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Small-molecule OPA1 inhibitors reverse mitochondrial adaptations to overcome therapy resistance in acute myeloid leukemia

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1. scibot 21 Oct 2025
  
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  DOI: 10.1126/sciadv.adx8662
  
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science.org/doi/10.1126/sciadv.adx8662
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Small-molecule OPA1 inhibitors reverse mitochondrial adaptations to overcome therapy resistance in acute myeloid leukemia

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  DOI: 10.1126/sciadv.adx8662
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12525776/
Apr 2025
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Mitochondrial Damage and ER Stress in CB1 Receptor Antagonist-Induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells

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  DOI: 10.1016/j.neuropharm.2025.110440
  
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sciencedirect.com/science/article/pii/S0028390825001467
Mar 2025
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1. scibot 20 Mar 2025
  
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52.53.155.43/efe97ca6a096570250e23749b40b07f441b6c115/PDF-html.html
Jan 2025
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Maternal phthalates exposure promotes neural stem cell differentiation into phagocytic astrocytes and synapse engulfment via IRE1α/XBP1s pathway

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1. scibot 03 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115126
  
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sciencedirect.com/science/article/pii/S2211124724014773
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Gut bacterial L-lysine alters metabolism and histone methylation to drive dendritic cell tolerance

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  DOI: 10.1016/j.celrep.2024.115125
  
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sciencedirect.com/science/article/pii/S2211124724014761
Sep 2024
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Cannabinoid combination targets NOTCH1-mutated T-cell acute lymphoblastic leukemia through the integrated stress response pathway

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1. scibot 18 Sep 2024
  
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  DOI: 10.7554/eLife.90854
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11390110/
Aug 2024
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MMP9 drives ferroptosis by regulating GPX4 and iron signaling

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.isci.2024.110622
  
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sciencedirect.com/science/article/pii/S2589004224018479
May 2024
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TUDCA alleviates atherosclerosis by inhibiting AIM2 inflammasome and enhancing cholesterol efflux capacity in macrophage

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1. scibot 26 May 2024
  
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  DOI: 10.1016/j.isci.2024.109849
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11112614/
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Targeting eIF2α in TBI-induced traumatic optic neuropathy: Effects of Salubrinal and the Integrated Stress Response Inhibitor

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1. scibot 10 May 2024
  
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  DOI: 10.1101/2024.02.15.580435
  
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52.53.155.43/e49e13012caa173776051da0a73c8b285e75644e/2024.02.15.580435v1.full-html.html
Mar 2024
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ER-stress response in retinal Müller glia occurs significantly earlier than amyloid pathology in the Alzheimer's mouse brain and retina

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1. scibot 26 Mar 2024
  
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  DOI: 10.1002/glia.24514
  
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onlinelibrary.wiley.com/doi/10.1002/glia.24514
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Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop

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1. scibot 07 Mar 2024
  
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  DOI: 10.1038/s12276-024-01190-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10985079/
Dec 2023
www.mdpi.com www.mdpi.com

Ascomylactam C Induces an Immunogenic Cell Death Signature via Mitochondria-Associated ER Stress in Lung Cancer and Melanoma

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1. scibot 01 Dec 2023
  
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  DOI: 10.3390/md21120600
  
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2. scibot 01 Dec 2023
  
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  DOI: 10.3390/md21120600
  
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mdpi.com/1660-3397/21/12/600
Oct 2023
www.cell.com www.cell.com

Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice

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1. scibot 13 Oct 2023
  
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  DOI: 10.1016/j.isci.2023.108082
  
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cell.com/iscience/abstract/S2589-0042(23)02159-4
Sep 2023
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Stress response mechanisms in protein misfolding diseases: Profiling a cellular model of Huntington's disease

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1. scibot 19 Sep 2023
  
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  DOI: 10.1016/j.abb.2023.109711
  
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sciencedirect.com/science/article/pii/S0003986123002102
Jun 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Brief Oxygen Exposure after Traumatic Brain Injury Hastens Recovery and Promotes Adaptive Chronic Endoplasmic Reticulum Stress Responses

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1. scibot 30 Jun 2023
  
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  DOI: 10.3390/ijms24129831
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10298247/
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Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis

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1. scibot 27 Jun 2023
  
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  DOI: 10.1016/j.freeradbiomed.2023.06.022
  
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sciencedirect.com/science/article/pii/S0891584923005099
May 2023
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Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR

