Hypothesis

45 Matching Annotations

Oct 2025
54.241.53.176 54.241.53.176

2025.09.25.678487v1.full-html.html

1
1. scibot 07 Oct 2025
  
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  RRID:AB_1640207
  
  DOI: 10.1101/2025.09.25.678487
  
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54.241.53.176/6242d0964f3f11ac8334753a1121987506367c6b/2025.09.25.678487v1.full-html.html
Aug 2025
www.mdpi.com www.mdpi.com

Assessing Determinants of Response to PARP Inhibition in Germline ATM Mutant Melanoma

1
1. scibot 05 Aug 2025
  
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  RRID:AB_1640207
  
  DOI: 10.3390/ijms26157420
  
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mdpi.com/1422-0067/26/15/7420
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

RECLASSIFICATION OF ATM MISSENSE VARIANTS OF UNCERTAIN SIGNIFICANCE BY INTEGRATING RESULTS FROM SYSTEMATIC FUNCTIONAL ASSAYS INTO AN ACMG POINTS-BASED FRAMEWORK

1
1. scibot 10 Jul 2025
  
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  RRID:AB_1640207
  
  DOI: 10.1158/1078-0432.CCR-24-3936
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12234152/
Mar 2025
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 24 Mar 2025
  
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  RRID:AB_1640207
  
  DOI: 10.1158/1078-0432.ccr-24-3936
  
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52.53.155.43/9d2d72079ea8ca48f04203f494da6924c0f290ae/PDF-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair

1
1. scibot 14 Mar 2025
  
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  RRID:AB_1640207
  
  DOI: 10.1126/sciadv.adt1241
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11900879/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells

1
1. scibot 08 Mar 2025
  
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  RRID:AB_1640207
  
  DOI: 10.1038/s41467-025-57229-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11882782/
www.sciencedirect.com www.sciencedirect.com

YTHDC1 cooperates with the THO complex to prevent RNA-damage-induced DNA breaks

1
1. scibot 04 Mar 2025
  
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  RRID:AB_1640207
  
  DOI: 10.1016/j.molcel.2025.02.003
  
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sciencedirect.com/science/article/pii/S109727652500108X
Dec 2024
www.sciencedirect.com www.sciencedirect.com

Mapping functional elements of the DNA damage response through base editor screens

1
1. scibot 12 Dec 2024
  
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  RRID:AB_1640207
  
  DOI: 10.1016/j.celrep.2024.115047
  
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sciencedirect.com/science/article/pii/S2211124724013986
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Single-cell analysis reveals host S phase drives large T antigen expression during BK polyomavirus infection

1
1. scibot 11 Dec 2024
  
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  RRID:AB_1640207
  
  DOI: 10.1371/journal.ppat.1012663
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11620372/
Sep 2024
www.sciencedirect.com www.sciencedirect.com

TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival

1
1. scibot 12 Sep 2024
  
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  AB_1640207
  
  DOI: 10.1016/j.cell.2024.08.020
  
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sciencedirect.com/science/article/pii/S0092867424009115
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Inhibition of Aberrantly Overexpressed Polo-like Kinase 4 Is a Potential Effective Treatment for DNA Damage Repair–Deficient Uterine Leiomyosarcoma

1
1. scibot 05 Sep 2024
  
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  RRID:AB_1640207
  
  DOI: 10.1158/1078-0432.CCR-23-3720
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11369621/
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

YZL-51N functions as a selective inhibitor of SIRT7 by NAD+ competition to impede DNA damage repair

1
1. scibot 01 Jul 2024
  
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  RRID:AB_1640207
  
  DOI: 10.1016/j.isci.2024.110014
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11214487/
May 2024
www.sciencedirect.com www.sciencedirect.com

Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations

1
1. scibot 23 May 2024
  
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  RRID:AB_1640207
  
  DOI: 10.1016/j.xcrm.2024.101578
  
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sciencedirect.com/science/article/pii/S2666379124002702
Apr 2024
www.sciencedirect.com www.sciencedirect.com

DNA-PK and ATM drive phosphorylation signatures that antagonistically regulate cytokine responses to herpesvirus infection or DNA damage

2
1. scibot 12 Apr 2024
  
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  RRID:AB_1640207
  
  DOI: 10.1016/j.cels.2024.03.003
  
  Resource: (Abcam Cat# ab81292, RRID:AB_1640207)
  
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  RRID:AB_1640207
2. scibot 12 Apr 2024
  
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  RRID:AB_1640207
  
  DOI: 10.1016/j.cels.2024.03.003
  
  Resource: (Abcam Cat# ab81292, RRID:AB_1640207)
  
