104 Matching Annotations
  1. Mar 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers
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    1. scibot 22 Mar 2024
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      DOI: 10.1038/s41467-024-46284-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC10951324/
  3. www.sciencedirect.com www.sciencedirect.com
    An engineering strategy to target activated EGFR with CAR T cells
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    1. scibot 19 Mar 2024
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      DOI: 10.1016/j.crmeth.2024.100728

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    sciencedirect.com/science/article/pii/S2667237524000511
  4. Feb 2024
  5. www.sciencedirect.com www.sciencedirect.com
    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
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    1. scibot 09 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113714

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    sciencedirect.com/science/article/pii/S2211124724000421
  6. www.sciencedirect.com www.sciencedirect.com
    Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR
    1
    1. scibot 06 Feb 2024
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      DOI: 10.1016/j.devcel.2024.01.010

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    sciencedirect.com/science/article/pii/S1534580724000303
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists
    1
    1. scibot 03 Feb 2024
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      DOI: 10.1016/j.isci.2024.108839

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    ncbi.nlm.nih.gov/pmc/articles/PMC10831936/
  8. Dec 2023
  9. www.sciencedirect.com www.sciencedirect.com
    EGFR-activated myofibroblasts promote metastasis of pancreatic cancer
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    1. scibot 29 Dec 2023
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      DOI: 10.1016/j.ccell.2023.12.002

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    sciencedirect.com/science/article/pii/S1535610823004300
  10. Nov 2023
  11. www.sciencedirect.com www.sciencedirect.com
    EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma
    1
    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.molcel.2023.10.025

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    sciencedirect.com/science/article/abs/pii/S1097276523008626
  12. Oct 2023
  13. www.science.org www.science.org
    Piezo1 activates noncanonical EGFR endocytosis and signaling
    1
    1. scibot 17 Oct 2023
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      DOI: 10.1126/sciadv.adi1328

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    science.org/doi/10.1126/sciadv.adi1328
  14. 52.53.155.43 52.53.155.43
    The T766M-EGFR lung cancer mutation promotes tumor growth by exploiting newfound assembly mechanisms in ligand-free EGFR oligomers
    1
    1. scibot 14 Oct 2023
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      DOI: 10.1101/2023.06.16.545259

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    52.53.155.43/e45e39aa6be90d4518c1365e2458466145a6420b/2023.06.16.545259v2.full-html.html
  15. www.sciencedirect.com www.sciencedirect.com
    Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.chembiol.2023.09.013

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    sciencedirect.com/science/article/abs/pii/S245194562300332X
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Piezo1 activates noncanonical EGFR endocytosis and signaling
    1
    1. scibot 05 Oct 2023
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      DOI: 10.1126/sciadv.adi1328

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    ncbi.nlm.nih.gov/pmc/articles/PMC10530101/
  17. Sep 2023
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Promoting the activity of a receptor tyrosine phosphatase with a novel pH‐responsive transmembrane agonist inhibits cancer‐associated phenotypes
    1
    1. scibot 02 Sep 2023
      RRID:AB_2096270

      DOI: 10.1002/pro.4742

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    ncbi.nlm.nih.gov/pmc/articles/PMC10461461/
  19. Aug 2023
  20. www.sciencedirect.com www.sciencedirect.com
    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
    1
    1. scibot 04 Aug 2023
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      DOI: 10.1016/j.ccell.2023.07.005

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    sciencedirect.com/science/article/pii/S1535610823002453
  21. Jun 2023
  22. www.sciencedirect.com www.sciencedirect.com
    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
    1
    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.canlet.2023.216264

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    sciencedirect.com/science/article/pii/S030438352300215X
  23. www.science.org www.science.org
    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
    2
    1. scibot 16 Jun 2023
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      DOI: 10.1126/sciadv.ade1155

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    2. scibot 12 Jun 2023
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      DOI: 10.1126/sciadv.ade1155

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    science.org/doi/10.1126/sciadv.ade1155
  24. dx.doi.org dx.doi.org
    LZTR1 mutation mediates oncogenesis through stabilization of EGFR and AXL
    1
    1. scibot 08 Jun 2023
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      DOI: 10.1158/2159-8290.CD-22-0376

