163 Matching Annotations
  1. Last 7 days
  2. www.science.org www.science.org
    Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer
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    1. scibot 18 Jul 2024
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    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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      DOI: 10.1126/science.adk0775

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  4. Jun 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC11154205/
  6. May 2024
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    BET inhibitors as a therapeutic intervention in gastrointestinal gene signature-positive castration-resistant prostate cancer
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    1. scibot 29 May 2024
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    The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects
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    sciencedirect.com/science/article/pii/S1074761324002310
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    Critical roles of the miR-17∼92 family in thymocyte development, leukemogenesis, and autoimmunity
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    sciencedirect.com/science/article/pii/S2211124724005898
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    The histone lysine methyltransferase MLL1 regulates the activation and functional specialization of regulatory T cells
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    sciencedirect.com/science/article/pii/S2211124724005503
  11. Apr 2024
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    ER-associated degradation adapter Sel1L is required for CD8+ T cell function and memory formation following acute viral infection
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    sciencedirect.com/science/article/pii/S2211124724004844
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    Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy
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    sciencedirect.com/science/article/pii/S2352396424001348
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    Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programs
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    sciencedirect.com/science/article/pii/S2211124724004017
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    The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells
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  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma
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    1. scibot 03 Apr 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10983107/
  17. Mar 2024
  18. www.sciencedirect.com www.sciencedirect.com
    Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma
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    sciencedirect.com/science/article/pii/S2666379124001149
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    A therapeutically targetable positive feedback loop between lnc-HLX-2-7, HLX, and MYC that promotes group 3 medulloblastoma
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    sciencedirect.com/science/article/pii/S2211124724002663
  20. Feb 2024
  21. www.sciencedirect.com www.sciencedirect.com
    Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1
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    sciencedirect.com/science/article/pii/S2211124724001657
  22. 52.53.155.43 52.53.155.43
    Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway
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  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    G-quadruplex DNA structure is a positive regulator of MYC transcription
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    1. scibot 21 Feb 2024
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      DOI: 10.1073/pnas.2320240121

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    ncbi.nlm.nih.gov/pmc/articles/PMC10873556/
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    Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer
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    sciencedirect.com/science/article/pii/S2212877824000310
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    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
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    BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor
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    biorxiv.org/content/10.1101/2023.09.28.560054v1
  27. Jan 2024
  28. www.sciencedirect.com www.sciencedirect.com
    Antitumor efficacy of a sequence-specific DNA-targeted γPNA-based c-Myc inhibitor
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    sciencedirect.com/science/article/pii/S2666379123005712
  29. Dec 2023
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery
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      DOI: 10.1038/s41467-023-43614-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC10730884/
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    ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factors
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    sciencedirect.com/science/article/pii/S221112472301553X
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    Subtype-selective prenylated isoflavonoids disrupt regulatory drivers of MYCN-amplified cancers
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      DOI: 10.1016/j.chembiol.2023.11.007

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    sciencedirect.com/science/article/pii/S2451945623004221
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    SON is an essential m6A target for hematopoietic stem cell fate
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      DOI: 10.1016/j.stem.2023.11.006

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    sciencedirect.com/science/article/pii/S1934590923003983
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    An oncogenic phenoscape of colonic stem cell polarization
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      DOI: 10.1016/j.cell.2023.11.004

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    sciencedirect.com/science/article/pii/S0092867423012217
  35. Nov 2023
  36. www.sciencedirect.com www.sciencedirect.com
    mTORC1 promotes cell growth via m6A-dependent mRNA degradation
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    sciencedirect.com/science/article/pii/S1097276521001787
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    Detection of early prognostic biomarkers for metastasis of Ewing's sarcoma in pediatric patients
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  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
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      DOI: 10.1126/science.adh5021

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    ncbi.nlm.nih.gov/pmc/articles/PMC10617673/
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    MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice
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      DOI: 10.1186/s40478-023-01654-2

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  40. Oct 2023
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    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
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  42. www.science.org www.science.org
    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
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    High-throughput identification of Toxoplasma gondii effector proteins that target host cell transcription
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      DOI: 10.1016/j.chom.2023.09.003

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    sciencedirect.com/science/article/pii/S1931312823003700
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    TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2
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    sciencedirect.com/science/article/pii/S2211124723012433
  45. Sep 2023
  46. www.cell.com www.cell.com
    Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation
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    cell.com/cell-reports/fulltext/S2211-1247(23)01090-2
  47. Aug 2023
  48. www.science.org www.science.org
    A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
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      DOI: 10.1126/scisignal.ade6737

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    Modelling Duchenne muscular dystrophy in vitro with newly generated, blood cell-derived induced pluripotent stem cell line ORIONi003-A
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      DOI: 10.1016/j.scr.2023.103187

