174 Matching Annotations
  1. Nov 2024
  2. www.sciencedirect.com www.sciencedirect.com
    FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma
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    1. scibot 11 Nov 2024
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    sciencedirect.com/science/article/pii/S1534580724006282
  3. Oct 2024
  4. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Transgenic sensors reveal compartment-specific effects of aggregation-prone proteins on subcellular proteostasis during aging
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    1. scibot 09 Oct 2024
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    pubmed.ncbi.nlm.nih.gov/39383859/
  5. Sep 2024
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    Paneth cell TNF signaling induces gut bacterial translocation and sepsis
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    1. scibot 10 Sep 2024
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    sciencedirect.com/science/article/pii/S1931312824003147
  7. Aug 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquitin-specific peptidase 22 controls integrin-dependent cancer cell stemness and metastasis
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    1. scibot 22 Aug 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11378969/
  9. Jul 2024
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance
    1
    1. scibot 19 Jul 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11225835/
  11. www.cell.com www.cell.com
    Regulation of the DLC3 tumor suppressor by a novel phosphoswitch
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    1. scibot 18 Jul 2024
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    cell.com/iscience/abstract/S2589-0042(24)01428-7
  12. Jun 2024
  13. elifesciences.org elifesciences.org
    RAPSYN-mediated neddylation of BCR-ABL alternatively determines the fate of Philadelphia chromosome-positive leukemia
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    1. scibot 14 Jun 2024
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      DOI: 10.7554/eLife.88375

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    elifesciences.org/articles/88375
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    FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity
    1
    1. scibot 04 Jun 2024
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    sciencedirect.com/science/article/pii/S2211124724006259
  15. May 2024
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    Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation
    1
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    sciencedirect.com/science/article/pii/S1534580724002995
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling
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    1. scibot 04 May 2024
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      DOI: 10.1158/0008-5472.CAN-23-2268

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    ncbi.nlm.nih.gov/pmc/articles/PMC11063763/
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Membrane-Targeted palGFP Predominantly Localizes to the Plasma Membrane but not to Neurosecretory Vesicle Membranes in Rat Oxytocin Neurons
    1
    1. scibot 02 May 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11058463/
  19. Apr 2024
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Trafficking of Connexin36 (Cx36) in the early secretory pathway
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    1. scibot 18 Apr 2024
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  21. Mar 2024
  22. www.sciencedirect.com www.sciencedirect.com
    Pneumococcal sialidase promotes bacterial survival by fine-tuning of pneumolysin-mediated membrane disruption
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    1. scibot 14 Mar 2024
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    sciencedirect.com/science/article/pii/S2211124724002900
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    Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
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    1. scibot 12 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113935

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    sciencedirect.com/science/article/pii/S2211124724002638
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
    2
    1. scibot 08 Mar 2024
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    sciencedirect.com/science/article/pii/S1097276524001291
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FH variant pathogenicity promotes purine salvage pathway dependence in kidney cancer
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      DOI: 10.1158/2159-8290.CD-22-0874

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    ncbi.nlm.nih.gov/pmc/articles/PMC10527600/
  26. Feb 2024
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    Neuronal reprogramming of mouse and human fibroblasts using transcription factors involved in suprachiasmatic nucleus development
    2
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    sciencedirect.com/science/article/pii/S2589004224002724
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    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
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    sciencedirect.com/science/article/pii/S2211124724000421
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    The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs
    1
    1. scibot 08 Feb 2024
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      DOI: 10.1016/j.molcel.2024.01.012

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    sciencedirect.com/science/article/pii/S1097276524000480
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    Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor
    1
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      DOI: 10.1016/j.chembiol.2024.01.002

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    sciencedirect.com/science/article/pii/S2451945624000382
  31. Jan 2024
  32. www.science.org www.science.org
    RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling
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    1. scibot 20 Jan 2024
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      DOI: 10.1126/scisignal.adg5289

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    science.org/doi/10.1126/scisignal.adg5289
  33. Dec 2023
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    B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling
    1
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    sciencedirect.com/science/article/pii/S1535610823003999
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    Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair
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      DOI: 10.1016/j.neuron.2023.11.011

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    sciencedirect.com/science/article/pii/S0896627323008851
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    ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells
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    sciencedirect.com/science/article/pii/S1535610823003951
  37. Nov 2023
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    Protocol for simultaneous detection of dual subcellular localized dengue virus protease by co-transfection
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    1. scibot 17 Nov 2023
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      DOI: 10.1016/j.xpro.2023.102697

