723 Matching Annotations
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    Lycium barbarum glycopeptide (wolfberry extract) slows N-methyl-N-nitrosourea-induced degradation of photoreceptors
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    1. scibot 24 Apr 2024
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    Principles of chromosome organization for meiotic recombination
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    Growth hormone promotes myelin repair after chronic hypoxia via triggering pericyte-dependent angiogenesis
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    Generation of an induced pluripotent stem cell line (SJTUGHi003-A) from a patient with Sorsby fundus dystrophy carrying c.484G>A mutation in TIMP3 gene
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    The growth factor EPIREGULIN promotes basal progenitor cell proliferation in the developing neocortex
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    Oligodendrocyte-derived laminin-γ1 regulates the blood-brain barrier and CNS myelination in mice
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    sciencedirect.com/science/article/pii/S2211124724004510
  8. Apr 2024
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    Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites
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    ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
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      DOI: 10.7554/eLife.89261

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    Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition
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    Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1
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      DOI: 10.7554/eLife.96891

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    Generation of three isogenic, gene-edited iPSC lines carrying the APOE-Christchurch mutation into the three common APOE variants: APOE2Ch, APOE3Ch and APOE4Ch
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    1. scibot 09 Apr 2024
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    A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation
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    Generation of human cerebral organoids with a structured outer subventricular zone
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    Tracing the origin of alveolar stem cells in lung repair and regeneration
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    Fibrous periosteum repairs bone fracture and maintains the healed bone throughout mouse adulthood
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    Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids
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  19. Mar 2024
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    Pten regulates endocytic trafficking of cell adhesion and Wnt signaling molecules to pattern the retina
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    FEAR antiviral response pathway is independent of interferons and countered by poxvirus proteins
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    Two-photon live imaging of direct glia-to-neuron conversion in the mouse cortex
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    Light regulation of rhodopsin distribution during outer segment renewal in murine rod photoreceptors
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    PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA
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    Characterizing enteric neurons in dopamine transporter (DAT)-Cre reporter mice reveals dopaminergic subtypes with dual-transmitter content
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    PRMT1 promotes pancreatic cancer development and resistance to chemotherapy
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    Poxvirus A51R proteins regulate microtubule stability and antagonize a cell-intrinsic antiviral response
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    sciencedirect.com/science/article/pii/S2211124724002109
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    ALK upregulates POSTN and WNT signaling to drive neuroblastoma
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    In vivo CRISPR screening directly targeting testicular cells
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    Quantifying differentiation of progenitor populations using cerebral organoid models for neurodevelopmental disorders
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    An early cell shape transition drives evolutionary expansion of the human forebrain
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    Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients
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  33. Feb 2024
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    Neuronal reprogramming of mouse and human fibroblasts using transcription factors involved in suprachiasmatic nucleus development
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    Parallel pathways carrying direction-and orientation-selective retinal signals to layer 4 of the mouse visual cortex
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    Atypical cofilin signaling drives dendritic cell migration through the extracellular matrix via nuclear deformation
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    Developmental remodeling repurposes larval neurons for sexual behaviors in adult Drosophila
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  38. www.jneurosci.org www.jneurosci.org
    EHBP1 is critically involved in dendritic arbor formation and is coupled to factors promoting actin filament formation
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      DOI: 10.1523/JNEUROSCI.0236-23.2023

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    Evolutionary analysis identifies a Golgi pathway and correlates lineage-specific factors with endomembrane organelle emergence in apicomplexans
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    Metabolic constraints on growth explain how developmental temperature scales synaptic connectivity relevant for behavior
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      DOI: 10.1101/2023.10.15.562389

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    Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury
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    Neonatal brain injury unravels transcriptional and signaling changes underlying the reactivation of cortical progenitors
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    Generation of an iPSC-line (BIONi010C-48) with restored P-glycoprotein functionality following transfection with the human MDR1 gene in the AAVS1 locus
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    Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice
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    Generation and characterization of a human iPSC line and gene-corrected isogenic line derived from a patient with a CELF2 gene mutation
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    C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line
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    Microphysiological Modeling of Vascular Adipose Tissue for Multi-Throughput Applications
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    Establishment of the induced pluripotent stem cell line SJTUGHi002-A from a CNGA1-related recessive retinitis pigmentosa patient
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    Protocol for neurogenin-2-mediated induction of human stem cell-derived neural progenitor cells
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    Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm
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    Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates
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  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NG2 Glia Reprogramming Induces Robust Axonal Regeneration After Spinal Cord Injury
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    Molecular profiling of human blastocysts reveals primitive endoderm defects among embryos of decreased implantation potential
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      Alexa Fluor 647 conjugated donkey anti-mouse IgG (H+L) Highly Cross-Adsorbed secondary antibodyThermo Fisher ScientificCat# A-31571

