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53 Matching Annotations

Apr 2024
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Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation

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1. scibot 24 Apr 2024
  
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  DOI: 10.1038/s41594-024-01294-7
  
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link.springer.com/article/10.1038/s41594-024-01294-7
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

XPA tumor variant leads to defects in NER that sensitize cells to cisplatin

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1. scibot 22 Mar 2024
  
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  DOI: 10.1093/narcan/zcae013
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10946055/
Feb 2024
www.biorxiv.org www.biorxiv.org

Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation

1
1. scibot 15 Feb 2024
  
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  RRID:AB_1587578
  
  DOI: 10.1101/2023.12.20.572718
  
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biorxiv.org/content/10.1101/2023.12.20.572718v1
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Prenatal hormone stress triggers embryonic cardiac hypertrophy outcome by ubiquitin-dependent degradation of mitochondrial mitofusin 2

1
1. scibot 09 Feb 2024
  
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  DOI: 10.1016/j.isci.2023.108690
  
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sciencedirect.com/science/article/pii/S2589004223027670
Dec 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Ubiquiton—An inducible, linkage-specific polyubiquitylation tool

1
1. scibot 16 Dec 2023
  
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  DOI: 10.1016/j.molcel.2023.11.016
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10804999/
Nov 2023
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Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescence

1
1. scibot 10 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113381
  
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sciencedirect.com/science/article/pii/S2211124723013931
Aug 2023
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Senescent cells form nuclear foci that contain the 26S proteasome

1
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  DOI: 10.1016/j.celrep.2023.112880
  
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sciencedirect.com/science/article/pii/S2211124723008914
Apr 2023
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DTX3L E3 ligase targets p53 for degradation at poly ADP-ribose polymerase-associated DNA damage sites

1
1. scibot 13 Apr 2023
  
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  DOI: 10.1016/j.isci.2023.106444
  
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sciencedirect.com/science/article/pii/S2589004223005217
Feb 2023
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Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport, generating compositionally diverse Importin β-1 granules

1
1. scibot 24 Feb 2023
  
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  DOI: 10.1016/j.celrep.2023.112134
  
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sciencedirect.com/science/article/pii/S2211124723001456
www.nature.com www.nature.com

The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system

1
1. scibot 04 Feb 2023
  
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  DOI: 10.1038/s41467-023-36058-2
  
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nature.com/articles/s41467-023-36058-2
Dec 2022
onlinelibrary.wiley.com onlinelibrary.wiley.com

Characterization of huntingtin interactomes and their dynamic responses in living cells by proximity proteomics

1
1. scibot 05 Dec 2022
  
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  DOI: 10.1111/jnc.15726
  
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onlinelibrary.wiley.com/doi/full/10.1111/jnc.15726
Sep 2022
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Identification of CUL4A-DDB1-WDFY1 as an E3 ubiquitin ligase complex involved in initiation of lysophagy

1
1. scibot 15 Sep 2022
  
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  RRID:AB_1587578
  
  DOI: 10.1016/j.celrep.2022.111349
  
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sciencedirect.com/science/article/pii/S2211124722011779
Aug 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

1
1. scibot 13 Aug 2022
  
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  RRID:AB_1587578
  
  DOI: 10.1016/j.cell.2016.07.019
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5002269/
Jun 2022
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Supramolecular assembly of GSK3α as a cellular response to amino acid starvation

1
1. scibot 22 Jun 2022
  
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  RRID:AB_1587578
  
  DOI: 10.1016/j.molcel.2022.05.025
  
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sciencedirect.com/science/article/pii/S1097276522004920
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Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration

1
1. scibot 17 Jun 2022
  
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  RRID:AB_1587578
  
  DOI: 10.1016/j.isci.2022.104519
  
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sciencedirect.com/science/article/pii/S2589004222007908
Mar 2022
www.embopress.org www.embopress.org

K27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation

1
1. scibot 31 Mar 2022
  
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  RRID:AB_1587578
  
  DOI: 10.15252/embj.2021110145
  
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embopress.org/doi/abs/10.15252/embj.2021110145
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A trio of ubiquitin ligases sequentially drives ubiquitylation and autophagic degradation of dysfunctional yeast proteasomes

1
1. scibot 18 Mar 2022
  
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  RRID:AB_1587578
  
  DOI: 10.1016/j.celrep.2022.110535
  
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sciencedirect.com/science/article/pii/S2211124722002765
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The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity

1
1. scibot 09 Mar 2022
  
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  RRID:AB_1587578
  
  DOI: 10.1016/j.celrep.2022.110434
  
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sciencedirect.com/science/article/pii/S2211124722001619
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Linkage reprogramming by tailor-made E3s reveals polyubiquitin chain requirements in DNA-damage bypass

1
1. scibot 09 Mar 2022
  
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  RRID:AB_1587578
  
  DOI: 10.1016/j.molcel.2022.02.016
  
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sciencedirect.com/science/article/pii/S1097276522001393
Jan 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Myeloid Fbxw7 Prevents Pulmonary Fibrosis by Suppressing TGF-β Production

1
1. scibot 22 Jan 2022
  
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  RRID:AB_1587578
  
  DOI: 10.3389/fimmu.2021.760138
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8767095/
Oct 2021
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TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson’s disease

1
1. scibot 13 Oct 2021
  
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  DOI: 10.1016/j.neuron.2021.09.031
  
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sciencedirect.com/science/article/pii/S0896627321007042
Sep 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease

