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An innovative engineered IL-10 monomer strengthens T cell-mediated anti-tumor responses through anti-PD-1 cis-delivery

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Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses

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1. scibot 17 Dec 2025
  
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  DOI: 10.1016/j.cell.2025.11.023
  
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sciencedirect.com:5037/science/article/pii/S0092867425013583
Dec 2025
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Depleting IL1R2+ Tumor-Infiltrating Regulatory T Cells with an ADCC-Prone Nanobody Construct Boosts the Efficacy of Anti–PD-1 Immunotherapy

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1. scibot 03 Dec 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-3095
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12666320/
Nov 2025
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MHC-II-restricted neoantigen vaccine reverses immune microenvironment and overcomes resistance to immune-checkpoint inhibitors in cold tumors

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1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.medj.2025.100936
  
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sciencedirect.com:5037/science/article/pii/S2666634025003630
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Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity

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1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.cell.2025.10.042
  
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sciencedirect.com:5037/science/article/pii/S0092867425012474
Oct 2025
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In situ extended immune activation instantly after tumor resection by oncolytic virus controls postoperative tumor recurrence

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1. scibot 08 Oct 2025
  
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  DOI: 10.1016/j.xcrm.2025.102399
  
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Eomesodermin+ CD4+ T cells are critical for curative immunotherapy outcomes

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  DOI: 10.1016/j.immuni.2025.09.004
  
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sciencedirect.com/science/article/pii/S1074761325004157
Sep 2025
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Synergically enhanced anti-tumor immunity of in vivo panCAR by circRNA vaccine boosting

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1. scibot 16 Sep 2025
  
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  DOI: 10.1016/j.xcrm.2025.102250
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12432353/
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Cancer cell and microenvironmental rewiring by ADAR1 loss impairs glioblastoma tumor growth and extends survival

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1. scibot 03 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116151
  
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sciencedirect.com/science/article/pii/S2211124725009222
Aug 2025
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Long-range deployment of tumor-antigen-specific cytotoxic T lymphocytes inhibits lung metastasis of breast cancer

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1. scibot 28 Aug 2025
  
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  DOI: 10.1016/j.devcel.2025.08.003
  
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sciencedirect.com/science/article/pii/S1534580725005039
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Biomimetic nanoimmunotherapy boosts spatiotemporal PANoptosis and reshapes desmoplastic tumor microenvironment

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102312
  
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2025.08.13.669552v1.full-html.html

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1. scibot 22 Aug 2025
  
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  DOI: 10.1101/2025.08.13.669552
  
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52.53.155.43/cbef6d49734833e21d46745b8a2764b4c745ed76/2025.08.13.669552v1.full-html.html
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1-s2.0-S2589004225010338-main-html.html

1
1. scibot 12 Aug 2025
  
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  AB_2075238
  
  DOI: 10.1016/j.isci.2025.112772
  
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52.53.155.43/8b0897d2d35a8ab9ab351db77e0eeb32b8358112/1-s2.0-S2589004225010338-main-html.html
Jul 2025
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Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102251
  
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Ce6 derivative photodynamic therapy triggers PANoptosis and enhances antitumor immunity with LAG3 blockade in cutaneous squamous cell carcinoma

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1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102239
  
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A Novel B7-H4xCD3 Bispecific T-cell Engager (PF-07260437) Synergizes with Breast Cancer Standard of Care and Immune Checkpoint Therapies

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1. scibot 04 Jul 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0379
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12214883/
Jun 2025
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Prolonged but finite antigen presentation promotes reversible defects of “helpless” memory CD8+ T cells

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1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.immuni.2025.05.025
  
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sciencedirect.com/science/article/pii/S1074761325002468
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Rapid group-2 innate lymphoid cell mobilization from the intestine aids in early lung defense and repair

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1. scibot 21 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115868
  
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sciencedirect.com/science/article/pii/S2211124725006394
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ILC3s sense gut microbiota through STING to initiate immune tolerance

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1. scibot 17 Jun 2025
  
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  DOI: 10.1016/j.immuni.2025.05.016
  
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1-s2.0-S2589004225010351-main (1)-html.html

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1. scibot 13 Jun 2025
  
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  DOI: 10.1016/j.isci.2025.112774
  
