150 Matching Annotations
  1. May 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Contrasting consequences of podocyte IGF1R inhibition
    1
    1. scibot 09 May 2024
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      DOI: 10.1016/j.isci.2024.109749

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    ncbi.nlm.nih.gov/pmc/articles/PMC11068853/
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Positive and negative feedback regulation of the TGF-β1 explains two equilibrium states in skin aging
    1
    1. scibot 08 May 2024
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      DOI: 10.1016/j.isci.2024.109708

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    ncbi.nlm.nih.gov/pmc/articles/PMC11066433/
  4. 52.53.155.43 52.53.155.43
    Beyond Glycolysis: Aldolase A is a Novel Effector in Reelin Mediated Dendritic Development
    1
    1. scibot 03 May 2024
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      DOI: 10.1101/2024.01.12.575269

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    52.53.155.43/fbcd9c91bc2c853b235998551e36869172c1a2d9/2024.01.12.575269v1.full-html.html
  5. www.sciencedirect.com www.sciencedirect.com
    Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas
    1
    1. scibot 03 May 2024
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      DOI: 10.1016/j.ccell.2024.04.007

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    sciencedirect.com/science/article/pii/S1535610824001314
  6. Apr 2024
  7. www.sciencedirect.com www.sciencedirect.com
    Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity
    2
    1. scibot 18 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114094

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    2. scibot 18 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114094

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    sciencedirect.com/science/article/pii/S2211124724004224
  8. www.sciencedirect.com www.sciencedirect.com
    Mutant FOXO1 controls an oncogenic network via enhancer accessibility
    1
    1. scibot 11 Apr 2024
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      DOI: 10.1016/j.xgen.2024.100537

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    sciencedirect.com/science/article/pii/S2666979X24000934
  9. Mar 2024
  10. www.sciencedirect.com www.sciencedirect.com
    Ankrd26 is a retinoic acid-responsive plasma membrane-binding and -shaping protein critical for proper cell differentiation
    2
    1. scibot 19 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113939

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      DOI: 10.1016/j.celrep.2024.113939

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    sciencedirect.com/science/article/pii/S2211124724002675
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer
    1
    1. scibot 03 Mar 2024
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      DOI: 10.1101/gad.351037.123

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    ncbi.nlm.nih.gov/pmc/articles/PMC10621596/
  12. Feb 2024
  13. 52.53.155.43 52.53.155.43
    RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation
    1
    1. scibot 22 Feb 2024
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      DOI: 10.1101/2023.10.05.561021

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    52.53.155.43/19126de606c776a10e00c0c9a385ef3636eaaf16/2023.10.05.561021v2.full (1)-html.html
  14. www.biorxiv.org www.biorxiv.org
    Simulated Microgravity Enhances Adipocyte Maturation and Glucose Uptake via Increased Cortical Actin Remodeling
    1
    1. scibot 15 Feb 2024
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      DOI: 10.1101/2024.01.30.578049

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    biorxiv.org/content/10.1101/2024.01.30.578049v1
  15. www.sciencedirect.com www.sciencedirect.com
    TMED2 promotes glioma tumorigenesis by being involved in EGFR recycling transport
    1
    1. scibot 14 Feb 2024
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      DOI: 10.1016/j.ijbiomac.2024.130055

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    sciencedirect.com/science/article/pii/S0141813024008584
  16. Jan 2024
  17. www.science.org www.science.org
    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
    1
    1. scibot 18 Jan 2024
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      DOI: 10.1126/sciadv.ade1282

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    science.org/doi/10.1126/sciadv.ade1282
  18. www.sciencedirect.com www.sciencedirect.com
    Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death
    1
    1. scibot 11 Jan 2024
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      DOI: 10.1016/j.cell.2023.12.015

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    sciencedirect.com/science/article/pii/S0092867423013478
  19. Dec 2023
  20. www.sciencedirect.com www.sciencedirect.com
    Epinephrine inhibits PI3Kα via the Hippo kinases
    1
    1. scibot 20 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113535

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    sciencedirect.com/science/article/pii/S2211124723015474
  21. Nov 2023
  22. www.sciencedirect.com www.sciencedirect.com
    Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria
    1
    1. scibot 10 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113389