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1. scibot 05 May 2023
  
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  DOI: 10.1016/j.celrep.2022.111092
  
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sciencedirect.com/science/article/pii/S2211124722008944
Mar 2023
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Large neutral amino acid levels tune perinatal neuronal excitability and survival

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1. scibot 30 Mar 2023
  
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  DOI: 10.1016/j.cell.2023.02.037
  
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sciencedirect.com/science/article/pii/S0092867423002155
europepmc.org europepmc.org

β-Cell glucokinase expression was increased in type 2 diabetes subjects with better glycemic control

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1. scibot 29 Mar 2023
  
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  DOI: 10.1111/1753-0407.13380
  
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europepmc.org/article/med/36942376
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The proteome and transcriptome of stress granules and P bodies during human T lymphocyte activation

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1. scibot 11 Mar 2023
  
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  DOI: 10.1016/j.celrep.2023.112211
  
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sciencedirect.com/science/article/pii/S221112472300222X
Nov 2022
academic.oup.com academic.oup.com

Ageing Impairs Adaptive Unfolded Protein Response and Drives Beta Cell Dedifferentiation in Human

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1. scibot 01 Nov 2022
  
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  DOI: 10.1210/clinem/dgac535
  
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academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac535/6705055
Aug 2022
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A Novel ER Stress Mediator TMTC3 Promotes Squamous Cell Carcinoma Progression by Activating GRP78/PERK Signaling Pathway

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1. scibot 26 Aug 2022
  
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  DOI: 10.7150/ijbs.72838
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9379397/
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Glutamine metabolism modulates chondrocyte inflammatory response

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1. scibot 22 Aug 2022
  
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  DOI: 10.7554/eLife.80725
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9371604/
Jun 2022
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Age-related endoplasmic reticulum stress represses testosterone synthesis via attenuation of the circadian clock in Leydig cells

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1. scibot 18 Jun 2022
  
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  DOI: 10.1016/j.theriogenology.2022.06.010
  
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sciencedirect.com/science/article/pii/S0093691X22002357
Apr 2022
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Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis

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  DOI: 10.1016/j.molcel.2022.03.016
  
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sciencedirect.com/science/article/pii/S1097276522002544
Mar 2022
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Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy

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1. scibot 24 Mar 2022
  
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  DOI: 10.1016/j.isci.2022.103973
  
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sciencedirect.com/science/article/pii/S2589004222002437
Jun 2021
onlinelibrary.wiley.com onlinelibrary.wiley.com

HIV-induced neuroinflammation inhibits oligodendrocyte maturation via glutamate-dependent activation of the PERK arm of the integrated stress response

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1. scibot 02 Jun 2021
  
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  DOI: 10.1002/glia.24033
  
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onlinelibrary.wiley.com/doi/10.1002/glia.24033
Apr 2021
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Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

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1. scibot 24 Apr 2021
  
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  DOI: 10.1016/j.cell.2020.08.009
  
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sciencedirect.com/science/article/pii/S009286742031000X
Feb 2021
www.nature.com www.nature.com

Urinary ERdj3 and mesencephalic astrocyte-derived neutrophic factor identify endoplasmic reticulum stress in glomerular disease

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1. scibot 25 Feb 2021
  
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  DOI: 10.1038/s41374-020-0416-5
  
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nature.com/articles/s41374-020-0416-5
Sep 2020
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Differential effects of integrase strand transfer inhibitors, elvitegravir and raltegravir, on oligodendrocyte maturation: A role for the integrated stress response

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1. scibot 25 Sep 2020
  
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  DOI: 10.1002/glia.23902
  
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onlinelibrary.wiley.com/doi/10.1002/glia.23902
Jan 2020
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

Betulinic acid alleviates endoplasmic reticulum stress‐mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice

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1. scibot 13 Jan 2020
  
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  DOI: 10.1111/bph.14570
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14570
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

Hydrogen sulfide regulates muscle RING finger‐1 protein S‐sulfhydration at Cys44 to prevent cardiac structural damage in diabetic cardiomyopathy

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1. scibot 12 Jan 2020
  
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  DOI: 10.1111/bph.14601
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14601
Nov 2018
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Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S2211124718312610
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AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1550413118301323
Nov 2017
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DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy

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1. scibot 08 Nov 2017
  
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  Curator: @chewbeccax
  
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sciencedirect.com/science/article/pii/S1534580717304598