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Wnt10b signaling regulates replication stress–induced chromosomal instability in human cancer

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1. scibot 07 Sep 2025
  
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  RRID:AB_2080323
  
  DOI: 10.26508/lsa.202503295
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12373720/
Jul 2025
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The mitotic ATR-Chk1 pathway promotes CDK1 activity for faithful chromosome segregation

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1. scibot 24 Jul 2025
  
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  RRID:AB_2080323
  
  DOI: 10.1016/j.celrep.2025.116019
  
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sciencedirect.com/science/article/pii/S2211124725007909
Nov 2024
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Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer

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1. scibot 15 Nov 2024
  
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  RRID:AB_2080323
  
  DOI: 10.1016/j.isci.2024.111283
  
  Resource: (Cell Signaling Technology Cat# 2349, RRID:AB_2080323)
  
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sciencedirect.com/science/article/pii/S2589004224025082
Sep 2024
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Transient splicing inhibition causes persistent DNA damage and chemotherapy vulnerability in triple-negative breast cancer

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1. scibot 17 Sep 2024
  
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  AB_2080323
  
  DOI: 10.1016/j.celrep.2024.114751
  
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sciencedirect.com/science/article/pii/S2211124724011021
Jun 2024
www.cell.com www.cell.com

CHK1 inhibitor SRA737 is active in PARP inhibitor resistant and CCNE1 amplified ovarian cancer

1
1. scibot 29 Jun 2024
  
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  RRID:AB_2080323
  
  DOI: 10.1016/j.isci.2024.109978
  
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cell.com/iscience/abstract/S2589-0042(24)01200-8
Dec 2023
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PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition

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1. scibot 20 Dec 2023
  
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  RRID:AB_2080323
  
  DOI: 10.1016/j.xcrm.2023.101326
  
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sciencedirect.com/science/article/pii/S2666379123005438
May 2023
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Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway

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1. scibot 17 May 2023
  
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  RRID:AB_2080323
  
  DOI: 10.1016/j.cell.2023.04.026
  
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sciencedirect.com/science/article/pii/S0092867423004221
Nov 2022
academic.oup.com academic.oup.com

Multiple-low-dose therapy: effective killing of high-grade serous ovarian cancer cells with ATR and CHK1 inhibitors

1
1. scibot 15 Nov 2022
  
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  RRID:AB_2080323
  
  DOI: 10.1093/narcan/zcac036
  
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academic.oup.com/narcancer/article/4/4/zcac036/6825304
Mar 2022
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Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome

1
1. scibot 04 Mar 2022
  
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  RRID:AB_2080323
  
  DOI: 10.1016/j.devcel.2022.02.013
  
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sciencedirect.com/science/article/pii/S153458072200079X
Jan 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer

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1. scibot 22 Jan 2022
  
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  RRID:AB_2080323
  
  DOI: 10.3390/cancers14020326
  
  Resource: (Cell Signaling Technology Cat# 2349, RRID:AB_2080323)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8773906/
Aug 2021
www.jbc.org www.jbc.org

Inhibition of checkpoint kinase 1 following gemcitabine-mediated S phase arrest results in CDC7- and CDK2-dependent replication catastrophe

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1. scibot 03 Aug 2021
  
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  AB_2080323
  
  DOI: 10.1074/jbc.RA118.005231
  
  Resource: (Cell Signaling Technology Cat# 2349, RRID:AB_2080323)
  
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jbc.org/content/294/6/1763.full
May 2021
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TopBP1 assembles nuclear condensates to switch on ATR signaling

1
1. scibot 08 May 2021
  
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  RRID:AB_2080323
  
  DOI: 10.1016/j.molcel.2020.12.049
  
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sciencedirect.com/science/article/pii/S1097276520309916
Jan 2021
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Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A

1
1. scibot 27 Jan 2021
  
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  RRID:AB_2080323
  
  DOI: 10.1016/j.celrep.2020.108680
  
  Resource: (Cell Signaling Technology Cat# 2349, RRID:AB_2080323)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2080323
  
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  RRIDCUR:Validated RRID:AB_2080323
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sciencedirect.com/science/article/pii/S2211124720316697
Jan 2020
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The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2080323
  
  DOI: 10.1016/j.celrep.2019.08.106
  
  Resource: (Cell Signaling Technology Cat# 2349, RRID:AB_2080323)
  
  Curator: @ethanbadger
  
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  RRID:AB_2080323 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124719311684
Nov 2017
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Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication

1
1. scibot 08 Nov 2017
  
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  Rabbit polyclonal anti-Phospho-Chk1 (Ser296)Cell SignalingCat# 2349
  
  Curator: @Jmenke
  
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  (Cell Signaling Technology Cat# 2349, RRID:AB_2080323)
  
  SciCrunch record: RRID:AB_2080323
  
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  RRID:AB_2080323 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S1097276517301727