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TDP-43 dysfunction compromises UPF1-dependent mRNA metabolism in ALS

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  DOI: 10.1016/j.neuron.2025.11.001
  
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Autoantibody-triggered podocyte membrane budding drives autoimmune kidney disease

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  DOI: 10.1016/j.cell.2025.11.010
  
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sciencedirect.com:5037/science/article/pii/S0092867425013066
Oct 2025
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Nuclear Galectin-1 promotes KRAS-dependent activation of pancreatic cancer stellate cells

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1. scibot 03 Oct 2025
  
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  DOI: 10.1073/pnas.2424051122
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12002210/
Sep 2025
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Repeats mimic pathogen-associated patterns across a vast evolutionary landscape

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  DOI: 10.1016/j.xgen.2025.101011
  
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sciencedirect.com/science/article/pii/S2666979X25002678
Aug 2025
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LAMP1 as a Target for PET Imaging in Adenocarcinoma Xenograft Models

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Jul 2025
52.53.155.43 52.53.155.43

watanabe-et-al-als-associated-rna-binding-proteins-promote-unc13a-transcription-through-rest-downregulation-html.html

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52.53.155.43/42423fb21c90eb6b2282f89153f3787d8f44c56d/watanabe-et-al-als-associated-rna-binding-proteins-promote-unc13a-transcription-through-rest-downregulation-html.html
May 2025
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MagIC-Cryo-EM, structural determination on magnetic beads for scarce macromolecules in heterogeneous samples

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  DOI: 10.7554/eLife.103486
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12092007/
Feb 2025
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The structure of the R2T complex reveals a different architecture from the related HSP90 cochaperone R2TP

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  DOI: 10.1016/j.str.2025.01.023
  
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sciencedirect.com/science/article/pii/S096921262500053X
Nov 2024
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Identification of ATP-Competitive Human CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function

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  DOI: 10.1158/1535-7163.MCT-23-0904
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11532780/
Aug 2024
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A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance

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  DOI: 10.1016/j.cell.2024.07.006
  
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stemcellres.biomedcentral.com stemcellres.biomedcentral.com

Pharmacological targeting of KDM6A and KDM6B, as a novel therapeutic strategy for treating craniosynostosis in Saethre-Chotzen syndrome

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1. scibot 02 Aug 2024
  
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stemcellres.biomedcentral.com/article/10.1186/s13287-020-02051-5
May 2024
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RNA quality control factors nucleate Clr4/SUV39H and trigger constitutive heterochromatin assembly

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  DOI: 10.1016/j.cell.2024.04.042
  
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sciencedirect.com/science/article/pii/S0092867424004689
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The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex

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  DOI: 10.1016/j.molcel.2024.04.007
  
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sciencedirect.com/science/article/pii/S1097276524002855
Apr 2024
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ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin

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  DOI: 10.7554/eLife.89261
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11006420/
Mar 2024
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Aβ*56 is a stable oligomer that impairs memory function in mice

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  DOI: 10.1016/j.isci.2024.109239
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10905009/
Dec 2023
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Ratcheted transport and sequential assembly of the yeast telomerase RNP

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  DOI: 10.1016/j.celrep.2023.113565
  
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sciencedirect.com/science/article/pii/S2211124723015772
Nov 2023
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Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly

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1. scibot 28 Nov 2023
  
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  DOI: 10.1016/j.molcel.2023.10.037
  
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sciencedirect.com/science/article/pii/S1097276523009085
Oct 2023
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Phosphorylated YBX2 is stabilized to promote glycolysis in brown adipocytes

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ncbi.nlm.nih.gov/pmc/articles/PMC10583057/
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The structural mechanism of dimeric DONSON in replicative helicase activation

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  DOI: 10.1016/j.molcel.2023.09.029
  
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Sep 2023
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A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment

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  DOI: 10.1186/s13059-023-03037-1
  
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link.springer.com/article/10.1186/s13059-023-03037-1
Aug 2023
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Identification of Selective ATP-Competitive CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function

1
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  DOI: 10.21203/rs.3.rs-3182731/v1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10441460/
May 2023
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Miniature RNAs are embedded in an exceptionally protein-rich mitoribosome via an elaborate assembly pathway

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  DOI: 10.1093/nar/gkad422
  
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academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad422/7173778
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DNA supercoiling restricts the transcriptional bursting of neighboring eukaryotic genes

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  DOI: 10.1016/j.molcel.2023.04.015
  
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Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

