155 Matching Annotations
  1. Apr 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy
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    1. scibot 11 Apr 2024
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    sciencedirect.com/science/article/pii/S2352396424001348
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    Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programs
    2
    1. scibot 09 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114073

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    sciencedirect.com/science/article/pii/S2211124724004017
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    The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells
    1
    1. scibot 04 Apr 2024
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      DOI: 10.1016/j.devcel.2024.03.018

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    sciencedirect.com/science/article/pii/S1534580724001837
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma
    1
    1. scibot 03 Apr 2024
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      DOI: 10.1016/j.xcrm.2024.101472

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    ncbi.nlm.nih.gov/pmc/articles/PMC10983107/
  6. Mar 2024
  7. www.sciencedirect.com www.sciencedirect.com
    Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma
    2
    1. scibot 29 Mar 2024
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      DOI: 10.1016/j.xcrm.2024.101468

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    2. scibot 29 Mar 2024
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      DOI: 10.1016/j.xcrm.2024.101468

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    sciencedirect.com/science/article/pii/S2666379124001149
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    A therapeutically targetable positive feedback loop between lnc-HLX-2-7, HLX, and MYC that promotes group 3 medulloblastoma
    1
    1. scibot 12 Mar 2024
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    sciencedirect.com/science/article/pii/S2211124724002663
  9. Feb 2024
  10. www.sciencedirect.com www.sciencedirect.com
    Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1
    1
    1. scibot 27 Feb 2024
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    sciencedirect.com/science/article/pii/S2211124724001657
  11. 52.53.155.43 52.53.155.43
    Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway
    1
    1. scibot 22 Feb 2024
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    52.53.155.43/4a182fdd92d1ce35b13f136f7657c6c9ec6a6224/2023.10.02.560521v1.full-html.html
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    G-quadruplex DNA structure is a positive regulator of MYC transcription
    1
    1. scibot 21 Feb 2024
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      DOI: 10.1073/pnas.2320240121

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    ncbi.nlm.nih.gov/pmc/articles/PMC10873556/
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    Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer
    1
    1. scibot 16 Feb 2024
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    sciencedirect.com/science/article/pii/S2212877824000310
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    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
    1
    1. scibot 09 Feb 2024
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    sciencedirect.com/science/article/pii/S2211124724000421
  15. www.biorxiv.org www.biorxiv.org
    BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor
    1
    1. scibot 04 Feb 2024
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      DOI: 10.1101/2023.09.28.560054

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    biorxiv.org/content/10.1101/2023.09.28.560054v1
  16. Jan 2024
  17. www.sciencedirect.com www.sciencedirect.com
    Antitumor efficacy of a sequence-specific DNA-targeted γPNA-based c-Myc inhibitor
    1
    1. scibot 09 Jan 2024
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      DOI: 10.1016/j.xcrm.2023.101354

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    sciencedirect.com/science/article/pii/S2666379123005712
  18. Dec 2023
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery
    1
    1. scibot 22 Dec 2023
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      DOI: 10.1038/s41467-023-43614-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC10730884/
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    ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factors
    1
    1. scibot 20 Dec 2023
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    sciencedirect.com/science/article/pii/S221112472301553X
  21. www.sciencedirect.com www.sciencedirect.com
    Subtype-selective prenylated isoflavonoids disrupt regulatory drivers of MYCN-amplified cancers
    1
    1. scibot 20 Dec 2023
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      DOI: 10.1016/j.chembiol.2023.11.007

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    sciencedirect.com/science/article/pii/S2451945623004221
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    SON is an essential m6A target for hematopoietic stem cell fate
    1
    1. scibot 17 Dec 2023
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      DOI: 10.1016/j.stem.2023.11.006

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    sciencedirect.com/science/article/pii/S1934590923003983
  23. www.sciencedirect.com www.sciencedirect.com
    An oncogenic phenoscape of colonic stem cell polarization
    2
    1. scibot 17 Dec 2023
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      DOI: 10.1016/j.cell.2023.11.004

