31 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acquisition of resistance to RAS inhibition is associated with the upregulation of macropinocytosis through both PI3K-dependent and -independent signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC13410306/
  3. Jul 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13343314/
  5. Jun 2026
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PI3K Regulates Wild-type RAS Signaling to Confer Resistance to KRAS Inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC13237827/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas
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    pmc.ncbi.nlm.nih.gov/articles/PMC13227558/
  8. May 2026
  9. www.sciencedirect.com www.sciencedirect.com
    Disrupted molecular glue complex drives RAS inhibitor resistance
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    sciencedirect.com/science/article/pii/S0092867426003326
  10. Apr 2026
  11. www.sciencedirect.com www.sciencedirect.com
    Anticancer activity of RAS-GTP inhibition in cholangiocarcinoma
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    sciencedirect.com/science/article/pii/S1535610826001741
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutant and Wild-type RAS Crosstalk and Stoichiometric Deficiencies are Determinants of Sensitivity to Targeted Therapies in KRASG12R Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13080315/
  13. Jan 2026
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12847887/
  15. www.sciencedirect.com www.sciencedirect.com
    Protocols to evaluate mutant specificity of an oncogene-targeting siRNA using orthogonal in vitro and in vivo approaches
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    sciencedirect.com/science/article/pii/S2666166725007294
  16. Nov 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12614194/
  18. Oct 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pancreatic Cells Are Resistant to KRASQ61L Expression due to Hyperactive ERK/MAPK Signaling and Apoptosis Induction
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    pmc.ncbi.nlm.nih.gov/articles/PMC12541299/
  20. www.sciencedirect.com www.sciencedirect.com
    P-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity
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    sciencedirect.com/science/article/pii/S221112472501174X
  21. www.science.org www.science.org
    Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer
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    science.org/doi/10.1126/scisignal.adu7145
  22. Jun 2025
  23. www.sciencedirect.com www.sciencedirect.com
    A first-in-class EGFR-directed KRAS G12V selective inhibitor
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    sciencedirect.com/science/article/pii/S1535610825002259
  24. Sep 2024
  25. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13725
  26. Aug 2024
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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    ncbi.nlm.nih.gov/pmc/articles/PMC11301402/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11301400/
  29. www.sciencedirect.com www.sciencedirect.com
    The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes
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    sciencedirect.com/science/article/pii/S2589004224017243
  30. Jul 2024
  31. www.science.org www.science.org
    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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    science.org/doi/10.1126/science.adk0775
  32. www.science.org www.science.org
    Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer
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    science.org/doi/10.1126/science.adk0850
  33. Feb 2024
  34. 52.53.155.43 52.53.155.43
    RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation
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    52.53.155.43/19126de606c776a10e00c0c9a385ef3636eaaf16/2023.10.05.561021v2.full (1)-html.html
  35. Oct 2023
  36. www.cell.com www.cell.com
    Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer
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    cell.com/cell-reports/abstract/S2211-1247(23)01014-8
  37. Sep 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion
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    sciencedirect.com/science/article/pii/S2211124723010537
  39. Jul 2022
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aberrant expression and subcellular localization of ECT2 drives colorectal cancer progression and growth
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    ncbi.nlm.nih.gov/pmc/articles/PMC9056178/
  41. May 2022
  42. elifesciences.org elifesciences.org
    Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs
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    elifesciences.org/articles/76495
  43. Dec 2021
  44. www.sciencedirect.com www.sciencedirect.com
    Identification of RAS mutant biomarkers for EGFR inhibitor sensitivity using a systems biochemical approach
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    sciencedirect.com/science/article/pii/S2211124721015904
  45. www.sciencedirect.com www.sciencedirect.com
    CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
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    sciencedirect.com/science/article/pii/S2211124721015461
  46. Jun 2021
  47. www.sciencedirect.com www.sciencedirect.com
    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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    sciencedirect.com/science/article/pii/S2211124721006628
  48. Sep 2020
  49. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System
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    pubmed.ncbi.nlm.nih.gov/32668202/
  50. www.mdpi.com www.mdpi.com
    Statin Drugs Plus Th1 Cytokines Potentiate Apoptosis and Ras Delocalization in Human Breast Cancer Lines and Combine with Dendritic Cell-Based Immunotherapy to Suppress Tumor Growth in a Mouse Model of HER-2pos Disease
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    mdpi.com/2076-393X/8/1/72
  51. Jan 2020
  52. www.sciencedirect.com www.sciencedirect.com
    Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling
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    sciencedirect.com/science/article/pii/S1097276519306896