38 Matching Annotations
  1. Last 7 days
  2. www.sciencedirect.com www.sciencedirect.com
    Activation of TREM2 via single-domain antibodies improves synaptic and cognitive function in 5×FAD mice
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    sciencedirect.com/science/article/pii/S2211124726011423
  3. Jul 2026
  4. www.sciencedirect.com www.sciencedirect.com
    Alzheimer’s disease-related mutations in APP influence colorectal tumor formation in a sex-dependent manner
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    sciencedirect.com/science/article/pii/S2589004226020213
  5. May 2026
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multiparity exacerbates Aβ accumulation and promotes cellular senescence in a mouse model of amyloidosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13154431/
  7. Apr 2026
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    Deletion of SPI1 in microglia exacerbates amyloid pathology by impairing microglial response in Alzheimer’s disease models
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    sciencedirect.com/science/article/pii/S0896627326001753
  9. Sep 2025
  10. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70185
  11. Apr 2025
  12. elifesciences.org elifesciences.org
    APP β-CTF triggers cell-autonomous synaptic toxicity independent of Aβ
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    elifesciences.org/articles/100968
  13. Feb 2025
  14. www.sciencedirect.com www.sciencedirect.com
    BACE1-dependent cleavage of GABAA receptor contributes to neural hyperexcitability and disease progression in Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S0896627325000789
  15. Aug 2024
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology, cognition, and behavior in APP/PS1 mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC11317949/
  17. www.pnas.org www.pnas.org
    A TNF receptor 2 agonist ameliorates neuropathology and improves cognition in an Alzheimer’s disease mouse model
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    pnas.org/doi/full/10.1073/pnas.2201137119
  18. Jul 2024
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    A new neuroprotective candidate TJ1 targeting amyloidogenesis in 5xFAD Alzheimer’s disease mice
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    sciencedirect.com/science/article/pii/S1567576924011743
  20. Oct 2023
  21. www.science.org www.science.org
    Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance
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    science.org/doi/10.1126/sciadv.abo3610
  22. Jun 2023
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model
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    ncbi.nlm.nih.gov/pmc/articles/PMC10074152/
  24. May 2023
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides
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    ncbi.nlm.nih.gov/pmc/articles/PMC10161466/
  26. Nov 2022
  27. www.researchsquare.com www.researchsquare.com
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    researchsquare.com/article/rs-7072571/'https://www.researchsquare.com/article/rs-7072571/v1
  28. Oct 2022
  29. alzres.biomedcentral.com alzres.biomedcentral.com
    Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ
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    alzres.biomedcentral.com/articles/10.1186/s13195-022-01096-3
  30. Sep 2022
  31. www.sciencedirect.com www.sciencedirect.com
    Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice
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    sciencedirect.com/science/article/pii/S2211124722012748
  32. Aug 2022
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance
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    ncbi.nlm.nih.gov/pmc/articles/PMC9299535/
  34. Jul 2022
  35. www.sciencedirect.com www.sciencedirect.com
    Inhibition of SIRT2 promotes APP acetylation and ameliorates cognitive impairment in APP/PS1 transgenic mice
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    sciencedirect.com/science/article/pii/S2211124722008609
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9205595/
  37. Aug 2021
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology
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    ncbi.nlm.nih.gov/pmc/articles/PMC8369003/
  39. May 2021
  40. www.sciencedirect.com www.sciencedirect.com
    Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model
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    sciencedirect.com/science/article/pii/S0944711320301562
  41. Feb 2021
  42. portlandpress.com portlandpress.com
    The cellular expression and proteolytic processing of the amyloid precursor protein is independent of TDP-43
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    portlandpress.com/bioscirep/article/40/4/BSR20200435/222674/The-cellular-expression-and-proteolytic-processing
  43. Sep 2020
  44. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Sleep deprivation regulates availability of PrPC and Aβ peptides which can impair interaction between PrPC and laminin and neuronal plasticity
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14960
  45. link.springer.com link.springer.com
    Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer’s disease
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    link.springer.com/article/10.1186/s40478-020-01013-5
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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    pmc.ncbi.nlm.nih.gov/articles/PMC7161547/
  47. Jan 2020
  48. jcb.rupress.org jcb.rupress.org
    A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor
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    jcb.rupress.org/content/218/2/644
  49. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Label‐free distribution of anti‐amyloid D‐AIP in Drosophila melanogaster: prevention of Aβ42‐induced toxicity without side effects in transgenic flies
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14720
  50. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Activation of peroxisome proliferator‐activated receptor delta suppresses BACE1 expression by up‐regulating SOCS1 in a JAK2/STAT1‐dependent manner
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14715
  51. www.sciencedirect.com www.sciencedirect.com
    Loss of Ataxin-1 Potentiates Alzheimer’s Pathogenesis by Elevating Cerebral BACE1 Transcription
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    sciencedirect.com/science/article/pii/S0092867419308438
  52. www.jneurosci.org www.jneurosci.org
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    jneurosci.org/content/38/18/4288
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    sciencedirect.com/science/article/pii/S2211124719300178
  54. Nov 2018
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6154927/
  56. actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com
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    actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0603-4
  57. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The non‐peptidic δ‐opioid receptor agonist Tan‐67 mediates neuroprotection post‐ischemically and is associated with altered amyloid precursor protein expression, maturation and processing in mice
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14265/full
  58. Nov 2017
  59. www.jneurosci.org www.jneurosci.org
    Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model
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    jneurosci.org/content/37/20/5099
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins
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    ncbi.nlm.nih.gov/pmc/articles/PMC5130271/