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Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size

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  DOI: 10.1152/ajpcell.00602.2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12551769/
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An atlas of ferroptosis-induced secretomes

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pmc.ncbi.nlm.nih.gov/articles/PMC12572367/
Sep 2025
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Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4

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  DOI: 10.1016/j.immuni.2025.09.003
  
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ER stress tolerance is regulated by copper-dependent PERK kinase activity

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sciencedirect.com/science/article/pii/S2211124725010897
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Adducins regulate morphology and fate of neural progenitors during neocortical neurogenesis

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sciencedirect.com/science/article/pii/S2211124725010472
Aug 2025
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The Tacrine‐Induced Endoplasmic Reticulum Stress in AChE‐Expressed Cells Leads to Improper Assembly and Transport of the Oligomeric Enzyme: Reversal by Trehalose

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pmc.ncbi.nlm.nih.gov/articles/PMC12322807/
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Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size

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1. scibot 01 Aug 2025
  
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  DOI: 10.1101/2025.07.23.666188
  
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biorxiv.org/content/10.1101/2025.07.23.666188v1
Jul 2025
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Artemisinin synergizes with CCCP in autophagic cell death induction via ER stress in uveal melanoma

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sciencedirect.com/science/article/pii/S2589004225012337
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Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL

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sciencedirect.com/science/article/pii/S0092867425007287
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Optogenetics-enabled discovery of integrated stress response modulators

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cell.com/cell/abstract/S0092-8674(25)00690-7
Jun 2025
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BAG2 releases SAMD4B upon sensing of arginine deficiency to promote tumor cell survival

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  DOI: 10.1016/j.molcel.2025.05.035
  
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cell.com/molecular-cell/fulltext/S1097-2765(25)00499-X
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Table 1 Resource table.

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  DOI: 10.1038/s41418-025-01517-4
  
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nature.com/articles/s41418-025-01517-4/tables/1
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VDAC1 is a target for pharmacologically induced insulin hypersecretion in β cells

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1. scibot 13 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115834
  
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sciencedirect.com/science/article/pii/S2211124725006059
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Magnesium-assisted hydrogen improves isoproterenol-induced heart failure

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1. scibot 12 Jun 2025
  
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  DOI: 10.4103/mgr.MEDGASRES-D-24-00135
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12124708/
May 2025
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Neuroserpin alleviates cerebral ischemia-reperfusion injury by suppressing ischemia-induced endoplasmic reticulum stress

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1. scibot 24 May 2025
  
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  DOI: 10.4103/NRR.NRR-D-24-00044
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12094565/
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Reducing Dietary Protein Enhances the Antitumor Effects of Chemotherapy through Immune-Mediated Mechanisms

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1. scibot 20 May 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0545
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617599/
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  DOI: 10.1101/2025.04.30.651453
  
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52.53.155.43/dd3c8f74e9cdc1e420d33be7f8443dfa69ebea7a/PDF-html.html
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ER stress disrupts insulin release in murine models of type 2 diabetes by impairing retromer action and constitutive secretion

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115691
  
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sciencedirect.com/science/article/pii/S2211124725004620
Apr 2025
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Integrated analysis of transcriptional and metabolic responses to mitochondrial stress

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  DOI: 10.1016/j.crmeth.2025.101027
  
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sciencedirect.com/science/article/pii/S2667237525000633
Mar 2025
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Bromocriptine improves glucose tolerance in obese mice via central dopamine D2 receptor-independent mechanism

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  DOI: 10.1371/journal.pone.0320157
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11940610/
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Lipid-metabolism-focused CRISPR screens identify enzymes of the mevalonate pathway as essential for prostate cancer growth

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52.53.155.43/089c935c8b8375c73eca3bfe64a1d2170a0cdb88/PDF-html.html
Feb 2025
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Membrane-tethered SCOTIN condensates elicit an endoplasmic reticulum stress response by sequestering luminal BiP

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  DOI: 10.1016/j.celrep.2025.115297
  
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Role of hepatocyte RIPK1 in maintaining liver homeostasis during metabolic challenges