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sciencedirect.com/science/article/pii/S2405471224000887
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SETD2 loss and ATR inhibition synergize to promote cGAS signaling and immunotherapy response in renal cell carcinoma

1
1. scibot 03 Apr 2024
  
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  RRID:AB_1640207
  
  DOI: 10.1158/1078-0432.CCR-23-1003
  
  Resource: (Abcam Cat# ab81292, RRID:AB_1640207)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10592192/
Mar 2024
www.sciencedirect.com www.sciencedirect.com

SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis

2
1. scibot 22 Mar 2024
  
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  RRID:AB_1640207
  
  DOI: 10.1016/j.celrep.2024.113975
  
  Resource: (Abcam Cat# ab81292, RRID:AB_1640207)
  
  Curator: @scibot
  
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  RRID:AB_1640207
2. scibot 22 Mar 2024
  
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  RRID:AB_1640207
  
  DOI: 10.1016/j.celrep.2024.113975
  
  Resource: (Abcam Cat# ab81292, RRID:AB_1640207)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2211124724003036
www.sciencedirect.com www.sciencedirect.com

Disruption of H3K36 methylation provokes cellular plasticity to drive aberrant glandular formation and squamous carcinogenesis

2
1. scibot 06 Mar 2024
  
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  RRID:AB_1640207
  
  DOI: 10.1016/j.devcel.2023.12.007
  
  Resource: (Abcam Cat# ab81292, RRID:AB_1640207)
  
  Curator: @scibot
  
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  RRID:AB_1640207
2. scibot 06 Mar 2024
  
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  RRID:AB_1640207
  
  DOI: 10.1016/j.devcel.2023.12.007
  
  Resource: (Abcam Cat# ab81292, RRID:AB_1640207)
  
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sciencedirect.com/science/article/pii/S1534580723006573
Jan 2024
www.sciencedirect.com www.sciencedirect.com

Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells

1
1. scibot 19 Jan 2024
  
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  RRID:AB_1640207
  
  DOI: 10.1016/j.xcrm.2023.101376
  
  Resource: (Abcam Cat# ab81292, RRID:AB_1640207)
  
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sciencedirect.com/science/article/pii/S2666379123006055
Nov 2023
www.sciencedirect.com www.sciencedirect.com

Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma

1
1. scibot 02 Nov 2023
  
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  RRID:AB_1640207
  
  DOI: 10.1016/j.celrep.2023.113307
  
  Resource: (Abcam Cat# ab81292, RRID:AB_1640207)
  
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sciencedirect.com/science/article/pii/S2211124723013190
Jun 2023
www.sciencedirect.com www.sciencedirect.com

Integrator facilitates RNAPII removal to prevent transcription-replication collisions and genome instability

1
1. scibot 09 Jun 2023
  
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  RRID:AB_1640207
  
  DOI: 10.1016/j.molcel.2023.05.015
  
  Resource: (Abcam Cat# ab81292, RRID:AB_1640207)
  
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sciencedirect.com/science/article/pii/S1097276523003714
Mar 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Drug–gene Interaction Screens Coupled to Tumor Data Analyses Identify the Most Clinically Relevant Cancer Vulnerabilities Driving Sensitivity to PARP Inhibition

1
1. scibot 29 Mar 2023
  
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  RRID:AB_1640207
  
  DOI: 10.1158/2767-9764.CRC-22-0119
  
  Resource: (Abcam Cat# ab81292, RRID:AB_1640207)
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10035383/
Oct 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

BK Polyomavirus Requires the Mismatch Repair Pathway for DNA Damage Response Activation

1
1. scibot 12 Oct 2022
  
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  RRID:AB_1640207
  
  DOI: 10.1128/jvi.02028-21
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9044952/
May 2022
www.sciencedirect.com www.sciencedirect.com

DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production

1
1. scibot 20 May 2022
  
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  RRID:AB_1640207
  
  DOI: 10.1016/j.molcel.2022.04.030
  
  Resource: (Abcam Cat# ab81292, RRID:AB_1640207)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1097276522003938
Apr 2022
www.sciencedirect.com www.sciencedirect.com

Heterochromatic repeat clustering imposes a physical barrier on homologous recombination to prevent chromosomal translocations

1
1. scibot 21 Apr 2022
  
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  RRID:AB_1640207
  
  DOI: 10.1016/j.molcel.2022.03.033
  
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sciencedirect.com/science/article/pii/S1097276522002891
Dec 2021
www.sciencedirect.com www.sciencedirect.com

