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H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations

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  DOI: 10.1016/j.molcel.2025.11.030
  
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sciencedirect.com:5037/science/article/pii/S1097276525009712
Dec 2025
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Interleukin-1/Toll-like receptor signaling potentiates macrophage olfactory receptor 2-driven atherosclerosis

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1. scibot 04 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116639
  
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sciencedirect.com:5037/science/article/pii/S2211124725014111
Nov 2025
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UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression

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  DOI: 10.1016/j.molcel.2025.10.030
  
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sciencedirect.com/science/article/pii/S1097276525008913
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A role for human senataxin in contending with pausing and backtracking during transcript elongation

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  DOI: 10.1016/j.molcel.2025.10.019
  
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sciencedirect.com/science/article/pii/S1097276525008603
Oct 2025
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N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells

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1. scibot 30 Oct 2025
  
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  DOI: 10.1016/j.stem.2025.10.003
  
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sciencedirect.com/science/article/pii/S1934590925003716
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Telomeres control human telomerase (TERT) expression through non-telomeric TRF2

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  DOI: 10.7554/eLife.104045
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12483519/
Sep 2025
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Pharmacologic interrogation of USP28 cellular function in p53 signaling

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  DOI: 10.1016/j.chembiol.2025.08.002
  
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sciencedirect.com/science/article/pii/S2451945625002326
Aug 2025
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Androgen receptor–mediated assisted loading of the glucocorticoid receptor modulates transcriptional responses in prostate cancer cells

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1. scibot 05 Aug 2025
  
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  DOI: 10.1101/gr.280224.124
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12315708/
Jul 2025
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Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling

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1. scibot 31 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116090
  
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sciencedirect.com/science/article/pii/S2211124725008617
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PELP1 coordinates the modular assembly and enzymatic activity of the rixosome complex

1
1. scibot 30 Jul 2025
  
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  DOI: 10.1126/sciadv.adw4603
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12292926/
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PELP1 coordinates the modular assembly and enzymatic activity of the rixosome complex

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1. scibot 29 Jul 2025
  
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  DOI: 10.1126/sciadv.adw4603
  
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science.org/doi/10.1126/sciadv.adw4603
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CUT&Tag and DiBioCUT&Tag enable investigation of the AT-rich epigenome of Plasmodium falciparum from low-input samples

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1. scibot 22 Jul 2025
  
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  DOI: 10.1016/j.crmeth.2025.101110
  
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cell.com/cell-reports-methods/abstract/S2667-2375(25)00146-8
May 2025
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A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.molcel.2025.04.026
  
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sciencedirect.com/science/article/pii/S1097276525004058
Apr 2025
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Aberrant phase separation drives membranous organelle remodeling and tumorigenesis

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1. scibot 24 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.04.001
  
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sciencedirect.com/science/article/pii/S1097276525003041
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Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation

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1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.ccell.2025.03.027
  
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sciencedirect.com/science/article/pii/S153561082500128X
Mar 2025
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Antagonistic roles for MITF and TFE3 in melanoma plasticity

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1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115474
  
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sciencedirect.com/science/article/pii/S2211124725002451
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Equine neutrophils selectively release neutrophil extracellular traps in response to chemical and bacterial agonists

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1. scibot 13 Mar 2025
  
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  RRID:AB_145841
  
  DOI: 10.3389/fvets.2025.1512343
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11891193/
Feb 2025
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KRAS4B oncogenic mutants promote non-small cell lung cancer progression via the interaction of deubiquitinase USP25 with RNF31

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1. scibot 14 Feb 2025
  
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  DOI: 10.1016/j.devcel.2025.01.015
  
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sciencedirect.com/science/article/pii/S1534580725000358
Dec 2024
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Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission

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1. scibot 21 Dec 2024
  
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  DOI: 10.1126/sciadv.adp7423
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11567002/
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Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission

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1. scibot 20 Dec 2024
  
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  DOI: 10.1126/sciadv.adp7423
  
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science.org/doi/10.1126/sciadv.adp7423
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Acute MeCP2 loss in adult mice reveals transcriptional and chromatin changes that precede neurological dysfunction and inform pathogenesis

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  DOI: 10.1016/j.neuron.2024.11.006
  
