128 Matching Annotations
  1. Last 7 days
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    STING orchestrates the neuronal inflammatory stress response in multiple sclerosis
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    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.cell.2024.05.031

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    sciencedirect.com/science/article/pii/S0092867424005762
  3. Jun 2024
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    Setdb1 protects genome integrity in murine muscle stem cells to allow for regenerative myogenesis and inflammation
    1
    1. scibot 07 Jun 2024
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      DOI: 10.1016/j.devcel.2024.05.012

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    sciencedirect.com/science/article/pii/S1534580724003290
  5. May 2024
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    Development of nitroalkene-based inhibitors to target STING-dependent inflammation
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    1. scibot 23 May 2024
      RRID:AB_1904036

      DOI: 10.1016/j.redox.2024.103202

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    sciencedirect.com/science/article/pii/S2213231724001800
  7. Apr 2024
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    Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity
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    1. scibot 30 Apr 2024
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      DOI: 10.1016/j.xcrm.2024.101528

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    sciencedirect.com/science/article/pii/S2666379124001976
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    Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers
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    1. scibot 26 Apr 2024
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      DOI: 10.1016/j.ccell.2024.04.004

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    sciencedirect.com/science/article/pii/S1535610824001284
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    Blocking cGAS-STING pathway promotes post-stroke functional recovery in an extended treatment window via facilitating remyelination
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    1. scibot 25 Apr 2024
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      DOI: 10.1016/j.medj.2024.03.018

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    sciencedirect.com/science/article/pii/S2666634024001302
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    ISGylation by HERCs facilitates STING activation
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    1. scibot 23 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114135

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    sciencedirect.com/science/article/pii/S2211124724004637
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    Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration
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    1. scibot 19 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114114

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    sciencedirect.com/science/article/pii/S221112472400442X
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SETD2 loss and ATR inhibition synergize to promote cGAS signaling and immunotherapy response in renal cell carcinoma
    1
    1. scibot 03 Apr 2024
      RRID:AB_1904036

      DOI: 10.1158/1078-0432.CCR-23-1003

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    ncbi.nlm.nih.gov/pmc/articles/PMC10592192/
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Galectin-1 mediates chronic STING activation in tumors to promote metastasis through MDSC recruitment
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    1. scibot 03 Apr 2024
      RRID:AB_1904036

      DOI: 10.1158/0008-5472.CAN-23-0046

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    ncbi.nlm.nih.gov/pmc/articles/PMC10592379/
  15. Mar 2024
  16. www.sciencedirect.com www.sciencedirect.com
    Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation
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    1. scibot 15 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113945

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    sciencedirect.com/science/article/pii/S2211124724002730
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    The transcription factor NF-κB orchestrates nucleosome remodeling during the primary response to Toll-like receptor 4 signaling
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    1. scibot 05 Mar 2024
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      DOI: 10.1016/j.immuni.2024.02.004

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    sciencedirect.com/science/article/pii/S1074761324000803
  18. www.sciencedirect.com www.sciencedirect.com
    HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity
    2
    1. scibot 01 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113870

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      DOI: 10.1016/j.celrep.2024.113870

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    sciencedirect.com/science/article/pii/S2211124724001980
  19. Feb 2024
  20. www.sciencedirect.com www.sciencedirect.com
    Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production
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    1. scibot 29 Feb 2024
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      DOI: 10.1016/j.immuni.2024.02.002

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    sciencedirect.com/science/article/pii/S1074761324000773
  21. aacrjournals.org aacrjournals.org
    RNA methyltransferase FTSJ3 regulates the type I interferon pathway to promote hepatocellular carcinoma immune evasion
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    1. scibot 23 Feb 2024
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      DOI: 10.1158/0008-5472.CAN-23-2049

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      DOI: 10.1158/0008-5472.CAN-23-2049

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    aacrjournals.org/cancerres/article/84/3/405/733849/RNA-Methyltransferase-FTSJ3-Regulates-the-Type-I
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    The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation
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    1. scibot 16 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113792