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52.53.155.43/4b335a8bbb2cbd12d3073f7f7af0232585278bec/1-s2.0-S2589004225010351-main (1)-html.html
May 2025
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Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis

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1. scibot 31 May 2025
  
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  DOI: 10.1016/j.immuni.2025.05.002
  
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Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.immuni.2025.04.030
  
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Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.ebiom.2025.105734
  
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sciencedirect.com/science/article/pii/S2352396425001781
Apr 2025
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Combination therapy with alisertib enhances the anti-tumor immunity induced by a liver cancer vaccine

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1. scibot 18 Apr 2025
  
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  DOI: 10.1016/j.isci.2025.112120
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11995041/
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Protocol for investigating the impact of transcription regulator deficiency on tumor-specific CD8+ T cell responses via adoptive cell transfer

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1. scibot 03 Apr 2025
  
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  DOI: 10.1016/j.xpro.2025.103703
  
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Mucosal multivalent NDV-based vaccine provides cross-reactive immune responses against SARS-CoV-2 variants in animal models

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  DOI: 10.3389/fimmu.2025.1524477
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11955676/
Mar 2025
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Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors

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1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.immuni.2025.02.027
  
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sciencedirect.com/science/article/pii/S1074761325000949
Feb 2025
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An epitope-directed mRNA vaccine inhibits tumor metastasis through the blockade of MICA/B α1/2 shedding

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1. scibot 25 Feb 2025
  
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  DOI: 10.1016/j.xcrm.2025.101981
  
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Potentiating anti-tumor immunity by re-engaging immune synapse molecules

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1. scibot 25 Feb 2025
  
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  DOI: 10.1016/j.xcrm.2025.101975
  
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A microRNA-regulated transcriptional state defines intratumoral CD8+ T cells that respond to immunotherapy

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  DOI: 10.1016/j.celrep.2025.115301
  
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sciencedirect.com/science/article/pii/S2211124725000725
Jan 2025
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The bacterial microbiome modulates the initiation of brain metastasis by impacting the gut-to-brain axis

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1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.isci.2025.111874
  
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52.53.155.43/7d89da942243a2eaf4b37b3c4318db932749cf0d/1-s2.0-S2589004225001348-main-html.html
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Gut bacterial L-lysine alters metabolism and histone methylation to drive dendritic cell tolerance

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1. scibot 03 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115125
  
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sciencedirect.com/science/article/pii/S2211124724014761
Dec 2024
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Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.cell.2024.11.031
  
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Interleukin-2 receptor signaling acts as a checkpoint that influences the distribution of regulatory T cell subsets

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1. scibot 18 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111248
  
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Commensal papillomavirus immunity preserves the homeostasis of highly mutated normal skin

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1. scibot 14 Dec 2024
  
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A yeast-based oral therapeutic delivers immune checkpoint inhibitors to reduce intestinal tumor burden

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Flt3L enhances clonal diversification and selective expansion of intratumoral CD8+ T cells while differentiating into effector-like cells

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Preclinical evaluation of a universal inactivated influenza B vaccine based on the mosaic hemagglutinin-approach

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Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint

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A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in mice

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Thymosin α1 reverses oncolytic adenovirus-induced M2 polarization of macrophages to improve antitumor immunity and therapeutic efficacy

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Tyzzerella nexilis strains enriched in mobile genetic elements are involved in progressive multiple sclerosis

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Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer

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The transcription regulator ID3 maintains tumor-specific memory CD8+ T cells in draining lymph nodes during tumorigenesis

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Epithelial organoid supports resident memory CD8 T cell differentiation

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Inherent preference for polyunsaturated fatty acids instigates ferroptosis of Treg cells that aggravates high-fat-diet-related colitis

1
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The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector and memory responses

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SWI/SNF chromatin remodeling factor BAF60b restrains inflammatory diseases by affecting regulatory T cell migration

2
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Intranasal SARS-CoV-2 Omicron variant vaccines elicit humoral and cellular mucosal immunity in female mice

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Glycoengineering-based anti-PD-1-iRGD peptide conjugate boosts antitumor efficacy through T cell engagement

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Glucagon-like peptide 1 receptor is a T cell-negative costimulatory molecule

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Immunotherapy-activated T cells recruit and skewlate-stage activated M1-like macrophagesthat are critical for therapeutic efficacy

