55 Matching Annotations
  1. May 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy
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    1. scibot 10 May 2024
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    sciencedirect.com/science/article/pii/S2666379124002441
  3. Apr 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication
    1
    1. scibot 20 Apr 2024
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    sciencedirect.com/science/article/pii/S1534580724002004
  5. Mar 2024
  6. www.sciencedirect.com www.sciencedirect.com
    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
    2
    1. scibot 08 Mar 2024
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    sciencedirect.com/science/article/pii/S1097276524001291
  7. Feb 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sirt6 regulates proliferation of neural precursor cells and cortical neurogenesis in mice
    1
    1. scibot 02 Feb 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10823065/
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
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    1. scibot 01 Feb 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10810864/
  10. Dec 2023
  11. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation
    1
    1. scibot 29 Dec 2023
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      DOI: 10.1002/advs.202305620

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    onlinelibrary.wiley.com/doi/10.1002/advs.202305620
  12. Nov 2023
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
    2
    1. scibot 04 Nov 2023
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    ncbi.nlm.nih.gov/pmc/articles/PMC10617673/
  14. aacrjournals.org aacrjournals.org
    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
    1
    1. scibot 03 Nov 2023
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    aacrjournals.org/cancerdiscovery/article/13/11/2412/729848/MRTX1719-Is-an-MTA-Cooperative-PRMT5-Inhibitor
  15. Oct 2023
  16. www.science.org www.science.org
    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
    1
    1. scibot 17 Oct 2023
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  17. Sep 2023
  18. www.cell.com www.cell.com
    Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation
    1
    1. scibot 01 Sep 2023
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    cell.com/cell-reports/fulltext/S2211-1247(23)01090-2
  19. Aug 2023
  20. www.sciencedirect.com www.sciencedirect.com
    Neuroendocrine lineage commitment of small cell lung cancers can be leveraged into p53-independent non-cytotoxic therapy
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    1. scibot 23 Aug 2023
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    sciencedirect.com/science/article/pii/S2211124723010276
  21. 52.53.155.43 52.53.155.43
    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
    2
    1. scibot 18 Aug 2023
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      DOI: 10.1016/j.xcrm.2023.101142

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    2. scibot 10 Aug 2023
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      DOI: 10.1016/j.xcrm.2023.101142

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  22. Jul 2023
  23. www.sciencedirect.com www.sciencedirect.com
    Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer
    1
    1. scibot 14 Jul 2023
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      DOI: 10.1016/j.xcrm.2023.101120

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    sciencedirect.com/science/article/pii/S2666379123002483
  24. Jun 2023
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis
    1
    1. scibot 17 Jun 2023
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      DOI: 10.1016/j.molcel.2022.12.004

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    ncbi.nlm.nih.gov/pmc/articles/PMC7614657/
  26. dx.doi.org dx.doi.org
    Somatic FGFR2 is required for germ cell maintenance in the mouse ovary
    1
    1. scibot 08 Jun 2023
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      DOI: 10.1210/endocr/bqad031

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    dx.doi.org/10.1210/endocr/bqad031
  27. www.sciencedirect.com www.sciencedirect.com
    5-Azacytidine- and retinoic-acid-induced reprogramming of DCCs into dormancy suppresses metastasis via restored TGF-β-SMAD4 signaling
    1
    1. scibot 02 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112560

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    sciencedirect.com/science/article/pii/S2211124723005715
  28. Apr 2023
  29. www.sciencedirect.com www.sciencedirect.com
    UTP18-mediated p21 mRNA instability drives adenoma-carcinoma progression in colorectal cancer
    1
    1. scibot 26 Apr 2023
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      DOI: 10.1016/j.celrep.2023.112423

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    sciencedirect.com/science/article/pii/S2211124723004345
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    Proteomic discovery of chemical probes that perturb protein complexes in human cells
    1
    1. scibot 21 Apr 2023
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      DOI: 10.1016/j.molcel.2023.03.026

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    sciencedirect.com/science/article/pii/S1097276523002393
  31. Mar 2023
  32. www.sciencedirect.com www.sciencedirect.com
    Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction
    1
    1. scibot 16 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112252

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    sciencedirect.com/science/article/pii/S2211124723002632
  33. Oct 2022
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sox9 mediates Autophagy-dependent vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosis
    1
    1. scibot 07 Oct 2022
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      DOI: 10.1016/j.isci.2022.105161

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    ncbi.nlm.nih.gov/pmc/articles/PMC9531173/
  35. Sep 2022
  36. www.sciencedirect.com www.sciencedirect.com
    A proliferative to invasive switch is mediated by srGAP1 downregulation through the activation of TGF-β2 signaling
    1
    1. scibot 22 Sep 2022
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      DOI: 10.1016/j.celrep.2022.111358

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    sciencedirect.com/science/article/pii/S2211124722011901
  37. Aug 2022
  38. www.sciencedirect.com www.sciencedirect.com
    Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer
    1
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    sciencedirect.com/science/article/pii/S221112472201035X
  39. Mar 2022
  40. www.sciencedirect.com www.sciencedirect.com
    Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch
    1
    1. scibot 09 Mar 2022
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      DOI: 10.1016/j.celrep.2022.110468

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    sciencedirect.com/science/article/pii/S2211124722002017
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    Deficiency of Mesencephalic Astrocyte-derived Neurotrophic Factor Affects Neurogenesis in Mouse Brain
    1
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      DOI: 10.1016/j.brainresbull.2022.02.019

