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    Aberrant zonal recycling of germinal center B cells impairs appropriate selection in lupus
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  3. Nov 2024
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    A multivalent adaptor mechanism drives the nuclear import of proteasomes
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  5. Sep 2024
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    FNIP1 suppresses colorectal cancer progression through inhibiting STAT3 phosphorylation and nuclear translocation
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    Untitled document
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    MED12 and CDK8/19 modulate androgen receptor activity and enzalutamide response in prostate cancer
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    Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming
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  10. Aug 2024
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    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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    Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer
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    Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling
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  14. Jul 2024
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    Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer
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    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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  17. Jun 2024
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    Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice
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  19. May 2024
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    BET inhibitors as a therapeutic intervention in gastrointestinal gene signature-positive castration-resistant prostate cancer
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    The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects
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    Critical roles of the miR-17∼92 family in thymocyte development, leukemogenesis, and autoimmunity
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    The histone lysine methyltransferase MLL1 regulates the activation and functional specialization of regulatory T cells
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  24. Apr 2024
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    ER-associated degradation adapter Sel1L is required for CD8+ T cell function and memory formation following acute viral infection
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    Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy
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    Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programs
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    The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells
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    STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma
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  30. Mar 2024
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    Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma
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    A therapeutically targetable positive feedback loop between lnc-HLX-2-7, HLX, and MYC that promotes group 3 medulloblastoma
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  33. Feb 2024
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    Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1
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    Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway
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    G-quadruplex DNA structure is a positive regulator of MYC transcription
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    Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer
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    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
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    BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor
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  40. Jan 2024
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    Antitumor efficacy of a sequence-specific DNA-targeted γPNA-based c-Myc inhibitor
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  42. Dec 2023
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    Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery
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    ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factors
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    Subtype-selective prenylated isoflavonoids disrupt regulatory drivers of MYCN-amplified cancers
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    sciencedirect.com/science/article/pii/S2451945623004221
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    SON is an essential m6A target for hematopoietic stem cell fate
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    sciencedirect.com/science/article/pii/S1934590923003983
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    An oncogenic phenoscape of colonic stem cell polarization
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    sciencedirect.com/science/article/pii/S0092867423012217
  48. Nov 2023
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    mTORC1 promotes cell growth via m6A-dependent mRNA degradation
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    sciencedirect.com/science/article/pii/S1097276521001787
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    Detection of early prognostic biomarkers for metastasis of Ewing's sarcoma in pediatric patients
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    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
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  95. Jul 2022
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    Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate
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    Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma
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    PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory
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  123. Aug 2021
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    IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation
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  132. Jul 2021
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    Pathogenic <i>FAM83G</i> palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling.
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    MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer
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    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
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    A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases
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    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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  146. May 2021
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  152. Apr 2021
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    Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma
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    Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors
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    MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer
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    Nanog is a promising chemo‐resistant stemness marker and therapeutic target by iron chelators for esophageal cancer
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      anti‐c‐Myc

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  159. Mar 2021
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    Embryonic Stem-Cell-Derived Extracellular Vesicles Maintain ESC Stemness by Activating FAK
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  161. Feb 2021
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    Tracking cells in epithelial acini by light sheet microscopy reveals proximity effects in breast cancer initiation
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  163. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration
    1
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  164. www.sciencedirect.com www.sciencedirect.com
    Generation of ORIONi001-A induced pluripotent stem cell line for in vitro modeling of sporadic form of amyotrophic lateral sclerosis
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      RRID:AB_1903938Cell

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  165. Nov 2020
  166. www.authorea.com www.authorea.com
    Natural Product Trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer
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    Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells
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  168. Oct 2020
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    Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation
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  171. Sep 2020
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    MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate
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  175. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
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    Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration
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    FBXW7 Confers Radiation Survival by Targeting p53 for Degradation
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    Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation
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    Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy
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    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
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  182. Aug 2020
  183. link.springer.com link.springer.com
    Rare osteosarcoma cell subpopulation protein array and profiling using imaging mass cytometry and bioinformatics analysis
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  184. Jan 2020
  185. www.sciencedirect.com www.sciencedirect.com
    Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection
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      RRID:AB_1903938

      DOI: 10.1016/j.celrep.2019.10.129

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  186. elifesciences.org elifesciences.org
    FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy
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    Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA
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    The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability
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      RRID:AB_1903938

      DOI: 10.1016/j.ccell.2019.10.004

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    YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression
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    Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer
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    A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
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    Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy
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    TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer
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    m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment
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    Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells
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    A Loss of Epigenetic Control Can Promote Cell Death through Reversing the Balance of Pathways in a Signaling Network
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    Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups
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    Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization
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    The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress
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    Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas
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    onlinelibrary.wiley.com/doi/full/10.1002/jcp.26830
  206. www.sciencedirect.com www.sciencedirect.com
    Let-7 Suppresses B Cell Activation through Restricting the Availability of Necessary Nutrients
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    sciencedirect.com/science/article/pii/S1550413117307209
  207. www.sciencedirect.com www.sciencedirect.com
    Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element
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    sciencedirect.com/science/article/pii/S0092867418304008
  208. www.sciencedirect.com www.sciencedirect.com
    B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells
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    sciencedirect.com/science/article/pii/S1074761318300293
  209. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns
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    ncbi.nlm.nih.gov/pmc/articles/PMC6643283/
  210. europepmc.org europepmc.org
    Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins.
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      Curator: @evieth

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    europepmc.org/articles/PMC5608509/
  211. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation
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    ncbi.nlm.nih.gov/pmc/articles/PMC5650077/
  212. Nov 2017
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    Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
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      Curator: @bandrow

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    sciencedirect.com/science/article/pii/S1074761317302339
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    Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
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      AB_1903938

      Curator: @Zeljana_Babic

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    sciencedirect.com/science/article/pii/S109727651730312X
  215. www.sciencedirect.com www.sciencedirect.com
    Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation
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      AB_1903938

      Curator: @gabimpine

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    sciencedirect.com/science/article/pii/S0092867417303586
  216. elifesciences.org elifesciences.org
    Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling
    2
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      AB_1903938

      Curator: @gabimpine

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      AB_1903938

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    elifesciences.org/content/5/e17047