41 Matching Annotations
  1. Sep 2026
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    Hypertranscription caused by p53 deficiency triggers nucleotide insufficiency that induces replication stress and genomic instability
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    sciencedirect.com/science/article/pii/S1097276526005502
  3. Jul 2026
  4. aacrjournals.org aacrjournals.org
    Antibody-Mediated Targeting of Secretory Protein SCUBE3 Suppresses Cancer Progression by Inhibiting Oncogenic Signaling and Inducing Anti-tumor Immunity
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    aacrjournals.org/cancerres/article/86/5/1252/774876/Antibody-Mediated-Targeting-of-Secretory-Protein
  5. May 2026
  6. www.sciencedirect.com www.sciencedirect.com
    A ZNF-nanobody fusion reveals SUMOylation-dependent changes in p53 protein localization
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    sciencedirect.com/science/article/pii/S2589004226010485
  7. Aug 2025
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
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    pmc.ncbi.nlm.nih.gov/articles/PMC12319521/
  9. Jun 2025
  10. www.sciencedirect.com www.sciencedirect.com
    Senescence and inflammation are unintended adverse consequences of CRISPR-Cas9/AAV6-mediated gene editing in hematopoietic stem cells
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    sciencedirect.com/science/article/pii/S2666379125002307
  11. May 2025
  12. www.sciencedirect.com www.sciencedirect.com
    Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target
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    sciencedirect.com/science/article/pii/S1535610825001734
  13. Apr 2025
  14. www.sciencedirect.com www.sciencedirect.com
    DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair
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    sciencedirect.com/science/article/pii/S2211124725002232
  15. Dec 2024
  16. academic.oup.com academic.oup.com
    CAF-1 promotes efficient PrimPol recruitment to nascent DNA for single-stranded DNA gap formation
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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae1068/7903364
  17. Nov 2024
  18. www.sciencedirect.com www.sciencedirect.com
    Profound synthetic lethality between SMARCAL1 and FANCM
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    sciencedirect.com/science/article/pii/S1097276524008566
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    A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR-Cas9 gene editing in hematopoietic stem and progenitor cells
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    sciencedirect.com/science/article/pii/S2666379124005949
  20. Sep 2024
  21. www.sciencedirect.com www.sciencedirect.com
    Protocol to study the direct binding of proteins to RNA:DNA hybrids or RNA-DNA chimeras in living cells using cross-linking immunoprecipitation
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    sciencedirect.com/science/article/pii/S266616672400457X
  22. Feb 2024
  23. 52.53.155.43 52.53.155.43
    53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication
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    52.53.155.43/9b07aa3872d935df1f2ff4d73fc96f76996bcf22/2023.09.27.559698v1.full-html.html
  24. Dec 2023
  25. www.sciencedirect.com www.sciencedirect.com
    53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication
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    sciencedirect.com/science/article/pii/S2211124723014249
  26. Oct 2023
  27. www.sciencedirect.com www.sciencedirect.com
    Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer
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    sciencedirect.com/science/article/pii/S2211124723011567
  28. Aug 2023
  29. www.sciencedirect.com www.sciencedirect.com
    Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1
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    sciencedirect.com/science/article/abs/pii/S1097276523005646
  30. Dec 2022
  31. www.sciencedirect.com www.sciencedirect.com
    POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells
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    sciencedirect.com/science/article/pii/S109727652201070X
  32. Oct 2021
  33. www.sciencedirect.com www.sciencedirect.com
    Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair
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    sciencedirect.com/science/article/pii/S0896627321007133
  34. www.sciencedirect.com www.sciencedirect.com
    Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males
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    sciencedirect.com/science/article/pii/S2211124721012778
  35. Sep 2021
  36. www.sciencedirect.com www.sciencedirect.com
    REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps
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    sciencedirect.com/science/article/pii/S1097276521006833
  37. Aug 2021
  38. academic.oup.com academic.oup.com
    Basal Autophagy Deficiency Causes Thyroid Follicular Epithelial Cell Death in Mice
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    academic.oup.com/endo/article/160/9/2085/5532589
  39. www.sciencedirect.com www.sciencedirect.com
    BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication
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    sciencedirect.com/science/article/pii/S2211124718316838
  40. www.sciencedirect.com www.sciencedirect.com
    Exocyst protein subnetworks integrate Hippo and mTOR signaling to promote virus detection and cancer
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    sciencedirect.com/science/article/pii/S2211124721009189
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC6458988/
  42. Jul 2021
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC6242708/
  44. Apr 2021
  45. www.sciencedirect.com www.sciencedirect.com
    Functional interrogation of DNA damage response variants with base editing screens
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    sciencedirect.com/science/article/pii/S0092867421000842
  46. Feb 2021
  47. www.sciencedirect.com www.sciencedirect.com
    A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability
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    sciencedirect.com/science/article/pii/S2211124720300292
  48. Dec 2020
  49. www.sciencedirect.com www.sciencedirect.com
    RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions
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    sciencedirect.com/science/article/pii/S2211124720315357
  50. www.sciencedirect.com www.sciencedirect.com
    Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
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    sciencedirect.com/science/article/pii/S1097276520308984
  51. www.sciencedirect.com www.sciencedirect.com
    DNA Damage Baseline Predicts Resilience to Space Radiation and Radiotherapy
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    sciencedirect.com/science/article/pii/S2211124720314236
  52. Sep 2020
  53. www.sciencedirect.com www.sciencedirect.com
    SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells
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    sciencedirect.com/science/article/pii/S2211124720311736
  54. academic.oup.com academic.oup.com
    Hormonal Regulation of Autophagy in Thyroid PCCL3 Cells and the Thyroids of Male Mice
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    academic.oup.com/jes/article/4/7/bvaa054/5837712
  55. www.sciencedirect.com www.sciencedirect.com
    A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability
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    sciencedirect.com/science/article/pii/S2211124720300292
  56. www.sciencedirect.com www.sciencedirect.com
    Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53-Deficient Cells
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    sciencedirect.com/science/article/pii/S2211124720303430
  57. May 2020
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    β-cell aging markers have heterogeneous distribution and are induced by insulin resistance
    1
    1. nPOD_Curator 15 May 2020
      Immunostaining and morphometric evaluation Paraffin sections were incubated overnight with primary antibody (Key Resources Table). For each antibody, sections were stained and imaged in parallel such that the staining intensity reflects the protein expression. For quantification, images were captured systematically covering the whole section in confocal mode on a Zeiss LSM 710 microscope. Every cluster of insulin-stained cells (3–7 cells) or islet (8 or more cells)/section was evaluated; sections were coded and read blindly. For each age, 3–4 animals were evaluated for each staining. For human samples, sections from one block from the body of the pancreas from donors as listed in Key Resources Table.

      Immunostaining and morphometric evaluation

      (includes p53BP1 and IGF1r)

      obiwan:Method RRID:AB_731540 RRID:AB_185520 PMID:28380379
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    ncbi.nlm.nih.gov/pmc/articles/PMC5471618/
  59. Jan 2020
  60. www.sciencedirect.com www.sciencedirect.com
    IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer
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    sciencedirect.com/science/article/pii/S1097276519304332
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint
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    ncbi.nlm.nih.gov/pmc/articles/PMC6561707/
  62. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1550413119301329
  63. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1934590919300712
  64. Nov 2018
  65. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1097276518307020
  66. www.sciencedirect.com www.sciencedirect.com
    Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair
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    sciencedirect.com/science/article/pii/S0092867418311176