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PRKCI-ECT2 copy number gain promotes developmental reprogramming and metastatic competence in lung adenocarcinoma

1
1. scibot 20 Jul 2026
  
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  DOI: 10.1016/j.celrep.2026.117697
  
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sciencedirect.com/science/article/pii/S2211124726007758
Jun 2026
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Organoid modeling of lung branching morphogenesis and epithelial lineage specification

1
1. scibot 22 Jun 2026
  
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  DOI: 10.1016/j.devcel.2026.05.012
  
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sciencedirect.com/science/article/pii/S1534580726001966
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Xenophagocytosis blockade enhances interspecies chimerism

1
1. scibot 06 Jun 2026
  
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  DOI: 10.1016/j.cell.2026.05.016
  
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sciencedirect.com/science/article/pii/S0092867426005751
Mar 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Chimeric brain models to study human glial-neuronal and macroglial-microglial interactions

1
1. scibot 18 Mar 2026
  
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  DOI: 10.1016/j.celrep.2025.116794
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12974579/
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Opposing lineage specifiers induce a protumor hybrid identity state in lung adenocarcinoma

1
1. scibot 03 Mar 2026
  
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  DOI: 10.1101/gad.352742.125
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12404196/
Feb 2026
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Distinct spatial patterning and transcriptomic landscapes of human neural organoids by localized delivery of morphogens

1
1. scibot 24 Feb 2026
  
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  DOI: 10.1016/j.stem.2026.01.008
  
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sciencedirect.com/science/article/pii/S1934590926000317
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Goal-directed learning in cortical organoids

1
1. scibot 20 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.116984
  
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sciencedirect.com/science/article/pii/S2211124726000628
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A single-cell time-series atlas of endothelial cell embryonic development

1
1. scibot 19 Feb 2026
  
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  DOI: 10.1016/j.cell.2026.01.002
  
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sciencedirect.com/science/article/pii/S0092867426000498
Dec 2025
journals.plos.org journals.plos.org

Deciphering the pathogenicity of three NKX2-1 variants in ultra-severe forms of childhood interstitial lung disease

1
1. scibot 23 Dec 2025
  
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  DOI: 10.1371/journal.pone.0338446
  
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journals.plos.org/plosone/article
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes

1
1. scibot 23 Nov 2025
  
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  DOI: 10.1158/2159-8290.CD-24-1565
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12469823/
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EML4-ALK variant-specific genetic interactions shape lung tumorigenesis

1
1. scibot 23 Nov 2025
  
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  DOI: 10.1158/2159-8290.CD-24-1417
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12479099/
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Hypoxia promotes airway differentiation in the human lung epithelium

1
1. scibot 21 Nov 2025
  
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  RRID:AB_1310784
  
  DOI: 10.1016/j.stem.2025.09.007
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7618356/
Oct 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Dysplastic lung repair fosters a tuberculosis-promoting microenvironment through maladaptive macrophage polarization

1
1. scibot 11 Oct 2025
  
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  AB_1310784
  
  DOI: 10.1371/journal.ppat.1013563
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12510645/
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Hypoxia promotes airway differentiation in the human lung epithelium

1
1. scibot 11 Oct 2025
  
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  RRID:AB_1310784
  
  DOI: 10.1016/j.stem.2025.09.007
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7618356/
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

BRAFV600E-Driven Lung Tumorigenesis Requires Ligand-Mediated Activation of ERBB Receptor Signaling

1
1. scibot 25 Sep 2025
  
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  RRID:AB_1310784
  
  DOI: 10.1101/2025.05.04.652129
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12248061/
Aug 2025
www.biorxiv.org www.biorxiv.org

L1CAM signaling through planar cell polarity generates SOX2+ metastatic progenitors in lung adenocarcinoma

1
1. scibot 27 Aug 2025
  
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  RRID:AB_1310784
  
  DOI: 10.1101/2025.08.22.671773
  
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biorxiv.org/content/10.1101/2025.08.22.671773v1
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Protocol for developing a mouse model of post-primary pulmonary tuberculosis after hematogenous spread in native lungs and lung implants