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    sciencedirect.com/science/article/pii/S2211124724001207
  23. Jan 2024
  24. www.sciencedirect.com www.sciencedirect.com
    Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.
    1
    1. scibot 19 Jan 2024
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      DOI: 10.1016/j.isci.2024.108808

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    sciencedirect.com/science/article/pii/S2589004224000294
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    Interferon-stimulated neutrophils as a predictor of immunotherapy response
    1
    1. scibot 09 Jan 2024
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      DOI: 10.1016/j.ccell.2023.12.005

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    sciencedirect.com/science/article/pii/S1535610823004336
  26. Nov 2023
  27. www.sciencedirect.com www.sciencedirect.com
    AGC kinase inhibitors regulate STING signaling through SGK-dependent and SGK-independent mechanisms
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    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.chembiol.2023.10.008

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    sciencedirect.com/science/article/abs/pii/S2451945623003690
  28. www.sciencedirect.com www.sciencedirect.com
    Gadd45β is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation
    1
    1. scibot 03 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113358

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    sciencedirect.com/science/article/pii/S2211124723013700
  29. www.sciencedirect.com www.sciencedirect.com
    Different modulation of STING/TBK1/IRF3 signaling by advanced glycation end products
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    1. scibot 02 Nov 2023
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      DOI: 10.1016/j.abb.2023.109808

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    sciencedirect.com/science/article/abs/pii/S0003986123003077
  30. Oct 2023
  31. www.sciencedirect.com www.sciencedirect.com
    Regulation of STING activity in DNA sensing by ISG15 modification
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    1. scibot 27 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113277

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    sciencedirect.com/science/article/pii/S2211124723012895
  32. 52.53.155.43 52.53.155.43
    Blocking oligomerization is the most viable strategy to inhibit STING
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    1. scibot 20 Oct 2023
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      DOI: 10.1101/2023.08.11.553045

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    52.53.155.43/b51af3efb3ab194b2ea96b77566b6b4cbbb36c40/2023.08.11.553045v1.full-html.html
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    Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy
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      DOI: 10.1016/j.molcel.2023.09.007

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    sciencedirect.com/science/article/pii/S1097276523007025
  34. Sep 2023
  35. www.sciencedirect.com www.sciencedirect.com
    Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection
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    1. scibot 08 Sep 2023
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      DOI: 10.1016/j.devcel.2023.08.013

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    sciencedirect.com/science/article/pii/S1534580723004094
  36. Jul 2023
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.
    1
    1. scibot 04 Jul 2023
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      DOI: 10.1101/2023.06.03.543579

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    ncbi.nlm.nih.gov/pmc/articles/PMC10274710/
  38. Jun 2023
  39. www.sciencedirect.com www.sciencedirect.com
    Suppression of TREX1 Deficiency-Induced Cellular Senescence and Interferonopathies by Inhibition of DNA Damage Response
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    1. scibot 27 Jun 2023
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      DOI: 10.1016/j.isci.2023.107090

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    sciencedirect.com/science/article/pii/S2589004223011677
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    A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity
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    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112655

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    sciencedirect.com/science/article/pii/S2211124723006666
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    The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-κB
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      DOI: 10.1016/j.celrep.2023.112586

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    sciencedirect.com/science/article/pii/S2211124723005971
  42. May 2023
  43. www.sciencedirect.com www.sciencedirect.com
    Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome
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    1. scibot 18 May 2023
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      DOI: 10.1016/j.isci.2023.106758

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    sciencedirect.com/science/article/pii/S2589004223008350
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    Human papillomavirus E5 suppresses immunity via inhibition of the immunoproteasome and STING pathway
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      DOI: 10.1016/j.celrep.2023.112508

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    sciencedirect.com/science/article/pii/S2211124723005193
  45. Apr 2023
  46. www.sciencedirect.com www.sciencedirect.com
    Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING
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      DOI: 10.1016/j.celrep.2023.112442

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    sciencedirect.com/science/article/pii/S2211124723004539
  47. www.sciencedirect.com www.sciencedirect.com
    C9ORF72 suppresses JAK-STAT mediated inflammation
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    1. scibot 26 Apr 2023
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      DOI: 10.1016/j.isci.2023.106579

