163 Matching Annotations
  1. Last 7 days
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    Trafficking of Connexin36 (Cx36) in the early secretory pathway
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    1. scibot 18 Apr 2024
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      DOI: 10.1101/2024.03.25.586643

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    ncbi.nlm.nih.gov/pmc/articles/PMC10996632/
  3. Mar 2024
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    Pneumococcal sialidase promotes bacterial survival by fine-tuning of pneumolysin-mediated membrane disruption
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    sciencedirect.com/science/article/pii/S2211124724002900
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    Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
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    1. scibot 08 Mar 2024
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    sciencedirect.com/science/article/pii/S1097276524001291
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    FH variant pathogenicity promotes purine salvage pathway dependence in kidney cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10527600/
  8. Feb 2024
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    Neuronal reprogramming of mouse and human fibroblasts using transcription factors involved in suprachiasmatic nucleus development
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    sciencedirect.com/science/article/pii/S2589004224002724
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    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
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    sciencedirect.com/science/article/pii/S2211124724000421
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    The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs
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    sciencedirect.com/science/article/pii/S1097276524000480
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    Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor
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    sciencedirect.com/science/article/pii/S2451945624000382
  13. Jan 2024
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    RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling
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    1. scibot 20 Jan 2024
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  15. Dec 2023
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    B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling
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    sciencedirect.com/science/article/pii/S1535610823003999
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    Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair
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      DOI: 10.1016/j.neuron.2023.11.011

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    sciencedirect.com/science/article/pii/S0896627323008851
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    ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells
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  19. Nov 2023
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    Protocol for simultaneous detection of dual subcellular localized dengue virus protease by co-transfection
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    sciencedirect.com/science/article/pii/S2666166723006640
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    Differential Ire1 determines loser cell fate in tumor-suppressive cell competition
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    1. scibot 10 Nov 2023
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    sciencedirect.com/science/article/pii/S2211124723013153
  22. Sep 2023
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    Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping
    2
    1. scibot 30 Sep 2023
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    sciencedirect.com/science/article/pii/S1097276523006585
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    SARS-CoV-2 Nsp15 suppresses type I interferon production by inhibiting IRF3 phosphorylation and nuclear translocation
    1
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    sciencedirect.com/science/article/pii/S2589004223017820
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    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
    1
    1. scibot 07 Sep 2023
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    sciencedirect.com/science/article/pii/S2211124723010811
  26. Aug 2023
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    Aberrant accumulation of Kras-dependent pervasive transcripts during tumor progression renders cancer cells dependent on PAF1 expression
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    52.53.155.43/491f3628ae56ca418965e7c0fc6856d1761b345d/PIIS2211124723009907-html.html
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    Hedgehog receptors exert immune-surveillance roles in the epidermis across species
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  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cannabinoid receptor type 1 (CB1R) inhibits hypothalamic leptin signaling via β-arrestin1 in complex with TC-PTP and STAT3
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      DOI: 10.1016/j.isci.2023.107207