1
1. scibot 02 Aug 2025
  
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  RRID:AB_1310784
  
  DOI: 10.1016/j.xpro.2025.103984
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12311599/
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Protocol for directed differentiation of human induced pluripotent stem cells into thyroid follicular epithelial cells

1
1. scibot 29 Jul 2025
  
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  RRID:AB_1310784
  
  DOI: 10.1016/j.xpro.2025.103979
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12311601/
52.53.155.43 52.53.155.43

Organoid modeling reveals the tumorigenic potential of the alveolar progenitor cell state

1
1. scibot 23 Jul 2025
  
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  RRID:AB_1310784
  
  DOI: 10.1038/s44318-025-00376-6
  
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52.53.155.43/1c70dafeeeda06325918fe95f6455c023d1ce5ae/March-2025-Carla-Kim-li-et-al-2025-organoid-modeling-reveals-the-tumorigenic-potential-of-the-alveolar-progenitor-cell-state-html.html
www.sciencedirect.com www.sciencedirect.com

Forebrain assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects

1
1. scibot 22 Jul 2025
  
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  RRID:AB_1310784
  
  DOI: 10.1016/j.neuron.2025.06.017
  
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sciencedirect.com/science/article/pii/S0896627325004751
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Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids

1
1. scibot 01 Jul 2025
  
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  RRID:AB_1310784
  
  DOI: 10.1016/j.cell.2025.05.041
  
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sciencedirect.com/science/article/pii/S0092867425006282
May 2025
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Generation of SFTPC-mCherry knock-in reporter human embryonic stem cell line, WAe001-A-2H, using CRISPR/Cas9-based gene targeting

1
1. scibot 18 May 2025
  
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  RRID:AB_1310784
  
  DOI: 10.1016/j.scr.2024.103597
  
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sciencedirect.com/science/article/pii/S1873506124002952
Apr 2025
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Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation

1
1. scibot 19 Apr 2025
  
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  RRID:AB_1310784
  
  DOI: 10.1016/j.ccell.2025.03.027
  
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sciencedirect.com/science/article/pii/S153561082500128X
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Transcriptional conservation and evolutionary divergence of cell types across mammalian hypothalamus development

1
1. scibot 09 Apr 2025
  
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  RRID:AB_1310784
  
  DOI: 10.1016/j.devcel.2025.03.009
  
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sciencedirect.com/science/article/pii/S153458072500156X
Mar 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225005565-main-html.html

1
1. scibot 28 Mar 2025
  
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  RRID:AB_1310784
  
  DOI: 10.1016/j.isci.2025.112295
  
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52.53.155.43/60bd8b63b5057b3a2fd52107fc36eb4f600f9b31/1-s2.0-S2589004225005565-main-html.html
52.53.155.43 52.53.155.43

Organoid modeling reveals the tumorigenic potential of the alveolar progenitor cell state

1
1. scibot 20 Mar 2025
  
  in Public
  
  RRID:AB_1310784
  
  DOI: 10.1038/s44318-025-00376-6
  
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52.53.155.43/1c70dafeeeda06325918fe95f6455c023d1ce5ae/March-2025-Carla-Kim-li-et-al-2025-organoid-modeling-reveals-the-tumorigenic-potential-of-the-alveolar-progenitor-cell-state-html.html
www.sciencedirect.com www.sciencedirect.com

m6A deficiency impairs hypothalamic neurogenesis of feeding-related neurons in mice and human organoids and leads to adult obesity in mice

1
1. scibot 20 Mar 2025
  
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  RRID:AB_1310784
  
  DOI: 10.1016/j.stem.2025.02.011
  
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sciencedirect.com/science/article/pii/S1934590925000797
Feb 2025
www.nature.com www.nature.com

PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors

1
1. scibot 25 Feb 2025
  
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  RRID:AB_1310784
  
  DOI: 10.1038/s41593-024-01865-3
  
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nature.com/articles/s41593-024-01865-3
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Protocol for 3D multiplexed fluorescent imaging of pulmonary TB lesions using Opal-TSA dyes for signal amplification

