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Distinct signaling mechanisms and proteome phenotypes are elicited by compartment-specific genetic defects of copper homeostasis

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1. scibot 28 Mar 2026
  
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  AB_2085424
  
  DOI: 10.64898/2026.01.13.699066
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12871135/
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Control of lysosome function by the GTPase-activating protein TBC1D9B and its binding partner TMEM55B

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1. scibot 24 Mar 2026
  
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  DOI: 10.1038/s41467-026-70345-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12992710/
Mar 2026
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De novo recovery of Ghana virus, an African bat Henipavirus, reveals differential tropism and attenuated pathogenicity compared to Nipah virus

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1. scibot 13 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117074
  
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sciencedirect.com/science/article/pii/S221112472600152X
Jan 2026
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SREBP-1 upregulates SOAT1 to promote tumor growth by preventing lipotoxicity

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1. scibot 27 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116896
  
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sciencedirect.com/science/article/pii/S2211124725016687
Dec 2025
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Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender

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1. scibot 04 Dec 2025
  
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  DOI: 10.1016/j.cmet.2025.11.002
  
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sciencedirect.com:5037/science/article/pii/S1550413125004863
Nov 2025
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Intracellular Interleukin-1α in Peritumoral Monocytes Induces IL8 Production and Inhibits Mitophagy to Promote Stemness and Metastasis of Hepatocellular Carcinoma

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1. scibot 07 Nov 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-3355
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12580797/
Aug 2025
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Protocol for differentiating murine 3T3-L1 and SVF-derived preadipocytes and isolating crude mitochondrial fractions

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.xpro.2025.104045
  
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sciencedirect.com/science/article/pii/S2666166725004514
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Collagen XVII Promotes Pancreatic Ductal Adenocarcinoma Tumor Growth through Regulation of PIK3R5

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1. scibot 14 Aug 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0392
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12340215/
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Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis

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1. scibot 14 Aug 2025
  
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  DOI: 10.1016/j.devcel.2025.07.014
  
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sciencedirect.com/science/article/pii/S153458072500471X
Jul 2025
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Opantimirs: A class of antagonizing microRNAs that upregulate Opa1 and improve mitochondrial and disuse myopathies

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1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102248
  
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journals.physiology.org journals.physiology.org

3-Mercaptopyruvate sulfurtransferase/hydrogen sulfide protects cerebral endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury via mitoprotection and inhibition of the RhoA/ROCK pathway

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1. scibot 09 Jul 2025
  
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  DOI: 10.1152/ajpcell.00014.2020
  
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journals.physiology.org/doi/10.1152/ajpcell.00014.2020
Jun 2025
www.nature.com www.nature.com

DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation

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1. scibot 18 Jun 2025
  
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  RRID:AB_2085424
  
  DOI: 10.1038/s41594-025-01581-x
  
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nature.com/articles/s41594-025-01581-x
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Mitochondrial fumarate inhibits Parkin-mediated mitophagy

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.molcel.2025.05.021
  
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sciencedirect.com/science/article/pii/S1097276525004605
May 2025
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Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration | Molecular Biology of the Cell

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1. scibot 19 May 2025
  
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  AB_2085424
  
  DOI: 10.1091/mbc.E24-11-0512
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11974963/
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A novel TRKB-activating internal tandem duplication characterizes a new mechanism of receptor tyrosine kinase activation

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1. scibot 19 May 2025
  
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  DOI: 10.1038/s41698-025-00928-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12065843/
www.cell.com www.cell.com

CD47-blocking antibody confers metabolic benefits against obesity

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1. scibot 19 May 2025
  
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  DOI: 10.1016/j.xcrm.2025.102089
  
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cell.com/cell-reports-medicine/abstract/S2666-3791(25)00162-4
Mar 2025
www.cell.com www.cell.com

Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response

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1. scibot 04 Mar 2025
  
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  DOI: 10.1016/j.cell.2025.01.043
  
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cell.com/cell/abstract/S0092-8674(25)00145-X
Feb 2025
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Protocol for assessing the clogging of the mitochondrial translocase of the outer membrane by precursor proteins in human cells