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    sciencedirect.com/science/article/pii/S2211124723014018
  23. Oct 2023
  24. www.sciencedirect.com www.sciencedirect.com
    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
    1
    1. scibot 27 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113198

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    sciencedirect.com/science/article/pii/S221112472301210X
  25. Aug 2023
  26. www.sciencedirect.com www.sciencedirect.com
    Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties
    1
    1. scibot 23 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112866

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    sciencedirect.com/science/article/pii/S221112472300877X
  27. Jul 2023
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation of the N-terminus of Syntaxin-16 controls interaction with mVps45 and GLUT4 trafficking in adipocytes
    1
    1. scibot 29 Jul 2023
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      DOI: 10.7717/peerj.15630

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    ncbi.nlm.nih.gov/pmc/articles/PMC10373645/
  29. Jun 2023
  30. www.sciencedirect.com www.sciencedirect.com
    Overcoming MET-mediated resistance in oncogene-driven NSCLC
    1
    1. scibot 23 Jun 2023
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      DOI: 10.1016/j.isci.2023.107006

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    sciencedirect.com/science/article/pii/S2589004223010830
  31. www.sciencedirect.com www.sciencedirect.com
    New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
    1
    1. scibot 08 Jun 2023
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      DOI: 10.1016/j.chembiol.2023.05.007

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    sciencedirect.com/science/article/pii/S2451945623001502
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hypomorphism of a Novel Long ERα Isoform Causes Severe Reproductive Dysfunctions in Female Mice
    1
    1. scibot 03 Jun 2023
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      DOI: 10.1210/endocr/bqac160

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    ncbi.nlm.nih.gov/pmc/articles/PMC10233398/
  33. onlinelibrary.wiley.com onlinelibrary.wiley.com
    PICT-1 regulates p53 splicing and sensitivity of medullary thyroid carcinoma cells to Everolimus
    1
    1. scibot 01 Jun 2023
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      DOI: 10.1111/jne.13187

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    onlinelibrary.wiley.com/doi/10.1111/jne.13187
  34. May 2023
  35. www.sciencedirect.com www.sciencedirect.com
    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
    1
    1. scibot 31 May 2023
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      DOI: 10.1016/j.celrep.2023.112570

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    sciencedirect.com/science/article/pii/S2211124723005818
  36. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Prenatal overexpression of platelet-derived growth factor receptor A results in central nervous system hypomyelination
    1
    1. scibot 05 May 2023
      2920

      DOI: 10.1002/brb3.2332

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    onlinelibrary.wiley.com/doi/full/10.1002/brb3.2332
  37. aacrjournals.org aacrjournals.org
    RASGRF1 Fusions Activate Oncogenic RAS Signaling and Confer Sensitivity to MEK Inhibition
    1
    1. scibot 05 May 2023
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      DOI: 10.1158/1078-0432.CCR-21-4291

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    aacrjournals.org/clincancerres/article/28/14/3091/706867/RASGRF1-Fusions-Activate-Oncogenic-RAS-Signaling
  38. Apr 2023
  39. www.sciencedirect.com www.sciencedirect.com
    PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion
    1
    1. scibot 29 Apr 2023
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      DOI: 10.1016/j.celrep.2023.112436

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    sciencedirect.com/science/article/pii/S2211124723004473
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
    1
    1. scibot 27 Apr 2023
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      DOI: 10.1126/sciadv.ade1282

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    ncbi.nlm.nih.gov/pmc/articles/PMC10115456/
  41. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial cannabinoid receptors gate corticosterone impact on novel object recognition
    1
    1. scibot 26 Apr 2023
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      DOI: 10.1016/j.neuron.2023.04.001

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    sciencedirect.com/science/article/pii/S0896627323002635
  42. www.sciencedirect.com www.sciencedirect.com
    Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness
    1
    1. scibot 21 Apr 2023
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      DOI: 10.1016/j.cmet.2023.03.021

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    sciencedirect.com/science/article/pii/S1550413123001262
  43. www.sciencedirect.com www.sciencedirect.com
    AKT activity orchestrates marginal zone B cell development in mice and humans
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      DOI: 10.1016/j.celrep.2023.112378

