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Identification and validation of novel small molecule inhibitors targeting FoxM1-DNA binding domain with anti-cancer potential

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1. scibot 19 Jul 2026
  
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  DOI: 10.1016/j.bbamcr.2026.120193
  
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sciencedirect.com/science/article/pii/S0167488926000923
Jun 2026
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DNA replication stress and translational repression converge to drive CDK1- and caspase-dependent apoptosis in Ewing sarcoma

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1. scibot 16 Jun 2026
  
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  DOI: 10.1038/s41388-026-03845-2
  
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nature.com/articles/s41388-026-03845-2
Mar 2026
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Macrophage metabolic exhaustion and PANoptotic cell death drive chronic tissue inflammation in rheumatoid arthritis

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1. scibot 10 Mar 2026
  
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  DOI: 10.1016/j.immuni.2026.01.019
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13020464/
Feb 2026
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Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis

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1. scibot 24 Feb 2026
  
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Targeting and dissociating HIF2α from the molecular chaperone Hsp70 triggers apoptosis in kidney cancer

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1. scibot 10 Feb 2026
  
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  DOI: 10.1038/s43856-025-01356-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12881505/
Jan 2026
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Pan-cancer N-glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as an actionable surface target

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1. scibot 27 Jan 2026
  
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  DOI: 10.1016/j.xcrm.2025.102578
  
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Dec 2025
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Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis

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1. scibot 19 Dec 2025
  
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  DOI: 10.7554/eLife.106699
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12700530/
Nov 2025
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UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression

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1. scibot 22 Nov 2025
  
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sciencedirect.com/science/article/pii/S1097276525008913
Oct 2025
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Catenibacterium mitsuokai promotes hepatocellular carcinogenesis by binding to hepatocytes and generating quinolinic acid

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1. scibot 01 Oct 2025
  
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sciencedirect.com/science/article/pii/S1550413125003869
Sep 2025
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Peach Gum Polysaccharide Prevents Chemotherapy-Induced Intestinal Injury and Degenerative Behavior

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1. scibot 07 Sep 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12375157/
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Hypoxic stress dysregulates functions of glioma-associated myeloid cells through epigenomic and transcriptional programs

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  DOI: 10.1016/j.celrep.2025.116222
  
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sciencedirect.com/science/article/pii/S2211124725009933
Aug 2025
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Peach Gum Polysaccharide Prevents Chemotherapy-Induced Intestinal Injury and Degenerative Behavior

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1. scibot 27 Aug 2025
  
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journals.sagepub.com/doi/full/10.1177/15347354251368410
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Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression

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1. scibot 08 Aug 2025
  
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  DOI: 10.1016/j.ccell.2025.07.012
  
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sciencedirect.com/science/article/pii/S1535610825003186
Jul 2025
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Identification of the pyroptosis, apoptosis, and necroptosis (PANoptosis) involved in osteogenic differentiation inhibition impaired by tumor necrosis factor-α

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1. scibot 02 Jul 2025
  
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  DOI: 10.1186/s40001-025-02702-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12211273/
May 2025
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Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity

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1. scibot 31 May 2025
  
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  DOI: 10.1016/j.chom.2025.05.004
  
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sciencedirect.com/science/article/pii/S1931312825001830
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A heterodimer of hemoglobin identifies theranostic targets on brain-metastasizing melanoma cells

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1. scibot 16 May 2025
  
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  DOI: 10.1002/ijc.35458
  
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onlinelibrary.wiley.com/doi/10.1002/ijc.35458
Jul 2024
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Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK

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1. scibot 30 Jul 2024
  
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  DOI: 10.1016/j.chom.2024.07.001
  
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cell.com/cell-host-microbe/fulltext/S1931-3128(24)00254-3
Jun 2024
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Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer

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1. scibot 28 Jun 2024
  
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  DOI: 10.1038/s41388-024-03081-6
  
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link.springer.com/article/10.1038/s41388-024-03081-6
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NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation

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1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.cell.2024.05.034
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11283362/
Apr 2024
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Caffeic acid does not protect human pancreatic β cells against stearic acid-induced ER stress and apoptosis

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1. scibot 25 Apr 2024
  
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  DOI: 10.1002/ejlt.202300206
  
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onlinelibrary.wiley.com/doi/full/10.1002/ejlt.202300206
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The chromatin remodeler CHD4 sustains Ewing Sarcoma cell survival by controlling global chromatin architecture

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1. scibot 19 Apr 2024
  
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  DOI: 10.1158/0008-5472.CAN-22-3950
  
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aacrjournals.org/cancerres/article/84/2/241/733111/The-Chromatin-Remodeler-CHD4-Sustains-Ewing
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Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer

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1. scibot 18 Apr 2024
  
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  DOI: 10.21203/rs.3.rs-4095949/v1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10996809/
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Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy

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1. scibot 09 Apr 2024
  
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sciencedirect.com/science/article/pii/S0006295224001813
Feb 2024
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241-html.html

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  DOI: 10.1158/0008-5472.can-22-3950
  
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52.53.155.43/ef1c2343cba3a29438101d6931686796493196a8/241-html.html
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p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway

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1. scibot 14 Feb 2024
  
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  DOI: 10.1016/j.xcrm.2024.101401
  
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H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in pediatric high-grade glioma cells

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sciencedirect.com/science/article/pii/S2211124724000354
Jun 2023
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Fancm has dual roles in the limiting of meiotic crossovers and germ cell maintenance in mammals

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1. scibot 30 Jun 2023
  
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  DOI: 10.1016/j.xgen.2023.100349
  
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Whole-genome CRISPR screen identifies RAVER1 regulates RIPK1-mediated inflammatory cell death, PANoptosis

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1. scibot 09 Jun 2023
  
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  DOI: 10.1016/j.isci.2023.106938
  
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sciencedirect.com/science/article/pii/S2589004223010155
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NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs

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  DOI: 10.1016/j.cell.2023.05.005
  
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sciencedirect.com/science/article/pii/S009286742300524X
Dec 2022
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Raptinal induces Gasdermin E-dependent pyroptosis in naive and therapy-resistant melanoma

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1. scibot 04 Dec 2022
  
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  DOI: 10.1158/1541-7786.MCR-22-0040
  
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aacrjournals.org/mcr/article/20/12/1811/711004/Raptinal-Induces-Gasdermin-E-Dependent-Pyroptosis
Oct 2022
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mcr-22-0040-html.html

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  DOI: 10.1158/1541-7786.MCR-22-0040
  
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52.53.155.43/727478f306d650986e0e949733013801988f63e4/mcr-22-0040-html.html
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Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation

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1. scibot 05 Oct 2022
  
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  DOI: 10.1016/j.celrep.2022.111434
  
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sciencedirect.com/science/article/pii/S221112472201275X
May 2022
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SETD4-mediated KU70 methylation suppresses apoptosis

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1. scibot 11 May 2022
  
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  DOI: 10.1016/j.celrep.2022.110794
  
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sciencedirect.com/science/article/pii/S2211124722005617
Feb 2022
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Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells

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1. scibot 11 Feb 2022
  
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  DOI: 10.1016/j.celrep.2022.110343
  
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sciencedirect.com/science/article/pii/S2211124722000596
Dec 2021
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Artemisinin Mediates Its Tumor-Suppressive Activity in Hepatocellular Carcinoma Through Targeted Inhibition of FoxM1

1
1. scibot 11 Dec 2021
  
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  AB_2068144
  
  DOI: 10.3389/fonc.2021.751271
  
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Oct 2021
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ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

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1. scibot 21 Oct 2021
  
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  RRID:AB_2068144
  
  DOI: 10.1016/j.celrep.2021.109858
  
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Jul 2021
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IGFBP-3 Induced by Ribotoxic Stress Traffics From the Endoplasmic Reticulum to the Nucleus in Mammary Epithelial Cells

1
1. scibot 31 Jul 2021
  
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  RRID:AB_2068144
  
  DOI: 10.1210/js.2018-00330
  
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academic.oup.com/jes/article/3/3/517/5257835
Dec 2020
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Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

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1. scibot 10 Dec 2020
  
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  RRID:AB_2068144
  
  DOI: 10.1016/j.cell.2020.11.025
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7674074/
Sep 2020
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An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages

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1. scibot 13 Sep 2020
  
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  RRID:AB_2068144
  
  DOI: 10.1016/j.celrep.2020.107959
  
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Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

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1. scibot 11 Sep 2020
  
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  RRID:AB_2068144
  
  DOI: 10.1016/j.cell.2020.03.040
  
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elifesciences.org elifesciences.org

Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma

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1. scibot 04 Sep 2020
  
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  RRID:AB_2068144
  
  DOI: 10.7554/eLife.53367
  
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bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

A non‐covalent inhibitor XMU‐MP‐3 overrides ibrutinib‐resistant BtkC481S mutation in B‐cell malignancies

1
1. scibot 03 Sep 2020
  
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  RRID:AB_2068144
  
  DOI: 10.1111/bph.14809
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14809
Jan 2020
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Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2068144
  
  DOI: 10.1016/j.ccell.2019.03.007
  
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Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2068144
  
  DOI: 10.1016/j.celrep.2019.07.063
  
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_2068144
  
  DOI: 10.1016/j.celrep.2019.02.076
  
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academic.oup.com academic.oup.com

IGFBP-3 Induced by Ribotoxic Stress Traffics From the Endoplasmic Reticulum to the Nucleus in Mammary Epithelial Cells

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2068144
  
  DOI: 10.1210/js.2018-00330
  
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academic.oup.com/jes/article/3/3/517/5257835
Nov 2018
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Systematic Functional Annotation of Somatic Mutations in Cancer

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sciencedirect.com/science/article/pii/S1535610818300217
Nov 2017
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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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1. scibot 08 Nov 2017
  
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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

1
1. scibot 08 Nov 2017
  
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  AB_2068144
  
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sciencedirect.com/science/article/pii/S2405471216304082
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Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation

1
1. scibot 08 Nov 2017
  
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  AB_2068144
  
  Curator: @kaitlinsung
  
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The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

1
1. scibot 08 Nov 2017
  
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  9491
  
  Curator: @bandrow
  
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