168 Matching Annotations
  1. Apr 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle
    1
    1. scibot 10 Apr 2024
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      DOI: 10.1038/s41598-024-58716-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10998866/
  3. Mar 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats
    1
    1. scibot 09 Mar 2024
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      DOI: 10.14814/phy2.15969

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    ncbi.nlm.nih.gov/pmc/articles/PMC10920058/
  5. www.sciencedirect.com www.sciencedirect.com
    MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors
    2
    1. scibot 07 Mar 2024
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      DOI: 10.1016/j.isci.2024.109188

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    2. scibot 06 Mar 2024
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      DOI: 10.1016/j.isci.2024.109188

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    sciencedirect.com/science/article/pii/S2589004224004097
  6. Feb 2024
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CREB3L4 promotes hepatocellular carcinoma progression and decreases sorafenib chemosensitivity by promoting RHEB-mTORC1 signaling pathway
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    1. scibot 03 Feb 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831937/
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    β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models
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    1. scibot 02 Feb 2024
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      DOI: 10.1016/j.biopha.2024.116217

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    sciencedirect.com/science/article/pii/S0753332224000982
  9. Jan 2024
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
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    1. scibot 06 Jan 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10839450/
  11. Dec 2023
  12. www.sciencedirect.com www.sciencedirect.com
    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
    1
    1. scibot 16 Dec 2023
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      DOI: 10.1016/j.molcel.2023.11.023

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    sciencedirect.com/science/article/pii/S1097276523009681
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metastatic or xenograft colorectal cancer induce divergent anabolic deficits and pro-inflammatory effectors of muscle wasting in a tumor-type dependent manner
    1
    1. scibot 02 Dec 2023
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      DOI: 10.1152/japplphysiol.00247.2022

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    ncbi.nlm.nih.gov/pmc/articles/PMC9678410/
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LP07 and LLC pre-clinical models of lung cancer induce divergent anabolic deficits and expression of pro-inflammatory effectors of muscle wasting
    1
    1. scibot 02 Dec 2023
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      DOI: 10.1152/japplphysiol.00246.2022

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    ncbi.nlm.nih.gov/pmc/articles/PMC9678411/
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    Nutrient-regulated control of lysosome function by signaling lipid conversion
    1
    1. scibot 02 Dec 2023
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      DOI: 10.1016/j.cell.2023.09.027

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    sciencedirect.com/science/article/pii/S0092867423010814
  16. Nov 2023
  17. www.sciencedirect.com www.sciencedirect.com
    The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency
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    1. scibot 28 Nov 2023
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    sciencedirect.com/science/article/abs/pii/S1550413123003856
  18. www.embopress.org www.embopress.org
    Breast adipose tissue-derived extracellular vesicles from obese women alter tumor cell metabolism
    1
    1. scibot 17 Nov 2023
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      DOI: 10.15252/embr.202357339

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    embopress.org/doi/full/10.15252/embr.202357339
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    CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions
    1
    1. scibot 02 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113306

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    sciencedirect.com/science/article/pii/S2211124723013189
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    CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline
    1
    1. scibot 02 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113269

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    sciencedirect.com/science/article/pii/S2211124723012810
  21. Oct 2023
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Spatiotemporal Regulation of De Novo and Salvage Purine Synthesis during Brain Development
    1
    1. scibot 14 Oct 2023
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      DOI: 10.1523/ENEURO.0159-23.2023

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  23. 52.53.155.43 52.53.155.43
    s41586-023-06657-6_reference-html.html
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    1. scibot 06 Oct 2023
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      DOI: 10.1038/s41586-023-06657-6

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      DOI: 10.1038/s41586-023-06657-6

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    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
    1
    1. scibot 06 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113202

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    sciencedirect.com/science/article/pii/S2211124723012147
  25. Sep 2023
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for high-sensitivity western blot on murine hematopoietic stem cells
    1
    1. scibot 30 Sep 2023
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      DOI: 10.1016/j.xpro.2023.102578

