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Multiomic characterization of microsatellite-stable colorectal cancer reveals distinct biology and targetable vulnerabilities

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1. scibot 24 Oct 2026
  
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  DOI: 10.1016/j.ccell.2026.09.014
  
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sciencedirect.com/science/article/pii/S1535610826004332
Sep 2026
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Bacteroides acidifaciens enriched by KRAS mutation promotes colorectal tumorigenesis

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  DOI: 10.1016/j.chom.2026.08.010
  
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sciencedirect.com/science/article/pii/S1931312826003525
Aug 2026
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RASA1 deficiency aggravates the lesion burden of cerebral cavernous malformations via the Ras/Raf/MAPK pathway

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1. scibot 11 Aug 2026
  
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  DOI: 10.1016/j.isci.2026.117126
  
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sciencedirect.com/science/article/pii/S2589004226025046
Jul 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

BRAF Inhibition–Associated Nuclear Remodeling is Linked to Cancer-Associated Fibroblast Activation

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1. scibot 18 Jul 2026
  
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  DOI: 10.1158/2767-9764.CRC-25-0682
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13373777/
May 2026
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Accumulated sotorasib-bound KRASG12C reactivates the MAPK pathway and drives sotorasib resistance via the DHX9-RAC1-PAK1 axis

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1. scibot 06 May 2026
  
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  DOI: 10.1016/j.celrep.2026.117338
  
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sciencedirect.com/science/article/pii/S221112472600416X
Apr 2026
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Mosperafenib, a novel paradox breaker BRAF inhibitor with potent preclinical activity in BRAF mutated colorectal cancer

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1. scibot 12 Apr 2026
  
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  DOI: 10.1158/1535-7163.MCT-25-0562
  
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aacrjournals.org/mct/article/25/4/599/776467/Mosperafenib-a-Novel-Paradox-Breaker-BRAF
Mar 2026
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Targeting the noncanonical function of metabolic enzyme PHGDH in driving PD-L1 expression and cancer immune evasion

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1. scibot 31 Mar 2026
  
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  DOI: 10.1016/j.xcrm.2026.102704
  
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sciencedirect.com/science/article/pii/S2666379126001217
www.biorxiv.org www.biorxiv.org

A Niclosamide Prodrug SSL-0024 with Enhanced Bioavailability Suppresses Hepatocellular Carcinoma via Multi-Pathway Signaling Inhibition

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1. scibot 19 Mar 2026
  
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  DOI: 10.64898/2026.03.06.710248
  
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biorxiv.org/content/10.64898/2026.03.06.710248v1
Dec 2025
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KSR1 mediates small-cell lung carcinoma tumor initiation and cisplatin resistance

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1. scibot 06 Dec 2025
  
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  DOI: 10.1158/1541-7786.MCR-24-0652
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12133430/
Sep 2025
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Histone demethylase LSD1 regulates lipid homeostasis during Cryptococcus neoformans infection

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  DOI: 10.1016/j.isci.2025.113405
  
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sciencedirect.com/science/article/pii/S2589004225016669
Aug 2025
www.degruyterbrill.com www.degruyterbrill.com

KRAS-driven pancreatic ductal adenocarcinoma cell lines harbour putative cancer stem cells

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1. scibot 05 Aug 2025
  
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  DOI: 10.1515/oncologie-2025-0171
  
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degruyterbrill.com/document/doi/10.1515/oncologie-2025-0171/html
Apr 2025
www.nature.com www.nature.com

Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways

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1. scibot 04 Apr 2025
  
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  DOI: 10.1038/s41598-025-95766-5
  
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nature.com/articles/s41598-025-95766-5
Nov 2024
52.53.155.43 52.53.155.43

can-24-1817-html.html

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1. scibot 14 Nov 2024
  
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  DOI: 10.1158/0008-5472.can-24-1817
  
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52.53.155.43/65dca824591f5654591dc592fd6476e0cd35e8bf/can-24-1817-html.html
Jul 2024
www.cell.com www.cell.com

Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK

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1. scibot 30 Jul 2024
  
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  DOI: 10.1016/j.chom.2024.07.001
  
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cell.com/cell-host-microbe/fulltext/S1931-3128(24)00254-3
52.53.155.43 52.53.155.43

Cancer-associated endocrine cells participate in pancreatic carcinogenesis

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1. scibot 25 Jul 2024
  
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  DOI: 10.1053/j.gastro.2024.07.016
  
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52.53.155.43/00ed7388bef43fd34d4811e77f0e00ce1748f907/1-s2.0-S0016508524052259-main-html.html
Apr 2024
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A senescence restriction point acting on chromatin integrates oncogenic signals

