40 Matching Annotations
  1. Nov 2024
  2. www.sciencedirect.com www.sciencedirect.com
    A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR-Cas9 gene editing in hematopoietic stem and progenitor cells
    1
    1. scibot 14 Nov 2024
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    sciencedirect.com/science/article/pii/S2666379124005949
  3. Jul 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication
    1
    1. scibot 14 Jul 2024
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      DOI: 10.1016/j.isci.2024.110144

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    ncbi.nlm.nih.gov/pmc/articles/PMC11233922/
  5. Jun 2024
  6. www.sciencedirect.com www.sciencedirect.com
    Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
    1
    1. scibot 04 Jun 2024
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    sciencedirect.com/science/article/pii/S1534580724003277
  7. May 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors
    1
    1. scibot 02 May 2024
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      DOI: 10.1016/j.xgen.2024.100550

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    ncbi.nlm.nih.gov/pmc/articles/PMC11099347/
  9. Apr 2024
  10. rupress.org rupress.org
    DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response
    2
    1. scibot 25 Apr 2024
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      DOI: 10.1083/jcb.202303141

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    2. scibot 25 Apr 2024
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      DOI: 10.1083/jcb.202303141

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    rupress.org/jcb/article/223/5/e202303141/276604/DUX4-induced-HSATII-transcription-causes-KDM2A-B
  11. Mar 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor acidosis-induced DNA damage response and tetraploidy enhance sensitivity to ATM and ATR inhibitors
    1
    1. scibot 16 Mar 2024
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      DOI: 10.1038/s44319-024-00089-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC10933359/
  13. Feb 2024
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Temozolomide sensitizes ARID1A-mutated cancers to PARP inhibitors
    1
    1. scibot 16 Feb 2024
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      DOI: 10.1158/0008-5472.CAN-22-3646

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    ncbi.nlm.nih.gov/pmc/articles/PMC10527942/
  15. Jan 2024
  16. www.sciencedirect.com www.sciencedirect.com
    Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells
    1
    1. scibot 19 Jan 2024
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      DOI: 10.1016/j.xcrm.2023.101376

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    sciencedirect.com/science/article/pii/S2666379123006055
  17. Sep 2023
  18. 52.53.155.43 52.53.155.43
    can-22-3646-html.html
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    1. scibot 22 Sep 2023
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  19. www.sciencedirect.com www.sciencedirect.com
    The interplay of TARG1 and PARG protects against genomic instability
    1
    1. scibot 12 Sep 2023
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      DOI: 10.1016/j.celrep.2023.113113

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    sciencedirect.com/science/article/pii/S2211124723011245
  20. Aug 2023
  21. www.sciencedirect.com www.sciencedirect.com
    The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway
    1
    1. scibot 05 Aug 2023
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      DOI: 10.1016/j.isci.2023.107449

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    sciencedirect.com/science/article/pii/S2589004223015262
  22. Jul 2023
  23. www.sciencedirect.com www.sciencedirect.com
    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
    1
    1. scibot 14 Jul 2023
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      DOI: 10.1016/j.ccell.2023.06.007

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    sciencedirect.com/science/article/pii/S1535610823002179
  24. www.nature.com www.nature.com
    Kinome-wide CRISPR-Cas9 knockout screens revealed PLK1 as a therapeutic target for osteosarcoma
    1
    1. scibot 08 Jul 2023
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      DOI: 10.1038/s41420-023-01526-7

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    nature.com/articles/s41420-023-01526-7
  25. Apr 2023
  26. www.sciencedirect.com www.sciencedirect.com
    A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer
    1
    1. scibot 19 Apr 2023
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      DOI: 10.1016/j.xcrm.2023.101015

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    sciencedirect.com/science/article/pii/S2666379123001258
  27. www.sciencedirect.com www.sciencedirect.com
    SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology
    1
    1. scibot 06 Apr 2023
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      DOI: 10.1016/j.molcel.2023.02.004

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    sciencedirect.com/science/article/pii/S1097276523000837
  28. Nov 2022
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway
    1
    1. scibot 09 Nov 2022
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      DOI: 10.1016/j.isci.2022.105342

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    ncbi.nlm.nih.gov/pmc/articles/PMC9633742/
  30. Apr 2022
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress
    1
    1. scibot 05 Apr 2022
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      DOI: 10.1038/s41598-022-09308-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC8971416/
  32. Mar 2022
  33. www.sciencedirect.com www.sciencedirect.com
    Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome
    1
    1. scibot 04 Mar 2022
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      DOI: 10.1016/j.devcel.2022.02.013

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    sciencedirect.com/science/article/pii/S153458072200079X
  34. Jan 2022
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
    1
    1. scibot 05 Jan 2022
      RRID:AB_2244927

