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Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis

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Nov 2025
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UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression

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Oct 2025
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Catenibacterium mitsuokai promotes hepatocellular carcinogenesis by binding to hepatocytes and generating quinolinic acid

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Sep 2025
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Peach Gum Polysaccharide Prevents Chemotherapy-Induced Intestinal Injury and Degenerative Behavior

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Hypoxic stress dysregulates functions of glioma-associated myeloid cells through epigenomic and transcriptional programs

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Aug 2025
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Peach Gum Polysaccharide Prevents Chemotherapy-Induced Intestinal Injury and Degenerative Behavior

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Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression

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Jul 2025
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Identification of the pyroptosis, apoptosis, and necroptosis (PANoptosis) involved in osteogenic differentiation inhibition impaired by tumor necrosis factor-α

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May 2025
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Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity

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A heterodimer of hemoglobin identifies theranostic targets on brain-metastasizing melanoma cells

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onlinelibrary.wiley.com/doi/10.1002/ijc.35458
Jul 2024
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Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK

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cell.com/cell-host-microbe/fulltext/S1931-3128(24)00254-3
Jun 2024
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Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer

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NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation

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Apr 2024
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Caffeic acid does not protect human pancreatic β cells against stearic acid-induced ER stress and apoptosis

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The chromatin remodeler CHD4 sustains Ewing Sarcoma cell survival by controlling global chromatin architecture

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  DOI: 10.1158/0008-5472.CAN-22-3950
  
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aacrjournals.org/cancerres/article/84/2/241/733111/The-Chromatin-Remodeler-CHD4-Sustains-Ewing
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Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer

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Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy

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Feb 2024
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241-html.html

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p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway

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H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in pediatric high-grade glioma cells

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Jun 2023
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Fancm has dual roles in the limiting of meiotic crossovers and germ cell maintenance in mammals

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Whole-genome CRISPR screen identifies RAVER1 regulates RIPK1-mediated inflammatory cell death, PANoptosis

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NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs

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sciencedirect.com/science/article/pii/S009286742300524X
Dec 2022
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Raptinal induces Gasdermin E-dependent pyroptosis in naive and therapy-resistant melanoma

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  DOI: 10.1158/1541-7786.MCR-22-0040
  
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aacrjournals.org/mcr/article/20/12/1811/711004/Raptinal-Induces-Gasdermin-E-Dependent-Pyroptosis
Oct 2022
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mcr-22-0040-html.html

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Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation

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May 2022
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SETD4-mediated KU70 methylation suppresses apoptosis

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Feb 2022
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Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells

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sciencedirect.com/science/article/pii/S2211124722000596
Dec 2021
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Artemisinin Mediates Its Tumor-Suppressive Activity in Hepatocellular Carcinoma Through Targeted Inhibition of FoxM1

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ncbi.nlm.nih.gov/pmc/articles/PMC8652299/
Oct 2021
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ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

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sciencedirect.com/science/article/pii/S2211124721013255
Jul 2021
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IGFBP-3 Induced by Ribotoxic Stress Traffics From the Endoplasmic Reticulum to the Nucleus in Mammary Epithelial Cells

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1. scibot 31 Jul 2021
  
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  DOI: 10.1210/js.2018-00330
  
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academic.oup.com/jes/article/3/3/517/5257835
Dec 2020
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Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

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1. scibot 10 Dec 2020
  
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  DOI: 10.1016/j.cell.2020.11.025
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7674074/
Sep 2020
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An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages

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1. scibot 13 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107959
  
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Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

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  DOI: 10.1016/j.cell.2020.03.040
  
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Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma

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  DOI: 10.7554/eLife.53367
  
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A non‐covalent inhibitor XMU‐MP‐3 overrides ibrutinib‐resistant BtkC481S mutation in B‐cell malignancies

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Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

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Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers

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  DOI: 10.1016/j.celrep.2019.07.063
  
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Untitled document

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  DOI: 10.1016/j.celrep.2019.02.076
  
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IGFBP-3 Induced by Ribotoxic Stress Traffics From the Endoplasmic Reticulum to the Nucleus in Mammary Epithelial Cells

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Systematic Functional Annotation of Somatic Mutations in Cancer

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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation

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The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

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