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  DOI: 10.7554/eLife.96798
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11785375/
Jan 2025
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Targeting the mevalonate pathway potentiates NUAK1 inhibition-induced immunogenic cell death and antitumor immunity

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  DOI: 10.1016/j.xcrm.2024.101913
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11866496/
Dec 2024
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IFRD1 is required for maintenance of bladder epithelial homeostasis

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1. scibot 13 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111282
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11613175/
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MYC Drives mRNA Pseudouridylation to Mitigate Proliferation-Induced Cellular Stress during Cancer Development

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  DOI: 10.1158/0008-5472.CAN-24-1102
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11609627/
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Endoplasmic reticulum stress-related deficits in calcium clearance promote neuronal dysfunction that is prevented by SERCA2 gene augmentation

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  DOI: 10.1016/j.xcrm.2024.101839
  
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sciencedirect.com/science/article/pii/S2666379124006104
Aug 2024
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Preliminary exploration of endoplasmic reticulum stress transmission in astrocytes and neurons, and its mediators

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  DOI: 10.22541/au.172258066.64851176/v1
  
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authorea.com/users/811586/articles/1213019-preliminary-exploration-of-endoplasmic-reticulum-stress-transmission-in-astrocytes-and-neurons-and-its-mediators
cellandbioscience.biomedcentral.com cellandbioscience.biomedcentral.com

Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α–AKT–mTOR pathway in esophageal squamous cell carcinoma

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cellandbioscience.biomedcentral.com/article/10.1186/s13578-021-00640-2
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Traumatic Optic Neuropathy Is Associated with Visual Impairment, Neurodegeneration, and Endoplasmic Reticulum Stress in Adolescent Mice

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  DOI: 10.3390/cells10050996
  
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mdpi.com/2073-4409/10/5/996
Jul 2024
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The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NFκB intracrine senescent noncanonical pathway

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1. scibot 23 Jul 2024
  
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  DOI: 10.1111/acel.14258
  
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onlinelibrary.wiley.com/doi/10.1111/acel.14258
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Human neural stem cell secretome relieves endoplasmic reticulum stress-induced apoptosis and improves neuronal functions after traumatic brain injury in a rat model

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1. scibot 09 Jul 2024
  
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  DOI: 10.1007/s10735-024-10192-7
  
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link.springer.com/article/10.1007/s10735-024-10192-7
May 2024
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NRAS mutant dictates AHCYL1-governed ER calcium homeostasis for melanoma tumor growth

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1. scibot 23 May 2024
  
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  DOI: 10.1158/1541-7786.MCR-23-0445
  
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aacrjournals.org/mcr/article/22/4/386/741848/NRAS-Mutant-Dictates-AHCYL1-Governed-ER-Calcium
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Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression

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1. scibot 08 May 2024
  
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  DOI: 10.1016/j.cmet.2024.04.014
  
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ER-associated degradation adapter Sel1L is required for CD8+ T cell function and memory formation following acute viral infection

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Adipocyte-Released Adipomes in Chagas Cardiomyopathy: Impact on Cardiac Metabolic and Immune Regulation

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Caffeic acid does not protect human pancreatic β cells against stearic acid-induced ER stress and apoptosis

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The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection

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miR-217 regulates normal and tumor cell fate following induction of Endoplasmic Reticulum Stress

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Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding

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A stagewise response to mitochondrial dysfunction in mitochondrial DNA maintenance disorders

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Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders

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A stagewise response to mitochondrial dysfunction in mitochondrial DNA maintenance disorders

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Ultrafine particulate matter pollution and dysfunction of endoplasmic reticulum Ca2+ store: A pathomechanism shared with amyotrophic lateral sclerosis motor neurons?

