78 Matching Annotations
  1. Last 7 days
  2. www.sciencedirect.com www.sciencedirect.com
    Ca2+/calmodulin-dependent protein kinase II β decodes ER Ca2+ transients to trigger autophagosome formation
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    1. scibot 03 Jan 2025
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      DOI: 10.1016/j.molcel.2024.12.005

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    sciencedirect.com/science/article/pii/S1097276524010001
  3. Oct 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Salsolinol as an RNA m6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy
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    1. scibot 02 Oct 2024
      RRID:AB_1279301

      DOI: 10.4103/NRR.NRR-D-23-01592

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    ncbi.nlm.nih.gov/pmc/articles/PMC11433901/
  5. Sep 2024
  6. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Muscle-derived IL-1β regulates EcSOD expression via the NBR1-p62-Nrf2 pathway in muscle during cancer cachexia
    1
    1. scibot 27 Sep 2024
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      DOI: 10.1113/JP286460

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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP286460
  7. Aug 2024
  8. www.sciencedirect.com www.sciencedirect.com
    Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence
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    1. scibot 23 Aug 2024
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    sciencedirect.com/science/article/pii/S1097276524006609
  9. Jul 2024
  10. www.sciencedirect.com www.sciencedirect.com
    Intracellular tau fragment droplets serve as seeds for tau fibrils
    1
    1. scibot 25 Jul 2024
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    sciencedirect.com/science/article/pii/S0969212624002363
  11. Jun 2024
  12. www.sciencedirect.com www.sciencedirect.com
    Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule
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    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.devcel.2024.04.020

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    sciencedirect.com/science/article/pii/S1534580724002958
  13. May 2024
  14. www.sciencedirect.com www.sciencedirect.com
    A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1
    1
    1. scibot 08 May 2024
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    sciencedirect.com/science/article/pii/S1550413124001359
  15. Apr 2024
  16. www.sciencedirect.com www.sciencedirect.com
    Individual Atg8 paralogs and a bacterial metabolite sequentially promote hierarchical CASM-xenophagy induction and transition
    1
    1. scibot 24 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114131

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    sciencedirect.com/science/article/pii/S2211124724004595
  17. Mar 2024
  18. www.sciencedirect.com www.sciencedirect.com
    Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
    2
    1. scibot 12 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113935

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    2. scibot 12 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113935

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    sciencedirect.com/science/article/pii/S2211124724002638
  19. Feb 2024
  20. www.sciencedirect.com www.sciencedirect.com
    UDP-glucose dehydrogenase supports autophagy-deficient PDAC growth via increasing hyaluronic acid biosynthesis
    1
    1. scibot 24 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113808

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    sciencedirect.com/science/article/pii/S2211124724001360
  21. link.springer.com link.springer.com
    The human OPA1delTTAG mutation induces adult onset and progressive auditory neuropathy in mice
    1
    1. scibot 14 Feb 2024
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      DOI: 10.1007/s00018-024-05115-4

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    link.springer.com/article/10.1007/s00018-024-05115-4
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EBAG9-deficient mice display decreased bone mineral density with suppressed autophagy
    1
    1. scibot 06 Feb 2024
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      DOI: 10.1016/j.isci.2024.108871

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    ncbi.nlm.nih.gov/pmc/articles/PMC10835455/
  23. Dec 2023
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62
    1
    1. scibot 22 Dec 2023
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      DOI: 10.1038/s41467-023-44033-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC10730909/
  25. Nov 2023
  26. www.sciencedirect.com www.sciencedirect.com
    Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescence
    1
    1. scibot 10 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113381

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    sciencedirect.com/science/article/pii/S2211124723013931
  27. Oct 2023
  28. www.biorxiv.org www.biorxiv.org
    Linear ubiquitination at damaged lysosomes induces local NF-κB activation and controls cell survival
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1101/2023.10.06.560832

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    biorxiv.org/content/10.1101/2023.10.06.560832v1
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy
    1
    1. scibot 07 Oct 2023
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      DOI: 10.1016/j.molcel.2023.09.004

