1,922 Matching Annotations
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    PARP inhibitors suppress tumours via centrosome error-induced senescence independent of DNA damage response
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    Molecular and cellular organization of odorant binding protein genes in Drosophila
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    RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells
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    Generation of two induced pluripotent stem cell lines (LVPEIi004-A and LVPEIi005-A) from probands with Leber Congenital Amaurosis 2 (LCA2) and harboring mutations in RPE65
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    ptx3a+ fibroblast/epicardial cells provide a transient macrophage niche to promote heart regeneration
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    Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence
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    Cooperation of Various Cytoskeletal Components Orchestrates Intercellular Spread of Mitochondria between B-Lymphoma Cells through Tunnelling Nanotubes
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  9. Apr 2024
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    Duox activation in Drosophila Malpighian tubules stimulates intestinal epithelial renewal through a countercurrent flow
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    Microglia aging in the hippocampus advances through intermediate states that drive inflammatory activation and cognitive decline
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    Generation of two induced pluripotent stem cell lines (LVPEIi007-B, LVPEIi008-B) from patients harboring homozygous mutation in ABCA4 (c.6088C>T) using non-integrative Sendai virus-based approach
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    Time-series reconstruction of the molecular architecture of human centriole assembly
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    Phosphoinositide detection at synapses of fixed murine hippocampal neurons
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    Functionally diverse thymic medullary epithelial cells interplay to direct central tolerance
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    Bacterial muropeptides promote OXPHOS and suppress mitochondrial stress in mammals
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    Truncating NFKB1 variants cause combined NLRP3 inflammasome activation and type I interferon signaling and predispose to necrotizing fasciitis
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    Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
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    Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer
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    The Legionella pneumophila effector DenR hijacks the host NRas proto-oncoprotein to downregulate MAPK signaling
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    Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss
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    Microtubule-associated protein MAP7 promotes tubulin posttranslational modifications and cargo transport to enable osmotic adaptation
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    Endometrial BMP2 Deficiency Impairs ITGB3-Mediated Trophoblast Invasion in Women with Repeated Implantation Failure
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      DOI: 10.1210/endocr/bqae002

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    Defects of renal tubular homeostasis and cystogenesis in the Pkhd1-knockout
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    Generation of one induced pluripotent stem cell line JUCGRMi004-A from a Charcot-Marie-Tooth disease type 1A (CMT1A) patient with PMP22 duplication
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    Generation of a TSC2 knockout embryonic stem cell line by CRISPR/Cas9 editing
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    Pooled CRISPR screening of high-content cellular phenotypes using ghost cytometry
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    Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling
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    Regulation of condensin II by self-suppression and release mechanisms
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    White and gray matter integrity evaluated by MRI-DTI can serve as noninvasive and reliable indicators of structural and functional alterations in chronic neurotrauma
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    Neuropeptides in the rat claustrum – An immunohistochemical detection
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    Matrilin-3 supports neuroprotection in ischemic stroke by suppressing astrocyte-mediated neuroinflammation
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    Maladaptation of dentate gyrus mossy cells mediates contextual discrimination deficit after traumatic stress
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  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cortical brain organoid slices (cBOS) for the study of human neural cells in minimal networks
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  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RhoA downregulation in the murine intestinal epithelium results in chronic Wnt activation and increased tumorigenesis
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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC10960274/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    XPA tumor variant leads to defects in NER that sensitize cells to cisplatin
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    Medioapical contractile pulses coordinated between cells regulate Drosophila eye morphogenesis
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    rupress.org/jcb/article/223/2/e202304041/276471/Medioapical-contractile-pulses-coordinated-between
  40. www.thelancet.com www.thelancet.com
    Female mice display sex-specific differences in cerebrovascular function and subarachnoid haemorrhage-induced injury
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    thelancet.com/journals/ebiom/article/PIIS2352-3964(24)00093-8/abstract
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting Chlamydia effectors from degradation
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      DOI: 10.7554/eLife.87386

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    Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity
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    A gut-derived hormone regulates cholesterol metabolism
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    TLR2 regulates hair follicle cycle and regeneration via BMP signaling
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    A novel GABAergic population in the medial vestibular nucleus maintains wakefulness and gates rapid eye movement sleep
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    Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment
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    Generation of Leber congenital amaurosis, type 12 patient-specific induced pluripotent stem cell line (LVPEIi006-A), harboring a homozygous mutation in RD3