      DOI: 10.1016/j.ccell.2019.04.011

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    ncbi.nlm.nih.gov/pmc/articles/PMC8717880/
  36. Dec 2021
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of ATM induces hypersensitivity to proton irradiation by upregulating toxic end joining
    1
    1. scibot 17 Dec 2021
      RRID:AB_2080501

      DOI: 10.1158/0008-5472.CAN-20-2960

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    ncbi.nlm.nih.gov/pmc/articles/PMC8260463/
  38. Sep 2021
  39. www.sciencedirect.com www.sciencedirect.com
    GAGE mediates radio resistance in cervical cancers via the regulation of chromatin accessibility
    1
    1. scibot 01 Sep 2021
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      DOI: 10.1016/j.celrep.2021.109621

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    sciencedirect.com/science/article/pii/S2211124721010597
  40. Jun 2021
  41. www.sciencedirect.com www.sciencedirect.com
    MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway
    1
    1. scibot 24 Jun 2021
      AB_2080501

      DOI: 10.1016/j.ebiom.2021.103441

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    sciencedirect.com/science/article/pii/S2352396421002346
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways
    1
    1. scibot 16 Jun 2021
      RRID:AB_2080501

      DOI: 10.3390/cancers13112840

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    ncbi.nlm.nih.gov/pmc/articles/PMC8201054/
  43. May 2021
  44. www.sciencedirect.com www.sciencedirect.com
    Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging
    1
    1. scibot 07 May 2021
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      DOI: 10.1016/j.molcel.2020.06.027

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    sciencedirect.com/science/article/pii/S1097276520304299
  45. Apr 2021
  46. www.sciencedirect.com www.sciencedirect.com
    Functional interrogation of DNA damage response variants with base editing screens
    1
    1. scibot 12 Apr 2021
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      DOI: 10.1016/j.cell.2021.01.041

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    sciencedirect.com/science/article/pii/S0092867421000842
  47. Mar 2021
  48. www.sciencedirect.com www.sciencedirect.com
    DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1
    1
    1. scibot 17 Mar 2021
      RRID:AB_2080501

      DOI: 10.1016/j.celrep.2021.108840

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    sciencedirect.com/science/article/pii/S2211124721001546
  49. Feb 2021
  50. www.sciencedirect.com www.sciencedirect.com
    FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells
    1
    1. scibot 27 Feb 2021
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      DOI: 10.1016/j.cell.2020.11.042

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    sciencedirect.com/science/article/pii/S0092867420316147
  51. elifesciences.org elifesciences.org
    The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure
    1
    1. scibot 24 Feb 2021
      RRID:AB_2080501

      DOI: 10.7554/eLife.61797

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    elifesciences.org/articles/61797
  52. Oct 2020
  53. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Rucaparib Treatment Alters p53 Oscillations in Single Cells to Enhance DNA-Double-Strand-Break-Induced Cell Cycle Arrest
    1
    1. scibot 20 Oct 2020
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      DOI: 10.1016/j.celrep.2020.108240

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    pubmed.ncbi.nlm.nih.gov/33053351/
  54. Sep 2020
  55. www.sciencedirect.com www.sciencedirect.com
    Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer
    1
    1. scibot 26 Sep 2020
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      DOI: 10.1016/j.celrep.2020.107745

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    sciencedirect.com/science/article/pii/S2211124720307257
  56. www.sciencedirect.com www.sciencedirect.com
    FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function
    1
    1. scibot 05 Sep 2020
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      DOI: 10.1016/j.celrep.2020.108018

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    sciencedirect.com/science/article/pii/S2211124720310032
  57. Jan 2020
  58. www.sciencedirect.com www.sciencedirect.com
    The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics
    1
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      DOI: 10.1016/j.celrep.2019.08.106

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    sciencedirect.com/science/article/pii/S2211124719311684
  59. www.sciencedirect.com www.sciencedirect.com
    Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity
    1
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      DOI: 10.1016/j.celrep.2019.07.070

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    sciencedirect.com/science/article/pii/S221112471930974X
  60. www.sciencedirect.com www.sciencedirect.com
    ATR Signaling Uncouples the Role of RAD51 Paralogs in Homologous Recombination and Replication Stress Response
    1
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      DOI: 10.1016/j.celrep.2019.09.008

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    sciencedirect.com/science/article/pii/S2211124719311854
  61. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.molcel.2019.04.024

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    sciencedirect.com/science/article/pii/S1097276519303168
  62. Nov 2018
  63. www.sciencedirect.com www.sciencedirect.com
    The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression
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    sciencedirect.com/science/article/pii/S1097276518300406
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Functional Annotation of Somatic Mutations in Cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC5926201/
  65. Nov 2017
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC5279869/
  67. www.sciencedirect.com www.sciencedirect.com
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    sciencedirect.com/science/article/pii/S2405471216304082