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      DOI: 10.1016/j.cell.2023.11.004

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    sciencedirect.com/science/article/pii/S0092867423012217
  24. Nov 2023
  25. www.sciencedirect.com www.sciencedirect.com
    mTORC1 promotes cell growth via m6A-dependent mRNA degradation
    1
    1. scibot 18 Nov 2023
      RRID:AB_1903938

      DOI: 10.1016/j.molcel.2021.03.010

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    sciencedirect.com/science/article/pii/S1097276521001787
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    Detection of early prognostic biomarkers for metastasis of Ewing's sarcoma in pediatric patients
    1
    1. scibot 10 Nov 2023
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      DOI: 10.1016/j.lfs.2023.122237

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    sciencedirect.com/science/article/pii/S002432052300872X
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
    2
    1. scibot 04 Nov 2023
      RRID:AB_1903938

      DOI: 10.1126/science.adh5021

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      DOI: 10.1126/science.adh5021

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    ncbi.nlm.nih.gov/pmc/articles/PMC10617673/
  28. link.springer.com link.springer.com
    MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice
    1
    1. scibot 03 Nov 2023
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      DOI: 10.1186/s40478-023-01654-2

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    link.springer.com/article/10.1186/s40478-023-01654-2
  29. Oct 2023
  30. www.sciencedirect.com www.sciencedirect.com
    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
    1
    1. scibot 27 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113198

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    sciencedirect.com/science/article/pii/S221112472301210X
  31. www.science.org www.science.org
    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
    1
    1. scibot 17 Oct 2023
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      DOI: 10.1126/science.adh5021

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    science.org/doi/10.1126/science.adh5021
  32. www.sciencedirect.com www.sciencedirect.com
    High-throughput identification of Toxoplasma gondii effector proteins that target host cell transcription
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.chom.2023.09.003

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    sciencedirect.com/science/article/pii/S1931312823003700
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    TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2
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      DOI: 10.1016/j.celrep.2023.113231

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    sciencedirect.com/science/article/pii/S2211124723012433
  34. Sep 2023
  35. www.cell.com www.cell.com
    Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation
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      DOI: 10.1016/j.celrep.2023.113079

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    cell.com/cell-reports/fulltext/S2211-1247(23)01090-2
  36. Aug 2023
  37. www.science.org www.science.org
    A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
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      DOI: 10.1126/scisignal.ade6737

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    science.org/doi/10.1126/scisignal.ade6737
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    Modelling Duchenne muscular dystrophy in vitro with newly generated, blood cell-derived induced pluripotent stem cell line ORIONi003-A
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      DOI: 10.1016/j.scr.2023.103187

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    sciencedirect.com/science/article/pii/S1873506123001733
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    Neuroendocrine lineage commitment of small cell lung cancers can be leveraged into p53-independent non-cytotoxic therapy
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    sciencedirect.com/science/article/pii/S2211124723010276
  40. 52.53.155.43 52.53.155.43
    A MYC-controlled redox switch protects B lymphoma cells from EGR1-dependent apoptosis
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    52.53.155.43/e4339d2342058d0ba733e06b854674a1d2f752a1/PIIS2211124723009725-html.html
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Homo-oxidized HSPB1 Protects H9c2 cells Against Oxidative stress via Activation of KEAP1/NRF2 Signaling Pathway
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      DOI: 10.1016/j.isci.2023.107443

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    ncbi.nlm.nih.gov/pmc/articles/PMC10415933/
  42. Jul 2023
  43. www.nature.com www.nature.com
    Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma
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      DOI: 10.1038/s41467-023-39717-6

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    nature.com/articles/s41467-023-39717-6
  44. Jun 2023
  45. www.sciencedirect.com www.sciencedirect.com
    A cancer-associated METTL14 mutation induces aberrant m6A modification, affecting tumor growth
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      DOI: 10.1016/j.celrep.2023.112688