1
1. scibot 25 Feb 2025
  
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  RRID:AB_1310784
  
  DOI: 10.1016/j.xpro.2025.103640
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11889971/
52.53.155.43 52.53.155.43

3D Multiplexed Immunohistochemistry Using Opal-TSA Amplification for Enhanced Imaging of Pulmonary TB Lesions

1
1. scibot 07 Feb 2025
  
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  RRID:AB_13107
  
  DOI: 10.1101/2024.10.23.619885
  
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52.53.155.43/886de1c0a239009e9934880da2e574f4036ba049/2024.10.23.619885.full-html.html
Jan 2025
www.sciencedirect.com www.sciencedirect.com

The potential of lazertinib and amivantamab combination therapy as a treatment strategy for uncommon EGFR-mutated NSCLC

1
1. scibot 28 Jan 2025
  
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  RRID:AB_1310784
  
  DOI: 10.1016/j.xcrm.2025.101929
  
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sciencedirect.com/science/article/pii/S2666379125000023
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Longitudinal single-cell profiles of lung regeneration after viral infection reveal persistent injury-associated cell states

1
1. scibot 16 Jan 2025
  
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  RRID:AB_1310784
  
  DOI: 10.1016/j.stem.2024.12.002
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11805657/
Nov 2024
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FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma

1
1. scibot 11 Nov 2024
  
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  AB:1310784
  
  DOI: 10.1016/j.devcel.2024.10.009
  
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sciencedirect.com/science/article/pii/S1534580724006282
Aug 2024
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Neuroepithelial bodies and terminal bronchioles are niches for distinctive club cells that repair the airways following acute notch inhibition

1
1. scibot 27 Aug 2024
  
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  AB_1310784
  
  DOI: 10.1016/j.celrep.2024.114654
  
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sciencedirect.com/science/article/pii/S2211124724010052
www.biorxiv.org www.biorxiv.org

Functional mapping of epigenetic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes

1
1. scibot 25 Aug 2024
  
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  RRID:AB_1310784
  
  DOI: 10.1101/2024.08.19.607671
  
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biorxiv.org/content/10.1101/2024.08.19.607671v1
May 2024
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Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer

1
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  DOI: 10.1016/j.ccell.2024.05.003
  
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Apr 2024
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Generation of human alveolar epithelial type I cells from pluripotent stem cells

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ncbi.nlm.nih.gov/pmc/articles/PMC11147407/
Feb 2024
52.53.155.43 52.53.155.43

A dynamic Hedgehog gradient orients tracheal cartilage rings

2
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  DOI: 10.1101/2023.09.25.559425
  
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Jan 2024
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Deep spatial proteomics reveals region-specific features of severe COVID-19-related pulmonary injury

1
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Patterning ganglionic eminences in developing human brain organoids using a morphogen-gradient-inducing device

1
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Human fetal brain self-organizes into long-term expanding organoids

1
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Oct 2023
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In vitro vascularized immunocompetent patient-derived model to test cancer therapies

1
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Acquisition of Neural Fate by Combination of BMP Blockade and Chromatin Modification

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Aug 2023
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Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice

1
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Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells

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Jul 2023
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Profiling transcriptomic responses of human stem cell-derived medium spiny neuron-like cells to exogenous phasic and tonic neurotransmitters

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Jun 2023
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RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition

1
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aacrjournals.org/cancerres/article/83/9/1490/726058/RBM10-Loss-Promotes-EGFR-Driven-Lung-Cancer-and
May 2023
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Atf3 defines a population of pulmonary endothelial cells essential for lung regeneration

1
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A prime editor mouse to model a broad spectrum of somatic mutations in vivo

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  DOI: 10.1038/s41587-023-01783-y
  
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nature.com/articles/s41587-023-01783-y
Apr 2023
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Early immune pressure initiated by tissue-resident memory T cells sculpts tumor evolution in non-small cell lung cancer

1
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Mar 2023
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Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma