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    ncbi.nlm.nih.gov/pmc/articles/PMC10519847/
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    Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells
    1
    1. scibot 30 Sep 2023
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      DOI: 10.1016/j.molcel.2023.08.032

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    sciencedirect.com/science/article/pii/S1097276523006950
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    WNK1 is required during male pachynema to sustain fertility.
    1
    1. scibot 29 Sep 2023
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      DOI: 10.1016/j.isci.2023.107616

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    sciencedirect.com/science/article/pii/S2589004223016930
  29. dx.doi.org dx.doi.org
    Insulin Signaling Is Preserved in Skeletal Muscle During Early Diabetic Ketoacidosis
    1
    1. scibot 14 Sep 2023
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      DOI: 10.1210/clinem/dgad464

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    dx.doi.org/10.1210/clinem/dgad464
  30. Aug 2023
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection
    1
    1. scibot 31 Aug 2023
      RRID:AB_10691384

      DOI: 10.1016/j.isci.2023.107552

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    ncbi.nlm.nih.gov/pmc/articles/PMC10460994/
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Short-term PI3K inhibition prevents breast cancer in preclinical models
    1
    1. scibot 10 Aug 2023
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      DOI: 10.1158/1940-6207.CAPR-22-0275

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    ncbi.nlm.nih.gov/pmc/articles/PMC9905287/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression
    1
    1. scibot 10 Aug 2023
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      DOI: 10.1016/j.isci.2023.107408

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    ncbi.nlm.nih.gov/pmc/articles/PMC10405072/
  34. Jul 2023
  35. www.sciencedirect.com www.sciencedirect.com
    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
    1
    1. scibot 27 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112868

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    sciencedirect.com/science/article/pii/S2211124723008793
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylated S6K1 and 4E-BP1 play different roles in constitutively active Rheb-mediated retinal ganglion cell survival and axon regeneration after optic nerve injury
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    1. scibot 25 Jul 2023
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      DOI: 10.4103/1673-5374.371372

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    ncbi.nlm.nih.gov/pmc/articles/PMC10360084/
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    Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
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    1. scibot 21 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112794

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    sciencedirect.com/science/article/pii/S2211124723008057
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    Development of small fluorescent probes for the analysis of autophagy kinetics
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    1. scibot 15 Jul 2023
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      DOI: 10.1016/j.isci.2023.107218

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    sciencedirect.com/science/article/pii/S2589004223012956
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    Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
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    1. scibot 08 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112764

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    sciencedirect.com/science/article/pii/S2211124723007751
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    Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells
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      DOI: 10.1016/j.celrep.2023.112749

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    sciencedirect.com/science/article/pii/S221112472300760X
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N-myc mediated translation control is a therapeutic vulnerability in medulloblastoma
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      DOI: 10.1158/0008-5472.CAN-22-0945

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    ncbi.nlm.nih.gov/pmc/articles/PMC9812901/
  42. 52.53.155.43 52.53.155.43
    mct-22-0224 (1)-html.html
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      DOI: 10.1158/1535-7163.mct-22-0224

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  43. Jun 2023
  44. www.sciencedirect.com www.sciencedirect.com
    Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”
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      DOI: 10.1016/j.celrep.2023.112632

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    sciencedirect.com/science/article/pii/S2211124723006435
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    Bursting translation on single mRNAs in live cells
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      DOI: 10.1016/j.molcel.2023.05.019

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    sciencedirect.com/science/article/pii/S1097276523003751
  46. May 2023
  47. www.sciencedirect.com www.sciencedirect.com
    Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity
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      DOI: 10.1016/j.cmet.2023.05.001

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    sciencedirect.com/science/article/pii/S155041312300178X
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    PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway
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      DOI: 10.1016/j.celrep.2023.112519

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    sciencedirect.com/science/article/pii/S2211124723005302
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    MicroRNA-31 induced by Fusobacterium nucleatum infection promotes colorectal cancer tumorigenesis
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      DOI: 10.1016/j.isci.2023.106770

