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Exploiting the polypharmacology of alectinib for synergistic RNA splicing disruption with RBM39 degraders

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116784
  
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sciencedirect.com/science/article/pii/S2211124725015566
Oct 2025
www.biorxiv.org www.biorxiv.org

L-asparaginase treatment induces a tumor metabolic plasticity and reveals a vulnerability to PARP1/2 inhibitor Olaparib, in B-cell lymphomas

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1. scibot 30 Oct 2025
  
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  DOI: 10.1101/2025.10.24.683536
  
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biorxiv.org/content/10.1101/2025.10.24.683536v1
Sep 2025
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Oxidative-stress-induced telomere instability drives T cell dysfunction in cancer

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1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.immuni.2025.08.008
  
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sciencedirect.com/science/article/pii/S1074761325003711
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Wnt10b signaling regulates replication stress–induced chromosomal instability in human cancer

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1. scibot 07 Sep 2025
  
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  DOI: 10.26508/lsa.202503295
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12373720/
Jul 2025
journals.biologists.com journals.biologists.com

CDX2 inducible microRNAs sustain colon cancer by targeting multiple DNA damage response pathway factors

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1. scibot 23 Jul 2025
  
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  DOI: 10.1242/jcs.258601
  
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journals.biologists.com/jcs/article/134/15/jcs258601/271222/CDX2-inducible-microRNAs-sustain-colon-cancer-by
Jun 2025
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CRISPR/Cas9 Screening Highlights PFKFB3 Gene as a Major Contributor to 5-Fluorouracil Resistance in Esophageal Cancer

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1. scibot 12 Jun 2025
  
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  DOI: 10.3390/cancers17101637
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12109790/
May 2025
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IMPDH inhibition induces DNA replication stress and ATR sensitivity in Merkel cell carcinoma

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.isci.2025.112567
  
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sciencedirect.com/science/article/pii/S2589004225008284
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Circular RNA circATM binds PARP1 to suppress Wnt/β-catenin signaling and induce cell cycle arrest in gastric cancer cells

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.jare.2025.04.033
  
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sciencedirect.com/science/article/pii/S2090123225002772
Feb 2025
bmccancer.biomedcentral.com bmccancer.biomedcentral.com

Combined inhibition of ribonucleotide reductase and WEE1 induces synergistic anticancer activity in Ewing’s sarcoma cells

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1. scibot 20 Feb 2025
  
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  DOI: 10.1186/s12885-025-13691-2
  
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bmccancer.biomedcentral.com/articles/10.1186/s12885-025-13691-2
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Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies

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1. scibot 11 Feb 2025
  
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  DOI: 10.1016/j.xcrm.2025.101964
  
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sciencedirect.com/science/article/pii/S2666379125000370
Dec 2024
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Transcriptional and functional regulation of cell cycle and UV response by PPARβ in human skin epidermal cells

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1. scibot 06 Dec 2024
  
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  DOI: 10.1096/fj.202401950R
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11610672/
Nov 2024
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Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer

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1. scibot 15 Nov 2024
  
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  DOI: 10.1016/j.isci.2024.111283
  
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sciencedirect.com/science/article/pii/S2589004224025082
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Acute multi-level response to defective de novo chromatin assembly in S-phase

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1. scibot 14 Nov 2024
  
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  DOI: 10.1016/j.molcel.2024.10.023
  
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sciencedirect.com/science/article/pii/S1097276524008633
Oct 2024
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Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts

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1. scibot 09 Oct 2024
  
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  DOI: 10.1016/j.molcel.2024.09.020
  
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sciencedirect.com/science/article/pii/S1097276524007767
Sep 2024
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Transient splicing inhibition causes persistent DNA damage and chemotherapy vulnerability in triple-negative breast cancer

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1. scibot 17 Sep 2024
  
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  DOI: 10.1016/j.celrep.2024.114751
  
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sciencedirect.com/science/article/pii/S2211124724011021
Aug 2024
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Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

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1. scibot 21 Aug 2024
  
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  DOI: 10.1126/science.adk0775
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11301402/
Jul 2024
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Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

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1. scibot 18 Jul 2024
  
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  DOI: 10.1126/science.adk0775
  
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science.org/doi/10.1126/science.adk0775
Jun 2024
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The ribotoxic stress response drives UV-mediated cell death

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1. scibot 06 Jun 2024
  
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  DOI: 10.1016/j.cell.2024.05.018
  
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sciencedirect.com/science/article/pii/S0092867424005270
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Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

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1. scibot 04 Jun 2024
  
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  DOI: 10.1016/j.devcel.2024.05.010
  
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sciencedirect.com/science/article/pii/S1534580724003277
May 2024
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Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations

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1. scibot 23 May 2024
  
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  DOI: 10.1016/j.xcrm.2024.101578
  