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1. scibot 24 Feb 2025
  
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  DOI: 10.1016/j.xpro.2025.103617
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11835637/
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Rhodoquinone carries electrons in the mammalian electron transport chain

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1. scibot 06 Feb 2025
  
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  DOI: 10.1016/j.cell.2024.12.007
  
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sciencedirect.com/science/article/pii/S009286742401420X
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A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation

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1. scibot 04 Feb 2025
  
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  DOI: 10.1016/j.molcel.2025.01.003
  
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sciencedirect.com/science/article/pii/S1097276525000036
Jan 2025
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OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth

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1. scibot 28 Jan 2025
  
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  DOI: 10.1016/j.molcel.2024.12.025
  
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sciencedirect.com/science/article/pii/S1097276524010669
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Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy

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1. scibot 16 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115205
  
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sciencedirect.com/science/article/pii/S2211124724015560
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HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis

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1. scibot 03 Jan 2025
  
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  DOI: 10.1016/j.devcel.2024.12.011
  
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sciencedirect.com/science/article/pii/S1534580724007330
Dec 2024
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Resistance to Spindle Inhibitors in Glioblastoma Depends on STAT3 and Therapy Induced Senescence

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1. scibot 11 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111311
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11617384/
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OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase

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1. scibot 05 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115038
  
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sciencedirect.com/science/article/pii/S2211124724013895
Nov 2024
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Opposing roles for AMPK in regulating distinct mitophagy pathways

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1. scibot 20 Nov 2024
  
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  DOI: 10.1016/j.molcel.2024.10.025
  
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sciencedirect.com/science/article/pii/S1097276524008657
Oct 2024
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Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration

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1. scibot 05 Oct 2024
  
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  AB_2085424
  
  DOI: 10.1101/2024.09.09.612106
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11419079/
Sep 2024
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Geranylgeranylated SCFFBXO10 regulates selective outer mitochondrial membrane proteostasis and function

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1. scibot 26 Sep 2024
  
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  DOI: 10.1016/j.celrep.2024.114783
  
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sciencedirect.com/science/article/pii/S2211124724011343
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Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma

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1. scibot 05 Sep 2024
  
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  DOI: 10.1016/j.xcrm.2024.101706
  
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sciencedirect.com/science/article/pii/S2666379124004270
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CLPB disaggregase dysfunction impacts the functional integrity of the proteolytic SPY complex

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1. scibot 18 Aug 2024
  
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  AB_2085424
  
  DOI: 10.1083/jcb.202305087
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10818064/
Jul 2024
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ATAD1 prevents clogging of TOM and damage caused by un-imported mitochondrial proteins

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1. scibot 26 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114473
  
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sciencedirect.com/science/article/pii/S2211124724008027
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AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

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1. scibot 18 Jul 2024
  
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  DOI: 10.1038/s41422-024-00985-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11442470/
May 2024
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle

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1. scibot 24 May 2024
  
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  DOI: 10.1113/JP285719
  
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physoc.onlinelibrary.wiley.com/doi/10.1113/JP285719
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SARS-CoV-2 infection exacerbates the cellular pathology of Parkinson’s disease in human dopaminergic neurons and a mouse model

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1. scibot 16 May 2024
  
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  DOI: 10.1016/j.xcrm.2024.101570
  
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sciencedirect.com/science/article/pii/S2666379124002623
Apr 2024
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Adipocyte-Released Adipomes in Chagas Cardiomyopathy: Impact on Cardiac Metabolic and Immune Regulation

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1. scibot 28 Apr 2024
  
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  DOI: 10.1016/j.isci.2024.109672
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11039351/
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25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages

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Cross-link assisted spatial proteomics to map sub-organelle proteomes and membrane protein topologies

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IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

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Mitochondrial biogenesis in white adipose tissue mediated by JMJD1A-PGC-1 axis limits age-related metabolic disease

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NEMF-mediated Listerin-independent mitochondrial translational surveillance by E3 ligase Pirh2 and mitochondrial protease ClpXP