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    Disease-causing Slack potassium channel mutations produce opposite effects on excitability of excitatory and inhibitory neurons
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    C17orf80 binds the mitochondrial genome to promote its replication
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  50. 52.53.155.43 52.53.155.43
    JNEUROSCI.0918-23.2024.full-html.html
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  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pip5k1γ regulates axon formation by limiting Rap1 activity
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    Cardiomyocyte-fibroblast interaction regulates ferroptosis and fibrosis after myocardial injury
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    OPA1 mediates muscle differentiation by promoting a metabolic switch via the supercomplex assembly factor SCAF1
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    The adhesion G-protein-coupled receptor mayo/CG11318 controls midgut development in Drosophila
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    An iPSC line (FINi003-A) from a male with a late-onset developmental and epileptic encephalopathy caused by a heterozygous gain-of-function p.E1211K variant in the SCN2A gene encoding the voltage-gated sodium channel Nav1.2
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    SARS-CoV-2 targets ribosomal RNA biogenesis
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    Generation and characterization of three CRISPR/Cas9 edited RB1 null hiPSC lines for retinoblastoma disease modelling
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    Biallelic pathogenic variants in DNAH3 cause male infertility in humans and mice
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    Genetic labeling of embryonically-born dentate granule neurons in young mice using the PenkCre mouse line
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  60. Feb 2024
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    Establishing a human-induced pluripotent stem cell line (SMUSHi003-A) from a patient with Charcot-Marie-Tooth disease and focal segmental glomerulosclerosis
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    Canonical Wnt signaling directs the generation of functional human PSC-derived atrioventricular canal cardiomyocytes in bioprinted cardiac tissues
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    SPOCK2 modulates neuropathic pain by interacting with MT1-MMP to regulate astrocytic MMP-2 activation in rats with chronic constriction injury
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    Evolutionary analysis identifies a Golgi pathway and correlates lineage-specific factors with endomembrane organelle emergence in apicomplexans
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    Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury
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  67. jneuroinflammation.biomedcentral.com jneuroinflammation.biomedcentral.com
    Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia
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    The β6 Integrin Negatively Regulates TLR7-Mediated Epithelial Immunity via Autophagy During Influenza A Virus Infection
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    Generation of a DMD loss-of-function mutant human embryonic stem cell lines by CRISPR base editing
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    Spine plasticity of dentate gyrus parvalbumin-positive interneurons is regulated by experience
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    PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma
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    Establishment of an induced pluripotent stem cell line from a Noonan syndrome patient with the heterozygote mutation p.S257L (c.770C>T) in RAF1 gene
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    Histological and biochemical changes in lymphatic vessels after skeletal muscle injury induced by lengthening contraction in male mice
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    Flow Cytometry Strategies for Rapidly Characterizing Heterogeneous Adipocyte Populations in 3D In Vitro Constructs
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    Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice
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    Quantitative and qualitative mutational impact of ionizing radiation on normal cells
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  79. www.sciencedirect.com www.sciencedirect.com
    ASICs mediate fast excitatory synaptic transmission for tactile discrimination
    1
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      DOI: 10.1016/j.neuron.2024.01.018

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  80. www.sciencedirect.com www.sciencedirect.com
    BLA DBS improves anxiety and fear by correcting weakened synaptic transmission from BLA to adBNST and CeL in a mouse model of foot shock
    2
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    Generation of two iPSC lines from Mowat-Wilson syndrome patients carrying heterozygous ZEB2 mutations
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    Proline restores mitochondrial function and reverses aging hallmarks in senescent cells
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    Spexin and nesfatin-1-expressing neurons in the male human claustrum
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    An enhanced broad-spectrum peptide inhibits Omicron variants in vivo
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  85. www.sciencedirect.com www.sciencedirect.com
    SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability
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  86. www.sciencedirect.com www.sciencedirect.com
    ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation
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  87. www.biorxiv.org www.biorxiv.org
    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
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    biorxiv.org/content/10.1101/2023.12.05.570182v1
  88. www.biorxiv.org www.biorxiv.org
    Targeting NGF but not VEGF or BDNF signaling reduces endometriosis-associated pain in mice
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    Generation of an induced pluripotent stem cell line (LVPEIi002-A) with heterozygous RB1 mutation using peri-orbital fat derived mesenchymal cells of a patient with inherited retinoblastoma
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  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of CD44 suppresses the formation of fibrotic scar after spinal cord injury via the JAK2/STAT3 signaling pathway
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  91. www.sciencedirect.com www.sciencedirect.com
    The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs
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    Adrenal Abcg1 controls cholesterol flux and steroidogenesis
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    An alternative splicing signature defines the basal-like phenotype and predicts worse clinical outcome in pancreatic cancer
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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis
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    Generation of hiPSCs (JUCGRMi003-A) from a patient with Parkinson’s disease with PARK2 mutation