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sciencedirect.com/science/article/pii/S0896627324008067
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lncRNAs maintain the functional phase state of nucleolar prion-like protein to facilitate rRNA processing

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  DOI: 10.1016/j.molcel.2024.10.036
  
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sciencedirect.com/science/article/pii/S1097276524008761
Nov 2024
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ARF alters PAF1 complex integrity to selectively repress oncogenic transcription programs upon p53 loss

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  DOI: 10.1016/j.molcel.2024.10.020
  
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sciencedirect.com/science/article/pii/S1097276524008608
Sep 2024
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ESR1 Fusions Invoke Breast Cancer Subtype-Dependent Enrichment of Ligand-Independent Oncogenic Signatures and Phenotypes

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1. scibot 15 Sep 2024
  
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  DOI: 10.1210/endocr/bqae111
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11384147/
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Key roles of C2/GAP domains in SYNGAP1-related pathophysiology

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  DOI: 10.1016/j.celrep.2024.114733
  
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sciencedirect.com/science/article/pii/S2211124724010842
Aug 2024
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The tyrosine phosphatases LAR and PTPRδ act as receptors of the nidogen-tetanus toxin complex

1
1. scibot 21 Aug 2024
  
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  AB_145841
  
  DOI: 10.1038/s44318-024-00164-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11329502/
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Sigma-1 receptor recruits LC3 mRNA to ER-associated omegasomes to promote localized LC3 translation enabling functional autophagy

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1. scibot 21 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114619
  
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sciencedirect.com/science/article/pii/S2211124724009690
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A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain

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  DOI: 10.1016/j.devcel.2024.07.007
  
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sciencedirect.com/science/article/pii/S153458072400443X
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Exclusive Characteristics of the p.E555K Dominant-Negative Variant in Autosomal Dominant E47 Deficiency

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1. scibot 01 Aug 2024
  
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  DOI: 10.1007/s10875-024-01758-x
  
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link.springer.com/article/10.1007/s10875-024-01758-x
Jul 2024
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ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer

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1. scibot 31 Jul 2024
  
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  DOI: 10.1158/2159-8290.CD-23-0539
  
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  RRID:AB_145841
  
  DOI: 10.1158/2159-8290.CD-23-0539
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11285331/
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Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response

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1. scibot 25 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114532
  
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sciencedirect.com/science/article/pii/S2211124724008611
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Assembly mechanism of Integrator’s RNA cleavage module

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1. scibot 25 Jul 2024
  
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  RRID:12-370
  
  DOI: 10.1016/j.molcel.2024.06.032
  
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sciencedirect.com/science/article/pii/S1097276524005392
www.cell.com www.cell.com

m6A modification inhibits miRNAs’ intracellular function, favoring their extracellular export for intercellular communication

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1. scibot 18 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114369
  
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cell.com/cell-reports/abstract/S2211-1247(24)00697-1
www.embopress.org www.embopress.org

The tyrosine phosphatases LAR and PTPRδ act as receptors of the nidogen-tetanus toxin complex

1
1. scibot 12 Jul 2024
  
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  AB_145841
  
  DOI: 10.1038/s44318-024-00164-8
  
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embopress.org/doi/10.1038/s44318-024-00164-8
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors

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1. scibot 24 May 2024
  
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  DOI: 10.1016/j.isci.2024.109860
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11108982/
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Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation

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1. scibot 14 May 2024
  
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  DOI: 10.1016/j.stem.2024.04.015
  
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O-GlcNAcylation of RBM14 contributes to elevated cellular O-GlcNAc through regulation of OGA protein stability

1
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HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression

1
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  DOI: 10.1093/narcan/zcae018
  
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The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells

1
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Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes

2
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Feb 2024
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Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection

1
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N6-methyladenosine modification of the mRNA for a key gene in purine nucleotide metabolism regulates virus proliferation in an insect vector

2
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HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance

3
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  DOI: 10.1101/2023.12.05.570182
  
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Dec 2023
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YAP targetome reveals activation of SPEM in gastric pre-neoplastic progression and regeneration

1
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Nov 2023
52.53.155.43 52.53.155.43

Guanylate Binding Protein 1 (GBP1) modulates proteasomal machinery in ovarian cancer

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ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers

1
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Sep 2023
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Variation in the CENP-A sequence association landscape across diverse inbred mouse strains