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    PUF partner interactions at a conserved interface shape the RNA-binding landscape and cell fate in Caenorhabditis elegans
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  55. Jan 2024
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    Interrogation of endothelial and mural cells in brain metastasis reveals key immune-regulatory mechanisms
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    Selective induction of human renal interstitial progenitor-like cell lineages from iPSCs reveals development of mesangial and EPO-producing cells
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    SARS-CoV-2 infection causes dopaminergic neuron senescence
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    Acinar-ductal cell rearrangement drives branching morphogenesis of the murine pancreas in an IGF/PI3K-dependent manner
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  60. www.science.org www.science.org
    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
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    A Cost-Effective and Efficient ex vivo, ex situ Human Whole Brain Perfusion Protocol for Immunohistochemistry
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    Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo
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    Derivation of induced pluripotent stem cell SHEHDNi002-A from a 68-year-old Chinese Han Parkinson’s disease patient carrying LRRK2 and DNAJC6 mutations
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    Two parabrachial Cck neurons involved in the feedback control of thirst or salt appetite
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  65. Dec 2023
  66. www.mdpi.com www.mdpi.com
    Separable Roles for Neur and Ubiquitin in Delta Signalling in the Drosophila CNS Lineages
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    An adeno-associated viral labeling approach to visualize the meso- and microanatomy of mechanosensory afferents and autonomic innervation of the rat urinary bladder
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      DOI: 10.1096/fj.202301113R

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    Basal spot junctions of Drosophila epithelial tissues respond to morphogenetic forces and regulate Hippo signaling
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    Loss of α-1,2-mannosidase MAN1C1 promotes tumorigenesis of intrahepatic cholangiocarcinoma through enhancing CD133-FIP200 interaction
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    Multipotent progenitors instruct ontogeny of the superior colliculus
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    Cell stretching activates an ATM mechano-transduction pathway that remodels cytoskeleton and chromatin
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  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Late gene therapy limits the restoration of retinal function in a mouse model of retinitis pigmentosa
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      DOI: 10.1038/s41467-023-44063-8

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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging
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      DOI: 10.7554/eLife.91263

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    Human iPSC-derived renal collecting duct organoid model cystogenesis in ADPKD
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  75. www.biorxiv.org www.biorxiv.org
    The role of desmoplakin for neuronal function in the dentate gyrus and anxiety-related behavior
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  76. Nov 2023
  77. www.sciencedirect.com www.sciencedirect.com
    Generation of heart and vascular system in rodents by blastocyst complementation
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    The γ-secretase substrate proteome and its role in cell signaling regulation
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    Developmental potency of human ES cell-derived mesenchymal stem cells revealed in mouse embryos following blastocyst injection
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    Preclinical Long-Term Safety of Intraspinal Transplantation of Human Dorsal Spinal GABA Neural Progenitor Cells
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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hippocampus Insulin Receptors Regulate Episodic and Spatial Memory Through Excitatory/Inhibitory Balance
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      DOI: 10.1177/17590914231206657

