61 Matching Annotations
  1. Jun 2024
  2. www.sciencedirect.com www.sciencedirect.com
    The ribotoxic stress response drives UV-mediated cell death
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    1. scibot 06 Jun 2024
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    sciencedirect.com/science/article/pii/S0092867424005270
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    Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
    1
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    sciencedirect.com/science/article/pii/S1534580724003277
  4. May 2024
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    Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations
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    1. scibot 23 May 2024
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      DOI: 10.1016/j.xcrm.2024.101578

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    sciencedirect.com/science/article/pii/S2666379124002702
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors
    1
    1. scibot 02 May 2024
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      DOI: 10.1016/j.xgen.2024.100550

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    ncbi.nlm.nih.gov/pmc/articles/PMC11099347/
  7. Apr 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SETD2 loss and ATR inhibition synergize to promote cGAS signaling and immunotherapy response in renal cell carcinoma
    1
    1. scibot 03 Apr 2024
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      DOI: 10.1158/1078-0432.CCR-23-1003

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    ncbi.nlm.nih.gov/pmc/articles/PMC10592192/
  9. Mar 2024
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor acidosis-induced DNA damage response and tetraploidy enhance sensitivity to ATM and ATR inhibitors
    1
    1. scibot 16 Mar 2024
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      DOI: 10.1038/s44319-024-00089-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC10933359/
  11. Feb 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 mediated Y-chromosome elimination affects human cells transcriptome
    1
    1. scibot 02 Feb 2024
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      DOI: 10.1186/s13578-024-01198-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC10829266/
  13. Jan 2024
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    Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells
    1
    1. scibot 19 Jan 2024
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    sciencedirect.com/science/article/pii/S2666379123006055
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    Oxidative guanine base damage plays a dual role in regulating productive ALT-associated homology-directed repair
    1
    1. scibot 09 Jan 2024
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      DOI: 10.1016/j.celrep.2023.113656

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    sciencedirect.com/science/article/pii/S2211124723016674
  16. Dec 2023
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    Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives
    1
    1. scibot 29 Dec 2023
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      DOI: 10.1016/j.isci.2023.108659

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    sciencedirect.com/science/article/pii/S2589004223027360
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FBXW7-loss sensitizes cells to ATR inhibition through induced mitotic catastrophe
    1
    1. scibot 23 Dec 2023
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    ncbi.nlm.nih.gov/pmc/articles/PMC10734389/
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    PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition
    1
    1. scibot 20 Dec 2023
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      DOI: 10.1016/j.xcrm.2023.101326

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    sciencedirect.com/science/article/pii/S2666379123005438
  20. Nov 2023
  21. www.sciencedirect.com www.sciencedirect.com
    Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma
    1
    1. scibot 02 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113307

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    sciencedirect.com/science/article/pii/S2211124723013190
  22. Oct 2023
  23. www.sciencedirect.com www.sciencedirect.com
    Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells
    1
    1. scibot 14 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113180

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    sciencedirect.com/science/article/pii/S2211124723011920
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    Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer
    1
    1. scibot 01 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113144

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    sciencedirect.com/science/article/pii/S2211124723011567
  25. Sep 2023
  26. www.sciencedirect.com www.sciencedirect.com
    The interplay of TARG1 and PARG protects against genomic instability
    1
    1. scibot 12 Sep 2023
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    sciencedirect.com/science/article/pii/S2211124723011245
  27. Aug 2023
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activator protein-1 (AP-1) signaling inhibits the growth of Ewing sarcoma cells in response to DNA replication stress
    1
    1. scibot 26 Aug 2023
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      DOI: 10.1158/2767-9764.CRC-23-0268

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    ncbi.nlm.nih.gov/pmc/articles/PMC10434289/
  29. 52.53.155.43 52.53.155.43
    crc-23-0268-html.html
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    1. scibot 11 Aug 2023
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  30. www.sciencedirect.com www.sciencedirect.com
    The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway
    1
    1. scibot 05 Aug 2023
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      DOI: 10.1016/j.isci.2023.107449

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    sciencedirect.com/science/article/pii/S2589004223015262
  31. Jul 2023
  32. www.sciencedirect.com www.sciencedirect.com
    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
    1
    1. scibot 14 Jul 2023
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      DOI: 10.1016/j.ccell.2023.06.007

