119 Matching Annotations
  1. Nov 2024
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bilateral regulation of EGFR activity and local PI(4,5)P2 dynamics in mammalian cells observed with superresolution microscopy
    1
    1. scibot 15 Nov 2024
      RRID:AB_2096270

      DOI: 10.7554/eLife.101652

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    pmc.ncbi.nlm.nih.gov/articles/PMC11548882/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dynamic roles of neutrophil extracellular traps in cancer cell adhesion and activation of Notch 1-mediated epithelial-to-mesenchymal transition in EGFR-driven lung cancer cells
    1
    1. scibot 07 Nov 2024
      RRID:AB_2096270

      DOI: 10.3389/fimmu.2024.1470620

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    pmc.ncbi.nlm.nih.gov/articles/PMC11487346/
  4. Oct 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis
    1
    1. scibot 05 Oct 2024
      RRID:AB_2096270

      DOI: 10.1083/jcb.202401167

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    ncbi.nlm.nih.gov/pmc/articles/PMC11449124/
  6. aacrjournals.org aacrjournals.org
    YAP-Mediated Repression of HRK Regulates Tumor Growth, Therapy Response, and Survival Under Tumor Environmental Stress in Neuroblastoma
    1
    1. scibot 02 Oct 2024
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      DOI: 10.1158/0008-5472.CAN-20-0025

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    aacrjournals.org/cancerres/article/80/21/4741/645935/YAP-Mediated-Repression-of-HRK-Regulates-Tumor
  7. Sep 2024
  8. www.sciencedirect.com www.sciencedirect.com
    Customised design of antisense oligonucleotides targeting EGFR driver mutants for personalised treatment of non-small cell lung cancer
    1
    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.ebiom.2024.105356

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    sciencedirect.com/science/article/pii/S235239642400392X
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts
    1
    1. scibot 05 Sep 2024
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      DOI: 10.1158/2767-9764.CRC-24-0020

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    ncbi.nlm.nih.gov/pmc/articles/PMC11370239/
  10. Aug 2024
  11. www.cell.com www.cell.com
    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
    1
    1. scibot 22 Aug 2024
      AB_2096270

      DOI: 10.1016/j.cell.2020.02.019

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    cell.com/cell/fulltext/S0092-8674(20)30163-X
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    Activation of limbal epithelial proliferation is partly controlled by the ACE2-LCN2 pathway
    1
    1. scibot 19 Aug 2024
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      DOI: 10.1016/j.isci.2024.110534

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    sciencedirect.com/science/article/pii/S2589004224017590
  13. www.sciencedirect.com www.sciencedirect.com
    In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
    1
    1. scibot 18 Aug 2024
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      DOI: 10.1016/j.xcrm.2024.101663

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    sciencedirect.com/science/article/pii/S266637912400377X
  14. Jul 2024
  15. www.cell.com www.cell.com
    Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK
    1
    1. scibot 30 Jul 2024
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      DOI: 10.1016/j.chom.2024.07.001

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    cell.com/cell-host-microbe/abstract/S1931-3128(24)00254-3
  16. www.sciencedirect.com www.sciencedirect.com
    Harnessing the CD44-targeted delivery of self-assembled hyaluronan nanogel to reverse the antagonism between Cisplatin and Gefitinib in NSCLC cancer therapy
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    1. scibot 24 Jul 2024
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      DOI: 10.1016/j.carbpol.2024.122521

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    sciencedirect.com/science/article/pii/S0144861724007471
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neddylation inhibition prevents acetaminophen-induced liver damage by enhancing the anabolic cardiolipin pathway
    1
    1. scibot 17 Jul 2024
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      DOI: 10.1016/j.xcrm.2024.101653

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    ncbi.nlm.nih.gov/pmc/articles/PMC11293357/
  18. www.cell.com www.cell.com
    TSPAN4 influences glioblastoma progression through regulating EGFR stability
    1
    1. scibot 16 Jul 2024
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      DOI: 10.1016/j.isci.2024.110417

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    cell.com/iscience/fulltext/S2589-0042(24)01642-0
  19. Jun 2024
  20. www.sciencedirect.com www.sciencedirect.com
    Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform
    1
    1. scibot 06 Jun 2024
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      DOI: 10.1016/j.celrep.2024.114313

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    sciencedirect.com/science/article/pii/S2211124724006417
  21. May 2024
  22. www.sciencedirect.com www.sciencedirect.com
    Targeted blocking of EGFR and GLUT1 by compound H reveals a new strategy for treatment of triple-negative breast cancer and nasopharyngeal carcinoma
    1
    1. scibot 07 May 2024
      3777

      DOI: 10.1016/j.ejps.2024.106789

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    sciencedirect.com/science/article/pii/S0928098724001003
  23. Mar 2024
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers
    1
    1. scibot 22 Mar 2024
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      DOI: 10.1038/s41467-024-46284-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC10951324/
  25. www.sciencedirect.com www.sciencedirect.com
    An engineering strategy to target activated EGFR with CAR T cells
    1
    1. scibot 19 Mar 2024
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      DOI: 10.1016/j.crmeth.2024.100728

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    sciencedirect.com/science/article/pii/S2667237524000511
  26. Feb 2024
  27. www.sciencedirect.com www.sciencedirect.com
    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
    1
    1. scibot 09 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113714