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    Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon
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    Amnion responses to intrauterine inflammation and effects of inhibition of TNF signaling in preterm Rhesus macaque
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  84. Oct 2023
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    Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method
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    Single-cell transcriptomics illuminates regulatory steps driving anterior-posterior patterning of Drosophila embryonic mesoderm
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    A Versatile Strategy for Genetic Manipulation of Cajal-Retzius Cells in the Adult Mouse Hippocampus
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  88. 52.53.155.43 52.53.155.43
    Embryo model completes gastrulation to neurulation and organogenesis
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    Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19
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    Tissue morphology influences the temporal program of human brain organoid development
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    Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy
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    PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
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  93. www.cell.com www.cell.com
    The heat shock protein Hsp27 controls mitochondrial function by modulating ceramide generation
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  94. Sep 2023
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    Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
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    KLRG1 expression on natural killer cells is associated with HIV persistence, and its targeting promotes the reduction of the viral reservoir
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    The local microenvironment drives activation of neutrophils in human brain tumors
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    Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration
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    A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease
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    Cryptotanshinone is a candidate therapeutic agent for interstitial lung disease associated with a BRICHOS-domain mutation of SFTPC
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    Assessing crosstalk in simultaneous multicolor single-molecule localization microscopy
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  102. Aug 2023
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    Involvement of neuronal tachykinin-like receptor at 86C in Drosophila disc repair via regulation of kynurenine metabolism
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    Electroacupuncture attenuates myocardial ischemia-reperfusion injury by inhibiting microglial engulfment of dendritic spines
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    Cofilin overactivation improves hippocampus-dependent short-term memory
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    VEGF signaling governs the initiation of biliary-mediated liver regeneration through the PI3K-mTORC1 axis
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    Unique functional responses differentially map onto genetic subtypes of dopamine neurons
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    A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors
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  109. 52.53.155.43 52.53.155.43
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    Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure
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  111. Jul 2023
  112. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Characterization of clock-related proteins and neuropeptides in Drosophila littoralis and their putative role in diapause
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    CCDC176 stabilizes microtubule doublets 1 and 9 to ensure proper sperm movement
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    Protocol for automated multivariate quantitative-image-based cytometry analysis by fluorescence microscopy of asynchronous adherent cells
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    Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions
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    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
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    Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain
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    LYVE-1+ macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer
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    Customization of the translational complex regulates mRNA-specific translation to control CNS regeneration
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  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inferring regulators of cell identity in the human adult pancreas
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    The kinesin Kif21b regulates radial migration of cortical projection neurons through a non-canonical function on actin cytoskeleton
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    Two parallel medial prefrontal cortex-amygdala pathways mediate memory deficits via glutamatergic projection in surgery mice
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  123. Jun 2023
  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activating FcγR function depends on endosomal-signaling platforms
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    PTK7 is a positive allosteric modulator of GPR133 signaling in glioblastoma
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    Isogenic human trophectoderm cells demonstrate the role of NDUFA4 and associated variants in ZIKV infection
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    Excitatory amino acid transporter 1 supports adult hippocampal neural stem cell self-renewal
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    SINE RNA of the imprinted miRNA clusters mediates constitutive type III interferon expression and antiviral protection in hemochorial placentas
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    “Disruption of Golgi markers by two RILP-directed shRNAs in neurons: a new role for RILP or a neuron-specific off-target phenotype?”
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    Extensive jejunal injury is repaired by migration and transdifferentiation of ileal enterocytes in zebrafish
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    Derivation of induced pluripotent stem cell SJTUi003-A from a 69-year-old Chinese Han Sporadic Alzheimer’s disease patient with APOEε3/ε4 genetic background
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  132. www.nature.com www.nature.com
    Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates and humans
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    A single-cell level comparison of human inner ear organoids with the human cochlea and vestibular organs
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    Activity-dependent local protection and lateral inhibition control synaptic competition in developing mitral cells in mice
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  135. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intermittent theta burst stimulation attenuates oxidative stress and reactive astrogliosis in the streptozotocin-induced model of Alzheimer’s disease-like pathology
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  136. May 2023
  137. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    retro-Tango enables versatile retrograde circuit tracing in Drosophila
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    Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2
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    In the mouse cortex, oligodendrocytes regain a plastic capacity, transforming into astrocytes after acute injury
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    PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway
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    Multimodal characterization of murine gastruloid development
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    Towards discovering a novel family of peptides targeting neuroinflammatory states of brain microglia and astrocytes
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  143. www.sciencedirect.com www.sciencedirect.com
    Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells
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    Dichotomous ovarian cancer-initiating potential of Pax8+ cells revealed by a mouse genetic mosaic model
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    Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture