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    ncbi.nlm.nih.gov/pmc/articles/PMC10552648/
  30. Jul 2023
  31. 52.53.155.43 52.53.155.43
    NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62
    1
    1. scibot 19 Jul 2023
      RRID:AB_1279301

      DOI: 10.1101/2023.06.05.543428

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    52.53.155.43/5185b06857919afc7fae38712332798a8a903a3a/2023.06.05.543428v1.full-html.html
  32. www.sciencedirect.com www.sciencedirect.com
    AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b-/-Grn-/- mice
    1
    1. scibot 15 Jul 2023
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      DOI: 10.1016/j.isci.2023.107247

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    sciencedirect.com/science/article/pii/S258900422301324X
  33. www.sciencedirect.com www.sciencedirect.com
    Development of small fluorescent probes for the analysis of autophagy kinetics
    1
    1. scibot 15 Jul 2023
      RRID:AB_1279301

      DOI: 10.1016/j.isci.2023.107218

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    sciencedirect.com/science/article/pii/S2589004223012956
  34. Jun 2023
  35. www.embopress.org www.embopress.org
    Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response
    1
    1. scibot 15 Jun 2023
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      DOI: 10.15252/embj.2022113349

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    embopress.org/doi/10.15252/embj.2022113349
  36. www.jneurosci.org www.jneurosci.org
    Chronic neuronal inactivity utilizes the mTOR-TFEB pathway to drive transcription-dependent autophagy for homeostatic up-scaling
    1
    1. scibot 01 Jun 2023
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      DOI: 10.1523/JNEUROSCI.0146-23.2023

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    jneurosci.org/content/43/15/2631
  37. May 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex
    1
    1. scibot 17 May 2023
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      DOI: 10.1016/j.devcel.2023.04.015

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    sciencedirect.com/science/article/pii/S1534580723001910
  39. www.nature.com www.nature.com
    Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance
    1
    1. scibot 05 May 2023
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      DOI: 10.1038/s41467-022-31905-0

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    nature.com/articles/s41467-022-31905-0
  40. Apr 2023
  41. www.sciencedirect.com www.sciencedirect.com
    Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration
    1
    1. scibot 27 Apr 2023
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      DOI: 10.1016/j.neuron.2023.04.006

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    sciencedirect.com/science/article/pii/S0896627323002684
  42. www.biorxiv.org www.biorxiv.org
    Optineurin provides a mitophagy contact site for TBK1 activation
    1
    1. scibot 12 Apr 2023
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      DOI: 10.1101/2023.02.24.529790

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    biorxiv.org/content/10.1101/2023.02.24.529790v1
  43. Mar 2023
  44. www.mdpi.com www.mdpi.com
    NAADP-Evoked Ca2+ Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes
    1
    1. scibot 18 Mar 2023
      RRID:AB_1279301

      DOI: 10.3390/ijms24065593

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    mdpi.com/1422-0067/24/6/5593
  45. Feb 2023
  46. www.sciencedirect.com www.sciencedirect.com
    Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport, generating compositionally diverse Importin β-1 granules
    1
    1. scibot 24 Feb 2023
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      DOI: 10.1016/j.celrep.2023.112134

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    sciencedirect.com/science/article/pii/S2211124723001456
  47. Nov 2022
  48. www.sciencedirect.com www.sciencedirect.com
    Bortezomib inhibits ZIKV/DENV by interfering with viral polyprotein cleavage via the ERAD pathway
    1
    1. scibot 09 Nov 2022
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      DOI: 10.1016/j.chembiol.2022.10.003

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    sciencedirect.com/science/article/pii/S2451945622003579
  49. Oct 2022
  50. www.sciencedirect.com www.sciencedirect.com
    Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify autophagosome initiation sites
    1
    1. scibot 05 Oct 2022
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      DOI: 10.1016/j.cell.2022.09.001