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The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells

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The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells

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Human Wharton’s jelly-derived mesenchymal stromal cells promote bone formation in immunodeficient mice when administered into a bone microenvironment

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Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis

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Luteal Lipid Droplets: A Novel Platform for Steroid Synthesis

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Two RNA-binding proteins mediate the sorting of miR223 from mitochondria into exosomes

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FUNDC1: a key mediator of adenosine A2BR activation-induced inhibition of cardiac mitophagy under ischemia/reperfusion conditions

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Human Tim8a, Tim8b and Tim13 are auxiliary assembly factors of mature Complex IV

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APOE expression and secretion are modulated by mitochondrial dysfunction

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Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer

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Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals

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Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis

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Two RNA-binding proteins mediate the sorting of miR223 from mitochondria into exosomes

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DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma

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ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells

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EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer

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Mechanisms of IRF2BPL-related disorders and identification of a potential therapeutic strategy

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The Mitochondrial RNA Granule Modulates Manganese-Dependent Cell Toxicity

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Architecture of the outbred brown fat proteome defines regulators of metabolic physiology

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Estrogen-related receptor alpha drives mitochondrial biogenesis and resistance to neoadjuvant chemoradiation in esophageal cancer

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A molecular interactome of the glioblastoma perivascular niche reveals integrin binding sialoprotein as a mediator of tumor cell migration

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Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesis

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Ubiquitination of phosphatidylethanolamine in organellar membranes

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STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization

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Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα

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Small RNAs derived from tRNA fragmentation regulate the functional maturation of neonatal β cells

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Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma

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cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model

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Non-coding 7S RNA inhibits transcription via mitochondrial RNA polymerase dimerization

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Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage

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Quantitative super-resolution microscopy reveals promoting mitochondrial interconnectivity protects against AKI

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Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness

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Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells

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TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis

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Interplay between protein acetylation and ubiquitination controls MCL1 protein stability

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Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain

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Roles of autophagy in relation to mitochondrial stress responses of HeLa cells to lamellarin cytotoxicity

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Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism

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Overexpression of α-synuclein inhibits mitochondrial Ca2+ trafficking between the endoplasmic reticulum and mitochondria through MAMs by altering the GRP75–IP3R interaction

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In vivo identification of GTPase interactors by mitochondrial relocalization and proximity biotinylation

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Mitochondrial estrogen receptors alter mitochondrial priming and response to endocrine therapy in breast cancer cells

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Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress

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Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability

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Neuronal Pentraxin 1 Promotes Hypoxic-Ischemic Neuronal Injury by Impairing Mitochondrial Biogenesis via Interactions With Active Bax[6A7] and Mitochondrial Hexokinase II - Md Al Rahim, Shabarish Thatipamula, Giulio M. Pasinetti, Mir Ahamed Hossain, 2021

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NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma

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Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation

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Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth

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BPS Publications

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Metabolism, Oxidative Stress and Cell Signaling: Mitochondrial-specific autophagy linked to mitochondrial dysfunction following traumatic freeze injury in mice

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The exocyst complex regulates insulin-stimulated glucose uptake of skeletal muscle cells

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Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma

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Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults

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Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals

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Succinate Can Shuttle Reducing Power from the Hypoxic Retina to the O2-Rich Pigment Epithelium

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Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation

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Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress

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UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity

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The exocyst complex regulates insulin-stimulated glucose uptake of skeletal muscle cells | American Journal of Physiology-Endocrinology and Metabolism

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Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

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Peroxynitrite supports a metabolic reprogramming in merlin-deficient Schwann cells and promotes cell survival

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A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells

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The Translational Landscape of the Human Heart

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IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties

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Acquired Expression of Mutant Mitofusin 2 Causes Progressive Neurodegeneration and Abnormal Behavior

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Multiple polycomb epigenetic regulatory proteins are active in normal and regenerating adult olfactory epithelium

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Systematic Functional Annotation of Somatic Mutations in Cancer

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Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses

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The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer

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Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex

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MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria

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