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Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates

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Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis

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Cryptotanshinone is a candidate therapeutic agent for interstitial lung disease associated with a BRICHOS-domain mutation of SFTPC

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Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression

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Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons

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Bacterial effector restricts liquid-liquid phase separation of ZPR1 to antagonize host UPRER

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BPS Publications

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Berberine ameliorates obesity by inducing GDF15 secretion by brown adipocytes

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Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR

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Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma

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Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals

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Coronavirus Subverts ER-phagy by Hijacking FAM134B and ATL3 into p62 Condensates to Facilitate Viral Replication

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VMP1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms

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TUG-891 inhibits neuronal endoplasmic reticulum stress and... : Neural Regeneration Research

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Remodeling of the Ribosomal Quality Control and Protein Translation by a Viral Ubiquitin Deconjugase

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Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity

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Selenium Protects Mouse Hypothalamic Cells from Glucocorticoid-Induced Endoplasmic Reticulum Stress Vulnerability and Insulin Signaling Impairment

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Valproate reduces retinal ganglion cell apoptosis in rats... : Neural Regeneration Research

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Oxygen-carrying sequential preservation mitigates liver grafts ischemia-reperfusion injury

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Neuroprotective Effects of Neuropeptide Y on Human Neuroblastoma SH-SY5Y Cells in Glutamate Excitotoxicity and ER Stress Conditions

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De novo sphingolipid biosynthesis necessitates detoxification in cancer cells

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Lack of COL6/collagen VI causes megakaryocyte dysfunction by impairing autophagy and inducing apoptosis

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OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy

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IRE1α overexpression in malignant cells limits tumor progression by inducing an anti-cancer immune response

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Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma

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Transmissible ER stress between macrophages and tumor cells configures tumor microenvironment

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Small molecule-mediated insulin hypersecretion induces transient ER stress response and loss of beta cell function

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Calcineurin/NFATc2 and PI3K/AKT signaling maintains β-cell identity and function during metabolic and inflammatory stress

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TIMP2 mediates endoplasmic reticulum stress contributing to sepsis-induced acute kidney injury

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Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy

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PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen

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The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer

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The endoplasmic reticulum stress-mediated unfolded protein response protects against infection of goat endometrial epithelial cells by Trueperella pyogenes via autophagy

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Autophagic and apoptotic cell death induced by the quinoline derivative 2-(6-methoxynaphthalen-2-yl)quinolin-4-amine in pancreatic cancer cells is via ER stress and inhibition of Akt/mTOR signaling pathway

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Molecular Investigation of the Unfolded Protein Response in Select Human Tauopathies

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Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection

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The portrait of liver cancer is shaped by mitochondrial genetics

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Self-developed NF-κB inhibitor 270 protects against LPS-induced acute kidney injury and lung injury through improving inflammation

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AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia

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β-catenin links cell seeding density to global gene expression during mouse embryonic stem cell differentiation

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TXNIP links anticipatory unfolded protein response to estrogen reprogramming glucose metabolism in breast cancer cells

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ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue

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Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress

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Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian Cancers

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Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors

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Untitled document

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Untitled document

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Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress

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Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells

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Neuronal VCP loss of function recapitulates FTLD-TDP pathology

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Identification of a class of non-conventional ER-stress-response-derived immunogenic peptides

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Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells

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Pridopidine reduces mutant huntingtin-induced endoplasmic reticulum stress by modulation of the Sigma-1 receptor

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Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress

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Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling

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Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism

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Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans

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Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

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Stem cell transplantation rescued a primary open-angle glaucoma mouse model

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CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance

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A novel HDAC6 inhibitor improves myelination of Schwann cells in a model of Charcot‐Marie‐Tooth disease type 1A

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Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress

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Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer

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Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex

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Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer

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GCAP neuronal calcium sensor proteins mediate photoreceptor cell death in the rd3 mouse model of LCA12 congenital blindness by involving endoplasmic reticulum stress

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5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-mediated Apoptosis.

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BPS Publications

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The N-Degron Pathway Mediates ER-phagy

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Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

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Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade

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BPS Publications

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Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain

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Profile of the Unfolded Protein Response in Rat Cerebellar Cortical Development

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Untitled document

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p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

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TFAP2 transcription factors are regulators of lipid droplet biogenesis

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Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11

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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

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Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance

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Untitled document

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Cannabinoid Receptor Type 1 Agonist ACEA Protects Neurons from Death and Attenuates Endoplasmic Reticulum Stress-Related Apoptotic Pathway Signaling

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Angiotensin II Causes β-Cell Dysfunction Through an ER Stress-Induced Proinflammatory Response

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