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  1. Last 7 days
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    NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors
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    1. scibot 02 May 2024
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    sciencedirect.com/science/article/pii/S2666979X2400106X
  3. Apr 2024
  4. rupress.org rupress.org
    DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response
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    rupress.org/jcb/article/223/5/e202303141/276604/DUX4-induced-HSATII-transcription-causes-KDM2A-B
  5. Mar 2024
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    Tumor acidosis-induced DNA damage response and tetraploidy enhance sensitivity to ATM and ATR inhibitors
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    1. scibot 16 Mar 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10933359/
  7. Feb 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Temozolomide sensitizes ARID1A-mutated cancers to PARP inhibitors
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    1. scibot 16 Feb 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10527942/
  9. Jan 2024
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    Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells
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    sciencedirect.com/science/article/pii/S2666379123006055
  11. Sep 2023
  12. 52.53.155.43 52.53.155.43
    can-22-3646-html.html
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    The interplay of TARG1 and PARG protects against genomic instability
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    1. scibot 12 Sep 2023
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    sciencedirect.com/science/article/pii/S2211124723011245
  14. Aug 2023
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    The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway
    1
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    sciencedirect.com/science/article/pii/S2589004223015262
  16. Jul 2023
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    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
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    1. scibot 14 Jul 2023
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    sciencedirect.com/science/article/pii/S1535610823002179
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    Kinome-wide CRISPR-Cas9 knockout screens revealed PLK1 as a therapeutic target for osteosarcoma
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    1. scibot 08 Jul 2023
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    nature.com/articles/s41420-023-01526-7
  19. Apr 2023
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    A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer
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    1. scibot 19 Apr 2023
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    sciencedirect.com/science/article/pii/S2666379123001258
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    SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology
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    1. scibot 06 Apr 2023
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    sciencedirect.com/science/article/pii/S1097276523000837
  22. Nov 2022
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway
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    1. scibot 09 Nov 2022
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    ncbi.nlm.nih.gov/pmc/articles/PMC9633742/
  24. Apr 2022
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress
    1
    1. scibot 05 Apr 2022
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      DOI: 10.1038/s41598-022-09308-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC8971416/
  26. Mar 2022
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    Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome
    1
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    sciencedirect.com/science/article/pii/S153458072200079X
  28. Jan 2022
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8717880/
  30. Dec 2021
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of ATM induces hypersensitivity to proton irradiation by upregulating toxic end joining
    1
    1. scibot 17 Dec 2021
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      DOI: 10.1158/0008-5472.CAN-20-2960

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    ncbi.nlm.nih.gov/pmc/articles/PMC8260463/
  32. Sep 2021
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    GAGE mediates radio resistance in cervical cancers via the regulation of chromatin accessibility
    1
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    sciencedirect.com/science/article/pii/S2211124721010597
  34. Jun 2021
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    MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway
    1
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    sciencedirect.com/science/article/pii/S2352396421002346
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways
    1
    1. scibot 16 Jun 2021
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      DOI: 10.3390/cancers13112840

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    ncbi.nlm.nih.gov/pmc/articles/PMC8201054/
  37. May 2021
  38. www.sciencedirect.com www.sciencedirect.com
    Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging
    1
    1. scibot 07 May 2021
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      DOI: 10.1016/j.molcel.2020.06.027

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    sciencedirect.com/science/article/pii/S1097276520304299
  39. Apr 2021
  40. www.sciencedirect.com www.sciencedirect.com
    Functional interrogation of DNA damage response variants with base editing screens
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      DOI: 10.1016/j.cell.2021.01.041

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    sciencedirect.com/science/article/pii/S0092867421000842
  41. Mar 2021
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    DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1
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    sciencedirect.com/science/article/pii/S2211124721001546
  43. Feb 2021
  44. www.sciencedirect.com www.sciencedirect.com
    FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells
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    sciencedirect.com/science/article/pii/S0092867420316147
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure
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    1. scibot 24 Feb 2021
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      DOI: 10.7554/eLife.61797

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    ncbi.nlm.nih.gov/pmc/articles/PMC7877914/
  46. Oct 2020
  47. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Rucaparib Treatment Alters p53 Oscillations in Single Cells to Enhance DNA-Double-Strand-Break-Induced Cell Cycle Arrest
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    1. scibot 20 Oct 2020
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      DOI: 10.1016/j.celrep.2020.108240

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    pubmed.ncbi.nlm.nih.gov/33053351/
  48. Sep 2020
  49. www.sciencedirect.com www.sciencedirect.com
    Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer
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    1. scibot 26 Sep 2020
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    sciencedirect.com/science/article/pii/S2211124720307257
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    FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function
    1
    1. scibot 05 Sep 2020
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    sciencedirect.com/science/article/pii/S2211124720310032
  51. Jan 2020
  52. www.sciencedirect.com www.sciencedirect.com
    The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics
    1
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      DOI: 10.1016/j.celrep.2019.08.106

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    sciencedirect.com/science/article/pii/S2211124719311684
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    Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity
    1
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      DOI: 10.1016/j.celrep.2019.07.070

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    sciencedirect.com/science/article/pii/S221112471930974X
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    ATR Signaling Uncouples the Role of RAD51 Paralogs in Homologous Recombination and Replication Stress Response
    1
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      DOI: 10.1016/j.celrep.2019.09.008

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    sciencedirect.com/science/article/pii/S2211124719311854
  55. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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      DOI: 10.1016/j.molcel.2019.04.024

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    sciencedirect.com/science/article/pii/S1097276519303168
  56. Nov 2018
  57. www.sciencedirect.com www.sciencedirect.com
    The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression
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    sciencedirect.com/science/article/pii/S1097276518300406
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Functional Annotation of Somatic Mutations in Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC5926201/
  59. Nov 2017
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    ncbi.nlm.nih.gov/pmc/articles/PMC5279869/
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    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    sciencedirect.com/science/article/pii/S2405471216304082