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RNA exonuclease REXO4 resolves m6A-marked R-loops and suppresses anti-tumor immunity

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1. scibot 21 Jul 2026
  
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  DOI: 10.1016/j.molcel.2026.06.036
  
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sciencedirect.com/science/article/pii/S1097276526004259
Jul 2026
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Flavin adenine dinucleotide is an endogenous suppressor for cytosolic DNA and RNA sensors to modulate innate immunity

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1. scibot 14 Jul 2026
  
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  DOI: 10.1016/j.immuni.2026.06.010
  
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sciencedirect.com/science/article/pii/S107476132600261X
Jun 2026
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VEGFR2 inhibition potentiates STING-mediated antitumor immunity

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1. scibot 22 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117576
  
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sciencedirect.com/science/article/pii/S2211124726006546
Apr 2026
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SFPQ prevents MDA5-mediated activation of innate immunity and preserves cell viability

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1. scibot 25 Apr 2026
  
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  DOI: 10.1016/j.celrep.2026.117291
  
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sciencedirect.com/science/article/pii/S2211124726003694
Mar 2026
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ADAR1 regulates dsRNA formation in nuclear and mitochondrial transcripts through editing-dependent and -independent mechanisms

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1. scibot 10 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117026
  
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sciencedirect.com/science/article/pii/S221112472600104X
Jan 2026
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p57 increases immunotherapy efficacy by promoting cGAS-STING-mediated innate sensing in hepatocellular carcinoma

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116769
  
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sciencedirect.com/science/article/pii/S2211124725015414
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Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated immune response to DNA damage

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.ccell.2025.12.013
  
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sciencedirect.com/science/article/pii/S1535610825005471
Sep 2025
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Argonaute 2 Inhibits RIG-I Signaling via Competition for Viral RNA Binding

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1. scibot 20 Sep 2025
  
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  DOI: 10.1016/j.isci.2025.113391
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12424427/
Aug 2025
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1-s2.0-S2589004225016529-main-html.html

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1. scibot 20 Aug 2025
  
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  DOI: 10.1016
  
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52.53.155.43/4f4fe074a3a34390503819ded993b7919366019b/1-s2.0-S2589004225016529-main-html.html
Jul 2025
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TNF-α-NF-κB activation through pathological α-Synuclein disrupts the BBB and exacerbates axonopathy

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116001
  
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sciencedirect.com/science/article/pii/S2211124725007727
Jun 2025
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Systematic profiling reveals betaine as an exercise mimetic for geroprotection

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1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.cell.2025.06.001
  
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cell.com/cell/fulltext/S0092-8674(25)00635-X
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The human neural cell atlas of Zika virus infection in developing brain tissue

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.xcrm.2025.102189
  
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sciencedirect.com/science/article/pii/S2666379125002629
May 2025
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KSHV miRNAs target STING to evade innate immunity and facilitate KSHV lytic reactivation from latency

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115741
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00512-1
Apr 2025
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The low-dose CHK1 inhibitor prexasertib triggers VDAC1 dephosphorylation to activate mtDNA-STING signaling and synergize immunotherapy

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1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115605
  
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sciencedirect.com/science/article/pii/S2211124725003766
Mar 2025
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Determining the Bordetella LPS structural features that influence TLR4 downstream signaling

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1. scibot 13 Mar 2025
  
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  DOI: 10.3389/fmicb.2025.1540534
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11895810/
Jan 2025
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Anti-herpetic tau preserves neurons via the cGAS-STING-TBK1 pathway in Alzheimer’s disease

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1. scibot 03 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115109
  
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sciencedirect.com/science/article/pii/S2211124724014608
Dec 2024
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Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3

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1. scibot 24 Dec 2024
  
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  DOI: 10.1016/j.immuni.2024.11.020
  
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sciencedirect.com/science/article/pii/S1074761324005351
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The N-degron pathway mediates the autophagic degradation of cytosolic mitochondrial DNA during sterile innate immune responses

