 10.1016/j.devcel.2024.05.011
  
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sciencedirect.com/science/article/pii/S1534580724003289
Dec 2023
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MORG1 limits mTORC1 signaling by inhibiting Rag GTPases

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1. scibot 16 Dec 2023
  
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  DOI: 10.1016/j.molcel.2023.11.023
  
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sciencedirect.com/science/article/pii/S1097276523009681
Nov 2023
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Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative disease

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  DOI: 10.1016/j.celrep.2023.113436
  
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sciencedirect.com/science/article/pii/S2211124723014481
Oct 2023
www.cell.com www.cell.com

CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression

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  DOI: 10.1016/j.cmet.2023.09.012
  
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cell.com/cell-metabolism/fulltext/S1550-4131(23)00368-6
Sep 2023
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CCDC50 promotes tumor growth through regulation of lysosome homeostasis

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1. scibot 12 Sep 2023
  
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  DOI: 10.15252/embr.202356948
  
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embopress.org/doi/full/10.15252/embr.202356948
Jul 2023
52.53.155.43 52.53.155.43

A dual hit of α-synuclein internalization and immune challenge leads to formation and maintenance of Lewy body-like inclusions in human dopaminergic neurons

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1. scibot 18 Jul 2023
  
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  DOI: 10.1101/2023.05.29.542776
  
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52.53.155.43/295724fe7577204c05a5e312c5e68d353e69e1f1/2023.05.29.542776v1.full-html.html
Apr 2023
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Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates

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1. scibot 26 Apr 2023
  
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  DOI: 10.1016/j.devcel.2023.04.004
  
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sciencedirect.com/science/article/pii/S1534580723001570
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Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation

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1. scibot 19 Apr 2023
  
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  DOI: 10.1016/j.cmet.2023.03.019
  
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sciencedirect.com/science/article/pii/S1550413123001249
Mar 2023
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TRIM28 represses renal cell carcinoma cell proliferation by inhibiting TFE3/KDM6A-regulated autophagy

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1. scibot 22 Mar 2023
  
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  DOI: 10.1016/j.jbc.2023.104621
  
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sciencedirect.com/science/article/pii/S0021925823002636
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Repurposing Tamoxifen as Potential Host-Directed Therapeutic for Tuberculosis

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1. scibot 05 Mar 2023
  
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  DOI: 10.1128/mbio.03024-22
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9973281/
Feb 2023
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Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity

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1. scibot 23 Feb 2023
  
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  DOI: 10.1016/j.isci.2023.106169
  
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sciencedirect.com/science/article/pii/S2589004223002468
Jan 2023
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A central role for regulated protein stability in the control of TFE3 and MITF by nutrients

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1. scibot 06 Jan 2023
  
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  RRID:AB_11220225
  
  DOI: 10.1016/j.molcel.2022.12.013
  
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sciencedirect.com/science/article/pii/S1097276522011704
Dec 2022
journals.asm.org journals.asm.org

Repurposing Tamoxifen as Potential Host-Directed Therapeutic for Tuberculosis

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1. scibot 13 Dec 2022
  
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  RRID:AB_11220225
  
  DOI: 10.1128/mbio.03024-22
  
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journals.asm.org/doi/10.1128/mbio.03024-22
Nov 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Dysregulated endolysosomal trafficking in cells arrested in the G1 phase of the host cell cycle impairs Salmonella vacuolar replication

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1. scibot 19 Nov 2022
  
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  DOI: 10.1080/15548627.2021.1999561
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9450962/
Jun 2022
rupress.org rupress.org

ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling

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1. scibot 09 Jun 2022
  
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  RRID:AB_11220225
  
  DOI: 10.1083/jcb.202106046
  
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rupress.org/jcb/article/221/7/e202106046/213259/ER-lysosome-lipid-transfer-protein-VPS13C-PARK23
Dec 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Combined Inhibition of p38MAPK and PIKfyve Synergistically Disrupts Autophagy to Selectively Target Cancer Cells

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  DOI: 10.1158/0008-5472.CAN-20-3371
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8178204/
Oct 2021
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Repurposing diphenylbutylpiperidine-class antipsychotic drugs for host-directed therapy of Mycobacterium tuberculosis and Salmonella enterica infections

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1. scibot 08 Oct 2021
  
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  DOI: 10.1038/s41598-021-98980-z
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8490354/
Aug 2021
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Untitled document

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  DOI: 10.1016/j.molcel.2017.04.027
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5446411/
europepmc.org europepmc.org

Untitled document

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  DOI: 10.7554/eLife.40856
  
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europepmc.org/articles/PMC6292694/
Jul 2021
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An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis

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  DOI: 10.1016/j.molcel.2019.10.016
  
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sciencedirect.com/science/article/pii/S1097276519307944
emboj.embopress.org emboj.embopress.org

Untitled document

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  DOI: 10.15252/embj.2019101496
  
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Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis

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  DOI: 10.1016/j.chembiol.2021.06.003
  
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sciencedirect.com/science/article/pii/S2451945621003020
Jun 2021
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Oncogene-regulated release of extracellular vesicles

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  DOI: 10.1016/j.devcel.2021.05.014
  
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sciencedirect.com/science/article/pii/S1534580721004433
May 2021
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Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity

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  DOI: 10.1016/j.devcel.2020.10.010
  
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sciencedirect.com/science/article/pii/S1534580720308005
Jan 2020
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  DOI: 10.7554/eLife.40856
  
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Untitled document

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  DOI: 10.15252/embj.2019101496
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6463212/
Nov 2017
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Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

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1. scibot 08 Nov 2017
  
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sciencedirect.com/science/article/pii/S109727651730312X