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    PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression
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    Cell-autonomous targeting of arabinogalactan by host immune factors inhibits mycobacterial growth
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    Osimertinib covalently binds to CD34 and eliminates myeloid leukemia stem/progenitor cells
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    Development of sexual dimorphism of skeletal muscles through the adrenal cortex, caused by androgen-induced global gene suppression
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    Chronic social defeat stress induces anxiety-like behaviors via downregulation of serotonin transporter in the prefrontal serotonergic system in mice
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    SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion
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  102. Jan 2024
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    Regulation of condensin II by self-suppression and release mechanisms
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    Selective vulnerability of layer 5a corticostriatal neurons in Huntington’s disease
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    P. mirabilis-derived pore-forming haemolysin, HpmA drives intestinal alpha-synuclein aggregation in a mouse model of neurodegeneration
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    Generation of a patient-specific iPSC cell line with cardiac arrhythmias and dilated cardiomyopathy (CBRCULi016-A), an isogenic control (CBRCULi016-A-1), and a paternal control (CBRCULi017-A)
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    Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk
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    ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis
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    Predicting gene-level sensitivity to JAK-STAT signaling perturbation using a mechanistic-to-machine learning framework
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    PAPAS promotes differentiation of mammary epithelial cells and suppresses breast carcinogenesis
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  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitophagy promotes resistance to BH3 mimetics in acute myeloid leukemia
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  112. 52.53.155.43 52.53.155.43
    Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors
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      DOI: 10.1126/sciimmunol.abq2424

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  113. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Avoidance and escape conditioning adjust adult neurogenesis to conserve a fit hippocampus in adult male rodents
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    DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication
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    The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export
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  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapy-induced normal tissue damage promotes breast cancer metastasis
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  117. Dec 2023
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    Generation of a control iPS cell line (JUCGRMi005-A) with no abnormalities in Parkinson's disease-related genes
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    Generation of CRISPR-Cas9 edited human induced pluripotent stem cell line carrying BAG3 V468M mutation in its BAG domain
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    Generation of three clones (JUCGRMi002-A, B, C) of induced pluripotent stem cells from a Parkinson’s disease patient with SNCA duplication
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  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression
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  122. www.sciencedirect.com www.sciencedirect.com
    Generation and characterization of a human induced pluripotent stem cell line heterozygous for a NOTCH1 mutation (NCHi014-A)
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  123. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Mechanisms of aquaporin-4 vesicular trafficking in mammalian cells
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      DOI: 10.1111/jnc.16029

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    Generation of a human induced pluripotent stem cell line (SMUSHi002-A) from an ALS patient carrying a heterozygous mutation c.1562G > A in the FUS gene
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    Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model
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    MEK-inhibitors decrease Nfix in muscular dystrophy but induce unexpected calcifications, partially rescued with Cyanidin diet
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    Age-dependent loss of cohesion protection in human oocytes
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    Feeder-Free Generation and Characterization of Endocardial and Cardiac Valve Cells from Human Pluripotent Stem Cells
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    A mitochondrial inside-out iron-calcium signal reveals drug targets for Parkinson’s disease
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    Apoptosis releases hydrogen sulfide to inhibit Th17 cell differentiation
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    Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling
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    Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair
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    HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function
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    Purkinje-cell-specific MeCP2 deficiency leads to motor deficits and autistic-like behavior due to aberrations in PTP1B-TrkB-SK signaling
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    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
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    Generation of a control iPS cell line (JUCGRMi006-A) with no abnormalities in Parkinson's disease-related genes
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  137. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging
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    Increased OCT3 expression in adipose tissue with aging: implications for lipid turnover and insulin resistance in women
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    Exploiting the endogenous yeast nuclear proteome to identify short linear motifs in vivo
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    PP2A-B55SUR-6 promotes nuclear envelope breakdown in C. elegans embryos
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    Role of miR-379 in high-fat diet-induced kidney injury and dysfunction
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    Male cuticular pheromones stimulate removal of the mating plug and promote re-mating through pC1 neurons in Drosophila females
