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Mar 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Transient proliferation by reversible YAP and mitogen control of the cyclin D1/p27 ratio

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1. scibot 11 Mar 2026
  
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  DOI: 10.1038/s42003-026-09590-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12957376/
Feb 2026
54.241.53.176 54.241.53.176

1-s2.0-S2589004226003718-main-html.html

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54.241.53.176/f373af50e20ad2f683c3912e0dfb19a86e14ace7/1-s2.0-S2589004226003718-main-html.html
Jan 2026
www.nature.com www.nature.com

CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 induction

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1. scibot 27 Jan 2026
  
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  DOI: 10.1038/s41467-025-67865-4
  
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nature.com/articles/s41467-025-67865-4
Dec 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence

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  DOI: 10.1038/s44318-025-00608-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12669767/
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CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen

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  DOI: 10.1038/s41523-025-00851-7
  
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  DOI: 10.1038/s41523-025-00851-7
  
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nature.com/articles/s41523-025-00851-7
Oct 2025
www.sciencedirect.com www.sciencedirect.com

USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization

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sciencedirect.com/science/article/pii/S221112472501143X
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Catenibacterium mitsuokai promotes hepatocellular carcinogenesis by binding to hepatocytes and generating quinolinic acid

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  DOI: 10.1016/j.cmet.2025.09.001
  
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sciencedirect.com/science/article/pii/S1550413125003869
Sep 2025
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A covalent inhibitor targeting Cys16 on RhoA in colorectal cancer

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  DOI: 10.1016/j.chembiol.2025.08.004
  
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sciencedirect.com/science/article/pii/S2451945625002557
Aug 2025
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YTHDF proteins and m6A-RNA clients undergo autophagic turnover during contact inhibition

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  DOI: 10.1016/j.celrep.2025.116188
  
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sciencedirect.com/science/article/pii/S2211124725009593
May 2025
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Circular RNA circATM binds PARP1 to suppress Wnt/β-catenin signaling and induce cell cycle arrest in gastric cancer cells

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.jare.2025.04.033
  
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sciencedirect.com/science/article/pii/S2090123225002772
Mar 2025
52.53.155.43 52.53.155.43

PDF-html.html

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1. scibot 25 Mar 2025
  
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  DOI: 10.1210/endocr/bqaf052
  
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  DOI: 10.1210/endocr/bqaf052
  
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52.53.155.43/2c711cfab92471c2b26281241cdeab4098b3b2b7/bqaf052-html.html
Aug 2024
www.mdpi.com www.mdpi.com

A Novel Monoclonal Antibody Targeting Cancer-Specific Plectin Has Potent Antitumor Activity in Ovarian Cancer

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1. scibot 02 Aug 2024
  
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  DOI: 10.3390/cells10092218
  
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mdpi.com/2073-4409/10/9/2218/htm
Jul 2024
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IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma

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1. scibot 24 Jul 2024
  
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  DOI: 10.1016/j.ccell.2024.05.026
  
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sciencedirect.com/science/article/pii/S1535610824002174
May 2024
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Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy

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1. scibot 10 May 2024
  
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  DOI: 10.1016/j.xcrm.2024.101552
  
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sciencedirect.com/science/article/pii/S2666379124002441
Apr 2024
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Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication

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  DOI: 10.1016/j.devcel.2024.03.032
  
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sciencedirect.com/science/article/pii/S1534580724002004
Mar 2024
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CDK-independent role of D-type cyclins in regulating DNA mismatch repair

2
1. scibot 08 Mar 2024
  
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  DOI: 10.1016/j.molcel.2024.02.010
  
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sciencedirect.com/science/article/pii/S1097276524001291
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Sirt6 regulates proliferation of neural precursor cells and cortical neurogenesis in mice

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1. scibot 02 Feb 2024
  
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  DOI: 10.1016/j.isci.2023.108706
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10823065/
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Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer

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  DOI: 10.1038/s41698-024-00496-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10810864/
Dec 2023
onlinelibrary.wiley.com onlinelibrary.wiley.com

Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation

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  DOI: 10.1002/advs.202305620
  
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onlinelibrary.wiley.com/doi/10.1002/advs.202305620
Nov 2023
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The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

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  DOI: 10.1126/science.adh5021
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10617673/
aacrjournals.org aacrjournals.org

MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer

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1. scibot 03 Nov 2023
  
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  DOI: 10.1158/2159-8290.CD-23-0669
  
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aacrjournals.org/cancerdiscovery/article/13/11/2412/729848/MRTX1719-Is-an-MTA-Cooperative-PRMT5-Inhibitor
Oct 2023
www.science.org www.science.org

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

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1. scibot 17 Oct 2023
  
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science.org/doi/10.1126/science.adh5021
Sep 2023
www.cell.com www.cell.com

Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation

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  DOI: 10.1016/j.celrep.2023.113079
  
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cell.com/cell-reports/fulltext/S2211-1247(23)01090-2
Aug 2023
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Neuroendocrine lineage commitment of small cell lung cancers can be leveraged into p53-independent non-cytotoxic therapy

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  DOI: 10.1016/j.celrep.2023.113016
  
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L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab

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  DOI: 10.1016/j.xcrm.2023.101142
  
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  DOI: 10.1016/j.xcrm.2023.101142
  
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52.53.155.43/bb31ad2b14838f5cede2aca897c595e2febf2f88/PIIS2666379123002951-html.html
Jul 2023
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Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer

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  DOI: 10.1016/j.xcrm.2023.101120
  
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sciencedirect.com/science/article/pii/S2666379123002483
Jun 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis

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  DOI: 10.1016/j.molcel.2022.12.004
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7614657/
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Somatic FGFR2 is required for germ cell maintenance in the mouse ovary

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  DOI: 10.1210/endocr/bqad031
  
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dx.doi.org/10.1210/endocr/bqad031
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5-Azacytidine- and retinoic-acid-induced reprogramming of DCCs into dormancy suppresses metastasis via restored TGF-β-SMAD4 signaling

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  DOI: 10.1016/j.celrep.2023.112560
  
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sciencedirect.com/science/article/pii/S2211124723005715
Apr 2023
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UTP18-mediated p21 mRNA instability drives adenoma-carcinoma progression in colorectal cancer

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  DOI: 10.1016/j.celrep.2023.112423
  
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sciencedirect.com/science/article/pii/S2211124723004345
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Proteomic discovery of chemical probes that perturb protein complexes in human cells

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1. scibot 21 Apr 2023
  
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  DOI: 10.1016/j.molcel.2023.03.026
  
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sciencedirect.com/science/article/pii/S1097276523002393
Mar 2023
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Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction

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  DOI: 10.1016/j.celrep.2023.112252
  
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sciencedirect.com/science/article/pii/S2211124723002632
Oct 2022
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Sox9 mediates Autophagy-dependent vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosis

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A proliferative to invasive switch is mediated by srGAP1 downregulation through the activation of TGF-β2 signaling

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Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer

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Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch

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Deficiency of Mesencephalic Astrocyte-derived Neurotrophic Factor Affects Neurogenesis in Mouse Brain

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CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities

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T63 induces apoptosis in nasopharyngeal carcinoma cells through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway

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CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism

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Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways

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RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site

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MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer

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PBRM1 loss in kidney cancer unbalances the proximal tubule master transcription factor hub to repress proximal tubule differentiation

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RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway

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An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors

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Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression

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MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway

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MicroRNA-29 is an essential regulator of brain maturation through regulation of CH methylation

1
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Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer

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Isorhamnetin Inhibits Human Gallbladder Cancer Cell Proliferation and Metastasis via PI3K/AKT Signaling Pathway Inactivation

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A novel ligand of the translationally controlled tumor protein (TCTP) identified by virtual drug screening for cancer differentiation therapy

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  DOI: 10.1007/s10637-020-01042-w
  
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Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

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  DOI: 10.1016/j.ccell.2019.12.006
  
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Long noncoding RNA SOX2OT promotes the proliferation of pancreatic cancer by binding to FUS

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  p27
  
  DOI: 10.1002/ijc.32827
  
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RABL6A is an essential driver of MPNSTs that negatively regulates the RB1 pathway and sensitizes tumor cells to CDK4/6 inhibitors

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  DOI: 10.1158/1078-0432.CCR-19-2706
  
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GRWD1 promotes cell proliferation and migration in non-small cell lung cancer by activating the Notch pathway

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The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling

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Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells

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Untitled document

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Untitled document

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Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G0/G1 Arrest by Inhibiting Deubiquitinase USP2a

1
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Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

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Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis

1
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