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    sciencedirect.com/science/article/pii/S0092867422011230
  51. Sep 2022
  52. www.sciencedirect.com www.sciencedirect.com
    Identification of CUL4A-DDB1-WDFY1 as an E3 ubiquitin ligase complex involved in initiation of lysophagy
    1
    1. scibot 15 Sep 2022
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      DOI: 10.1016/j.celrep.2022.111349

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    sciencedirect.com/science/article/pii/S2211124722011779
  53. www.sciencedirect.com www.sciencedirect.com
    The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction
    1
    1. scibot 11 Sep 2022
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      DOI: 10.1016/j.chom.2022.08.008

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    sciencedirect.com/science/article/pii/S1931312822004073
  54. Jul 2022
  55. www.sciencedirect.com www.sciencedirect.com
    Acetylation of p62 regulates base excision repair through interaction with APE1
    1
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      RRID:AB_1279301

      DOI: 10.1016/j.celrep.2022.111116

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    sciencedirect.com/science/article/pii/S2211124722009226
  56. Apr 2022
  57. www.sciencedirect.com www.sciencedirect.com
    CCT2 is an aggrephagy receptor for clearance of solid protein aggregates
    1
    1. scibot 07 Apr 2022
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      DOI: 10.1016/j.cell.2022.03.005

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    sciencedirect.com/science/article/pii/S0092867422002653
  58. Mar 2022
  59. www.sciencedirect.com www.sciencedirect.com
    Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis
    1
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      RRID:AB_1279301

      DOI: 10.1016/j.celrep.2022.110444

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    sciencedirect.com/science/article/pii/S2211124722001711
  60. Feb 2022
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYC and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma
    1
    1. scibot 16 Feb 2022
      RRID: AB_1279301

      DOI: 10.1158/0008-5472.CAN-21-1677

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    ncbi.nlm.nih.gov/pmc/articles/PMC7611539/
  62. Nov 2021
  63. www.sciencedirect.com www.sciencedirect.com
    ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress
    1
    1. scibot 09 Nov 2021
      RRID:AB_1279301

      DOI: 10.1016/j.devcel.2021.10.006

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    sciencedirect.com/science/article/pii/S1534580721008078
  64. Sep 2021
  65. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Overexpression of α-synuclein inhibits mitochondrial Ca2+ trafficking between the endoplasmic reticulum and mitochondria through MAMs by altering the GRP75–IP3R interaction
    1
    1. scibot 14 Sep 2021
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      DOI: 10.1002/jnr.24952

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    onlinelibrary.wiley.com/doi/10.1002/jnr.24952
  66. Aug 2021
  67. www.sciencedirect.com www.sciencedirect.com
    Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination
    1
    1. scibot 08 Aug 2021
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      DOI: 10.1016/j.neuron.2018.05.039

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    sciencedirect.com/science/article/pii/S0896627318304379
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates
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  69. Jul 2021
  70. www.sciencedirect.com www.sciencedirect.com
    Intrinsically Disordered Protein TEX264 Mediates ER-phagy
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      Rabbit polyclonal anti-p62

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  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The optineurin/TIA1 pathway inhibits aberrant stress granule formation and reduces ubiquitinated TDP-43
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      DOI: 10.1016/j.isci.2021.102733

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    Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis
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      DOI: 10.1016/j.chembiol.2021.06.003

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  73. May 2021
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    Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity
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  75. Apr 2021
  76. www.sciencedirect.com www.sciencedirect.com
    Autophagosome content profiling using proximity biotinylation proteomics coupled to protease digestion in mammalian cells
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  77. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity
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    Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin
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  79. www.cell.com www.cell.com
    β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells
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      DOI: 10.1016/j.cub.2021.01.081

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    cell.com/current-biology/abstract/S0960-9822(21)00146-9
  80. Mar 2021
  81. www.sciencedirect.com www.sciencedirect.com
    Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling
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  82. Feb 2021
  83. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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      DOI: 10.1111/bph.15350

