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28 Matching Annotations

Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in pancreatic cancer cells

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1. scibot 30 Jan 2026
  
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  DOI: 10.1038/s41419-025-08362-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12847887/
Oct 2025
advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com

Erucic Acid, Derived by Lactobacillus Crispatus, Induces Ferroptosis in Cervical Cancer Organoids Through the PPAR-δ Signaling Pathway

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1. scibot 23 Oct 2025
  
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  DOI: 10.1002/advs.202512599
  
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advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202512599
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Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses

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1. scibot 01 Oct 2025
  
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  DOI: 10.1016/j.ccell.2025.09.003
  
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sciencedirect.com/science/article/pii/S1535610825003952
Sep 2025
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PDE7A inhibition suppresses triple-negative breast cancer by attenuating de novo pyrimidine biosynthesis

1
1. scibot 17 Sep 2025
  
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  DOI: 10.1016/j.xcrm.2025.102356
  
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sciencedirect.com/science/article/pii/S266637912500429X
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Mdm2 targeting via PROteolysis TArgeting Chimeras (PROTAC) is efficient in p53 wildtype, p53-mutated, and abemaciclib-resistant estrogen receptor-positive cell lines and superior to mdm2 inhibition

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1. scibot 04 Jun 2025
  
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  DOI: 10.1186/s12885-025-14361-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12128487/
Apr 2025
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LncRNA SLNCR phenocopies the E2F1 DNA binding site to promote melanoma progression

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1. scibot 24 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115608
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12172627/
Mar 2025
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CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety

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1. scibot 11 Mar 2025
  
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  DOI: 10.1016/j.ccell.2025.02.006
  
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sciencedirect.com/science/article/pii/S1535610825000583
Feb 2025
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KRASG12D-driven pentose phosphate pathway remodeling imparts a targetable vulnerability synergizing with MRTX1133 for durable remissions in PDAC

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1. scibot 20 Feb 2025
  
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  DOI: 10.1016/j.xcrm.2025.101966
  
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sciencedirect.com/science/article/pii/S2666379125000394
aacrjournals.org aacrjournals.org

Targeting GPC2 on intraocular and CNS metastatic retinoblastomas with local and systemic delivery of CAR T-cells

1
1. scibot 13 Feb 2025
  
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  DOI: 10.1158/1078-0432.CCR-24-0221
  
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aacrjournals.org/clincancerres/article/30/16/3578/746772/Targeting-GPC2-on-Intraocular-and-CNS-Metastatic
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs

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1. scibot 25 Jan 2025
  
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  DOI: 10.1158/0008-5472.CAN-23-2115
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11250573/
Aug 2024
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E2F1-associated purine synthesis pathway is a major component of the MET-DNA damage response network

1
1. scibot 01 Aug 2024
  
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  RRID:AB_2096936
  
  DOI: 10.1158/2767-9764.CRC-23-0370
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11288008/
Jul 2024
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Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton

1
1. scibot 17 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114510
  
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sciencedirect.com/science/article/pii/S2211124724008398
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The RNA binding proteins LARP4A and LARP4B promote sarcoma and carcinoma growth and metastasis

1
1. scibot 28 Mar 2024
  
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  RRID:AB_2096936
  
  DOI: 10.1016/j.isci.2024.109288
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10963253/
Feb 2024
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Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma

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1. scibot 14 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113771
  
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sciencedirect.com/science/article/pii/S2211124724000998
Aug 2023
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FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth

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1. scibot 03 Aug 2023
  
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  RRID:AB_2096936
  
  DOI: 10.1016/j.celrep.2023.112886
  
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sciencedirect.com/science/article/pii/S2211124723008975
Oct 2022
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E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance

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1. scibot 05 Oct 2022
  
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  DOI: 10.1016/j.celrep.2022.111436
  
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sciencedirect.com/science/article/pii/S2211124722012773
Aug 2022
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Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression

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1. scibot 23 Aug 2022
  
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  RRID:AB_2096936
  
  DOI: 10.1016/j.molcel.2022.07.014
  
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sciencedirect.com/science/article/pii/S1097276522007109
Mar 2022
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Targeting HNRNPM inhibits cancer stemness and enhances antitumor immunity in Wnt-activated hepatocellular carcinoma

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1. scibot 24 Mar 2022
  
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  DOI: 10.1016/j.jcmgh.2022.02.006
  
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sciencedirect.com/science/article/pii/S2352345X22000339
Jan 2022
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Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells

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1. scibot 16 Jan 2022
  
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  DOI: 10.1016/j.celrep.2021.110236
  
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sciencedirect.com/science/article/pii/S2211124721017459
May 2021
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Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer

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1. scibot 07 May 2021
  
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  DOI: 10.1016/j.molcel.2020.04.027
  
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sciencedirect.com/science/article/pii/S1097276520302690
Apr 2021
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Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG

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1. scibot 14 Apr 2021
  
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  DOI: 10.1016/j.celrep.2021.108994
  
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sciencedirect.com/science/article/pii/S2211124721003089
Jan 2021
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A FOXO-dependent replication checkpoint restricts proliferation of damaged cells

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1. scibot 27 Jan 2021
  
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  DOI: 10.1016/j.celrep.2020.108675
  
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sciencedirect.com/science/article/pii/S2211124720316648
Sep 2020
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CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma

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1. scibot 07 Sep 2020
  
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  DOI: 10.1016/j.ccell.2020.01.007
  
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sciencedirect.com/science/article/pii/S1535610820300465
Jan 2020
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_2096936
  
  DOI: 10.1016/j.celrep.2018.12.016
  
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sciencedirect.com/science/article/pii/S2211124718319272
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Untitled document

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  DOI: 10.1016/j.molcel.2019.03.020
  
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sciencedirect.com/science/article/pii/S1097276519302242
Nov 2018
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Cross Talk between One-Carbon Metabolism, Eph Signaling, and Histone Methylation Promotes Neural Stem Cell Differentiation

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S221112471830723X
europepmc.org europepmc.org

A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ Size

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1. scibot 05 Nov 2018
  
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europepmc.org/articles/PMC5722641/
Nov 2017
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Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis

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1. scibot 08 Nov 2017
  
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sciencedirect.com/science/article/pii/S1074761317302789