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1. scibot 24 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115094
  
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sciencedirect.com/science/article/pii/S2211124724014451
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MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115104
  
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sciencedirect.com/science/article/pii/S2211124724014554
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Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of macrophages in sepsis

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1. scibot 14 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115060
  
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sciencedirect.com/science/article/pii/S2211124724014116
Jun 2024
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IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility

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1. scibot 04 Jun 2024
  
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  DOI: 10.1016/j.celrep.2021.108891
  
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sciencedirect.com/science/article/pii/S2211124721002059
May 2024
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Development of nitroalkene-based inhibitors to target STING-dependent inflammation

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1. scibot 23 May 2024
  
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  DOI: 10.1016/j.redox.2024.103202
  
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sciencedirect.com/science/article/pii/S2213231724001800
Apr 2024
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Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity

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1. scibot 30 Apr 2024
  
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  DOI: 10.1016/j.xcrm.2024.101528
  
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sciencedirect.com/science/article/pii/S2666379124001976
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SETD2 loss and ATR inhibition synergize to promote cGAS signaling and immunotherapy response in renal cell carcinoma

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1. scibot 03 Apr 2024
  
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  DOI: 10.1158/1078-0432.CCR-23-1003
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10592192/
Feb 2024
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SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion

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1. scibot 02 Feb 2024
  
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  DOI: 10.1016/j.cell.2024.01.008
  
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sciencedirect.com/science/article/pii/S0092867424000102
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Mutations in the non-catalytic polyproline motif destabilize TREX1 and amplify cGAS-STING signaling

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1. scibot 01 Feb 2024
  
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  DOI: 10.1101/2024.01.04.574136
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10802300/
Jan 2024
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DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells

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1. scibot 19 Jan 2024
  
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  DOI: 10.1016/j.isci.2023.108760
  
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sciencedirect.com/science/article/pii/S2589004223028377
Nov 2023
www.embopress.org www.embopress.org

SIRT2 negatively regulates the cGAS-STING pathway by deacetylating G3BP1

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1. scibot 03 Nov 2023
  
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  RRID:AB_1523836
  
  DOI: 10.15252/embr.202357500
  
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embopress.org/doi/10.15252/embr.202357500
Oct 2023
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SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing

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1. scibot 28 Oct 2023
  
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  DOI: 10.1016/j.immuni.2023.10.001
  
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sciencedirect.com/science/article/pii/S1074761323004417
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Regulation of STING activity in DNA sensing by ISG15 modification

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1. scibot 27 Oct 2023
  
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  DOI: 10.1016/j.celrep.2023.113277
  
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sciencedirect.com/science/article/pii/S2211124723012895
Jul 2023
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MEF2A suppresses stress responses that trigger DDX41-dependent IFN production

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1. scibot 21 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112805
  
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sciencedirect.com/science/article/pii/S2211124723008161
Jun 2023
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Cancer cell-autonomous cGAS-STING response confers drug resistance

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  DOI: 10.1016/j.chembiol.2023.05.005
  
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sciencedirect.com/science/article/pii/S2451945623001411
Apr 2023
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Innate immune pathway modulator screen identifies STING pathway activation as a strategy to inhibit multiple families of arbo and respiratory viruses

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1. scibot 29 Apr 2023
  
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  DOI: 10.1016/j.xcrm.2023.101024
  
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sciencedirect.com/science/article/pii/S2666379123001349
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The mechanism of STING autoinhibition and activation

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1. scibot 22 Apr 2023
  
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  DOI: 10.1016/j.molcel.2023.03.029
  
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sciencedirect.com/science/article/pii/S1097276523002435
Mar 2023
europepmc.org europepmc.org

UBL7 enhances antiviral innate immunity by promoting Lys27-linked polyubiquitination of MAVS

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1. scibot 23 Mar 2023
  
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  DOI: 10.1016/j.celrep.2023.112272
  
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europepmc.org/article/med/36943869
Dec 2022
www.embopress.org www.embopress.org

DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma

2
1. scibot 31 Dec 2022
  
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  RRID:AB_1523836
  
  DOI: 10.15252/embj.2022111961
  
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2. scibot 31 Dec 2022
  
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  RRID:AB_1523836
  
  DOI: 10.15252/embj.2022111961
  
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embopress.org/doi/10.15252/embj.2022111961
Nov 2022
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AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity

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1. scibot 17 Nov 2022
  
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  RRID:AB_1523836
  
  DOI: 10.1016/j.molcel.2022.10.026
  
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sciencedirect.com/science/article/pii/S1097276522010541
Oct 2022
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Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas

1
1. scibot 07 Oct 2022
  
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  RRID:AB_1523836
  
  DOI: 10.1016/j.molcel.2022.09.007
  
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sciencedirect.com/science/article/pii/S1097276522008966
Apr 2022
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Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS

1
1. scibot 27 Apr 2022
  
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  RRID:AB_1523836
  
  DOI: 10.1016/j.molcel.2022.03.034
  
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sciencedirect.com/science/article/pii/S1097276522002908
Mar 2022
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The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity

1
1. scibot 09 Mar 2022
  
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  RRID:AB_1523836
  
  DOI: 10.1016/j.celrep.2022.110434
  
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sciencedirect.com/science/article/pii/S2211124722001619
Feb 2022
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FEZ1 phosphorylation regulates HSPA8 localization and interferon-stimulated gene expression

1
1. scibot 16 Feb 2022
  
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  RRID:AB_1523836
  
  DOI: 10.1016/j.celrep.2022.110396
  
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sciencedirect.com/science/article/pii/S2211124722001176
Oct 2021
www.cell.com www.cell.com

Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains

1
1. scibot 13 Oct 2021
  
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  DOI: 10.1016/j.immuni.2021.09.008
  
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cell.com/immunity/fulltext/S1074-7613(21)00393-9
Sep 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

STING nuclear partners contribute to innate immune signaling responses

1
1. scibot 22 Sep 2021
  
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  RRID:AB_1523836
  
  DOI: 10.1016/j.isci.2021.103055
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8436130/
Aug 2021
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Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity

1
1. scibot 28 Aug 2021
  
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  RRID:AB_1523836
  
  DOI: 10.1016/j.molcel.2021.07.040
  
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sciencedirect.com/science/article/pii/S1097276521006249
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Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death

1
1. scibot 07 Aug 2021
  
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  RRID:AB_1523836
  
  DOI: 10.1016/j.cell.2021.07.026
  
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sciencedirect.com/science/article/pii/S0092867421008850
Jul 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity

1
1. scibot 14 Jul 2021
  
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  RRID:AB_1523836
  
  DOI: 10.1016/j.cell.2019.01.016
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8274936/
May 2021
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Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion

1
1. scibot 20 May 2021
  
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  RRID:AB_1523836
  
  DOI: 10.1016/j.molcel.2021.05.002
  
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sciencedirect.com/science/article/pii/S1097276521003592
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TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology

1
1. scibot 07 May 2021
  
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  RRID:AB_1523836
  
  DOI: 10.1016/j.molcel.2020.10.018
  
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sciencedirect.com/science/article/pii/S1097276520307255
Apr 2021
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cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing

1
1. scibot 12 Apr 2021
  
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  RRID:AB_1523836
  
  DOI: 10.1016/j.molcel.2021.01.024
  
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sciencedirect.com/science/article/pii/S1097276521000447
Mar 2021
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IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility

1
1. scibot 24 Mar 2021
  
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  RRID:AB_1523836
  
  DOI: 10.1016/j.celrep.2021.108891
  
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sciencedirect.com/science/article/pii/S2211124721002059
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ER-directed TREX1 limits cGAS activation at micronuclei

