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  1. Last 7 days
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    Brown adipose tissue CoQ deficiency activates the integrated stress response and FGF21-dependent mitohormesis
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  3. Apr 2024
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    Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress
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    Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding
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    Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy
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    Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells
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    sciencedirect.com/science/article/pii/S0092867424003039
  8. Mar 2024
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    Brown adipose tissue CoQ deficiency activates the integrated stress response and FGF21-dependent mitohormesis
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    Brown adipose tissue CoQ deficiency activates the integrated stress response and FGF21-dependent mitohormesis
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    Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders
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    sciencedirect.com/science/article/pii/S2211124724002286
  12. Feb 2024
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    Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway
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    The HRI branch of the integrated stress response selectively triggers mitophagy
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  15. Nov 2023
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    Tamoxifen for the treatment of myeloproliferative neoplasms: A Phase II clinical trial and exploratory analysis
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    K6-linked ubiquitylation marks formaldehyde-induced RNA-protein crosslinks for resolution
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    Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth
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    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
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    Micheliolide exerts effects in myeloproliferative neoplasms through inhibiting STAT3/5 phosphorylation via covalent binding to STAT3/5 proteins
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  21. Oct 2023
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    The intrinsically disordered region of eIF5B stimulates IRES usage and nucleates biological granule formation
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  23. Sep 2023
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    Intralumenal docking of Connexin 36 channels in the ER isolates mis-trafficked protein
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    sciencedirect.com/science/article/pii/S0021925823023104
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  26. Aug 2023
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    Lysosomal cystine governs ferroptosis sensitivity in cancer via cysteine stress response
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    FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress
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  29. Jul 2023
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    Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome
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    sciencedirect.com/science/article/abs/pii/S0896627323004762
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    Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons
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    Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
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    Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2
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  34. Jun 2023
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    Brief Oxygen Exposure after Traumatic Brain Injury Hastens Recovery and Promotes Adaptive Chronic Endoplasmic Reticulum Stress Responses
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    A mitochondrial iron-responsive pathway regulated by DELE1
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    Astrocytic deletion of protein kinase R-like ER kinase (PERK) does not affect learning and memory in aged mice but worsens outcome from experimental stroke
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  38. Apr 2023
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    Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids
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  40. Mar 2023
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    Remodeling of the Ribosomal Quality Control and Protein Translation by a Viral Ubiquitin Deconjugase
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  42. Feb 2023
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stress Granules determine the Development of Obesity-associated Pancreatic Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9357213/
  44. Dec 2022
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    BRCA1 mediates protein homeostasis through the ubiquitination of PERK and IRE1
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  46. Nov 2022
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    Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response
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    A systemic cell stress signal confers neuronal resilience toward oxidative stress in a Hedgehog-dependent manner
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  49. Oct 2022
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    An unusual mode of baseline translation adjusts cellular protein synthesis capacity to metabolic needs
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    sciencedirect.com/science/article/pii/S2211124722013171
  51. Sep 2022
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    Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice
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    Prolonged Exposure to Insulin Inactivates Akt and Erk1/2 and Increases Pancreatic Islet and INS1E β-Cell Apoptosis
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    Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling
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    Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice
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  110. Sep 2020
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    5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-mediated Apoptosis.
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  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  115. Jan 2020
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    TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling
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    Glial pathology in a novel spontaneous mutant mouse of the Eif2b5 gene: a vanishing white matter disease model
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    Betulinic acid alleviates endoplasmic reticulum stress‐mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice
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    p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
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    Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death
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    Prolonged Exposure to Insulin Inactivates Akt and Erk1/2 and Increases Pancreatic Islet and INS1E β-Cell Apoptosis
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    Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells
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  129. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Hydrogen sulfide regulates muscle RING finger‐1 protein S‐sulfhydration at Cys44 to prevent cardiac structural damage in diabetic cardiomyopathy
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  130. Nov 2018
  131. www.sciencedirect.com www.sciencedirect.com
    PKR Senses Nuclear and Mitochondrial Signals by Interacting with Endogenous Double-Stranded RNAs
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    Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells
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    Chemical chaperone treatment improves levels and distributions of connexins in Cx50D47A mouse lenses
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    Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
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    Neuronal activity‐dependent local activation of dendritic unfolded protein response promotes expression of brain‐derived neurotrophic factor in cell soma
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  140. Nov 2017
  141. elifesciences.org elifesciences.org
    Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult
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    Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules
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