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    sciencedirect.com/science/article/pii/S2666166723006640
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    Differential Ire1 determines loser cell fate in tumor-suppressive cell competition
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    1. scibot 10 Nov 2023
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    sciencedirect.com/science/article/pii/S2211124723013153
  40. Sep 2023
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    Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping
    2
    1. scibot 30 Sep 2023
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    sciencedirect.com/science/article/pii/S1097276523006585
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    SARS-CoV-2 Nsp15 suppresses type I interferon production by inhibiting IRF3 phosphorylation and nuclear translocation
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    sciencedirect.com/science/article/pii/S2589004223017820
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    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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    sciencedirect.com/science/article/pii/S2211124723010811
  44. Aug 2023
  45. 52.53.155.43 52.53.155.43
    Aberrant accumulation of Kras-dependent pervasive transcripts during tumor progression renders cancer cells dependent on PAF1 expression
    2
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    52.53.155.43/491f3628ae56ca418965e7c0fc6856d1761b345d/PIIS2211124723009907-html.html
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    Hedgehog receptors exert immune-surveillance roles in the epidermis across species
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  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cannabinoid receptor type 1 (CB1R) inhibits hypothalamic leptin signaling via β-arrestin1 in complex with TC-PTP and STAT3
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      DOI: 10.1016/j.isci.2023.107207

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    ncbi.nlm.nih.gov/pmc/articles/PMC10392084/
  48. Jul 2023
  49. www.sciencedirect.com www.sciencedirect.com
    Inositol polyphosphate multikinase modulates redox signaling through nuclear factor erythroid 2-related factor 2 and glutathione metabolism
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      DOI: 10.1016/j.isci.2023.107199

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    sciencedirect.com/science/article/pii/S2589004223012762
  50. Jun 2023
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    Differential localization of dengue virus protease affects cell homeostasis and triggers to thrombocytopenia
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    sciencedirect.com/science/article/pii/S258900422301101X
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    Faulty Metabolism: A Potential Instigator of an Aggressive Phenotype in Cdk5-dependent Medullary Thyroid Carcinoma
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      DOI: 10.1101/2023.06.13.544755

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    biorxiv.org/content/10.1101/2023.06.13.544755v1
  53. May 2023
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    p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS
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    The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells
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    Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity
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    Transcriptional kinetic synergy: A complex landscape revealed by integrating modeling and synthetic biology
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    Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells
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  61. Mar 2023
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    CARD-only proteins regulate in vivo inflammasome responses and ameliorate gout
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  63. Feb 2023
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    CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
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    Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
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    Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues
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    HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease
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    Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging
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  70. Dec 2022
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    Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension
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    Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer
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    NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step
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    V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans
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    NetrinG1+ cancer-associated fibroblasts generate unique extracellular vesicles that support the survival of pancreatic cancer cells under nutritional stress
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  77. Sep 2022
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    Endothelial caveolin-1 regulates cerebral thrombo-inflammation in acute ischemia/reperfusion injury
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    Early-life vitamin B12 orchestrates lipid peroxidation to ensure reproductive success via SBP-1/SREBP1 in Caenorhabditis elegans
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    A biochemical reconstitution approach to identify autophagy receptors for aggrephagy in mammalian cells
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    CANCER-ASSOCIATED SF3B1 MUTATIONS CONFER A BRCA-LIKE CELLULAR PHENOTYPE AND SYNTHETIC LETHALITY TO PARP INHIBITORS
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    CHAMP1 binds to REV7/FANCV and promotes homologous recombination repair
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    ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain
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    Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia
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    Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer
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    Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status
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  89. Jul 2022
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    AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation
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    Filter trapping protocol to detect aggregated proteins in human cell lines
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    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
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  98. Nov 2021
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    Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response
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    Tumor-derived extracellular vesicles regulate tumor-infiltrating regulatory T cells via the inhibitory immunoreceptor CD300a
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    Mechanistic Insights into COVID-19 by Global Analysis of the SARS-CoV-2 3CLpro Substrate Degradome
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    Tyrosine Phosphorylation of DEPTOR Functions as a Molecular Switch to Activate mTOR Signaling
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  104. Sep 2021
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    Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages
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  106. Aug 2021
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    SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer
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    Compartmentalization-Aided Interaction Screening Reveals Extensive High-Order Complexes within the SARS-CoV-2 Proteome
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    The ER Membrane Protein Complex Promotes Biogenesis of Dengue and Zika Virus Non-structural Multi-pass Transmembrane Proteins to Support Infection
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    Histone deacetylase 6 promotes growth of glioblastoma through the MKK7/JNK/c‐Jun signaling pathway
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    Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila
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    In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8–16-mer Oligomer Species
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    BK channel clustering is required for normal behavioral alcohol sensitivity in C . elegans
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    Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites
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    HIV-1 Envelope Overcomes NLRP3-Mediated Inhibition of F-Actin Polymerization for Viral Entry
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    The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3
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    p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
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    NS5A Promotes Constitutive Degradation of IP3R3 to Counteract Apoptosis Induced by Hepatitis C Virus
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    The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment
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    The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress
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    Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth
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    Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1
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    A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism
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    The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma
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      Curator: @Jmenke

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    AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity
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    CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis
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  206. Nov 2017
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    Rac1 Dosage Is Crucial for Normal Endochondral Bone Growth
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    Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib
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    Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
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    Different Doublecortin (DCX) Patient Alleles Show Distinct Phenotypes in Cultured Neurons EVIDENCE FOR DIVERGENT LOSS-OF-FUNCTION AND “OFF-PATHWAY” CELLULAR MECHANISMS
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      Rabbit monoclonal

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