38 Matching Annotations
  1. Aug 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
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    pmc.ncbi.nlm.nih.gov/articles/PMC12319521/
  3. Jun 2025
  4. www.sciencedirect.com www.sciencedirect.com
    Senescence and inflammation are unintended adverse consequences of CRISPR-Cas9/AAV6-mediated gene editing in hematopoietic stem cells
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    sciencedirect.com/science/article/pii/S2666379125002307
  5. May 2025
  6. www.sciencedirect.com www.sciencedirect.com
    Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target
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    sciencedirect.com/science/article/pii/S1535610825001734
  7. Apr 2025
  8. www.sciencedirect.com www.sciencedirect.com
    DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair
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    sciencedirect.com/science/article/pii/S2211124725002232
  9. Dec 2024
  10. academic.oup.com academic.oup.com
    CAF-1 promotes efficient PrimPol recruitment to nascent DNA for single-stranded DNA gap formation
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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae1068/7903364
  11. Nov 2024
  12. www.sciencedirect.com www.sciencedirect.com
    Profound synthetic lethality between SMARCAL1 and FANCM
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    sciencedirect.com/science/article/pii/S1097276524008566
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    A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR-Cas9 gene editing in hematopoietic stem and progenitor cells
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    sciencedirect.com/science/article/pii/S2666379124005949
  14. Sep 2024
  15. www.sciencedirect.com www.sciencedirect.com
    Protocol to study the direct binding of proteins to RNA:DNA hybrids or RNA-DNA chimeras in living cells using cross-linking immunoprecipitation
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    sciencedirect.com/science/article/pii/S266616672400457X
  16. Feb 2024
  17. 52.53.155.43 52.53.155.43
    53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication
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    52.53.155.43/9b07aa3872d935df1f2ff4d73fc96f76996bcf22/2023.09.27.559698v1.full-html.html
  18. Dec 2023
  19. www.sciencedirect.com www.sciencedirect.com
    53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication
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    sciencedirect.com/science/article/pii/S2211124723014249
  20. Oct 2023
  21. www.sciencedirect.com www.sciencedirect.com
    Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer
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    sciencedirect.com/science/article/pii/S2211124723011567
  22. Aug 2023
  23. www.sciencedirect.com www.sciencedirect.com
    Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1
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    sciencedirect.com/science/article/abs/pii/S1097276523005646
  24. Dec 2022
  25. www.sciencedirect.com www.sciencedirect.com
    POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells
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    sciencedirect.com/science/article/pii/S109727652201070X
  26. Oct 2021
  27. www.sciencedirect.com www.sciencedirect.com
    Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair
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    sciencedirect.com/science/article/pii/S0896627321007133
  28. www.sciencedirect.com www.sciencedirect.com
    Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males
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    sciencedirect.com/science/article/pii/S2211124721012778
  29. Sep 2021
  30. www.sciencedirect.com www.sciencedirect.com
    REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps
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    sciencedirect.com/science/article/pii/S1097276521006833
  31. Aug 2021
  32. academic.oup.com academic.oup.com
    Basal Autophagy Deficiency Causes Thyroid Follicular Epithelial Cell Death in Mice
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    academic.oup.com/endo/article/160/9/2085/5532589
  33. www.sciencedirect.com www.sciencedirect.com
    BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication
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    sciencedirect.com/science/article/pii/S2211124718316838
  34. www.sciencedirect.com www.sciencedirect.com
    Exocyst protein subnetworks integrate Hippo and mTOR signaling to promote virus detection and cancer
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    sciencedirect.com/science/article/pii/S2211124721009189
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC6458988/
  36. Jul 2021
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC6242708/
  38. Apr 2021
  39. www.sciencedirect.com www.sciencedirect.com
    Functional interrogation of DNA damage response variants with base editing screens
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    sciencedirect.com/science/article/pii/S0092867421000842
  40. Feb 2021
  41. www.sciencedirect.com www.sciencedirect.com
    A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability
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    sciencedirect.com/science/article/pii/S2211124720300292
  42. Dec 2020
  43. www.sciencedirect.com www.sciencedirect.com
    RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions
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    sciencedirect.com/science/article/pii/S2211124720315357
  44. www.sciencedirect.com www.sciencedirect.com
    Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
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    sciencedirect.com/science/article/pii/S1097276520308984
  45. www.sciencedirect.com www.sciencedirect.com
    DNA Damage Baseline Predicts Resilience to Space Radiation and Radiotherapy
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    sciencedirect.com/science/article/pii/S2211124720314236
  46. Sep 2020
  47. www.sciencedirect.com www.sciencedirect.com
    SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells
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    sciencedirect.com/science/article/pii/S2211124720311736
  48. academic.oup.com academic.oup.com
    Hormonal Regulation of Autophagy in Thyroid PCCL3 Cells and the Thyroids of Male Mice
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    academic.oup.com/jes/article/4/7/bvaa054/5837712
  49. www.sciencedirect.com www.sciencedirect.com
    A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability
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    sciencedirect.com/science/article/pii/S2211124720300292
  50. www.sciencedirect.com www.sciencedirect.com
    Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53-Deficient Cells
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    sciencedirect.com/science/article/pii/S2211124720303430
  51. May 2020
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    β-cell aging markers have heterogeneous distribution and are induced by insulin resistance
    1
    1. nPOD_Curator 15 May 2020
      Immunostaining and morphometric evaluation Paraffin sections were incubated overnight with primary antibody (Key Resources Table). For each antibody, sections were stained and imaged in parallel such that the staining intensity reflects the protein expression. For quantification, images were captured systematically covering the whole section in confocal mode on a Zeiss LSM 710 microscope. Every cluster of insulin-stained cells (3–7 cells) or islet (8 or more cells)/section was evaluated; sections were coded and read blindly. For each age, 3–4 animals were evaluated for each staining. For human samples, sections from one block from the body of the pancreas from donors as listed in Key Resources Table.

      Immunostaining and morphometric evaluation

      (includes p53BP1 and IGF1r)

      obiwan:Method RRID:AB_731540 RRID:AB_185520 PMID:28380379
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    ncbi.nlm.nih.gov/pmc/articles/PMC5471618/
  53. Jan 2020
  54. www.sciencedirect.com www.sciencedirect.com
    IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer
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    sciencedirect.com/science/article/pii/S1097276519304332
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint
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    ncbi.nlm.nih.gov/pmc/articles/PMC6561707/
  56. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1550413119301329
  57. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1934590919300712
  58. Nov 2018
  59. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1097276518307020
  60. www.sciencedirect.com www.sciencedirect.com
    Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair
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    sciencedirect.com/science/article/pii/S0092867418311176