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Ubiquitin chain editing promotes p97/VCP-dependent removal of RPA from DNA

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1. scibot 03 Oct 2026
  
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  DOI: 10.1016/j.molcel.2026.09.004
  
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sciencedirect.com/science/article/pii/S1097276526006210
Jun 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A CHK1-mediated phosphorylation switch suppresses human Topoisomerase 1-associated genomic instability

1
1. scibot 18 Jun 2026
  
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  DOI: 10.1038/s44318-026-00783-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13270093/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The modulation of AUF1 regulates the R-loop resolution activating the immune response in DDR

1
1. scibot 06 Jun 2026
  
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  DOI: 10.1016/j.isci.2026.115900
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13196424/
Apr 2026
54.241.53.176 54.241.53.176

1-s2.0-S2589004226010862-main-html.html

1
1. scibot 11 Apr 2026
  
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  RRID:AB_185548
  
  DOI: 10.1016/j.isci.2026.115711
  
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54.241.53.176/be028d43344bab6907bc9e771fd88e2dec1a0cd7/1-s2.0-S2589004226010862-main-html.html
Mar 2026
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Microhomology-mediated end joining acts directly on replication forks to repair single-ended double-strand breaks

1
1. scibot 17 Mar 2026
  
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  DOI: 10.1016/j.molcel.2026.02.016
  
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sciencedirect.com/science/article/pii/S1097276526001309
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Histone Deacetylase Inhibitors Target DNA Replication Regulators and Replication Stress in Ewing Sarcoma Cells

1
1. scibot 01 Jul 2025
  
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  DOI: 10.1158/2767-9764.CRC-25-0058
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12202856/
Jun 2025
52.53.155.43 52.53.155.43

PDF-html.html

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1. scibot 12 Jun 2025
  
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  DOI: 10.1158/2767-9764.crc-25-0058
  
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52.53.155.43/6f95ee3860ed32eb2fc3447b03e264cd8239544f/PDF-html.html
Jul 2024
52.53.155.43 52.53.155.43

PPAR_Interaction_with_UBR5_ATMIN_Promot-html.html

1
1. scibot 23 Jul 2024
  
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  RRID:AB_185548
  
  DOI: 10.1016/j.celrep.2019.01.013
  
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52.53.155.43/dff7bc1da9f5df512f47678d2bc141ea46c650fc/PPAR_Interaction_with_UBR5_ATMIN_Promot-html.html
Jun 2024
www.cell.com www.cell.com

CHK1 inhibitor SRA737 is active in PARP inhibitor resistant and CCNE1 amplified ovarian cancer

1
1. scibot 29 Jun 2024
  
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  DOI: 10.1016/j.isci.2024.109978
  
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cell.com/iscience/abstract/S2589-0042(24)01200-8
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RTF2 controls replication repriming and ribonucleotide excision at the replisome

1
1. scibot 06 Mar 2024
  
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  DOI: 10.1038/s41467-024-45947-z
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10908796/
Feb 2024
aacrjournals.org aacrjournals.org

A Phase 1 Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-Dose Gemcitabine in Metastatic Pancreatic Adenocarcinoma Patients

1
1. scibot 24 Feb 2024
  
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  RRID:AB_185548
  
  DOI: 10.1158/1078-0432.CCR-23-2005
  
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aacrjournals.org/clincancerres/article/29/24/5047/731678/A-Phase-I-Expansion-Cohort-Study-Evaluating-the
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SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion

1
1. scibot 02 Feb 2024
  
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  RRID:AB_185548
  
  DOI: 10.1016/j.cell.2024.01.008
  
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sciencedirect.com/science/article/pii/S0092867424000102
Dec 2023
52.53.155.43 52.53.155.43

ccr-23-2005-html.html

1
1. scibot 01 Dec 2023
  
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  RRID:AB_185548
  
  DOI: 10.1158/1078-0432.ccr-23-2005
  
  Resource: (Bethyl Cat# A300-244A, RRID:AB_185548)
  