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    sciencedirect.com/science/article/pii/S1535610823002179
  33. Jun 2023
  34. www.sciencedirect.com www.sciencedirect.com
    DHX9-mediated pathway contributes to the malignant phenotype of Myelodysplastic syndromes
    1
    1. scibot 09 Jun 2023
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      DOI: 10.1016/j.isci.2023.106962

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    sciencedirect.com/science/article/pii/S2589004223010398
  35. Apr 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response
    1
    1. scibot 20 Apr 2023
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      DOI: 10.1016/j.celrep.2023.112400

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    sciencedirect.com/science/article/pii/S2211124723004114
  37. Jan 2023
  38. www.sciencedirect.com www.sciencedirect.com
    SUMOylation of HNRNPA2B1 modulates RPA dynamics during unperturbed replication and genotoxic stress responses
    1
    1. scibot 26 Jan 2023
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      DOI: 10.1016/j.molcel.2023.01.003

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    sciencedirect.com/science/article/pii/S1097276523000035
  39. Jul 2022
  40. www.sciencedirect.com www.sciencedirect.com
    Guiding ATR and PARP inhibitor combinationswith chemogenomic screens
    1
    1. scibot 13 Jul 2022
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      DOI: 10.1016/j.celrep.2022.111081

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    sciencedirect.com/science/article/pii/S2211124722008798
  41. Jun 2022
  42. www.sciencedirect.com www.sciencedirect.com
    MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression
    1
    1. scibot 03 Jun 2022
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      DOI: 10.1016/j.celrep.2022.110879

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    sciencedirect.com/science/article/pii/S2211124722006544
  43. May 2022
  44. www.sciencedirect.com www.sciencedirect.com
    DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
    1
    1. scibot 20 May 2022
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      DOI: 10.1016/j.molcel.2022.04.030

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    sciencedirect.com/science/article/pii/S1097276522003938
  45. Apr 2022
  46. aacrjournals.org aacrjournals.org
    Rational Combination of CRM1 Inhibitor Selinexor and Olaparib Shows Synergy in Ovarian Cancer Cell Lines and Mouse Models
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    1. scibot 22 Apr 2022
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      DOI: 10.1158/1535-7163.MCT-21-0370

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    aacrjournals.org/mct/article/20/12/2352/675163/Rational-Combination-of-CRM1-Inhibitor-Selinexor
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress
    1
    1. scibot 05 Apr 2022
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      DOI: 10.1038/s41598-022-09308-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC8971416/
  48. Mar 2022
  49. www.sciencedirect.com www.sciencedirect.com
    BMI-1 regulates DNA end resection and homologous recombination repair
    1
    1. scibot 23 Mar 2022
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      DOI: 10.1016/j.celrep.2022.110536

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    sciencedirect.com/science/article/pii/S2211124722002777
  50. Jan 2022
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer
    1
    1. scibot 22 Jan 2022
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      DOI: 10.3390/cancers14020326

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    ncbi.nlm.nih.gov/pmc/articles/PMC8773906/
  52. www.sciencedirect.com www.sciencedirect.com
    Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells
    1
    1. scibot 16 Jan 2022
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      DOI: 10.1016/j.celrep.2021.110236

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    sciencedirect.com/science/article/pii/S2211124721017459
  53. www.sciencedirect.com www.sciencedirect.com
    ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization
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      DOI: 10.1016/j.celrep.2021.110216

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    sciencedirect.com/science/article/pii/S2211124721017204
  54. Dec 2021
  55. www.sciencedirect.com www.sciencedirect.com
    Assessing kinetics and recruitment of DNA repair factors using high content screens
    1
    1. scibot 29 Dec 2021
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      DOI: 10.1016/j.celrep.2021.110176

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    sciencedirect.com/science/article/pii/S2211124721016764
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    NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis
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      DOI: 10.1016/j.cmet.2021.11.011

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    sciencedirect.com/science/article/pii/S1550413121005398
  57. www.sciencedirect.com www.sciencedirect.com
    CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
    1
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      DOI: 10.1016/j.celrep.2021.110060

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    sciencedirect.com/science/article/pii/S2211124721015461
  58. Oct 2021
  59. www.sciencedirect.com www.sciencedirect.com
    Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress
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      DOI: 10.1016/j.molcel.2021.09.029

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    sciencedirect.com/science/article/pii/S109727652100798X
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    Shift in MSL1 alternative polyadenylation in response to DNA damage protects cancer cells from chemotherapeutic agent-induced apoptosis
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    1. scibot 13 Oct 2021
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      DOI: 10.1016/j.celrep.2021.109815

