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IDH1 Reprograms Nucleotide Metabolism by Inducing Chromatin Remodeling and DHODH Transcription to Drive Chemoresistance in Nasopharyngeal Carcinoma

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1. scibot 12 Jul 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-2313
  
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aacrjournals.org/cancerres/article/86/8/2004/782636/IDH1-Reprograms-Nucleotide-Metabolism-by-Inducing
Jul 2026
54.241.53.176 54.241.53.176

koe-et-al-2026-n-linked-glycosylation-regulates-snat2-trafficking-and-stability-in-pancreatic-ductal-adenocarcinoma-html.html

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1. scibot 03 Jul 2026
  
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  DOI: 10.1074/jbc.m002965200
  
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54.241.53.176/92e8acfcbd89398cad71ee7f85cc54b6eafd6123/koe-et-al-2026-n-linked-glycosylation-regulates-snat2-trafficking-and-stability-in-pancreatic-ductal-adenocarcinoma-html.html
Jun 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice

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1. scibot 02 Jun 2026
  
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  DOI: 10.1038/s42255-026-01520-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13218935/
May 2026
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DHODH-Mediated Suppression of Ferroptosis Supports Radioresistance and Represents a Therapeutic Vulnerability in Lung Cancer

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1. scibot 19 May 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-3728
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13179828/
Apr 2026
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Mitochondrial ACSS1 links acetate metabolism to pyrimidine biosynthesis in nutrient-stressed B-cell lymphomas

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1. scibot 09 Apr 2026
  
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  DOI: 10.1016/j.canlet.2026.218488
  
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sciencedirect.com/science/article/pii/S030438352600251X
Dec 2025
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HMOX1 drives dihydroartemisinin-sensitized ferroptosis antagonized by mitochondrial fusion

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1. scibot 25 Dec 2025
  
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  DOI: 10.1016/j.isci.2025.114382
  
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sciencedirect.com/science/article/pii/S2589004225026434
Nov 2025
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UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.molcel.2025.10.030
  
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sciencedirect.com/science/article/pii/S1097276525008913
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An immunometabolic prodrug strategy overcomes DHODH inhibitor resistance in refractory melanoma

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1. scibot 18 Nov 2025
  
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  DOI: 10.1186/s13046-025-03566-6
  
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link.springer.com/article/10.1186/s13046-025-03566-6
Oct 2025
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HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis

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1. scibot 11 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116382
  
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sciencedirect.com/science/article/pii/S2211124725011532
Sep 2025
www.biorxiv.org www.biorxiv.org

Mitochondrial ACSS1 Links Acetate Metabolism to Pyrimidine Biosynthesis in Nutrient-Stressed B-Cell Lymphomas

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1. scibot 09 Sep 2025
  
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  DOI: 10.1101/2025.08.29.673065
  
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biorxiv.org/content/10.1101/2025.08.29.673065v1
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SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer

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1. scibot 03 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116139
  
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sciencedirect.com/science/article/pii/S2211124725009106
Jul 2025
www.biorxiv.org www.biorxiv.org

Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice

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1. scibot 30 Jul 2025
  
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  DOI: 10.1101/2025.07.23.666448
  
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biorxiv.org/content/10.1101/2025.07.23.666448v1
Apr 2025
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1-s2.0-S2589004225006248-main-html.html

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1. scibot 10 Apr 2025
  
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  RRID:AB_2091723
  
  DOI: 10.1016/j.isci.2025.112363
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12053632/
Aug 2024
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Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.neuron.2024.07.020
  
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sciencedirect.com/science/article/pii/S0896627324005427
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OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response

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1. scibot 21 Aug 2024
  
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  AB_2091723
  
  DOI: 10.1016/j.molcel.2024.07.020
  
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sciencedirect.com/science/article/pii/S109727652400618X
May 2024
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Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers

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1. scibot 17 May 2024
  
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  DOI: 10.1016/j.molcel.2024.04.009
  
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sciencedirect.com/science/article/pii/S1097276524003241
Dec 2023
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SMURF2 predisposes cancer cell toward ferroptosis in GPX4-independent manners by promoting GSTP1 degradation

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1. scibot 01 Dec 2023
  
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  DOI: 10.1016/j.molcel.2023.10.042
  
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sciencedirect.com/science/article/pii/S1097276523009139
Nov 2022
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Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma

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1. scibot 11 Nov 2022
  
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  DOI: 10.1016/j.ccell.2022.10.009
  
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sciencedirect.com/science/article/pii/S1535610822005001
Aug 2022
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A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma

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1. scibot 22 Aug 2022
  
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  DOI: 10.1016/j.ccell.2022.07.012
  
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sciencedirect.com/science/article/pii/S1535610822003257
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De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

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1. scibot 22 Aug 2022
  
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  DOI: 10.1016/j.ccell.2022.07.011
  
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sciencedirect.com/science/article/pii/S1535610822003245
Jul 2021
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Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

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1. scibot 31 Jul 2021
  
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  DOI: 10.1016/j.cmet.2018.10.014
  
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sciencedirect.com/science/article/pii/S1550413118306466
Jan 2020
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Untitled document

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.cmet.2019.02.001
  
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  RRID:AB_2091723 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1550413119300658