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    sciencedirect.com/science/article/pii/S221112472300699X
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    DHX9-mediated pathway contributes to the malignant phenotype of Myelodysplastic syndromes
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    sciencedirect.com/science/article/pii/S2589004223010398
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    Arginine depletion attenuates renal cystogenesis in tuberous sclerosis complex model
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    1. scibot 08 Jun 2023
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      DOI: 10.1016/j.xcrm.2023.101073

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    sciencedirect.com/science/article/pii/S2666379123001921
  48. May 2023
  49. www.sciencedirect.com www.sciencedirect.com
    Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity
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    Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate
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    IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation
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  108. Jul 2021
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    Pathogenic <i>FAM83G</i> palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling.
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    MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer
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    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
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    A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases
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  116. Jun 2021
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    Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome
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    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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  122. May 2021
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  128. Apr 2021
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    Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma
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    Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance
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    Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors
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    MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer
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    Nanog is a promising chemo‐resistant stemness marker and therapeutic target by iron chelators for esophageal cancer
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  135. Mar 2021
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    Embryonic Stem-Cell-Derived Extracellular Vesicles Maintain ESC Stemness by Activating FAK
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  137. Feb 2021
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    Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration
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    Generation of ORIONi001-A induced pluripotent stem cell line for in vitro modeling of sporadic form of amyotrophic lateral sclerosis
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  141. Nov 2020
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    Natural Product Trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer
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    Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells
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    Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration
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    Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation
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    Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy
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      c-Myc

      DOI: 10.1074/jbc.RA119.012376

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    ncbi.nlm.nih.gov/pmc/articles/PMC7212655/
  157. www.sciencedirect.com www.sciencedirect.com
    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
    1
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      RRID:AB_1903938

      DOI: 10.1016/j.celrep.2020.107764

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    sciencedirect.com/science/article/pii/S2211124720307440
  158. Aug 2020
  159. link.springer.com link.springer.com
    Rare osteosarcoma cell subpopulation protein array and profiling using imaging mass cytometry and bioinformatics analysis
    1
    1. scibot 29 Aug 2020
      c-Myc

      DOI: 10.1186/s12885-020-07203-7

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  160. Jan 2020
  161. www.sciencedirect.com www.sciencedirect.com
    Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection
    1
    1. scibot 13 Jan 2020
      RRID:AB_1903938

      DOI: 10.1016/j.celrep.2019.10.129

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  162. elifesciences.org elifesciences.org
    FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy
    1
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      RRID:AB_1903938

      DOI: 10.7554/eLife.47327

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  163. www.sciencedirect.com www.sciencedirect.com
    Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA
    1
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      RRID:AB_1903938

      DOI: 10.1016/j.chembiol.2019.11.010

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    sciencedirect.com/science/article/pii/S2451945619303927
  164. www.sciencedirect.com www.sciencedirect.com
    The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability
    1
    1. scibot 13 Jan 2020
      RRID:AB_1903938

      DOI: 10.1016/j.ccell.2019.10.004

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  165. www.sciencedirect.com www.sciencedirect.com
    YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression
    1
    1. scibot 13 Jan 2020
      RRID:AB_1903938

      DOI: 10.1016/j.celrep.2019.03.021

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  166. www.sciencedirect.com www.sciencedirect.com
    Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer
    1
    1. scibot 13 Jan 2020
      RRID:AB_1903938

      DOI: 10.1016/j.celrep.2019.08.076

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  167. www.sciencedirect.com www.sciencedirect.com
    A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
    1
    1. scibot 13 Jan 2020
      RRID:AB_1903938

      DOI: 10.1016/j.ccell.2019.10.002

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  168. www.sciencedirect.com www.sciencedirect.com
    Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy
    1
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      RRID:AB_1903938

      DOI: 10.1016/j.cell.2019.05.041

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  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer
    1
    1. scibot 13 Jan 2020
      RRID:AB_1903938