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    ncbi.nlm.nih.gov/pmc/articles/PMC10392084/
  30. Jul 2023
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    Inositol polyphosphate multikinase modulates redox signaling through nuclear factor erythroid 2-related factor 2 and glutathione metabolism
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    sciencedirect.com/science/article/pii/S2589004223012762
  32. Jun 2023
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    Differential localization of dengue virus protease affects cell homeostasis and triggers to thrombocytopenia
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    Faulty Metabolism: A Potential Instigator of an Aggressive Phenotype in Cdk5-dependent Medullary Thyroid Carcinoma
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    biorxiv.org/content/10.1101/2023.06.13.544755v1
  35. May 2023
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    p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS
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    sciencedirect.com/science/article/pii/S2211124723004904
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    The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells
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    sciencedirect.com/science/article/pii/S235239642200336X
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    Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity
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    sciencedirect.com/science/article/pii/S2211124723004588
  39. Apr 2023
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    Transcriptional kinetic synergy: A complex landscape revealed by integrating modeling and synthetic biology
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    sciencedirect.com/science/article/pii/S2405471223000558
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    Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells
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    sciencedirect.com/science/article/pii/S2211124723003881
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    Metaboverse enables automated discovery and visualization of diverse metabolic regulatory patterns
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    nature.com/articles/s41556-023-01117-9
  43. Mar 2023
  44. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    CARD-only proteins regulate in vivo inflammasome responses and ameliorate gout
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    pubmed.ncbi.nlm.nih.gov/36930645/
  45. Feb 2023
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
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    ncbi.nlm.nih.gov/pmc/articles/PMC9884621/
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    Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
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    sciencedirect.com/science/article/pii/S1097276523000382
  48. Jan 2023
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    Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues
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    sciencedirect.com/science/article/pii/S1550413122005770
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    HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease
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    sciencedirect.com/science/article/pii/S2211124722018800
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    Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging
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  52. Dec 2022
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    Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension
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    Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer
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  55. Nov 2022
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    NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step
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    V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans
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    NetrinG1+ cancer-associated fibroblasts generate unique extracellular vesicles that support the survival of pancreatic cancer cells under nutritional stress
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  59. Sep 2022
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    Endothelial caveolin-1 regulates cerebral thrombo-inflammation in acute ischemia/reperfusion injury
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    Early-life vitamin B12 orchestrates lipid peroxidation to ensure reproductive success via SBP-1/SREBP1 in Caenorhabditis elegans
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    CANCER-ASSOCIATED SF3B1 MUTATIONS CONFER A BRCA-LIKE CELLULAR PHENOTYPE AND SYNTHETIC LETHALITY TO PARP INHIBITORS
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    ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain
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    Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer
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    Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status
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    Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease
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    CCT2 is an aggrephagy receptor for clearance of solid protein aggregates
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  78. Feb 2022
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    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
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  80. Nov 2021
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    Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response
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    Tumor-derived extracellular vesicles regulate tumor-infiltrating regulatory T cells via the inhibitory immunoreceptor CD300a
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  83. Oct 2021
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    Mechanistic Insights into COVID-19 by Global Analysis of the SARS-CoV-2 3CLpro Substrate Degradome
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    Tyrosine Phosphorylation of DEPTOR Functions as a Molecular Switch to Activate mTOR Signaling
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  86. Sep 2021
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    Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages
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  88. Aug 2021
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    SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer
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    Compartmentalization-Aided Interaction Screening Reveals Extensive High-Order Complexes within the SARS-CoV-2 Proteome
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    The ER Membrane Protein Complex Promotes Biogenesis of Dengue and Zika Virus Non-structural Multi-pass Transmembrane Proteins to Support Infection
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    Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains
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    Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes
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  100. Jul 2021
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    hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids
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    The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3
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    T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation
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    Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer
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    USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication
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      GFP (D5.1) XP Rabbit mAb

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    Effects of sex steroids on the spinal gastrin-releasing peptide system controlling male sexual function in rats
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  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Translation stress and collided ribosomes are co-activators of cGAS
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    N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation
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    Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion
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    SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts
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    Actin Polymerization and ESCRT Trigger Recruitment of the Fusogens Syntaxin-2 and EFF-1 to Promote Membrane Repair in C. elegans
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    mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways
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    Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging
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    Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation
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    PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression
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    MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer
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    HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration
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    Plasmodium transcription repressor AP2‐O3 regulates sex‐specific identity of gene expression in female gametocytes
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    GPR120 regulates pancreatic polypeptide secretion from male mouse islets via PLC-mediated calcium mobilization
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    Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1
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    Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma
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    BK channel density is regulated by endoplasmic reticulum associated degradation and influenced by the SKN-1A/NRF1 transcription factor
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    Nestin selectively facilitates the phosphorylation of the Lissencephaly-linked protein doublecortin (DCX) by cdk5/p35 to regulate growth cone morphology and Sema3a sensitivity in developing neurons.
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    Threonine ADP-Ribosylation of Ubiquitin by a Bacterial Effector Family Blocks Host Ubiquitination
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    Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis
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    Genomic innovation of ATD alleviates mistranslation associated with multicellularity in Animalia
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    The integrity of cochlear hair cells is established and maintained through the localization of Dia1 at apical junctional complexes and stereocilia
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    The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death
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    Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer
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    Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer
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    The Drosophila Ortholog of Mammalian Transcription Factor Sox9 Regulates Intestinal Homeostasis and Regeneration at an Appropriate Level
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    In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8–16-mer Oligomer Species
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    CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis
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