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    Ex utero monkey embryogenesis from blastocyst to early organogenesis
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  147. www.mdpi.com www.mdpi.com
    Discrepancy in the Usage of GFAP as a Marker of Satellite Glial Cell Reactivity
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    Downregulation of CD73/A2AR-Mediated Adenosine Signaling as a Potential Mechanism of Neuroprotective Effects of Theta-Burst Transcranial Magnetic Stimulation in Acute Experimental Autoimmune Encephalomyelitis
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    Differentiation of stem cell-derived pancreatic progenitors into insulin-secreting islet clusters in a multiwell-based static 3D culture system
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    Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy
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    Replication stress impairs chromosome segregation and preimplantation development in human embryos
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    Miniaturized and multiplexed high-content screening of drug and immune sensitivity in a multichambered microwell chip
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  153. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Experience-dependent flexibility in a molecularly diverse central-to-peripheral auditory feedback system
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    Generation of iPSC lines from peripheral blood mononuclear cells from five healthy donors
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    Cross-activation of FGF, NODAL, and WNT pathways constrains BMP-signaling-mediated induction of the totipotent state in mouse embryonic stem cells
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  156. Apr 2023
  157. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Late gene therapy limits the restoration of retinal function in a mouse model of retinitis pigmentosa
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    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
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    Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells
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    A Prime Editor efficiently repaired human induced pluripotent stem cells with AR gene mutation (c.2710G > A; p. V904M)
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    Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir
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    Identifying constitutive and context-specific molecular-tension-sensitive protein recruitment within focal adhesions
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  163. www.biorxiv.org www.biorxiv.org
    Conformational dynamics of lipid transfer domains provide a general framework to decode their functional mechanism
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    Cell-type-specific responses to the microbiota across all tissues of the larval zebrafish
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    Molecular and cellular changes in the post-traumatic spinal ... : Neural Regeneration Research
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  166. link.springer.com link.springer.com
    Possible frequent multiple mitochondrial DNA copies in a single nucleoid in HeLa cells
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  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids
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  168. Mar 2023
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    Polarity inversion reorganizes the stem cell compartment of the trophoblast lineage
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    A gut-secreted peptide suppresses arousability from sleep
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  171. www.biorxiv.org www.biorxiv.org
    Dopaminergic axons track somatic signaling in behaving mice
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    Mapping of clonal lineages across developmental stages in human neural differentiation
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    Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets
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    Cell proliferation and glial cell marker expression in the wall of the third ventricle in the tuberal region of the male mouse hypothalamus during postnatal development
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    Protocol to engineer apical-out airway organoids using suspension culture of human airway basal stem cell aggregates
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    Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma
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    hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung’s disease
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    Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye
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    Tcf21 marks visceral adipose mesenchymal progenitors and functions as a rate-limiting factor during visceral adipose tissue development
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    Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression
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  183. www.nature.com www.nature.com
    Generating human blastoids modeling blastocyst-stage embryos and implantation
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    Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages
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    Decorating chromatin for enhanced genome editing using CRISPR-Cas9
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    D-2-hydroxyglutarate dehydrogenase governs adult neural stem cell activation and promotes histone acetylation via ATP-citrate lyase
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    Specialized cells that sense tissue mechanics to regulate Drosophila morphogenesis
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    All-optical physiology resolves a synaptic basis for behavioral timescale plasticity
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    Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer
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    Macrophage-orbital fibroblast interaction and hypoxia promote inflammation and adipogenesis in Graves´ orbitopathy
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    Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons
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    Use of metabolic glycoengineering and pharmacological inhibitors to assess lipid and protein sialylation on cells
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    Protrusion growth driven by myosin-generated force
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    Structural and functional map for forelimb movement phases between cortex and medulla
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    Generation of a human embryonic stem cell line (SKLRMe004-A) carrying NKX2.5-EGFP and TBX5-Tdtomato dual fluorescent reporters
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  197. Dec 2022
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    Depression-Associated Negr1 Gene-Deficiency Induces Alterations in the Monoaminergic Neurotransmission Enhancing Time-Dependent Sensitization to Amphetamine in Male Mice
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    ΔNp63 drives dysplastic alveolar remodeling and restricts epithelial plasticity upon severe lung injury
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    Single cell RNA sequencing of the adult Drosophila eye reveals distinct clusters and novel marker genes for all major cell types
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    An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion
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    MOSPD2 is an endoplasmic reticulum–lipid droplet tether functioning in LD homeostasis
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  203. www.nature.com www.nature.com
    Table 1 Antibodies and dyes compatible with mLSR-3D
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  204. Nov 2022
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    Upregulation of Ca2+-binding proteins contributes to VTA dopamine neuron survival in the early phases of Alzheimer’s disease in Tg2576 mice
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    mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity
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    Activation of Wnt/β-catenin signaling by Zeb1 in endothelial progenitors induces vascular quiescence entry
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    Reconstitution of human adrenocortical specification and steroidogenesis using induced pluripotent stem cells
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    MPS1 localizes to end-on microtubule-attached kinetochores to promote microtubule release
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