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Neuroinflammatory stress preferentially impacts synaptic MAPK signaling and mitochondria in excitatory neurons

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Feb 2026
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Impact of Tau overexpression on DNA replication dynamics in centromeres of human neural progenitor cells

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Rapid remodeling of NTP levels enables immediate translational adaptation to energy stress in yeast

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pmc.ncbi.nlm.nih.gov/articles/PMC7618711/
Aug 2025
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Electrochemical coupling at the plasma membrane by mouse voltage-sensitive phosphatase requires association with basigin

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YTHDF proteins and m6A-RNA clients undergo autophagic turnover during contact inhibition

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Mitochondrial damage triggers the concerted degradation of negative regulators of neuronal autophagy

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Jun 2025
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1-s2.0-S2589004225012350-main-html.html

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Mar 2025
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The STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cells

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pmc.ncbi.nlm.nih.gov/articles/PMC12035956/
Jan 2025
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Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation

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Dec 2024
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Expanding GABAergic Neuronal Diversity in iPSC-Derived Disease Models

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pmc.ncbi.nlm.nih.gov/articles/PMC11642846/
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Determinants of chemoselectivity in ubiquitination by the J2 family of ubiquitin-conjugating enzymes

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Design principles to tailor Hsp104 therapeutics

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Sep 2024
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Scar/WAVE drives actin protrusions independently of its VCA domain using proline-rich domains

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1. scibot 27 Sep 2024
  
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Aug 2024
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The FXR1 network acts as a signaling scaffold for actomyosin remodeling

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Jul 2024
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Aging Differentially Affects Axonal Autophagosome Formation and Maturation

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ncbi.nlm.nih.gov/pmc/articles/PMC10621248/
May 2024
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Arginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine-to-cysteine substitutants

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Identification of novel and distinct FGF23 signaling in a Klotho-dependent and -independent manner

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1. scibot 03 May 2024
  
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biorxiv.org/content/10.1101/2024.01.18.576116v1
Apr 2024
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Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner

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1. scibot 30 Apr 2024
  
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Dec 2023
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Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures

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ncbi.nlm.nih.gov/pmc/articles/PMC10749327/
Nov 2023
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Visualizing the chaperone-mediated folding trajectory of the G protein β5 β-propeller

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Oct 2023
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The anaphase-promoting complex controls a ubiquitination-phosphoprotein axis in chromatin during neurodevelopment

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Aug 2023
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RNA polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation

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Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression

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Jul 2023
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The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling

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Feb 2023
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Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes

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Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology

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CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication

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ncbi.nlm.nih.gov/pmc/articles/PMC9884621/
Jan 2023
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Zinc-finger protein Zpr1 is a bespoke chaperone essential for eEF1A biogenesis

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Dec 2022
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A minimal construct of nuclear-import receptor Karyopherin-β2 defines the regions critical for chaperone and disaggregation activity

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Jul 2022
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Self-assembly of pericentriolar material in interphase cells lacking centrioles

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  DOI: 10.7554/eLife.77892
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9307276/
Jun 2022
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METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance

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  DOI: 10.7554/eLife.72780
  
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elifesciences.org/articles/72780
Apr 2022
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The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade

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Jan 2022
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The enteric pathogen Cryptosporidium parvum exports proteins into the cytosol of the infected host cell

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  DOI: 10.7554/eLife.70451
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8687662/
Dec 2021
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APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain

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1. scibot 23 Dec 2021
  
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  DOI: 10.1016/j.molcel.2021.11.031
  
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Nov 2021
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DNAJB6b-enriched small extracellular vesicles decrease polyglutamine aggregation in in vitro and in vivo models of Huntington disease

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  DOI: 10.1016/j.isci.2021.103282
  
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Systemic inflammation induced the delayed reduction of excitatory synapses in the CA3 during ageing

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Oncogene-dependent sloppiness in mRNA translation

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Luciferase reporter assays to monitor interferon signaling modulation by SARS-CoV-2 proteins

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An additional NF-κB site allows HIV-1 subtype C to evade restriction by nuclear PYHIN proteins

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Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites

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Untitled document

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  DOI: 10.1210/en.2017-00677
  
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Elimination of vision-guided target attraction in Aedes aegypti using CRISPR

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wellcomeopenresearch.org wellcomeopenresearch.org

Pathogenic <i>FAM83G</i> palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling.

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FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates

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NLRP3 Regulates IL-4 Expression in TOX+ CD4+ T Cells of Cutaneous T Cell Lymphoma to Potentially Promote Disease Progression

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Budding epithelial morphogenesis driven by cell-matrix versus cell-cell adhesion

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ZFP36L1 plays an ambiguous role in the regulation of cell expansion and negatively regulates CDKN1A in chronic myeloid leukemia cells

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Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities

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Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population

1
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The bone microenvironment invigorates metastatic seeds for further dissemination

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BBLN-1 is essential for intermediate filament organization and apical membrane morphology

1
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Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins

1
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Differential role of cytosolic Hsp70s in longevity assurance and protein quality control

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Therapeutic genetic variation revealed in diverse Hsp104 homologs

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IFI16 knockdown in primary HIV-1 target cells

1
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Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors

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Precise Temporal Regulation of Post-transcriptional Repressors Is Required for an Orderly Drosophila Maternal-to-Zygotic Transition

1
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β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia

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Genome-wide Nucleotide-Resolution Mapping of DNA Replication Patterns, Single-Strand Breaks, and Lesions by GLOE-Seq

1
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A Conserved PDZ-Binding Motif in aPKC Interacts with Par-3 and Mediates Cortical Polarity

1
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elifesciences.org elifesciences.org

Oomycete small RNAs bind to the plant RNA-induced silencing complex for virulence

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  DOI: 10.7554/eLife.56096
  
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The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness

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Co-dependent Assembly of Drosophila piRNA Precursor Complexes and piRNA Cluster Heterochromatin

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Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

1
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ERK1/2 Phosphorylation of FHOD Connects Signaling and Nuclear Positioning Alternations in Cardiac Laminopathy

1
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Differing intrinsic biological properties between forebrain and spinal oligodendroglial lineage cells

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onlinelibrary.wiley.com/doi/full/10.1111/jnc.14074
Nov 2018
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Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice

1
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Untitled document

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Activation of the NLRP3 inflammasome in microglia: the role of ceramide

1
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  RRID:AB_1850025
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RRID:AB_1850025

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scibot

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onlinelibrary.wiley.com/doi/10.1111/jnc.14225/full

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