The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability

1
1. scibot 09 Dec 2021
  
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  RRID:AB_1640207
  
  DOI: 10.1016/j.celrep.2021.110080
  
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sciencedirect.com/science/article/pii/S2211124721015710
Nov 2021
www.cell.com www.cell.com

MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts

1
1. scibot 30 Nov 2021
  
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  RRID:AB_1640207
  
  DOI: 10.1016/j.molcel.2021.11.002
  
  Resource: (Abcam Cat# ab81292, RRID:AB_1640207)
  
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cell.com/molecular-cell/fulltext/S1097-2765(21)00952-7
Aug 2021
onlinelibrary.wiley.com onlinelibrary.wiley.com

Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm

1
1. scibot 15 Aug 2021
  
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  AB_1640207
  
  DOI: 10.1002/advs.202100779
  
  Resource: (Abcam Cat# ab81292, RRID:AB_1640207)
  
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onlinelibrary.wiley.com/doi/10.1002/advs.202100779
Jun 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability

1
1. scibot 18 Jun 2021
  
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  RRID:AB_1640207
  
  DOI: 10.1016/j.isci.2021.102534
  
  Resource: (Abcam Cat# ab81292, RRID:AB_1640207)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8184511/
May 2021
www.sciencedirect.com www.sciencedirect.com

AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation

1
1. scibot 09 May 2021
  
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  RRID:AB_1640207
  
  DOI: 10.1016/j.molcel.2021.04.010
  
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sciencedirect.com/science/article/pii/S1097276521003154
www.sciencedirect.com www.sciencedirect.com

The ZATT-TOP2A-PICH Axis Drives Extensive Replication Fork Reversal to Promote Genome Stability

1
1. scibot 08 May 2021
  
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  AB_1640207
  
  DOI: 10.1016/j.molcel.2020.11.007
  
  Resource: (Abcam Cat# ab81292, RRID:AB_1640207)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1097276520307851
Feb 2021
www.sciencedirect.com www.sciencedirect.com

A FOXO-dependent replication checkpoint restricts proliferation of damaged cells

1
1. scibot 24 Feb 2021
  
  in Public
  
  AB_81292
  
  DOI: 10.1016/j.celrep.2020.108675
  
  Resource: (Abcam Cat# ab81292, RRID:AB_1640207)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_1640207
  
  Curator comments: ATM (phospho S1981) antibody [EP1890Y] Abcam Cat# ab81292
  
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  RRID:AB_1640207 RRIDCUR:Unresolved RRIDCUR:NotRRID
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RRIDCUR:Unresolved

RRIDCUR:NotRRID

RRID:AB_1640207

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sciencedirect.com/science/article/pii/S2211124720316648
elifesciences.org elifesciences.org

The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure

1
1. scibot 24 Feb 2021
  
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  RRID:AB_1640207
  
  DOI: 10.7554/eLife.61797
  
  Resource: (Abcam Cat# ab81292, RRID:AB_1640207)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_1640207
  
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  RRID:AB_1640207 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_1640207

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elifesciences.org/articles/61797
www.nature.com www.nature.com

Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51

1
1. scibot 09 Feb 2021
  
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  RRID:AB_1640207
  
  DOI: 10.1038/s41418-020-00733-4
  
  Resource: (Abcam Cat# ab81292, RRID:AB_1640207)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_1640207
  
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  RRID:AB_1640207 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_1640207

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nature.com/articles/s41418-020-00733-4
Jan 2021
www.sciencedirect.com www.sciencedirect.com

Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A

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1. scibot 27 Jan 2021
  
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  RRID:AB_1640207
  
  DOI: 10.1016/j.celrep.2020.108680
  
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A FOXO-dependent replication checkpoint restricts proliferation of damaged cells

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1. scibot 27 Jan 2021
  
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  DOI: 10.1016/j.celrep.2020.108675
  
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sciencedirect.com/science/article/pii/S2211124720316648
Sep 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome

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1. scibot 25 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.108179
  
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METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation

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1. scibot 23 Sep 2020
  
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  DOI: 10.1016/j.molcel.2020.06.017
  
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Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage

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1. scibot 08 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.01.074
  
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Jan 2020
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PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.08.085
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6880866/
Nov 2018
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MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation

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1. scibot 05 Nov 2018
  
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Nov 2017
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ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks

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1. scibot 08 Nov 2017
  
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A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability

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1. scibot 08 Nov 2017
  
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  Curator: @Zeljana_Babic
  
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sciencedirect.com/science/article/pii/S0092867417305378