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    sciencedirect.com/science/article/pii/S2211124723003893
  44. www.sciencedirect.com www.sciencedirect.com
    N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer
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      DOI: 10.1016/j.xcrm.2023.101002

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    sciencedirect.com/science/article/pii/S266637912300112X
  45. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Oncogene-mediated nuclear accumulation of lactate promotes epigenetic alterations to induce cancer cell proliferation
    1
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      DOI: 10.1002/jcb.30381

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    onlinelibrary.wiley.com/doi/10.1002/jcb.30381
  46. www.sciencedirect.com www.sciencedirect.com
    Site-1 protease inhibits mitochondrial respiration by controlling the TGF-β target gene Mss51
    1
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      DOI: 10.1016/j.celrep.2023.112336

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    sciencedirect.com/science/article/pii/S2211124723003479
  47. Mar 2023
  48. www.ijbs.com www.ijbs.com
    IFNγ blockade in capillary leak site improves tumour chemotherapy by inhibiting lactate-induced endocytosis of vascular endothelial-cadherins
    1
    1. scibot 30 Mar 2023
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      DOI: 10.7150/ijbs.78248

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    ijbs.com/v19p1490.htm
  49. Feb 2023
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuroprotective Effects of a Multi-Herbal Extract on Axonal and Synaptic Disruption in Vitro and Cognitive Impairment in Vivo
    1
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      DOI: 10.3233/ADR-220056

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    ncbi.nlm.nih.gov/pmc/articles/PMC9912829/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of DNA damage response by trimeric G-proteins
    1
    1. scibot 09 Feb 2023
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      DOI: 10.1016/j.isci.2023.105973

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    ncbi.nlm.nih.gov/pmc/articles/PMC9900518/
  52. www.sciencedirect.com www.sciencedirect.com
    IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment
    1
    1. scibot 03 Feb 2023
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      DOI: 10.1016/j.ccell.2023.01.003

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    sciencedirect.com/science/article/pii/S153561082300003X
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity
    1
    1. scibot 01 Feb 2023
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      DOI: 10.1016/j.isci.2023.105962