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    dx.doi.org/10.1158/2159-8290.CD-22-0376
  25. May 2023
  26. academic.oup.com academic.oup.com
    Mechanisms of estradiol-induced EGF-like factor expression and oocyte maturation via G protein-coupled estrogen receptor
    1
    1. scibot 05 May 2023
      RRID:AB_2096270

      DOI: 10.1210/endocr/bqaa190

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    academic.oup.com/endo/article/161/12/bqaa190/5929646
  27. Apr 2023
  28. www.sciencedirect.com www.sciencedirect.com
    IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma
    1
    1. scibot 27 Apr 2023
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      DOI: 10.1016/j.isci.2023.106639

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    sciencedirect.com/science/article/pii/S2589004223007162
  29. www.nature.com www.nature.com
    Single targeting of MET in EGFR-mutated and MET-amplified non-small cell lung cancer
    1
    1. scibot 18 Apr 2023
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      DOI: 10.1038/s41416-023-02264-4

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    nature.com/articles/s41416-023-02264-4
  30. Feb 2023
  31. 52.53.155.43 52.53.155.43
    cd-22-0376-html.html
    1
    1. scibot 17 Feb 2023
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      DOI: 10.1158/2159-8290.CD-22-0376

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    52.53.155.43/a051cdc9b66cfe47aeb3f39770c1ce7cd380afb2/cd-22-0376-html.html
  32. www.sciencedirect.com www.sciencedirect.com
    CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance
    1
    1. scibot 16 Feb 2023
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      DOI: 10.1016/j.ccell.2023.01.007

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    sciencedirect.com/science/article/pii/S1535610823000077
  33. www.sciencedirect.com www.sciencedirect.com
    Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation
    1
    1. scibot 11 Feb 2023
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      DOI: 10.1016/j.chembiol.2023.01.007

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    sciencedirect.com/science/article/pii/S2451945623000302
  34. www.cell.com www.cell.com
    The developmental basis of fingerprint pattern formation and variation
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    1. scibot 10 Feb 2023
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      DOI: 10.1016/j.cell.2023.01.015

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    cell.com/cell/fulltext/S0092-8674(23)00045-4
  35. Jan 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling
    1
    1. scibot 24 Jan 2023
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      DOI: 10.1016/j.celrep.2023.112031

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    sciencedirect.com/science/article/pii/S2211124723000426
  37. Dec 2022
  38. www.sciencedirect.com www.sciencedirect.com
    ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells
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    1. scibot 20 Dec 2022
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      DOI: 10.1016/j.devcel.2022.11.015

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    sciencedirect.com/science/article/pii/S1534580722008152
  39. www.sciencedirect.com www.sciencedirect.com
    EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer
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    1. scibot 18 Dec 2022
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      DOI: 10.1016/j.celrep.2022.111827

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    sciencedirect.com/science/article/pii/S2211124722017193
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    Immunological profiles of human oligodendrogliomas define two distinct molecular subtypes
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      DOI: 10.1016/j.ebiom.2022.104410

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    sciencedirect.com/science/article/pii/S2352396422005928
  41. www.sciencedirect.com www.sciencedirect.com
    KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition
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    1. scibot 17 Dec 2022
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      DOI: 10.1016/j.ccell.2022.11.015

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    sciencedirect.com/science/article/pii/S1535610822005621
  42. Nov 2022
  43. www.sciencedirect.com www.sciencedirect.com
    RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation
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    1. scibot 10 Nov 2022
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      DOI: 10.1016/j.isci.2022.105184

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    sciencedirect.com/science/article/pii/S2589004222014560
  44. www.sciencedirect.com www.sciencedirect.com
    Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling
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      DOI: 10.1016/j.celrep.2022.111581

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    sciencedirect.com/science/article/pii/S2211124722014462
  45. Jun 2022
  46. www.sciencedirect.com www.sciencedirect.com
    Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma
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    sciencedirect.com/science/article/pii/S221112472200777X
  47. May 2022
  48. www.sciencedirect.com www.sciencedirect.com
    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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    sciencedirect.com/science/article/pii/S1097276522004348
  49. aacrjournals.org aacrjournals.org
    Triple targeting of HER receptors overcomes heregulin-mediated resistance to EGFR blockade in colorectal cancer
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      DOI: 10.1158/1535-7163.MCT-21-0818