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    sciencedirect.com/science/article/pii/S1873506123001733
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    Neuroendocrine lineage commitment of small cell lung cancers can be leveraged into p53-independent non-cytotoxic therapy
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  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  66. Feb 2023
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    Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling
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  74. Nov 2022
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    Title: Generation and characterization of a human induced pluripotent stem cell (iPSC) line from a patient with congenital heart disease (CHD)
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  82. Jul 2022
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    Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate
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    CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
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    Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian Cancers
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    PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory
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    PBRM1 loss in kidney cancer unbalances the proximal tubule master transcription factor hub to repress proximal tubule differentiation
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    Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor
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    LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice
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    MEK inhibition overcomes resistance to EphA2-targeted therapy in uterine cancer
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  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation
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  119. Jul 2021
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    Pathogenic <i>FAM83G</i> palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling.
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    MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer
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    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
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    A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases
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  127. Jun 2021
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    Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome
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    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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    SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B
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    A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways
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  132. elifesciences.org elifesciences.org
    PHAROH lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR
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  133. May 2021
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    N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation
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    Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK
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    Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses
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    Glutamine Metabolism Controls Chondrocyte Identity and Function
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  139. Apr 2021
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    Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma
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    Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors
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    MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer
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    Nanog is a promising chemo‐resistant stemness marker and therapeutic target by iron chelators for esophageal cancer
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      anti‐c‐Myc

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    mTORC1 promotes cell growth via m6A-dependent mRNA degradation
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  146. Mar 2021
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    Embryonic Stem-Cell-Derived Extracellular Vesicles Maintain ESC Stemness by Activating FAK
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  148. Feb 2021
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    Tracking cells in epithelial acini by light sheet microscopy reveals proximity effects in breast cancer initiation
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  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration
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    Generation of ORIONi001-A induced pluripotent stem cell line for in vitro modeling of sporadic form of amyotrophic lateral sclerosis
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      RRID:AB_1903938Cell

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  152. Nov 2020
  153. www.authorea.com www.authorea.com
    Natural Product Trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer
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    Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells
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  155. Oct 2020
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    Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation
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    MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia
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  158. Sep 2020
  159. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation
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  160. www.cell.com www.cell.com
    Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains
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  161. www.sciencedirect.com www.sciencedirect.com
    MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate
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  162. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System
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      DOI: 10.1016/j.chembiol.2020.06.012

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  163. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration
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  164. www.sciencedirect.com www.sciencedirect.com
    FBXW7 Confers Radiation Survival by Targeting p53 for Degradation
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  165. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531
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  166. www.sciencedirect.com www.sciencedirect.com
    Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation
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  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy
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    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
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  169. Aug 2020
  170. link.springer.com link.springer.com
    Rare osteosarcoma cell subpopulation protein array and profiling using imaging mass cytometry and bioinformatics analysis
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  171. Jan 2020
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    Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection
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      DOI: 10.1016/j.celrep.2019.10.129

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  173. elifesciences.org elifesciences.org
    FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy
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  174. www.sciencedirect.com www.sciencedirect.com
    Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA
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      DOI: 10.1016/j.chembiol.2019.11.010

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    The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability
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      RRID:AB_1903938

      DOI: 10.1016/j.ccell.2019.10.004

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    YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression
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      DOI: 10.1016/j.celrep.2019.03.021

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    Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer
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      DOI: 10.1016/j.celrep.2019.08.076

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    A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
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      RRID:AB_1903938

      DOI: 10.1016/j.ccell.2019.10.002

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    Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy
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      DOI: 10.1016/j.cell.2019.05.041

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  180. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer
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      RRID:AB_1903938

      DOI: 10.1016/j.ebiom.2019.06.046

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  181. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment
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      RRID:AB_1903938

      DOI: 10.1016/j.celrep.2019.07.032

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      RRID:AB_1903938

      DOI: 10.1016/j.molcel.2018.11.006

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  183. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      RRID:AB_1903938

      DOI: 10.1016/j.cell.2019.03.005

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  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells
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      RRID:AB_1903938

      DOI: 10.1038/s41408-018-0165-5

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      RRID:AB_1903938

      DOI: 10.7554/eLife.40396

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  187. Nov 2018
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    A Loss of Epigenetic Control Can Promote Cell Death through Reversing the Balance of Pathways in a Signaling Network
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    Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups
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    Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization
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      AB_1903938

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    The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress
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  192. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas
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    Let-7 Suppresses B Cell Activation through Restricting the Availability of Necessary Nutrients
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    Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element
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    B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells
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  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns
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  197. europepmc.org europepmc.org
    Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins.
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  198. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation
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  199. Nov 2017
  200. www.sciencedirect.com www.sciencedirect.com
    Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
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      CSTCat#5605S

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    Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
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    Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation
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      RRID:AB_1903938 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0092867417303586
  203. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling
    2
    1. scibot 08 Nov 2017
      AB_1903938

      Curator: @gabimpine

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      (Cell Signaling Technology Cat# 5605S, RRID:AB_1903938)

      SciCrunch record: RRID:AB_1903938

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      RRID:AB_1903938 RRIDCUR:Validated
    2. scibot 08 Nov 2017
      AB_1903938

      Resource used:

      (Cell Signaling Technology Cat# 5605S, RRID:AB_1903938)

      SciCrunch record: RRID:AB_1903938

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_1903938
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    ncbi.nlm.nih.gov/pmc/articles/PMC5036965/