1
1. scibot 22 Sep 2021
  
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  RRID:AB_1587578
  
  DOI: 10.1016/j.celrep.2021.109754
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8423903/
Aug 2021
www.nature.com www.nature.com

Rewiring of the ubiquitinated proteome determines ageing in C. elegans

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1. scibot 15 Aug 2021
  
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  DOI: 10.1038/s41586-021-03781-z
  
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nature.com/articles/s41586-021-03781-z
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Untitled document

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1. scibot 12 Aug 2021
  
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  RRID:AB_1587578
  
  DOI: 10.1016/j.chom.2017.09.007
  
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sciencedirect.com/science/article/pii/S1931312817303955
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Untitled document

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1. scibot 10 Aug 2021
  
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  RRID:AB_1587578
  
  DOI: 10.1016/j.molcel.2018.11.015
  
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sciencedirect.com/science/article/pii/S1097276518309857
www.embopress.org www.embopress.org

Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway

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1. scibot 07 Aug 2021
  
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  RRID:AB_1587578
  
  DOI: 10.15252/embj.2020107413
  
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embopress.org/doi/abs/10.15252/embj.2020107413
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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1. scibot 06 Aug 2021
  
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  RRID:AB_1587578
  
  DOI: 10.1016/j.celrep.2019.04.015
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6508666/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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1. scibot 02 Aug 2021
  
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  RRID:AB_1587578
  
  DOI: 10.7554/eLife.24425
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5484619/
Jul 2021
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Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death

1
1. scibot 31 Jul 2021
  
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  Rabbit monoclonal anti-K48 Ubiquitin
  
  DOI: 10.1016/j.celrep.2019.11.014
  
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  Curator: @ethanbadger
  
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sciencedirect.com/science/article/pii/S2211124719314858
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Untitled document

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1. scibot 29 Jul 2021
  
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  DOI: 10.1016/j.chom.2017.09.007
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5644667/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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1. scibot 29 Jul 2021
  
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  DOI: 10.7554/eLife.21465
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5370187/
elifesciences.org elifesciences.org

Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense

1
1. scibot 27 Jul 2021
  
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  AB_1587578
  
  DOI: 10.7554/eLife.21465
  
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  Curator: @Zeljana_Babic
  
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  RRIDCUR:Validated RRID:AB_1587578
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elifesciences.org/content/6/e21465
rupress.org rupress.org

Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination

1
1. scibot 23 Jul 2021
  
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  05-1307
  
  DOI: 10.1083/jcb.202006043
  
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rupress.org/jcb/article/220/6/e202006043/211984/Parkin-independent-mitophagy-via-Drp1-mediated
May 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

In situ architecture of neuronal α-Synuclein inclusions

1
1. scibot 05 May 2021
  
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  DOI: 10.1038/s41467-021-22108-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8046968/
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

1
1. scibot 23 Apr 2021
  
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  RRID:AB_1587578
  
  DOI: 10.1016/j.cell.2021.03.048
  
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  RRID:AB_1587578 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0092867421003792
Feb 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Raloxifene is a female-specific proteostasis therapeutic in the spinal cord

1
1. scibot 27 Feb 2021
  
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  RRID:AB_1587578
  
  DOI: 10.1210/endocr/bqaa221
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7774777/
Sep 2020
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Mitochondrial Regulation of the 26S Proteasome

1
1. scibot 17 Sep 2020
  
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  RRID:AB_1587578
  
  DOI: 10.1016/j.celrep.2020.108059
  
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rupress.org rupress.org

Critical role of mitochondrial ubiquitination and the OPTN–ATG9A axis in mitophagy

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1. scibot 08 Sep 2020
  
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  RRID:AB_1587578
  
  DOI: 10.1083/jcb.201912144
  
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Auto-ubiquitination of NEDD4-1 Recruits USP13 to Facilitate Autophagy through Deubiquitinating VPS34

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1. scibot 06 Sep 2020
  
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  RRID:AB_1587578
  
  DOI: 10.1016/j.celrep.2020.01.088
  
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Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit

1
1. scibot 04 Sep 2020
  
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  K48-linked Polyubiquitin
  
  DOI: 10.1016/j.stem.2020.01.018
  
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Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28

1
1. scibot 03 Sep 2020
  
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  Ubiquitin-K48
  
  DOI: 10.1016/j.molcel.2019.12.023
  
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Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair

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1. scibot 03 Sep 2020
  
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  RRID:AB_1587578
  
  DOI: 10.1016/j.cell.2020.02.010
  
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Jan 2020
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Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway

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1. scibot 13 Jan 2020
  
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  RRID:AB_1587578
  
  DOI: 10.1016/j.str.2017.10.007
  
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www.embopress.org www.embopress.org

The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8

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1. scibot 13 Jan 2020
  
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  RRID:AB_1587578
  
  DOI: 10.15252/embj.2019102361
  
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Nov 2018
europepmc.org europepmc.org

Untitled document

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europepmc.org/articles/PMC5644667/
Nov 2017
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Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling

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Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling

1
1. scibot 08 Nov 2017
  
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Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy

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1. scibot 08 Nov 2017
  
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  AB_1587578
  
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Untitled document

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elifesciences.org elifesciences.org

Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses

1
1. scibot 08 Nov 2017
  
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  AB_1587578
  
  Curator: @chewbeccax
  
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Untitled document

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Untitled document

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The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

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1. scibot 08 Nov 2017
  
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  AB_1587578
  
  Curator: @gabimpine
  
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