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    sciencedirect.com/science/article/pii/S2211124724000421
  28. www.sciencedirect.com www.sciencedirect.com
    Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR
    1
    1. scibot 06 Feb 2024
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      DOI: 10.1016/j.devcel.2024.01.010

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    sciencedirect.com/science/article/pii/S1534580724000303
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists
    1
    1. scibot 03 Feb 2024
      RRID:AB_2096270

      DOI: 10.1016/j.isci.2024.108839

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    ncbi.nlm.nih.gov/pmc/articles/PMC10831936/
  30. Dec 2023
  31. www.sciencedirect.com www.sciencedirect.com
    EGFR-activated myofibroblasts promote metastasis of pancreatic cancer
    1
    1. scibot 29 Dec 2023
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      DOI: 10.1016/j.ccell.2023.12.002

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    sciencedirect.com/science/article/pii/S1535610823004300
  32. Nov 2023
  33. www.sciencedirect.com www.sciencedirect.com
    EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma
    1
    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.molcel.2023.10.025

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    sciencedirect.com/science/article/abs/pii/S1097276523008626
  34. Oct 2023
  35. www.science.org www.science.org
    Piezo1 activates noncanonical EGFR endocytosis and signaling
    1
    1. scibot 17 Oct 2023
      RRID:AB_2096270

      DOI: 10.1126/sciadv.adi1328

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    science.org/doi/10.1126/sciadv.adi1328
  36. 52.53.155.43 52.53.155.43
    The T766M-EGFR lung cancer mutation promotes tumor growth by exploiting newfound assembly mechanisms in ligand-free EGFR oligomers
    1
    1. scibot 14 Oct 2023
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      DOI: 10.1101/2023.06.16.545259

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    52.53.155.43/e45e39aa6be90d4518c1365e2458466145a6420b/2023.06.16.545259v2.full-html.html
  37. www.sciencedirect.com www.sciencedirect.com
    Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor
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    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.chembiol.2023.09.013

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    sciencedirect.com/science/article/abs/pii/S245194562300332X
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Piezo1 activates noncanonical EGFR endocytosis and signaling
    1
    1. scibot 05 Oct 2023
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      DOI: 10.1126/sciadv.adi1328

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    ncbi.nlm.nih.gov/pmc/articles/PMC10530101/
  39. Sep 2023
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Promoting the activity of a receptor tyrosine phosphatase with a novel pH‐responsive transmembrane agonist inhibits cancer‐associated phenotypes
    1
    1. scibot 02 Sep 2023
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      DOI: 10.1002/pro.4742

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    ncbi.nlm.nih.gov/pmc/articles/PMC10461461/
  41. Aug 2023
  42. www.sciencedirect.com www.sciencedirect.com
    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
    1
    1. scibot 04 Aug 2023
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      DOI: 10.1016/j.ccell.2023.07.005

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    sciencedirect.com/science/article/pii/S1535610823002453
  43. Jun 2023
  44. www.sciencedirect.com www.sciencedirect.com
    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
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    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.canlet.2023.216264

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    sciencedirect.com/science/article/pii/S030438352300215X
  45. www.science.org www.science.org
    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
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    1. scibot 16 Jun 2023
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      DOI: 10.1126/sciadv.ade1155

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      DOI: 10.1126/sciadv.ade1155

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    science.org/doi/10.1126/sciadv.ade1155
  46. dx.doi.org dx.doi.org
    LZTR1 mutation mediates oncogenesis through stabilization of EGFR and AXL
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    1. scibot 08 Jun 2023
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      DOI: 10.1158/2159-8290.CD-22-0376

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    dx.doi.org/10.1158/2159-8290.CD-22-0376
  47. May 2023
  48. academic.oup.com academic.oup.com
    Mechanisms of estradiol-induced EGF-like factor expression and oocyte maturation via G protein-coupled estrogen receptor
    1
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      DOI: 10.1210/endocr/bqaa190

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    academic.oup.com/endo/article/161/12/bqaa190/5929646
  49. Apr 2023
  50. www.sciencedirect.com www.sciencedirect.com
    IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma
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      DOI: 10.1016/j.isci.2023.106639

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    sciencedirect.com/science/article/pii/S2589004223007162
  51. www.nature.com www.nature.com
    Single targeting of MET in EGFR-mutated and MET-amplified non-small cell lung cancer
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      DOI: 10.1038/s41416-023-02264-4

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    nature.com/articles/s41416-023-02264-4
  52. Feb 2023
  53. 52.53.155.43 52.53.155.43
    cd-22-0376-html.html
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  54. www.sciencedirect.com www.sciencedirect.com
    CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance
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      DOI: 10.1016/j.ccell.2023.01.007

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    sciencedirect.com/science/article/pii/S1535610823000077
  55. www.sciencedirect.com www.sciencedirect.com
    Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation
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    sciencedirect.com/science/article/pii/S2451945623000302
  56. www.cell.com www.cell.com
    The developmental basis of fingerprint pattern formation and variation
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      DOI: 10.1016/j.cell.2023.01.015

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    cell.com/cell/fulltext/S0092-8674(23)00045-4
  57. Jan 2023
  58. www.sciencedirect.com www.sciencedirect.com
    Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling
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      DOI: 10.1016/j.celrep.2023.112031

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    ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells
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    EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer
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    Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities
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    NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation
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    mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
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