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52.53.155.43/8373d350712629607ae5ff64c6434e7646ebbbe9/ccr-23-2005-html.html
Nov 2023
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Replicative stress in gastroesophageal premalignancy is associated with chromosomal instability and sensitivity to DNA damage response inhibitors

1
1. scibot 04 Nov 2023
  
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  DOI: 10.1016/j.isci.2023.108169
  
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sciencedirect.com/science/article/pii/S2589004223022460
Sep 2023
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The interplay of TARG1 and PARG protects against genomic instability

1
1. scibot 12 Sep 2023
  
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  RRID:AB_185548
  
  DOI: 10.1016/j.celrep.2023.113113
  
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sciencedirect.com/science/article/pii/S2211124723011245
Nov 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Replication stress defines distinct molecular subtypes across cancers

1
1. scibot 19 Nov 2022
  
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  AB_185548
  
  DOI: 10.1158/2767-9764.crc-22-0168
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9648410/
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Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2

1
1. scibot 16 Nov 2022
  
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  RRID:AB_185548
  
  DOI: 10.1016/j.celrep.2022.111670
  
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sciencedirect.com/science/article/pii/S2211124722015443
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation

1
1. scibot 14 Aug 2021
  
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  RRID:AB_185548
  
  DOI: 10.1093/nar/gkz076
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6486545/
Jun 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability

1
1. scibot 18 Jun 2021
  
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  RRID:AB_185548
  
  DOI: 10.1016/j.isci.2021.102534
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8184511/
Apr 2021
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Functional interrogation of DNA damage response variants with base editing screens

1
1. scibot 12 Apr 2021
  
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  DOI: 10.1016/j.cell.2021.01.041
  
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sciencedirect.com/science/article/pii/S0092867421000842
Mar 2021
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MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity

1
1. scibot 03 Mar 2021
  
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  RRID:AB_185548
  
  DOI: 10.1016/j.celrep.2021.108808
  
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sciencedirect.com/science/article/pii/S2211124721001224
Jan 2021
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A Disease-Causing Single Amino Acid Deletion in the Coiled-Coil Domain of RAD50 Impairs MRE11 Complex Functions in Yeast and Humans

1
1. scibot 05 Jan 2021
  
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  AB_185548
  
  DOI: 10.1016/j.celrep.2020.108559
  
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sciencedirect.com/science/article/pii/S2211124720315485
Jan 2020
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Untitled document

1
1. scibot 13 Jan 2020
  
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  RRID:AB_185548
  
  DOI: 10.1016/j.celrep.2019.01.013
  
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sciencedirect.com/science/article/pii/S221112471930021X
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Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection

1
1. scibot 13 Jan 2020
  
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  RRID:AB_185548
  
  DOI: 10.1016/j.molcel.2019.04.003
  
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sciencedirect.com/science/article/pii/S1097276519302734
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DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors

1
1. scibot 13 Jan 2020
  
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  RRID:AB_185548
  
  DOI: 10.1016/j.ccell.2019.02.004
  
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sciencedirect.com/science/article/pii/S1535610819300996
academic.oup.com academic.oup.com

Untitled document

1
1. scibot 12 Jan 2020
  
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  RRID:AB_185548
  
  DOI: 10.1093/nar/gkz076
  
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  Curator: @evieth
  
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academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz076/5364135
Nov 2018
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Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase

1
1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1097276518305586
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The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations

1
1. scibot 05 Nov 2018
  
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  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S1097276517310080
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Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers

1
1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1097276517307141
Nov 2017
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RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination

1
1. scibot 08 Nov 2017
  
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  AB_185548
  
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sciencedirect.com/science/article/pii/S1097276517302782
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RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health

1
1. scibot 08 Nov 2017
  
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  AB_185548
  
  Curator: @Zeljana_Babic
  
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sciencedirect.com/science/article/pii/S1097276517302770