108 Matching Annotations
  1. Last 7 days
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    Neddylation inhibition prevents acetaminophen-induced liver damage by enhancing the anabolic cardiolipin pathway
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    TSPAN4 influences glioblastoma progression through regulating EGFR stability
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    cell.com/iscience/abstract/S2589-0042(24)01642-0
  4. Jun 2024
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    Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform
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    sciencedirect.com/science/article/pii/S2211124724006417
  6. May 2024
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    Targeted blocking of EGFR and GLUT1 by compound H reveals a new strategy for treatment of triple-negative breast cancer and nasopharyngeal carcinoma
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    sciencedirect.com/science/article/pii/S0928098724001003
  8. Mar 2024
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers
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    ncbi.nlm.nih.gov/pmc/articles/PMC10951324/
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    An engineering strategy to target activated EGFR with CAR T cells
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    sciencedirect.com/science/article/pii/S2667237524000511
  11. Feb 2024
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    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
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    Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR
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    Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831936/
  15. Dec 2023
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    EGFR-activated myofibroblasts promote metastasis of pancreatic cancer
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    sciencedirect.com/science/article/pii/S1535610823004300
  17. Nov 2023
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    EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma
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    sciencedirect.com/science/article/abs/pii/S1097276523008626
  19. Oct 2023
  20. www.science.org www.science.org
    Piezo1 activates noncanonical EGFR endocytosis and signaling
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  21. 52.53.155.43 52.53.155.43
    The T766M-EGFR lung cancer mutation promotes tumor growth by exploiting newfound assembly mechanisms in ligand-free EGFR oligomers
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    Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor
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  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Piezo1 activates noncanonical EGFR endocytosis and signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10530101/
  24. Sep 2023
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    Promoting the activity of a receptor tyrosine phosphatase with a novel pH‐responsive transmembrane agonist inhibits cancer‐associated phenotypes
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    ncbi.nlm.nih.gov/pmc/articles/PMC10461461/
  26. Aug 2023
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    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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    sciencedirect.com/science/article/pii/S1535610823002453
  28. Jun 2023
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    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
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    sciencedirect.com/science/article/pii/S030438352300215X
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    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
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    LZTR1 mutation mediates oncogenesis through stabilization of EGFR and AXL
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  32. May 2023
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    Mechanisms of estradiol-induced EGF-like factor expression and oocyte maturation via G protein-coupled estrogen receptor
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  34. Apr 2023
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    IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma
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    sciencedirect.com/science/article/pii/S2589004223007162
  36. www.nature.com www.nature.com
    Single targeting of MET in EGFR-mutated and MET-amplified non-small cell lung cancer
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  37. Feb 2023
  38. 52.53.155.43 52.53.155.43
    cd-22-0376-html.html
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    CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance
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    Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation
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  41. www.cell.com www.cell.com
    The developmental basis of fingerprint pattern formation and variation
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    cell.com/cell/fulltext/S0092-8674(23)00045-4
  42. Jan 2023
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    Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling
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    sciencedirect.com/science/article/pii/S2211124723000426
  44. Dec 2022
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    ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells
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    EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer
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    sciencedirect.com/science/article/pii/S2211124722017193
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    Immunological profiles of human oligodendrogliomas define two distinct molecular subtypes
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    KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition
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    sciencedirect.com/science/article/pii/S1535610822005621
  49. Nov 2022
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    RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation
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    sciencedirect.com/science/article/pii/S2589004222014560
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    Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling
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    sciencedirect.com/science/article/pii/S2211124722014462
  52. Jun 2022
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    Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma
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    sciencedirect.com/science/article/pii/S221112472200777X
  54. May 2022
  55. www.sciencedirect.com www.sciencedirect.com
    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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    sciencedirect.com/science/article/pii/S1097276522004348
  56. aacrjournals.org aacrjournals.org
    Triple targeting of HER receptors overcomes heregulin-mediated resistance to EGFR blockade in colorectal cancer
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      DOI: 10.1158/1535-7163.MCT-21-0818

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    aacrjournals.org/mct/article/21/5/799/694777/Triple-Targeting-of-HER-Receptors-Overcomes
  57. aacrjournals.org aacrjournals.org
    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
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    aacrjournals.org/cancerdiscovery/article/12/5/1378/694560/EGFR-Inhibition-Potentiates-FGFR-Inhibitor-Therapy
  58. Apr 2022
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epidermal growth factor deficiency predisposes to progressive renal disease
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      DOI: 10.1096/fj.202101837R

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    Increased efficacy of gefitinib on cisplatin-resistant wild-type epidermal growth factor receptor non-small cell lung cancer cells
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  63. Jan 2022
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    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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  65. Dec 2021
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    SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes
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    Synergy of epidermal growth factor (EGFR) and angiotensin II (AT1R) receptor determines composition and temporal pattern of transcriptome variation
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    Tubular microdomains of Rab7-endosomes retrieve TrkA, a mechanism disrupted in Charcot-Marie-Tooth 2B
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    Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities
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  83. Jul 2021
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    Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication
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    Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling
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    Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells
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    Glioblastoma Cell Resistance to EGFR and MET Inhibition Can Be Overcome via Blockade of FGFR-SPRY2 Bypass Signaling
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    Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis
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    Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer
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    Challenges and Reinterpretation of Antibody-Based Research on Phosphorylation of Tyr307 on PP2Ac
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  116. www.sciencedirect.com www.sciencedirect.com
    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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  117. www.sciencedirect.com www.sciencedirect.com
    Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC
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  118. Jan 2020
  119. dev.biologists.org dev.biologists.org
    The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking
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  120. www.sciencedirect.com www.sciencedirect.com
    Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma
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    EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis
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    Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling
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    Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells
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    Genotype-Fitness Maps of EGFR-Mutant Lung Adenocarcinoma Chart the Evolutionary Landscape of Resistance for Combination Therapy Optimization
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    Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors
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  126. www.sciencedirect.com www.sciencedirect.com
    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
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    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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  128. www.sciencedirect.com www.sciencedirect.com
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  129. www.sciencedirect.com www.sciencedirect.com
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  130. Nov 2018
  131. watermark.silverchair.com watermark.silverchair.com
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  132. www.sciencedirect.com www.sciencedirect.com
    Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors
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    Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization
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  135. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  136. www.sciencedirect.com www.sciencedirect.com
    EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics
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    Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling
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    Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer
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  139. europepmc.org europepmc.org
    Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex.
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    PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K
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  141. Nov 2017
  142. www.sciencedirect.com www.sciencedirect.com
    Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer
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      3777

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  143. www.sciencedirect.com www.sciencedirect.com
    mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
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  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TACE/ADAM17 Is Essential for Oligodendrocyte Development and CNS Myelination
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