1
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Aug 2023
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PIIS221112472300952X-html.html

1
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Jul 2023
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FOXA2 controls the anti-oxidant response in FH-deficient cells

1
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Jun 2023
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Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation

1
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  DOI: 10.1016/j.neuron.2023.05.033
  
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QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism

1
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  DOI: 10.1016/j.cell.2023.05.047
  
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(R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers

1
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(A) Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis

1
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Apr 2023
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Time-dependent regulation of cytokine production by RNA binding proteins defines T cell effector function

1
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USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities

1
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SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology

1
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Mar 2023
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Protocol for the identification and expression analysis of a cytoplasmic membrane-localized protein STING

1
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Loss of E-cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma

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CHD1 promotes sensitivity to Aurora kinase inhibitors by suppressing interaction of AURKA with its coactivator TPX2

1
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  DOI: 10.1158/0008-5472.CAN-22-0631
  
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MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function

1
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  DOI: 10.7554/eLife.83806
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9977283/
Feb 2023
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E6AP AZUL interaction with UBQLN1/2 in cells, condensates, and an AlphaFold-NMR integrated structure

1
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Role of FGF10/FGFR2b Signaling in Homeostasis and Regeneration of Adult Lacrimal Gland and Corneal Epithelium Proliferation

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  DOI: 10.1167/iovs.64.1.21
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9896866/
Jan 2023
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EKLF/Klf1 regulates erythroid transcription by its pioneering activity and selective control of RNA Pol II pause-release

1
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  DOI: 10.1016/j.celrep.2022.111830
  
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Loss of epigenetic information as a cause of mammalian aging

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  DOI: 10.1016/j.cell.2022.12.027
  
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Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin

1
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Nov 2022
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Allosteric potentiation of GABAA receptor single-channel conductance by netrin-1 during neuronal-excitation-induced inhibitory synaptic homeostasis

1
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  DOI: 10.1016/j.celrep.2022.111584
  
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sciencedirect.com/science/article/pii/S2211124722014498
Oct 2022
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Off-the-shelf proximity biotinylation using ProtA-TurboID

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  DOI: 10.1038/s41596-022-00748-w
  
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nature.com/articles/s41596-022-00748-w
Sep 2022
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Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo

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  DOI: 10.1007/s00401-022-02491-8
  
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Histone H1 regulates non-coding RNA turnover on chromatin in a m6A-dependent manner

1
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  DOI: 10.1016/j.celrep.2022.111329
  
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PRG-1 prevents neonatal stimuli-induced persistent hyperalgesia and memory dysfunction via NSF/Glu/GluR2 signaling

1
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can-22-0631-html.html

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The BASP1 transcriptional corepressor modifies chromatin through lipid-dependent and lipid-independent mechanisms

1
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NMDA receptor-targeted enrichment of CaMKIIα improves fear memory

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Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1

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Development and Validation of Arc Nanobodies: New Tools for Probing Arc Dynamics and Function

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Histone chaperone FACT complex coordinates with HIF to mediate an expeditious transcription program to adapt to poorly oxygenated cancers

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Vitamin D receptor, STAT3, and TET2 cooperate to establish tolerogenesis

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ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization

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NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis

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The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics

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Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma

1
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Synaptotagmin-11 inhibits spontaneous neurotransmission through vti1a

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Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription

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Manipulation of TAD reorganization by chemical-dependent genome linking

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Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice

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Establishment of a second generation homozygous CRISPRa human induced pluripotent stem cell (hiPSC) line for enhanced levels of endogenous gene activation

1
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  DOI: 10.1016/j.scr.2021.102518
  
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FACT is recruited to the +1 nucleosome of transcribed genes and spreads in a Chd1-dependent manner

1
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Untitled document

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A Translational Repression Complex in Developing Mammalian Neural Stem Cells that Regulates Neuronal Specification

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  DOI: 10.1016/j.neuron.2017.12.045
  
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Jul 2021
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Untitled document

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  DOI: 10.1016/j.devcel.2018.11.009
  
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Untitled document

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Novel Endogenous, Insulin-Stimulated Akt2 Protein Interaction Partners in L6 Myoblasts

3
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Establishment of two homozygous CRISPR interference (CRISPRi) knock-in human induced pluripotent stem cell (hiPSC) lines for titratable endogenous gene repression

1
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The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline.