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    sciencedirect.com/science/article/pii/S2211124721012791
  61. Aug 2021
  62. www.sciencedirect.com www.sciencedirect.com
    Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis
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      DOI: 10.1016/j.ccell.2021.07.006

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    sciencedirect.com/science/article/pii/S1535610821003834
  63. europepmc.org europepmc.org
    Untitled document
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      DOI: 10.7554/eLife.40856

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    europepmc.org/articles/PMC6292694/
  64. Jul 2021
  65. www.sciencedirect.com www.sciencedirect.com
    mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
    1
    1. scibot 29 Jul 2021
      Chk1

      DOI: 10.1016/j.ccell.2017.09.013

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  66. Jun 2021
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways
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      RRID:AB_2080320

      DOI: 10.3390/cancers13112840

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  68. May 2021
  69. www.sciencedirect.com www.sciencedirect.com
    CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress
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      RRID:AB_2080320

      DOI: 10.1016/j.molcel.2020.10.008

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  70. Apr 2021
  71. www.sciencedirect.com www.sciencedirect.com
    Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress
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      RRID:AB_2080320

      DOI: 10.1016/j.ccell.2021.02.014

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  72. Feb 2021
  73. www.sciencedirect.com www.sciencedirect.com
    FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells
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      DOI: 10.1016/j.cell.2020.11.042

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  74. www.sciencedirect.com www.sciencedirect.com
    The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma
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      DOI: 10.1016/j.molcel.2020.12.046

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  75. Dec 2020
  76. www.sciencedirect.com www.sciencedirect.com
    Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
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      RRID:AB_2080320

      DOI: 10.1016/j.molcel.2020.12.006

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  77. www.sciencedirect.com www.sciencedirect.com
    Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA Damage
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      RRID:AB_2080320

      DOI: 10.1016/j.celrep.2020.108449

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  78. Oct 2020
  79. www.sciencedirect.com www.sciencedirect.com
    Persistent DNA Damage and Senescence in the Placenta Impacts Developmental Outcomes of Embryos
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      DOI: 10.1016/j.devcel.2020.05.025

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  80. Sep 2020
  81. www.sciencedirect.com www.sciencedirect.com
    Genome-wide Nucleotide-Resolution Mapping of DNA Replication Patterns, Single-Strand Breaks, and Lesions by GLOE-Seq
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  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The integrated stress response induces R-loops and hinders replication fork progression
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      DOI: 10.1038/s41419-020-2727-2

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  83. www.sciencedirect.com www.sciencedirect.com
    FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function
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  84. Jan 2020
  85. academic.oup.com academic.oup.com
    Synergistic Highly Potent Targeted Drug Combinations in different Pheochromocytoma Models including Human Tumor Cultures
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      RRID:AB_2080320

      DOI: 10.1210/en.2019-00410

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  86. www.sciencedirect.com www.sciencedirect.com
    The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics
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      RRID:AB_2080320

      DOI: 10.1016/j.celrep.2019.08.106

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  87. www.sciencedirect.com www.sciencedirect.com
    Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium
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      RRID:AB_2080320

      DOI: 10.1016/j.celrep.2019.06.043

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    sciencedirect.com/science/article/pii/S2211124719308162
  88. www.sciencedirect.com www.sciencedirect.com
    IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer
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      AB_2080320

      DOI: 10.1016/j.molcel.2019.05.036

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  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      RRID:AB_2080320

      DOI: 10.7554/eLife.40856

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    ncbi.nlm.nih.gov/pmc/articles/PMC6292694/
  90. www.sciencedirect.com www.sciencedirect.com
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      RRID:AB_2080320

      DOI: 10.1016/j.molcel.2019.04.024

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    sciencedirect.com/science/article/pii/S1097276519303168
  91. www.sciencedirect.com www.sciencedirect.com
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      RRID:AB_2080320

      DOI: 10.1016/j.molcel.2018.12.008

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    sciencedirect.com/science/article/pii/S1097276518310621
  92. Nov 2018
  93. www.sciencedirect.com www.sciencedirect.com
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      RRID:AB_2080320

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    sciencedirect.com/science/article/pii/S2211124718314529
  94. www.sciencedirect.com www.sciencedirect.com
    MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation
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      RRID:AB_2080320

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    sciencedirect.com/science/article/pii/S1535610818302691
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Functional Annotation of Somatic Mutations in Cancer
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      RRID:AB_2080320

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