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    aacrjournals.org/mct/article/21/5/799/694777/Triple-Targeting-of-HER-Receptors-Overcomes
  50. aacrjournals.org aacrjournals.org
    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
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    aacrjournals.org/cancerdiscovery/article/12/5/1378/694560/EGFR-Inhibition-Potentiates-FGFR-Inhibitor-Therapy
  51. Apr 2022
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epidermal growth factor deficiency predisposes to progressive renal disease
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      DOI: 10.1096/fj.202101837R

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    ncbi.nlm.nih.gov/pmc/articles/PMC9185668/
  53. www.sciencedirect.com www.sciencedirect.com
    Tissue remodeling by an opportunistic pathogen triggers allergic inflammation
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      DOI: 10.1016/j.immuni.2022.04.001

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    sciencedirect.com/science/article/pii/S1074761322001728
  54. Feb 2022
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased efficacy of gefitinib on cisplatin-resistant wild-type epidermal growth factor receptor non-small cell lung cancer cells
    1
    1. scibot 05 Feb 2022
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      DOI: 10.21037/tcr-20-1441

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    ncbi.nlm.nih.gov/pmc/articles/PMC8798197/
  56. Jan 2022
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
    1
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      DOI: 10.1016/j.ccell.2019.04.011

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    ncbi.nlm.nih.gov/pmc/articles/PMC8717880/
  58. Dec 2021
  59. www.cell.com www.cell.com
    SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes
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      DOI: 10.1016/j.celrep.2021.110155

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    Synergy of epidermal growth factor (EGFR) and angiotensin II (AT1R) receptor determines composition and temporal pattern of transcriptome variation
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    Tubular microdomains of Rab7-endosomes retrieve TrkA, a mechanism disrupted in Charcot-Marie-Tooth 2B
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    Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities
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    Challenges and Reinterpretation of Antibody-Based Research on Phosphorylation of Tyr307 on PP2Ac
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  111. Jan 2020
  112. dev.biologists.org dev.biologists.org
    The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking
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      DOI: 10.1242/dev.174615

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  113. www.sciencedirect.com www.sciencedirect.com
    Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma
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  114. www.sciencedirect.com www.sciencedirect.com
    EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis
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  115. www.sciencedirect.com www.sciencedirect.com
    Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling
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      DOI: 10.1016/j.cmet.2019.06.014

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  116. www.sciencedirect.com www.sciencedirect.com
    Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells
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  117. www.sciencedirect.com www.sciencedirect.com
    Genotype-Fitness Maps of EGFR-Mutant Lung Adenocarcinoma Chart the Evolutionary Landscape of Resistance for Combination Therapy Optimization
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      DOI: 10.1016/j.cels.2019.10.002

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  118. www.sciencedirect.com www.sciencedirect.com
    Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors
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  119. www.sciencedirect.com www.sciencedirect.com
    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
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      DOI: 10.1016/j.ccell.2018.10.001

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  120. www.sciencedirect.com www.sciencedirect.com
    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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  121. www.sciencedirect.com www.sciencedirect.com
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  122. www.sciencedirect.com www.sciencedirect.com
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  123. Nov 2018
  124. watermark.silverchair.com watermark.silverchair.com
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  125. www.sciencedirect.com www.sciencedirect.com
    Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors
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  126. www.sciencedirect.com www.sciencedirect.com
    Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization
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  127. www.sciencedirect.com www.sciencedirect.com
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  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  129. www.sciencedirect.com www.sciencedirect.com
    EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics
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  130. www.sciencedirect.com www.sciencedirect.com
    Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling
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  131. www.sciencedirect.com www.sciencedirect.com
    Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer
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  132. europepmc.org europepmc.org
    Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex.
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  133. www.sciencedirect.com www.sciencedirect.com
    PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K
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  134. Nov 2017
  135. www.sciencedirect.com www.sciencedirect.com
    Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer
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      3777

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  136. www.sciencedirect.com www.sciencedirect.com
    mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
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      Curator: @chewbeccax

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  137. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TACE/ADAM17 Is Essential for Oligodendrocyte Development and CNS Myelination
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      Curator: @jcabotaj

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