1
1. scibot 01 Mar 2021
  
  in Public
  
  RRID:AB_152383
  
  DOI: 10.1016/j.molcel.2020.12.037
  
  Resource: (Abcam Cat# ab76493, RRID:AB_1523836)
  
  Curator: @bandrow
  
  SciCrunch record: RRID:AB_1523836
  
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sciencedirect.com/science/article/pii/S1097276520309588
Jan 2021
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MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

1
1. scibot 22 Jan 2021
  
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  RRID:AB_1523836
  
  DOI: 10.1016/j.celrep.2020.108628
  
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sciencedirect.com/science/article/pii/S221112472031617X
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A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA

1
1. scibot 08 Jan 2021
  
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  RRID:AB_1523836
  
  DOI: 10.1016/j.celrep.2020.108586
  
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sciencedirect.com/science/article/pii/S2211124720315758
Sep 2020
www.sciencedirect.com www.sciencedirect.com

The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice

1
1. scibot 23 Sep 2020
  
  in Public
  
  RRID:AB_1523836
  
  DOI: 10.1016/j.neuron.2020.03.005
  
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sciencedirect.com/science/article/pii/S0896627320301914
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ADAR1 Facilitates KSHV Lytic Reactivation by Modulating the RLR-Dependent Signaling Pathway

1
1. scibot 15 Sep 2020
  
  in Public
  
  RRID:AB_1523836
  
  DOI: 10.1016/j.celrep.2020.107564
  
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sciencedirect.com/science/article/pii/S2211124720305131
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mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

1
1. scibot 09 Sep 2020
  
  in Public
  
  RRID:AB_1523836
  
  DOI: 10.1016/j.immuni.2020.02.002
  
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sciencedirect.com/science/article/pii/S107476132030073X
Jan 2020
www.sciencedirect.com www.sciencedirect.com

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_1523836
  
  DOI: 10.1016/j.cell.2019.05.035
  
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sciencedirect.com/science/article/pii/S009286741930563X
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MAVS O-GlcNAcylation Is Essential for Host Antiviral Immunity against Lethal RNA Viruses

1
1. scibot 13 Jan 2020
  
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  RRID:AB_1523836
  
  DOI: 10.1016/j.celrep.2019.07.085
  
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sciencedirect.com/science/article/pii/S2211124719310010
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Untitled document

1
1. scibot 13 Jan 2020
  
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  RRID:AB_1523836
  
  DOI: 10.1016/j.cell.2019.01.016
  
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sciencedirect.com/science/article/pii/S0092867419300492
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Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING

1
1. scibot 12 Jan 2020
  
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  RRID:AB_1523836
  
  DOI: 10.1016/j.molcel.2019.02.038
  
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sciencedirect.com/science/article/pii/S1097276519301492
Nov 2018
www.sciencedirect.com www.sciencedirect.com

IFIT1 Exerts Opposing Regulatory Effects on the Inflammatory and Interferon Gene Programs in LPS-Activated Human Macrophages

1
1. scibot 05 Nov 2018
  
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  RRID:AB_1523836
  
  Curator: @evieth
  
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sciencedirect.com/science/article/pii/S2211124718314177
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Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation

1
1. scibot 05 Nov 2018
  
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  RRID:AB_1523836
  
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sciencedirect.com/science/article/pii/S1931312817304389
Nov 2017
bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com

The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing

2
1. scibot 08 Nov 2017
  
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  AB_1523836
  
  Curator: @gabimpine
  
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  RRID:AB_1523836 RRIDCUR:Validated
2. scibot 08 Nov 2017
  
  in Public
  
  AB_1523836
  
  Curator: @gabimpine
  
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  (Abcam Cat# ab76493, RRID:AB_1523836)
  
  SciCrunch record: RRID:AB_1523836
  
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bmcbiol.biomedcentral.com/articles/10.1186/s12915-016-0292-z
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Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses

1
1. scibot 08 Nov 2017
  
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  AB_1523836
  
  Curator: @chewbeccax
  
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sciencedirect.com/science/article/pii/S1931312817302032

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