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    sciencedirect.com/science/article/pii/S0361923022000582
  42. www.sciencedirect.com www.sciencedirect.com
    CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities
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    1. scibot 02 Mar 2022
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      DOI: 10.1016/j.celrep.2022.110448

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    sciencedirect.com/science/article/pii/S2211124722001759
  43. Feb 2022
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    T63 induces apoptosis in nasopharyngeal carcinoma cells through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway
    1
    1. scibot 05 Feb 2022
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      DOI: 10.21037/tcr-20-1677

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    ncbi.nlm.nih.gov/pmc/articles/PMC8797319/
  45. Dec 2021
  46. www.sciencedirect.com www.sciencedirect.com
    CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism
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    1. scibot 11 Dec 2021
      RRID:AB_2077850

      DOI: 10.1016/j.isci.2021.103538

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    sciencedirect.com/science/article/pii/S2589004221015091
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways
    1
    1. scibot 11 Dec 2021
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      DOI: 10.3389/fcell.2021.773048

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    ncbi.nlm.nih.gov/pmc/articles/PMC8652204/
  48. Nov 2021
  49. www.sciencedirect.com www.sciencedirect.com
    RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site
    1
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      DOI: 10.1016/j.celrep.2021.109934

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    sciencedirect.com/science/article/pii/S2211124721014078
  50. Oct 2021
  51. www.sciencedirect.com www.sciencedirect.com
    MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer
    1
    1. scibot 29 Oct 2021
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      DOI: 10.1016/j.isci.2021.103224

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    sciencedirect.com/science/article/pii/S2589004221011925
  52. Sep 2021
  53. www.sciencedirect.com www.sciencedirect.com
    PBRM1 loss in kidney cancer unbalances the proximal tubule master transcription factor hub to repress proximal tubule differentiation
    1
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    sciencedirect.com/science/article/pii/S2211124721012018
  54. Jul 2021
  55. link.springer.com link.springer.com
    RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway
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      P27

      DOI: 10.1186/s40659-019-0268-x

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    link.springer.com/article/10.1186/s40659-019-0268-x
  56. www.sciencedirect.com www.sciencedirect.com
    An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors
    2
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      DOI: 10.1016/j.ebiom.2016.06.007

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    sciencedirect.com/science/article/pii/S2352396416302511
  57. Jun 2021
  58. www.cell.com www.cell.com
    Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression
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      DOI: 10.1016/j.isci.2021.102653

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    cell.com/iscience/abstract/S2589-0042(21)00621-0
  59. www.sciencedirect.com www.sciencedirect.com
    MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway
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      DOI: 10.1016/j.ebiom.2021.103441

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    sciencedirect.com/science/article/pii/S2352396421002346
  60. Apr 2021
  61. www.sciencedirect.com www.sciencedirect.com
    MicroRNA-29 is an essential regulator of brain maturation through regulation of CH methylation
    1
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      RRID:AB_2077850

      DOI: 10.1016/j.celrep.2021.108946

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    sciencedirect.com/science/article/pii/S2211124721002606
  62. Mar 2021
  63. www.sciencedirect.com www.sciencedirect.com
    Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer
    1
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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Isorhamnetin Inhibits Human Gallbladder Cancer Cell Proliferation and Metastasis via PI3K/AKT Signaling Pathway Inactivation
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      RRID:AB_2077850

      DOI: 10.3389/fphar.2021.628621

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  65. Jan 2021
  66. link.springer.com link.springer.com
    A novel ligand of the translationally controlled tumor protein (TCTP) identified by virtual drug screening for cancer differentiation therapy
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      RRID:AB_2077850

      DOI: 10.1007/s10637-020-01042-w

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  67. Sep 2020
  68. www.sciencedirect.com www.sciencedirect.com
    Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
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      RRID:AB_2077850

      DOI: 10.1016/j.ccell.2019.12.006

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  69. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Long noncoding RNA SOX2OT promotes the proliferation of pancreatic cancer by binding to FUS
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    1. scibot 04 Sep 2020
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      DOI: 10.1002/ijc.32827

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  70. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    RABL6A is an essential driver of MPNSTs that negatively regulates the RB1 pathway and sensitizes tumor cells to CDK4/6 inhibitors
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      p27

      DOI: 10.1158/1078-0432.CCR-19-2706

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  71. Jan 2020
  72. www.sciencedirect.com www.sciencedirect.com
    GRWD1 promotes cell proliferation and migration in non-small cell lung cancer by activating the Notch pathway
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      DOI: 10.1016/j.yexcr.2019.111806

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  73. www.sciencedirect.com www.sciencedirect.com
    The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling
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    1. scibot 13 Jan 2020
      RRID:AB_2077850

      DOI: 10.1016/j.celrep.2019.06.055

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  74. www.sciencedirect.com www.sciencedirect.com
    Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells
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    1. scibot 13 Jan 2020
      RRID:AB_2077850

      DOI: 10.1016/j.cels.2019.11.001

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  75. Nov 2018
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  77. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S235239641830238X
  78. Nov 2017
  79. www.sciencedirect.com www.sciencedirect.com
    Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G0/G1 Arrest by Inhibiting Deubiquitinase USP2a
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      AB_2077850

      Curator: @Zeljana_Babic

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  80. www.sciencedirect.com www.sciencedirect.com
    Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation
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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis
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      AB_2077850

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