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BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

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Jun 2026
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An orally active dual CBP/p300 degrader targets core dependencies of multiple myeloma

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p16 expression confers sensitivity to CDK2 inhibitors in cyclin E1–driven ovarian cancers

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Inhibition of USP7 destabilizes the noncanonical PRC1.1 complex and induces neuroblastoma differentiation

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Aug 2025
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Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells

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May 2025
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KDM3A and KDM3B regulate alternative splicing in mouse pluripotent stem cells

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Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis

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Feb 2025
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CDK9 inhibition by dinaciclib is a therapeutic vulnerability in epithelioid hemangioendothelioma

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Jan 2025
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A genetically encoded fluorescent biosensor for visualization of acetyl-CoA in live cells

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Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy

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Dec 2024
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H4K20me3-Mediated Repression of Inflammatory Genes is a Characteristic and Targetable Vulnerability of Persister Cancer Cells

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Nov 2024
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can-24-0529-html.html

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May 2024
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2024.04.30.591961v1.full-html.html

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Mar 2024
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MOF-mediated acetylation of UHRF1 enhances UHRF1 E3 ligase activity to facilitate DNA methylation maintenance

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Feb 2024
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The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells

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The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells

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journals.physiology.org/doi/10.1152/ajpcell.00293.2023
Dec 2023
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ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factors

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Nov 2023
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Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies

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Aug 2023
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MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC

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Jul 2023
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Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis

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Jun 2023
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Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity

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May 2023
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Methylated histones on mitotic chromosomes promote Topoisomerase IIα function for high fidelity chromosome segregation.

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Mar 2023
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Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer

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Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes

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ncbi.nlm.nih.gov/pmc/articles/PMC9988578/
Dec 2022
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Mechanisms of IRF2BPL-related disorders and identification of a potential therapeutic strategy

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BAF complex maintains glioma stem cells in pediatric H3K27M-glioma

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aacrjournals.org/cancerdiscovery/article/12/12/2880/711164/BAF-Complex-Maintains-Glioma-Stem-Cells-in
Nov 2022
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Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation

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Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins

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Cytoplasmic pool of U1 spliceosome protein SNRNP70 shapes the axonal transcriptome and regulates motor connectivity

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Aug 2022
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CHAMP1 binds to REV7/FANCV and promotes homologous recombination repair

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ccr-21-3603-html.html

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52.53.155.43/de81104a0064110ab6f8eb2e443412de8e9dbc9e/ccr-21-3603-html.html
Mar 2022
academic.oup.com academic.oup.com

Mst1/2 is necessary for satellite cell differentiation to promote muscle regeneration

1
1. scibot 02 Mar 2022
  
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  DOI: 10.1093/stmcls/sxab010
  
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academic.oup.com/stmcls/advance-article/doi/10.1093/stmcls/sxab010/6511691
Jan 2022
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SKI-G-801, an AXL kinase inhibitor, blocks metastasis through inducing anti-tumor immune responses and potentiates anti-PD-1 therapy in mouse cancer models

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onlinelibrary.wiley.com/doi/10.1002/cti2.1364
Aug 2021
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Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer

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  DOI: 10.1038/s41467-021-24687-4
  
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nature.com/articles/s41467-021-24687-4
Jul 2021
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Untitled document

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  DOI: 10.1111/jnc.14144
  
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onlinelibrary.wiley.com/doi/full/10.1111/jnc.14144
May 2021
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Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis

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  DOI: 10.1016/j.cmet.2021.03.003
  
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sciencedirect.com/science/article/pii/S1550413121001108
Apr 2021
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Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor

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Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas

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sciencedirect.com/science/article/pii/S153561082030369X
Feb 2021
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Myeloid-derived Growth Factor Promotes Intestinal Glucagon-like Peptide-1 Production in Male Mice with Type 2 Diabetes

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1. scibot 24 Feb 2021
  
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  DOI: 10.1210/endocr/bqaa003
  
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academic.oup.com/endo/article/161/2/bqaa003/5698328
Dec 2020
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Translation in amino-acid-poor environments is limited by tRNAGln charging

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  DOI: 10.7554/eLife.62307
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7744096/
Nov 2020
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G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program

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  DOI: 10.1016/j.celrep.2020.108341
  
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An epilepsy‐associated ACTL6B variant captures neuronal hyperexcitability in a human induced pluripotent stem cell model

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  DOI: 10.1002/jnr.24747
  
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onlinelibrary.wiley.com/doi/10.1002/jnr.24747
Sep 2020
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Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2

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sciencedirect.com/science/article/pii/S2211124720301613
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Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis

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ncbi.nlm.nih.gov/pmc/articles/PMC7321798/
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Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

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  DOI: 10.1016/j.cell.2020.03.052
  
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sciencedirect.com/science/article/pii/S0092867420303457
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PRC1 Catalytic Activity Is Central to Polycomb System Function

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  DOI: 10.1016/j.molcel.2019.12.001
  
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Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity

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An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling

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  DOI: 10.1016/j.chom.2019.10.004
  
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sciencedirect.com/science/article/pii/S1931312819305281
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Untitled document

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  DOI: 10.1016/j.molcel.2019.03.024
  
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sciencedirect.com/science/article/pii/S109727651930228X
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Untitled document

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  DOI: 10.1016/j.cell.2019.03.032
  
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sciencedirect.com/science/article/pii/S0092867419303277
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MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis

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  DOI: 10.1016/j.molcel.2018.09.031
  
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sciencedirect.com/science/article/pii/S1097276518308025
Nov 2018
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MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation

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sciencedirect.com/science/article/pii/S1535610818302691
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EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation

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sciencedirect.com/science/article/pii/S1535610818302290
Nov 2017
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Inhibition of histone deacetylase 1 or 2 reduces induced cytokine expression in microglia through a protein synthesis independent mechanism

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onlinelibrary.wiley.com/doi/10.1111/jnc.14144/full