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    Nucleolus activity-dependent recruitment and biomolecular condensation by pH sensing
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    Estrogen-dependent expression and function of secretogranin 2a in female-specific peptidergic neurons
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    Genetic labeling of embryonically-born dentate granule neurons in young mice using the PenkCre mouse line
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    Optogenetic activation of the ventral tegmental area-hippocampal pathway facilitates rapid adaptation to changes in spatial goals
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    Generation of heart and vascular system in rodents by blastocyst complementation
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    β-adrenergic receptor regulates embryonic epithelial extensibility through actomyosin inhibition
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    Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis
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    Brain metastasis-associated fibroblasts secrete fucosylated PVR/CD155 that induces breast cancer invasion
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    Single-cell analysis of shared signatures and transcriptional diversity during zebrafish development
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    The androgen receptor in mesenchymal progenitors regulates skeletal muscle mass via Igf1 expression in male mice
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    SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction
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    Fiber-deficient diet inhibits colitis through the regulation of the niche and metabolism of a gut pathobiont
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    CLMP is a tumor suppressor that determines all-trans retinoic acid response in colorectal cancer
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    Generation of induced pluripotent stem cell lines IRMBi003-A and IRMBi003-B from a healthy donor to model Alzheimer’s disease
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    Incorporation of human iPSC-derived stromal cells creates a pancreatic cancer organoid with heterogeneous cancer-associated fibroblasts
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    Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory ganglia
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    Differential Ire1 determines loser cell fate in tumor-suppressive cell competition
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    Allele-specific expression reveals genetic drivers of tissue regeneration in mice
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  162. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systemic and intrinsic functions of ATRX in glial cell fate and CNS myelination in male mice
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  163. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chromatin accessibility profiling of targeted cell populations with laser capture microdissection coupled to ATAC-seq
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  164. journals.physiology.org journals.physiology.org
    2022 Cannon lecture: an ode to signal transduction: how the growth hormone pathway revealed insight into height, malignancy, and obesity
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  165. 52.53.155.43 52.53.155.43
    2022 Cannon Lecture: An ode to signal transduction - how the growth hormone pathway revealed insight into height, malignancy and obesity
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  166. www.sciencedirect.com www.sciencedirect.com
    Replicative stress in gastroesophageal premalignancy is associated with chromosomal instability and sensitivity to DNA damage response inhibitors
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    Sigma-1 Receptor Inhibition Reduces Mechanical Allodynia and Modulate Neuroinflammation in Chronic Neuropathic Pain
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  168. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
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    Blood flow patterns switch VEGFR2 activity through differential S-nitrosylation and S-oxidation
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    IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development
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    Generation of induced pluripotent stem cell lines from pediatric patients with congenital myotonic dystrophy (CBRCULi012-A and CBRCULi013-A) and Age-Matched controls (CBRCULi010-A and CBRCULi011-A)
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  172. www.biorxiv.org www.biorxiv.org
    Structural and Mechanistic Usage and Preference of Human, Dog, and Bat Receptors by Rabies Virus
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    Pigmented skin exhibits accelerated wound healing compared to the nonpigmented skin in Guinea pig model
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    GABAergic-like dopamine synapses in the brain
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  175. Oct 2023
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    β1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4
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    Bordetella spp. block eosinophil recruitment to suppress the generation of early mucosal protection
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    Generation of an induced pluripotent stem cell line (IGGi002A) from nasal cells of a cystic fibrosis patient homozygous for the G542X-CFTR mutation
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    Serotonin reduction in post-acute sequelae of viral infection
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    Probing cerebral malaria inflammation in 3D human brain microvessels
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    Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages
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    Single-cell and spatial analyses reveal a tradeoff between murine mammary proliferation and lineage programs associated with endocrine cues
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    The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A
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    Shiga toxin targets the podocyte causing hemolytic uremic syndrome through endothelial complement activation
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    Regulation of STING activity in DNA sensing by ISG15 modification
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    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
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  187. www.biorxiv.org www.biorxiv.org
    Bnip3 expression is strongly associated with reelin-positive entorhinal cortex layer II neurons
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  188. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MircroRNA-92b as a Negative Regulator of the TGF-β Signaling by Targeting the Type I Receptor
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  189. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The developmental hierarchy and scarcity of replicative slender trypanosomes in blood challenges their role in infection maintenance
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