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    sciencedirect.com/science/article/pii/S2589004223006569
  48. Mar 2023
  49. europepmc.org europepmc.org
    Saturated fatty acids dampen the immunogenicity of cancer by suppressing STING
    1
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      DOI: 10.1016/j.celrep.2023.112303

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    europepmc.org/article/med/36952341
  50. europepmc.org europepmc.org
    Pharmacological boosting of cGAS activation sensitizes chemotherapy by enhancing antitumor immunity
    1
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      DOI: 10.1016/j.celrep.2023.112275

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    europepmc.org/article/med/36943864
  51. www.sciencedirect.com www.sciencedirect.com
    4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING
    1
    1. scibot 02 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112145

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    sciencedirect.com/science/article/pii/S2211124723001560
  52. Jan 2023
  53. www.sciencedirect.com www.sciencedirect.com
    A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3
    1
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      DOI: 10.1016/j.isci.2023.105935

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    sciencedirect.com/science/article/pii/S2589004223000123
  54. www.sciencedirect.com www.sciencedirect.com
    Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner
    1
    1. scibot 21 Jan 2023
      RRID:AB_1904036

      DOI: 10.1016/j.celrep.2023.112002

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    sciencedirect.com/science/article/pii/S221112472300013X
  55. Dec 2022
  56. www.sciencedirect.com www.sciencedirect.com
    Cancer cell-derived type I interferons instruct tumor monocyte polarization
    1
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    Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages
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  58. Nov 2022
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    AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity
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  60. Oct 2022
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    Vimentin inhibits type I interferon production by disrupting the TBK1-IKKε-IRF3 axis
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    Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation
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  63. Sep 2022
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    Ku proteins promote DNA binding and condensation of cyclic GMP-AMP synthase
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  65. Aug 2022
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    The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways
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    The redox cycling of STAT2 maintains innate immune homeostasis
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    The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging
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    DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages
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  70. Jul 2022
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    LncNSPL facilitates influenza A viral immune escape by restricting TRIM25-mediated K63-linked RIG-I ubiquitination
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  72. Jun 2022
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    The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity
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  74. rupress.org rupress.org
    ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling
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  75. May 2022
  76. www.sciencedirect.com www.sciencedirect.com
    STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program
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    Protocol to induce and assess cGAS-STING pathway activation in vitro
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    Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy
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    The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis
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  80. Apr 2022
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    Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS
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  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of Il6 expression by single CpG methylation in downstream of Il6 transcription initiation site
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  83. Mar 2022
  84. www.sciencedirect.com www.sciencedirect.com
    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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      Cell Signaling Tehnology cat# 4302

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  85. Feb 2022
  86. www.sciencedirect.com www.sciencedirect.com
    CASCADE: high-throughput characterization of regulatory complex binding altered by non-coding variants
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  87. Jan 2022
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    Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription
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    STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses
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  90. Nov 2021
  91. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  92. www.sciencedirect.com www.sciencedirect.com
    IRF3-binding lncRNA-ISIR strengthens interferon production in viral infection and autoinflammation
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  93. Oct 2021
  94. www.sciencedirect.com www.sciencedirect.com
    Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
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  95. Sep 2021
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    The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation
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  97. Aug 2021
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    Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity
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    Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE
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    Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection
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    An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication
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  102. Jul 2021
  103. www.nature.com www.nature.com
    Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C
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  104. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing
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  105. Jun 2021
  106. www.cell.com www.cell.com
    Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity
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  107. www.sciencedirect.com www.sciencedirect.com
    Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation
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      RRID:AB_1904036

      DOI: 10.1016/j.celrep.2021.109272

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    A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression
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    Translation stress and collided ribosomes are co-activators of cGAS
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      DOI: 10.1016/j.molcel.2021.05.018

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  110. May 2021
  111. www.sciencedirect.com www.sciencedirect.com
    The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake
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    BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse
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      DOI: 10.1016/j.stem.2020.06.022