2
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  DOI: 10.7554/eLife.26116
  
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Jun 2021
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Suv4-20h2 protects against influenza virus infection by suppression of chromatin loop formation

1
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H3K27 demethylases are dispensable for activation of Polycomb-regulated injury response genes in peripheral nerve.

1
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  12-370
  
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May 2021
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Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions

1
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  DOI: 10.1016/j.stem.2021.04.023
  
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Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress

1
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  DOI: 10.1016/j.molcel.2021.02.038
  
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Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging

1
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  DOI: 10.1016/j.molcel.2020.06.027
  
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Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas

1
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  DOI: 10.1016/j.immuni.2020.11.002
  
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m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development

1
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  DOI: 10.1016/j.immuni.2020.05.003
  
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sciencedirect.com/science/article/pii/S1074761320301849
Feb 2021
academic.oup.com academic.oup.com

Control of the anterior pituitary cell lineage regulator POU1F1 by the stem cell determinant Musashi

1
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  DOI: 10.1210/endocr/bqaa245
  
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academic.oup.com/endo/article/162/3/bqaa245/6054984
Sep 2020
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Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer

1
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  DOI: 10.1016/j.celrep.2019.12.056
  
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PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin

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Neutrophil Swarming in Damaged Tissue Is Orchestrated by Connexins and Cooperative Calcium Alarm Signals

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  DOI: 10.1016/j.cub.2020.05.030
  
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LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice

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Acetylation of UHRF1 Regulates Hemi-methylated DNA Binding and Maintenance of Genome-wide DNA Methylation

1
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Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity

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  DOI: 10.1523/JNEUROSCI.1076-19.2019
  
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Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer

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Generation of homozygous CRISPRa human induced pluripotent stem cell (hiPSC) lines for sustained endogenous gene activation

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  DOI: 10.1016/j.scr.2020.101944
  
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Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion

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  DOI: 10.1016/j.celrep.2020.107879
  
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Differential stability of miR-9-5p and miR-9-3p in the brain is determined by their unique cis- and trans-acting elements

1
1. scibot 03 Sep 2020
  
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  DOI: 10.1523/ENEURO.0094-20.2020
  
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A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production

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Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation

1
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Meiotic Kinetochores Fragment into Multiple Lobes upon Cohesin Loss in Aging Eggs

1
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  DOI: 10.1016/j.cub.2019.09.006
  
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Histone Recycling by FACT and Spt6 during Transcription Prevents the Scrambling of Histone Modifications

1
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Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf

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A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling

1
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  DOI: 10.1016/j.stem.2019.06.008
  
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Reconstruction of the Global Neural Crest Gene Regulatory Network In Vivo

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  DOI: 10.1016/j.devcel.2019.10.003
  
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Untitled document

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  DOI: 10.1016/j.devcel.2018.11.009
  
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Untitled document

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Untitled document

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  DOI: 10.7554/eLife.41913
  
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Untitled document

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Untitled document

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Untitled document

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CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation

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Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome

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PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification

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Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis

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Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch

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FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch

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A Method for the Acute and Rapid Degradation of Endogenous Proteins

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Pioneer Factors FOXA1 and FOXA2 Assist Selective Glucocorticoid Receptor Signaling in Human Endometrial Cells

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The Role of N-α-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting

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Myrf ER-Bound Transcription Factors Drive C. elegans Synaptic Plasticity via Cleavage-Dependent Nuclear Translocation

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Transcriptional Elongation of HSV Immediate Early Genes by the Super Elongation Complex Drives Lytic Infection and Reactivation from Latency

1
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Satb2 determines miRNA expression and long-term memory in the adult central nervous system

1
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ncbi.nlm.nih.gov/pmc/articles/PMC5207769/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Experimental reconstitution of chronic ER stress in the liver reveals feedback suppression of BiP mRNA expression

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1. scibot 08 Nov 2017
  
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  AB_145841
  
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  (Millipore Cat# 12-370, RRID:AB_145841)
  
  SciCrunch record: RRID:AB_145841
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_145841
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scibot

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ncbi.nlm.nih.gov/pmc/articles/PMC5179193/

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