      DOI: 10.1016/j.ebiom.2019.06.046

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    ncbi.nlm.nih.gov/pmc/articles/PMC6642315/
  170. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment
    1
    1. scibot 13 Jan 2020
      RRID:AB_1903938

      DOI: 10.1016/j.celrep.2019.07.032

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    ncbi.nlm.nih.gov/pmc/articles/PMC6818972/
  171. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:AB_1903938

      DOI: 10.1016/j.molcel.2018.11.006

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    sciencedirect.com/science/article/pii/S1097276518309481
  172. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:AB_1903938

      DOI: 10.1016/j.molcel.2018.11.006

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    ncbi.nlm.nih.gov/pmc/articles/PMC6375729/
  173. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:AB_1903938

      DOI: 10.1016/j.cell.2019.03.005

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  174. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells
    1
    1. scibot 13 Jan 2020
      RRID:AB_1903938

      DOI: 10.1038/s41408-018-0165-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC6333829/
  175. elifesciences.org elifesciences.org
    Untitled document
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    1. scibot 12 Jan 2020
      RRID:AB_1903938

      DOI: 10.7554/eLife.40396

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  176. Nov 2018
  177. www.sciencedirect.com www.sciencedirect.com
    A Loss of Epigenetic Control Can Promote Cell Death through Reversing the Balance of Pathways in a Signaling Network
    1
    1. scibot 05 Nov 2018
      RRID:AB_1903938

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1097276518306853
  178. www.sciencedirect.com www.sciencedirect.com
    Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups
    1
    1. scibot 05 Nov 2018
      RRID:AB_1903938

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1535610818303581
  179. www.sciencedirect.com www.sciencedirect.com
    Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization
    1
    1. scibot 05 Nov 2018
      AB_1903938

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S009286741831033X
  180. www.sciencedirect.com www.sciencedirect.com
    The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress
    1
    1. scibot 05 Nov 2018
      RRID:AB_1903938

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    sciencedirect.com/science/article/pii/S1550413118303905
  181. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas
    1
    1. scibot 05 Nov 2018
      RRID:AB_1903938

      Curator: @anp055

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    onlinelibrary.wiley.com/doi/full/10.1002/jcp.26830
  182. www.sciencedirect.com www.sciencedirect.com
    Let-7 Suppresses B Cell Activation through Restricting the Availability of Necessary Nutrients
    1
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      RRID:AB_1903938

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    sciencedirect.com/science/article/pii/S1550413117307209
  183. www.sciencedirect.com www.sciencedirect.com
    Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element
    1
    1. scibot 05 Nov 2018
      RRID:AB_1903938

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    sciencedirect.com/science/article/pii/S0092867418304008
  184. www.sciencedirect.com www.sciencedirect.com
    B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells
    1
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      RRID:AB_1903938

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    sciencedirect.com/science/article/pii/S1074761318300293
  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns
    1
    1. scibot 05 Nov 2018
      RRID:AB_1903938

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    ncbi.nlm.nih.gov/pmc/articles/PMC6643283/
  186. europepmc.org europepmc.org
    Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins.
    1
    1. scibot 05 Nov 2018
      RRID:AB_1903938

      Curator: @evieth

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    europepmc.org/articles/PMC5608509/
  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation
    1
    1. scibot 05 Nov 2018
      RRID:AB_1903938

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    ncbi.nlm.nih.gov/pmc/articles/PMC5650077/
  188. Nov 2017
  189. www.sciencedirect.com www.sciencedirect.com
    Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
    1
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      CSTCat#5605S

      Curator: @bandrow

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    sciencedirect.com/science/article/pii/S1074761317302339
  190. www.sciencedirect.com www.sciencedirect.com
    Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
    1
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      AB_1903938

      Curator: @Zeljana_Babic

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  191. www.sciencedirect.com www.sciencedirect.com
    Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation
    1
    1. scibot 08 Nov 2017
      AB_1903938

      Curator: @gabimpine

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  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling
    2
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      AB_1903938

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