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Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration

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Cbl-b mitigates the responsiveness of naive CD8+ T cells that experience extensive tonic T cell receptor signaling

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  DOI: 10.1126/scisignal.adh0439
  
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Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells

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The guanine nucleotide exchange factor Rin-like controls Tfh cell differentiation via CD28 signaling

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Feb 2024
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Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans

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DNA damage repair profiling of esophageal squamous cell carcinoma uncovers clinically relevant molecular subtypes with distinct prognoses and therapeutic vulnerabilities

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Dietary environmental factors shape the immune defense against Cryptosporidium infection

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Attenuation of allergen-specific immunotherapy for atopic dermatitis by ectopic colonization of Brevundimonas vesicularis in the intestine

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Intermittent fasting induced ketogenesis inhibits mouse epithelial ovarian cancer by promoting antitumor T cell response

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ApoE enhances mitochondrial metabolism via microRNA-142a/146a-regulated circuits that suppress hematopoiesis and inflammation in hyperlipidemia

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Aug 2023
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Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis

2
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Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection

1
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Comparison of DNA vaccines with AS03 as an adjuvant and an mRNA vaccine against SARS-CoV-2

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May 2023
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cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity

1
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Fusobacterium nucleatum-derived succinic acid induces tumor resistance to immunotherapy in colorectal cancer

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  DOI: 10.1016/j.chom.2023.04.010
  
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Feb 2023
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HMGB1/GPC3 dual targeting vaccine induces dendritic cells-mediated CD8+T cell immune response and elicits potential therapeutic effect in hepatocellular carcinoma

1
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  DOI: 10.1016/j.isci.2023.106143
  
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CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor

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  DOI: 10.1016/j.immuni.2022.12.002
  
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Ischemic stroke impacts the gut microbiome, ileal epithelial and immune homeostasis

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The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity

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B cell-mediated regulatory mechanisms control tumor-promoting intestinal inflammation

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Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes

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Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

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Balanced T and B cell responses are required for immune protection against Powassan virus in virus-like particle vaccination

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Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections

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Tnfrsf4-expressing regulatory T cells promote immune escape of chronic myeloid leukemia stem cells

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ILC3s control airway inflammation by limiting T cell responses to allergens and microbes

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BPS Publications

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  DOI: 10.1111/bph.15673
  
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Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria

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Arthritis flares mediated by tissue-resident memory T cells in the joint

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IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer’s disease

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Hemozoin-mediated inflammasome activation limits long-lived anti-malarial immunity

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Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease

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Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer

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Untitled document

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CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment

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Untitled document

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DHX15 is required to control RNA virus-induced intestinal inflammation

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Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function

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Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials

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TGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma

1
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Visualizing Synaptic Transfer of Tumor Antigens among Dendritic Cells

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Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis

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Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells

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Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration

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A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS

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An Agonistic Anti-CD137 Antibody Disrupts Lymphoid Follicle Structure and T-Cell-Dependent Antibody Responses

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Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis

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BPS Publications

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  DOI: 10.1111/bph.15203
  
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Chemokine-Adjuvanted Plasmid DNA Induces Homing of Antigen-Specific and Non–Antigen-Specific B and T Cells to the Intestinal and Genital Mucosae

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Long-Term Programming of CD8 T Cell Immunity by Perinatal Exposure to Glucocorticoids

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Cell Competition, the Kinetics of Thymopoiesis, and Thymus Cellularity Are Regulated by Double-Negative 2 to 3 Early Thymocytes

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T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development

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Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection

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B1 and Marginal Zone B Cells but Not Follicular B2 Cells Require Gpx4 to Prevent Lipid Peroxidation and Ferroptosis

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UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

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Ligand-Blocking and Membrane-Proximal Domain Targeting Anti-OX40 Antibodies Mediate Potent T Cell-Stimulatory and Anti-Tumor Activity

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Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer

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The Obese Liver Environment Mediates Conversion of NK Cells to a Less Cytotoxic ILC1-Like Phenotype

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Untitled document

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Untitled document

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Untitled document

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Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness

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Untitled document

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Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy

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Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations

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Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production

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Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells

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Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo

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Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy

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Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells

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The ghrelin/GOAT system regulates obesity-induced inflammation in male mice.

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