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    Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress
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  114. www.sciencedirect.com www.sciencedirect.com
    LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP
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    TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology
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    Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation
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  117. Apr 2021
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    Mutant p53 suppresses innate immune signaling to promote tumorigenesis
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    Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation
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  120. Mar 2021
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    Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback
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    Endogenous retrovirus expression activates type-I interferon signaling in an experimental mouse model of mesothelioma development
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  123. Feb 2021
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    FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells
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    Disruption of DNA polymerase ζ engages an innate immune response
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  126. Dec 2020
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    Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5
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  128. Sep 2020
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    Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1
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  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reactive oxygen species oxidize STING and suppress interferon production
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  131. www.sciencedirect.com www.sciencedirect.com
    TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
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    ADAR1 Facilitates KSHV Lytic Reactivation by Modulating the RLR-Dependent Signaling Pathway
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    Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity
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      RRID:AB_1904036

      DOI: 10.1016/j.immuni.2020.03.016

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    The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling
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      RRID:AB_1904036

      DOI: 10.1016/j.immuni.2020.03.004

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    A Non-structural 1 Protein G53D Substitution Attenuates a Clinically Tested Live Dengue Vaccine
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      RRID:AB_1904036

      DOI: 10.1016/j.celrep.2020.107617

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    sciencedirect.com/science/article/pii/S2211124720305660
  136. www.cell.com www.cell.com
    The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING
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      RRID: AB_1904036

      DOI: 10.1016/j.celrep.2018.11.097

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    cell.com/cell-reports/fulltext/S2211-1247(18)31888-6
  137. jvi.asm.org jvi.asm.org
    Middle East respiratory syndrome coronavirus nucleocapsid protein suppresses type I and type III interferon induction by targeting RIG-I signaling
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      IRF3

      DOI: 10.1128/JVI.00099-20

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  138. Jan 2020
  139. www.sciencedirect.com www.sciencedirect.com
    STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition
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      RRID:AB_1904036

      DOI: 10.1016/j.cell.2019.05.036

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    Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and III Interferons
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      RRID:AB_1904036

      DOI: 10.1016/j.immuni.2019.07.007

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    sciencedirect.com/science/article/pii/S1074761319303231
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    CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer
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      RRID:AB_1904036

      DOI: 10.1016/j.ccell.2019.11.003

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    sciencedirect.com/science/article/pii/S1535610819305239
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    Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection
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      RRID:AB_1904036

      DOI: 10.1016/j.immuni.2019.11.015

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    sciencedirect.com/science/article/pii/S1074761319304960
  143. www.sciencedirect.com www.sciencedirect.com
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      RRID:AB_1904036

      DOI: 10.1016/j.celrep.2018.11.097

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    sciencedirect.com/science/article/pii/S2211124718318886
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    Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS
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      RRID:AB_1904036

      DOI: 10.1016/j.cels.2018.10.010

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    NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25
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      RRID:AB_1904036

      DOI: 10.1016/j.chom.2019.02.013

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    sciencedirect.com/science/article/pii/S193131281930109X
  146. www.sciencedirect.com www.sciencedirect.com
    SLC19A1 Is an Importer of the Immunotransmitter cGAMP
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      RRID:AB_1904036

      DOI: 10.1016/j.molcel.2019.05.006

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    sciencedirect.com/science/article/pii/S1097276519303594
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      RRID:AB_1904036

      DOI: 10.1016/j.celrep.2019.01.030

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  148. www.sciencedirect.com www.sciencedirect.com
    Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production
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      RRID:AB_1904036

      DOI: 10.1016/j.immuni.2018.12.013

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    sciencedirect.com/science/article/pii/S0092867419303472
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      DOI: 10.1016/j.celrep.2019.01.029

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    sciencedirect.com/science/article/pii/S2211124719300385
  151. www.sciencedirect.com www.sciencedirect.com
    Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility
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      DOI: 10.1016/j.cell.2019.01.039

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    sciencedirect.com/science/article/pii/S0092867419301023
  152. Nov 2018
  153. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach
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    ncbi.nlm.nih.gov/pmc/articles/PMC3838897/
  154. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6114933/
  155. www.sciencedirect.com www.sciencedirect.com
    Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis
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  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy
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    An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses
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    Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling
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    Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function
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    InsP 3 R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca 2+ elevation and TBK1 activity
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    Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells
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    Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses
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