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  84. Jan 2021
  85. www.sciencedirect.com www.sciencedirect.com
    ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation
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      DOI: 10.1016/j.devcel.2020.12.010

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  86. Dec 2020
  87. www.mdpi.com www.mdpi.com
    Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux
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  88. www.sciencedirect.com www.sciencedirect.com
    Autophagy Is Required for Maturation of Surfactant-Containing Lamellar Bodies in the Lung and Swim Bladder
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    sciencedirect.com/science/article/pii/S2211124720314662
  89. Nov 2020
  90. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Distinct alpha‐Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH‐SY5Y cells
    1
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      DOI: 10.1111/jnc.15174

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  91. Sep 2020
  92. www.sciencedirect.com www.sciencedirect.com
    The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons
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      DOI: 10.1016/j.celrep.2020.02.060

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  93. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Changes in the cellular fatty acid profile drive the proteasomal degradation of α‐synuclein and enhance neuronal survival
    1
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      DOI: 10.1096/fj.202001344R

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  94. Jan 2020
  95. www.sciencedirect.com www.sciencedirect.com
    The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1
    1
    1. scibot 13 Jan 2020
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  96. elifesciences.org elifesciences.org
    A critical role of VMP1 in lipoprotein secretion
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      DOI: 10.7554/eLife.48834

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  97. www.sciencedirect.com www.sciencedirect.com
    Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy
    1
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      DOI: 10.1016/j.celrep.2019.11.058

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    sciencedirect.com/science/article/pii/S2211124719315499
  98. www.sciencedirect.com www.sciencedirect.com
    AUTACs: Cargo-Specific Degraders Using Selective Autophagy
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      DOI: 10.1016/j.molcel.2019.09.009

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  99. www.sciencedirect.com www.sciencedirect.com
    Septins Recognize and Entrap Dividing Bacterial Cells for Delivery to Lysosomes
    1
    1. scibot 13 Jan 2020
      RRID:AB_1279301

      DOI: 10.1016/j.chom.2018.11.005

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    sciencedirect.com/science/article/pii/S1931312818305626
  100. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.cub.2019.01.041

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  101. www.jneurosci.org www.jneurosci.org
    Light-Activated ROS Production Induces Synaptic Autophagy
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      DOI: 10.1523/JNEUROSCI.1317-18.2019

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    jneurosci.org/content/39/12/2163
  102. www.sciencedirect.com www.sciencedirect.com
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  103. www.sciencedirect.com www.sciencedirect.com
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      RRID:AB_1279301

      DOI: 10.1016/j.molcel.2018.12.017

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  104. onlinelibrary.wiley.com onlinelibrary.wiley.com
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      DOI: 10.1111/jnc.14222

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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14222
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defining host–pathogen interactions employing an artificial intelligence workflow
    1
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      DOI: 10.7554/eLife.40560

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  106. Nov 2018
  107. www.sciencedirect.com www.sciencedirect.com
    IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion
    1
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  108. www.sciencedirect.com www.sciencedirect.com
    FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis
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  109. www.sciencedirect.com www.sciencedirect.com
    Reactive Persulfides from Salmonella Typhimurium Downregulate Autophagy-Mediated Innate Immunity in Macrophages by Inhibiting Electrophilic Signaling
    1
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  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II
    1
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  111. www.nature.com www.nature.com
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  112. www.sciencedirect.com www.sciencedirect.com
    The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis
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    Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway
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  114. Nov 2017
  115. www.sciencedirect.com www.sciencedirect.com
    The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation
    1
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  116. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Overexpression of α‐synuclein in an astrocyte cell line promotes autophagy inhibition and apoptosis
    1
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      Curator: @patriciaelyse_

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    onlinelibrary.wiley.com/doi/10.1002/jnr.24092/full
  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1
    1
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      anti-P62

      Curator: @chewbeccax

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    ncbi.nlm.nih.gov/pmc/articles/PMC5127638/
  118. www.sciencedirect.com www.sciencedirect.com
    Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17
    1
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      AB_1279301

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