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  DOI: 10.1016/j.celrep.2024.114044
  
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sciencedirect.com/science/article/pii/S2211124724003723
Mar 2024
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The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies

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1. scibot 27 Mar 2024
  
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  DOI: 10.1080/15384047.2024.2332000
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
Sep 2023
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MAPK-ERK-CREB signaling pathway upregulates Nav1.6 in oxaliplatin-induced neuropathic pain in the rat

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1. scibot 29 Sep 2023
  
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  DOI: 10.1016/j.toxlet.2023.07.010
  
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sciencedirect.com/science/article/pii/S0378427423002254
Jun 2023
www.science.org www.science.org

HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis

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1. scibot 16 Jun 2023
  
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  DOI: 10.1126/sciadv.ade1155
  
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2. scibot 12 Jun 2023
  
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  DOI: 10.1126/sciadv.ade1155
  
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science.org/doi/10.1126/sciadv.ade1155
Apr 2023
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RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis

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1. scibot 18 Apr 2023
  
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  DOI: 10.15252/emmm.202217078
  
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embopress.org/doi/10.15252/emmm.202217078
Jan 2023
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Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma

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1. scibot 10 Jan 2023
  
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  DOI: 10.1016/j.immuni.2022.11.014
  
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sciencedirect.com/science/article/pii/S1074761322006045
Dec 2022
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The Agonist of Adenosine A1 Receptor Induced Desensitization of delta Opioid receptor-mediated Raf-1/MEK/ERK Signaling by Feedback Phosphorylation of Raf-1-Ser289/296/301

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1. scibot 17 Dec 2022
  
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  DOI: 10.1007/s11064-022-03843-2
  
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link.springer.com/article/10.1007/s11064-022-03843-2
Sep 2022
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A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration

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1. scibot 29 Sep 2022
  
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  DOI: 10.1016/j.devcel.2022.09.003
  
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sciencedirect.com/science/article/pii/S1534580722006335
Apr 2022
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Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation

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1. scibot 13 Apr 2022
  
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  DOI: 10.1016/j.molcel.2022.03.026
  
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sciencedirect.com/science/article/pii/S1097276522002647
Feb 2022
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CRAF dimerization with ARAF regulates KRAS-driven tumor growth

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1. scibot 11 Feb 2022
  
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  DOI: 10.1016/j.celrep.2022.110351
  
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2. scibot 09 Feb 2022
  
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  DOI: 10.1016/j.celrep.2022.110351
  
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sciencedirect.com/science/article/pii/S2211124722000675
Dec 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Association of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 With Angiotensin II Type 1 Receptor Impacts Mitochondrial Quality Control, Offering Promise for the Treatment of Vascular Senescence

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1. scibot 04 Dec 2021
  
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  DOI: 10.3389/fcvm.2021.788655
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8637926/
Jun 2021
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Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling

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1. scibot 15 Jun 2021
  
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  DOI: 10.1016/j.crmeth.2021.100015
  
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sciencedirect.com/science/article/pii/S2667237521000151
May 2021
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ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization

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1. scibot 05 May 2021
  
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  DOI: 10.1016/j.devcel.2020.05.011
  
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sciencedirect.com/science/article/pii/S1534580720304007
Feb 2021
onlinelibrary.wiley.com onlinelibrary.wiley.com

Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo

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1. scibot 25 Feb 2021
  
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  DOI: 10.1002/mc.23284
  
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onlinelibrary.wiley.com/doi/full/10.1002/mc.23284
Oct 2020
elifesciences.org elifesciences.org

Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila

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1. scibot 24 Oct 2020
  
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  DOI: 10.7554/eLife.57395
  
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elifesciences.org/articles/57395
Sep 2020
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Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis

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1. scibot 23 Sep 2020
  
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  DOI: 10.1016/j.cmet.2020.04.011
  
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sciencedirect.com/science/article/pii/S1550413120301935
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Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers

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1. scibot 17 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107764
  
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sciencedirect.com/science/article/pii/S2211124720307440
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Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids

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1. scibot 16 Sep 2020
  
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  DOI: 10.1016/j.cell.2020.05.053
  
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sciencedirect.com/science/article/pii/S0092867420306863
Jan 2020
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  DOI: 10.1016/j.devcel.2019.04.014
  
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  Curator: @ethanbadger
  
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Nov 2018
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Untitled document

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Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors

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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

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Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

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Systematic Functional Annotation of Somatic Mutations in Cancer

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Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity

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KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS

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Nov 2017
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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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