1
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Feb 2023
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Generation of telomeric repeat binding factor 1 (TRF1)-knockout human embryonic stem cell lines, KRIBBe010-A-95, KRIBBe010-A-96, and KRIBBe010-A-97, using CRISPR/Cas9 technology

1
1. scibot 16 Feb 2023
  
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Dec 2022
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Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis

1
1. scibot 30 Dec 2022
  
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Aug 2022
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Murine thyroid IL-4 expression worsens hypothyroidism under iodine restriction and mitigates Graves’ disease development

1
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Smarca4 inactivation promotes lineage-specific transformation and early metastatic features in the lung

1
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Jul 2022
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FoxA1 and FoxA2 control growth and cellular identity in NKX2-1-positive lung adenocarcinoma

1
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Klf5 defines alveolar epithelial type 1 cell lineage commitment during lung development and regeneration

1
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Jun 2022
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R-SPONDIN2+ mesenchymal cells form the bud tip progenitor niche during human lung development

1
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May 2022
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A versatile viral toolkit for functional discovery in the nervous system

1
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EMT, Stemness, and Drug Resistance in Biological Context: A 3D Tumor Tissue/In Silico Platform for Analysis of Combinatorial Treatment in NSCLC with Aggressive KRAS-Biomarker Signatures

1
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  DOI: 10.3390/cancers14092176
  
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mdpi.com/2072-6694/14/9/2176
Feb 2022
elifesciences.org elifesciences.org

Recapitulating human cardio-pulmonary co-development using simultaneous multilineage differentiation of pluripotent stem cells

1
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Jan 2022
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A functional taxonomy of tumor suppression in oncogenic KRAS-driven lung cancer

1
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ncbi.nlm.nih.gov/pmc/articles/PMC8292166/
Nov 2021
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A functional genetic toolbox for human tissue-derived organoids

1
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USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma

1
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ncbi.nlm.nih.gov/pmc/articles/PMC8553340/
Oct 2021
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NMDARs Drive the Expression of Neuropsychiatric Disorder Risk Genes Within GABAergic Interneuron Subtypes in the Juvenile Brain

1
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  DOI: 10.3389/fnmol.2021.712609
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8500094/
Sep 2021
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Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease

1
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Jul 2021
cercor.oxfordjournals.org cercor.oxfordjournals.org

The Role of Sonic Hedgehog in the Specification of Human Cortical Progenitors In Vitro

2
1. scibot 27 Jul 2021
  
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  rabbit monoclonal anti-Nkx2.1
  
  DOI: 10.1093/cercor/bhu183
  
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  monoclonal rabbit anti-Nkx2.1
  
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Differentiation of human pluripotent stem cells into functional airway basal stem cells

1
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  DOI: 10.1016/j.xpro.2021.100683
  
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Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis

1
1. scibot 14 Jul 2021
  
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  DOI: 10.1016/j.celrep.2021.109347
  
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Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells

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Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells

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Airway basal stem cells generate distinct subpopulations of PNECs

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Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma

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Generation of human pluripotent stem cell-derived fused organoids with oligodendroglia and myelin

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Imbalance of Excitatory/Inhibitory Neuron Differentiation in Neurodevelopmental Disorders with an NR2F1 Point Mutation

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Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction

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Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

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In Vitro and In Vivo Development of the Human Airway at Single-Cell Resolution

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MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate

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Derivation of self-renewing lung alveolar epithelial type II cells from human pluripotent stem cells

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Multi-lineage Lung Regeneration by Stem Cell Transplantation across Major Genetic Barriers

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Generation of Lungs by Blastocyst Complementation in Apneumic Fgf10-Deficient Mice

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Mutationally-activated PI3’-kinase-α promotes de-differentiation of lung tumors initiated by the BRAFV600E oncoprotein kinase

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  DOI: 10.7554/eLife.43668
  
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BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

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FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer

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OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome

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Chd2 Is Necessary for Neural Circuit Development and Long-Term Memory

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The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment

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Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification

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3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling

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Systematic Functional Annotation of Somatic Mutations in Cancer

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Untitled document

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Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity

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Untitled document

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Nov 2017
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Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

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  Curator: @kaitlinsung
  
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