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  DOI: 10.1016/j.isci.2023.106701
  
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sciencedirect.com/science/article/pii/S2589004223007782
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Aminoprocalcitonin protects against hippocampal neuronal death via preserving oxidative phosphorylation in refractory status epilepticus

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  DOI: 10.1038/s41420-023-01445-7
  
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nature.com/articles/s41420-023-01445-7
Nov 2022
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Nucleoporins facilitate ORC loading onto chromatin

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  DOI: 10.1016/j.celrep.2022.111590
  
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sciencedirect.com/science/article/pii/S2211124722014553
Oct 2022
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Nuclear mRNA metabolism drives selective basket assembly on a subset of nuclear pore complexes in budding yeast

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  DOI: 10.1016/j.molcel.2022.09.019
  
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Sep 2022
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Architecture of the yeast Pol III pre-termination complex and pausing mechanism on poly(dT) termination signals

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  DOI: 10.1016/j.celrep.2022.111316
  
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sciencedirect.com/science/article/pii/S2211124722011408
Jul 2022
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Sen1 is a key regulator of transcription-driven conflicts

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  DOI: 10.1016/j.molcel.2022.06.021
  
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sciencedirect.com/science/article/pii/S1097276522006049
Mar 2022
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The TFIIH complex is required to establish and maintain mitotic chromosome structure

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  DOI: 10.7554/eLife.75475
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8956287/
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Parathyroid Hormone Regulates Circulating Levels of Sclerostin and FGF23 in a Primary Hyperparathyroidism Model

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  DOI: 10.1210/jendso/bvac027
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8907412/
Jan 2022
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Plasmolipin regulates basolateral-to-apical transcytosis of ICAM-1 and leukocyte adhesion in polarized hepatic epithelial cells

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  DOI: 10.1007/s00018-021-04095-z
  
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link.springer.com/article/10.1007/s00018-021-04095-z
Nov 2021
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MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts

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1. scibot 30 Nov 2021
  
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  DOI: 10.1016/j.molcel.2021.11.002
  
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cell.com/molecular-cell/fulltext/S1097-2765(21)00952-7
Sep 2021
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Single-cell RNA-seq unravels alterations of the human spermatogonial stem cell compartment in patients with impaired spermatogenesis

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1. scibot 10 Sep 2021
  
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  DOI: 10.1016/j.xcrm.2021.100395
  
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sciencedirect.com/science/article/pii/S2666379121002536
Aug 2021
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Untitled document

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BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation

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Interleukin-22 signaling attenuates necrotizing enterocolitis by promoting epithelial cell regeneration

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Co-translational assembly and localized translation of nucleoporins in nuclear pore complex biogenesis

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Peroxiredoxin promotes longevity and H2O2-resistance in yeast through redox-modulation of protein kinase A

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G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

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Acute stress drives global repression through two independent RNA polymerase II stalling events in Saccharomyces

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Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer’s Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals

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The deubiquitylase Ubp15 couples transcription to mRNA export

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Constitutive CHK1 expression drives a pSTAT3-CIP2A circuit that promotes glioblastoma cell survival and growth

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Degradation of Non-coding RNAs Promotes Recycling of Termination Factors at Sites of Transcription

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mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis

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Replication Study: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis

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Transcriptome maps of general eukaryotic RNA degradation factors

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A multimolecular signaling complex including PrPC and LRP1 is strictly dependent on lipid rafts and is essential for the function of tissue Plasminogen Activator

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The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes

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PPARβ/δ recruits NCOR and regulates transcription reinitiation of ANGPTL4

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The Long Noncoding RNA Paupar Modulates PAX6 Regulatory Activities to Promote Alpha Cell Development and Function

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Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression

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Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS

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Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease

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The homeodomain transcription factor Prox1 is a direct target of SoxC proteins during developmental vertebrate neurogenesis

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Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

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Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression

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Molecular moieties masking Ca2+-dependent facilitation of voltage-gated Cav2.2 Ca2+ channels

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Densin-180 Controls the Trafficking and Signaling of L-Type Voltage-Gated Cav1.2 Ca2+ Channels at Excitatory Synapses

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jneurosci.org/content/37/18/4679
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Untitled document

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onlinelibrary.wiley.com onlinelibrary.wiley.com

Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α‐synuclein

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  Curator: @gabimpine
  
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onlinelibrary.wiley.com/doi/10.1002/jnr.24024/full
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Registered report: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis

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  Rabbit IgG isotype control
  
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elifesciences.org/content/4/e04796

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