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    ncbi.nlm.nih.gov/pmc/articles/PMC9883198/
  54. Jan 2023
  55. www.jneurosci.org www.jneurosci.org
    mTORC2 loss in oligodendrocyte progenitor cells results in regional hypomyelination in the central nervous system
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    Restricted physical activity after volumetric muscle loss alters whole-body and local muscle metabolism
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  57. Dec 2022
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    Dysregulation of ErbB4 Signaling Pathway in the Dorsal Hippocampus after Neonatal Hypoxia-Ischemia and Late Deficits in PV+ Interneurons, Synaptic Plasticity and Working Memory
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    Pleiotropic effects of Syntaxin16 identified by gene editing in cultured adipocytes
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  60. Nov 2022
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    Neuronal-epithelial cross-talk drives acinar specification via NRG1-ERBB3-mTORC2 signaling
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    Preclinical characterization and phase I clinical trial of CT053PTSA targets MET, AXL, and VEGFR2 in patients with advanced solid tumors
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    NetrinG1+ cancer-associated fibroblasts generate unique extracellular vesicles that support the survival of pancreatic cancer cells under nutritional stress
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  64. Sep 2022
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    Hepatic ER stress suppresses adipose browning through ATF4-CIRP-ANGPTL3 cascade
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    Na/K-ATPase Suppresses LPS-Induced Pro-Inflammatory Signaling Through Lyn
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    De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
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    Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways
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  72. Jul 2022
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    Small RNAs derived from tRNA fragmentation regulate the functional maturation of neonatal β cells
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    BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors
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    MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels
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  77. May 2022
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    Triple targeting of HER receptors overcomes heregulin-mediated resistance to EGFR blockade in colorectal cancer
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  79. Mar 2022
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    A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
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    Regulation of GTPase function by autophosphorylation
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    Interleukin-6 mimics insulin-dependent cellular distribution of some cytoskeletal proteins and Glut4 transporter without effect on glucose uptake in 3T3-L1 adipocytes
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    The KRAS-G12D mutation induces Metabolic Vulnerability in B-cell Acute Lymphoblastic Leukemia
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  85. Jan 2022
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    Nonphosphorylatable Src Ser75 Mutation Increases Ethanol Preference and Consumption in Mice
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    Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance
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  89. Dec 2021
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    A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis
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    CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
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  95. Nov 2021
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  97. Aug 2021
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    A fluorescent reporter assay of differential gene expression response to insulin in hepatocytes
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  101. Jul 2021
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    Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain
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    Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma
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    SARS-COV-2 Spike binding to ACE2 in living cells monitored by TR-FRET
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    Thyroid hormone receptor beta inhibits the PI3K-Akt-mTOR signaling axis in anaplastic thyroid cancer cell lines via genomic mechanisms
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  108. Jun 2021
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    Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression
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    OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin
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    Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma
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    β-elemene alleviates airway stenosis via the ILK/Akt pathway modulated by MIR143HG sponging miR-1275
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    Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling
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    Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library
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  115. May 2021
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    SMRT Regulates Metabolic Homeostasis and Adipose Tissue Macrophage Phenotypes in Tandem
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    Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity
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    The potassium channel Kv4.2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice
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    An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells
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    Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification
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  122. Apr 2021
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    Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference
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    A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance
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    A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation
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  126. Mar 2021
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    S1PR3–G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation
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    Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis
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  129. Feb 2021
  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PKN1 Is a Novel Regulator of Hippocampal GluA1 Levels
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    Development of a potent and selective chemical probe for the pleiotropic kinase CK2
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    A fluorescent reporter assay of differential gene expression response to insulin in hepatocytes
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  133. www.cell.com www.cell.com
    Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms
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    Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders
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  135. Nov 2020
  136. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Loss of Muscle Carnitine Palmitoyltransferase 2 Prevents Diet-Induced Obesity and Insulin Resistance despite Long-Chain Acylcarnitine Accumulation
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  138. Oct 2020
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    TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment
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  140. Sep 2020
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    A Live-Cell Screen for Altered Erk Dynamics Reveals Principles of Proliferative Control
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    Streptococcus pneumoniae Infection Promotes Histone H3 Dephosphorylation by Modulating Host PP1 Phosphatase
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    The endothelial barrier is not rate-limiting to insulin action in the myocardium of male mice
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    Topological Adaptation of Transmembrane Domains to the Force-Modulated Lipid Bilayer Is a Basis of Sensing Mechanical Force
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    Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer
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    Tau Reduction Prevents Key Features of Autism in Mouse Models
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    PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes
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    Gut hormone GIP induces inflammation and insulin resistance in the hypothalamus
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    IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β–Nrf2–BNIP3 Pathway
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      rabbit anti-AKT

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  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer
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      anti-pan-Akt

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  151. Jan 2020
  152. www.sciencedirect.com www.sciencedirect.com
    Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers
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    Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling
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    Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling
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  155. www.cell.com www.cell.com
    miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer
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    Naa10p Inhibits Beige Adipocyte-Mediated Thermogenesis through N-α-acetylation of Pgc1α
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    Genotype-Fitness Maps of EGFR-Mutant Lung Adenocarcinoma Chart the Evolutionary Landscape of Resistance for Combination Therapy Optimization
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    Screening the expression of several miRNAs from TaqMan Low Density Array in traumatic brain injury: miR‐219a‐5p regulates neuronal apoptosis by modulating CCNA2 and CACUL1
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    Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D
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    The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling
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    Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy
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    Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers
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    MicroRNA inhibition upregulates hippocampal A-type potassium current and reduces seizure frequency in a mouse model of epilepsy
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    Reciprocal Effects of Fibroblast Growth Factor Receptor Signaling on Dengue Virus Replication and Virion Production
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  165. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Light Entrains Diurnal Changes in Insulin Sensitivity of Skeletal Muscle via Ventromedial Hypothalamic Neurons
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  171. Nov 2018
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    Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC
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    Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling
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    Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy
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    Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance
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    A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer
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    Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy
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    Epiregulin (EREG) is upregulated through an IL‐1β autocrine loop in Caco‐2 epithelial cells with reduced CFTR function
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    Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells
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    Region-Specific Suppression of Hypothalamic Responses to Insulin To Adapt to Elevated Maternal Insulin Secretion During Pregnancy
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  185. Nov 2017
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    Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer
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    Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity
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  188. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis
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