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    sciencedirect.com/science/article/pii/S2589004223008477
  50. academic.oup.com academic.oup.com
    Whole-body and forearm muscle protein metabolism in patients with acromegaly before and after treatment
    1
    1. scibot 06 May 2023
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      DOI: 10.1210/clinem/dgad190

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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgad190/7111800
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    Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR
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    TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models
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    Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress
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    Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase
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    Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination
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  115. Aug 2021
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    Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling
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  124. Jul 2021
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    mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
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      4E-BP1

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    New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis
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    An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress
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  128. Jun 2021
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    OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin
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    MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages
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  131. May 2021
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    Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function
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    Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility
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    Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity
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    NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C
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    AP-2β/KCTD1 Control Distal Nephron Differentiation and Protect against Renal Fibrosis
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    HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis
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    Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth
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  139. Apr 2021
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    4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors
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    Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer
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    The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine
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    The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
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  145. Mar 2021
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    Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis
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    Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer
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      Anti-4EBP1 rabbit monoclonal

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  148. Feb 2021
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      anti-4E-BP1

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    Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation
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  152. Dec 2020
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    Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2
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  154. Nov 2020
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    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
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  156. Oct 2020
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    The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest
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  158. Sep 2020
  159. elifesciences.org elifesciences.org
    The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis
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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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    Vcp Overexpression and Leucine Supplementation Increase Protein Synthesis and Improve Fear Memory and Social Interaction of Nf1 Mutant Mice
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    Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α
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    Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in the dsRNA Response
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    Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters
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    p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas
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    NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression
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    Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy
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    mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux
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    TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress
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    p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
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    Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer
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    Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling
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  192. Nov 2018
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    Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides
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    Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool
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    Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
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    Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance
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    Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells
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    Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
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    mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma
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    A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice
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    sciencedirect.com/science/article/pii/S1550413117304904
  204. www.sciencedirect.com www.sciencedirect.com
    Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
    1
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      RRID:AB_2097841

      Curator: @chewbeccax

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    sciencedirect.com/science/article/pii/S1097276517304914
  205. www.sciencedirect.com www.sciencedirect.com
    Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
    1
    1. scibot 08 Nov 2017
      CSTCat#9644

      Curator: @bandrow

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    sciencedirect.com/science/article/pii/S1074761317302339
  206. www.sciencedirect.com www.sciencedirect.com
    mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
    1
    1. scibot 08 Nov 2017
      AB_2097841

      Curator: @chewbeccax

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      (Cell Signaling Technology Cat# 9644, RRID:AB_2097841)

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    sciencedirect.com/science/article/pii/S1097276517303945
  207. elifesciences.org elifesciences.org
    Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator
    1
    1. scibot 08 Nov 2017
      AB_2097841

      Curator: @kaitlinsung

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      (Cell Signaling Technology Cat# 9644, RRID:AB_2097841)

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    elifesciences.org/articles/23063
  208. www.sciencedirect.com www.sciencedirect.com
    L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
    3
    1. scibot 08 Nov 2017
      RRID: AB_2097841

      Curator: @bandrow

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      (Cell Signaling Technology Cat# 9644, RRID:AB_2097841)

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      RRID:AB_2097841
    2. scibot 08 Nov 2017
      AB_2097841

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      (Cell Signaling Technology Cat# 9644, RRID:AB_2097841)

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    3. scibot 08 Nov 2017
      AB_2097841

      Curator: @chewbeccax

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      (Cell Signaling Technology Cat# 9644, RRID:AB_2097841)

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      RRID:AB_2097841 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0092867416313137
  209. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic Removal of Matrix Metalloproteinase 9 Rescues the Symptoms of Fragile X Syndrome in a Mouse Model
    1
    1. scibot 08 Nov 2017
      AB_2097841

      Curator: @gabimpine

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      (Cell Signaling Technology Cat# 9644, RRID:AB_2097841)

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    ncbi.nlm.nih.gov/pmc/articles/PMC4107404/