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sciencedirect.com/science/article/pii/S2666379124002702
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NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors

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1. scibot 02 May 2024
  
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  DOI: 10.1016/j.xgen.2024.100550
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11099347/
Apr 2024
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SETD2 loss and ATR inhibition synergize to promote cGAS signaling and immunotherapy response in renal cell carcinoma

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1. scibot 03 Apr 2024
  
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  DOI: 10.1158/1078-0432.CCR-23-1003
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10592192/
Mar 2024
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Tumor acidosis-induced DNA damage response and tetraploidy enhance sensitivity to ATM and ATR inhibitors

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1. scibot 16 Mar 2024
  
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  DOI: 10.1038/s44319-024-00089-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10933359/
Feb 2024
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CRISPR/Cas9 mediated Y-chromosome elimination affects human cells transcriptome

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1. scibot 02 Feb 2024
  
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  DOI: 10.1186/s13578-024-01198-5
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10829266/
Jan 2024
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Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells

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1. scibot 19 Jan 2024
  
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  DOI: 10.1016/j.xcrm.2023.101376
  
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sciencedirect.com/science/article/pii/S2666379123006055
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Oxidative guanine base damage plays a dual role in regulating productive ALT-associated homology-directed repair

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1. scibot 09 Jan 2024
  
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  DOI: 10.1016/j.celrep.2023.113656
  
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sciencedirect.com/science/article/pii/S2211124723016674
Dec 2023
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Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives

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1. scibot 29 Dec 2023
  
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  DOI: 10.1016/j.isci.2023.108659
  
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FBXW7-loss sensitizes cells to ATR inhibition through induced mitotic catastrophe

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1. scibot 23 Dec 2023
  
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  DOI: 10.1158/2767-9764.CRC-23-0306
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10734389/
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PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition

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1. scibot 20 Dec 2023
  
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  DOI: 10.1016/j.xcrm.2023.101326
  
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sciencedirect.com/science/article/pii/S2666379123005438
Nov 2023
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Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma

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  DOI: 10.1016/j.celrep.2023.113307
  
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sciencedirect.com/science/article/pii/S2211124723013190
Oct 2023
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Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells

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  DOI: 10.1016/j.celrep.2023.113180
  
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Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer

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  DOI: 10.1016/j.celrep.2023.113144
  
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sciencedirect.com/science/article/pii/S2211124723011567
Sep 2023
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The interplay of TARG1 and PARG protects against genomic instability

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1. scibot 12 Sep 2023
  
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  DOI: 10.1016/j.celrep.2023.113113
  
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sciencedirect.com/science/article/pii/S2211124723011245
Aug 2023
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Activator protein-1 (AP-1) signaling inhibits the growth of Ewing sarcoma cells in response to DNA replication stress

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1. scibot 26 Aug 2023
  
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  DOI: 10.1158/2767-9764.CRC-23-0268
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10434289/
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1. scibot 11 Aug 2023
  
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  DOI: 10.1158/2767-9764.CRC-23-0268
  
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The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway

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Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling

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DHX9-mediated pathway contributes to the malignant phenotype of Myelodysplastic syndromes

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Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response

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SUMOylation of HNRNPA2B1 modulates RPA dynamics during unperturbed replication and genotoxic stress responses

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Guiding ATR and PARP inhibitor combinationswith chemogenomic screens

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MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression

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DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production

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Rational Combination of CRM1 Inhibitor Selinexor and Olaparib Shows Synergy in Ovarian Cancer Cell Lines and Mouse Models

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A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress

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BMI-1 regulates DNA end resection and homologous recombination repair

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CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer

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Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells

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ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization

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Assessing kinetics and recruitment of DNA repair factors using high content screens

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NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis

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CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment

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Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress

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Shift in MSL1 alternative polyadenylation in response to DNA damage protects cancer cells from chemotherapeutic agent-induced apoptosis

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Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis

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Untitled document

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mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability

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A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways

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CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress

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Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress

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FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

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The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma

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Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

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Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA Damage

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Persistent DNA Damage and Senescence in the Placenta Impacts Developmental Outcomes of Embryos

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Genome-wide Nucleotide-Resolution Mapping of DNA Replication Patterns, Single-Strand Breaks, and Lesions by GLOE-Seq

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The integrated stress response induces R-loops and hinders replication fork progression

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FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function

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Synergistic Highly Potent Targeted Drug Combinations in different Pheochromocytoma Models including Human Tumor Cultures

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The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics

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Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium

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IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer

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  DOI: 10.7554/eLife.40856
  
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  DOI: 10.1016/j.molcel.2019.04.024
  
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  DOI: 10.1016/j.molcel.2018.12.008
  
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MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation

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Systematic Functional Annotation of Somatic Mutations in Cancer

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