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HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis

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1. scibot 11 Oct 2025
  
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  RRID:AB_2097841
  
  DOI: 10.1016/j.celrep.2025.116382
  
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sciencedirect.com/science/article/pii/S2211124725011532
Oct 2025
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Arsenic regulates ALKBH1 abundance and substrate specificity to promote translation and tumorigenicity

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1. scibot 08 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116311
  
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sciencedirect.com/science/article/pii/S2211124725010824
Sep 2025
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mTOR inhibition reprograms cellular lipid homeostasis by inducing alternative lipid uptake and promoting cholesterol transport

1
1. scibot 19 Sep 2025
  
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  RRID:AB_2097841
  
  DOI: 10.1016/j.molcel.2025.08.021
  
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sciencedirect.com/science/article/pii/S1097276525007063
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OGFOD1 enables AML chemo- and nutrient stress resistance by regulating protein synthesis

1
1. scibot 17 Sep 2025
  
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  RRID:AB_2097841
  
  DOI: 10.1016/j.cmet.2025.08.008
  
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sciencedirect.com/science/article/pii/S155041312500381X
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Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer

1
1. scibot 10 Sep 2025
  
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  RRID:AB_2097841
  
  DOI: 10.1158/1541-7786.MCR-24-1045
  
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aacrjournals.org/mcr/article/23/9/765/764255/Novel-Metastasis-Suppressor-PI3KC2-Is-Mediated-by
Aug 2025
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Targeting the MYC oncogene with a selective bi-steric mTORC1 inhibitor elicits tumor regression in MYC-driven cancers

1
1. scibot 13 Aug 2025
  
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  DOI: 10.1016/j.chembiol.2025.07.004
  
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sciencedirect.com/science/article/pii/S2451945625002272
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Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size

1
1. scibot 01 Aug 2025
  
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  RRID:AB_2097841
  
  DOI: 10.1101/2025.07.23.666188
  
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biorxiv.org/content/10.1101/2025.07.23.666188v1
Jul 2025
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Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling

1
1. scibot 25 Jul 2025
  
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  AB_2097841
  
  DOI: 10.1126/science.adm9805
  
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science.org/doi/10.1126/science.adm9805
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FMRP drives mRNP targets into translationally silenced complexes

1
1. scibot 15 Jul 2025
  
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  RRID:AB_2097841
  
  DOI: 10.1016/j.molcel.2025.06.012
  
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sciencedirect.com/science/article/pii/S109727652500512X
Jun 2025
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PDF-html.html

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1. scibot 12 Jun 2025
  
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  DOI: 10.1158/0008-5472.can-24-3785
  
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52.53.155.43/6d05284590fa38103d7fbc1633c815ab1c347fcd/PDF-html.html
May 2025
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YTHDF1 differentiates the contributing roles of mTORC1 in aging

1
1. scibot 29 May 2025
  
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  RRID:AB_2097841
  
  DOI: 10.1016/j.molcel.2025.05.003
  
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sciencedirect.com/science/article/pii/S1097276525004083
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Lymphatic endothelial mTORC1 instructs metabolic and developmental signaling during lymphangiogenesis

1
1. scibot 17 May 2025
  
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  RRID:AB_2097841
  
  DOI: 10.1016/j.devcel.2025.04.012
  
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sciencedirect.com/science/article/pii/S1534580725002503
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Time Release Ion Matrix Regenerates Dystrophic Skeletal Muscle

1
1. scibot 19 Apr 2025
  
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  RRID:AB_2097841
  
  DOI: 10.21203/rs.3.rs-5968078/v1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11957216/
Mar 2025
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Induction of Triple-Negative Breast Cancer Cell Death and Chemosensitivity Using mTORC2-Directed RNAi Nanomedicine

1
1. scibot 21 Mar 2025
  
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  AB_2097841
  
  DOI: 10.1158/2767-9764.CRC-24-0261
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11921867/
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Cytotoxic Autophagy: A Novel Treatment Paradigm against Breast Cancer Using Oleanolic Acid and Ursolic Acid

1
1. scibot 06 Mar 2025
  
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  AB_2097841
  
  DOI: 10.3390/cancers16193367
  
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mdpi.com/2072-6694/16/19/3367
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A highland-adaptation variant near MCUR1 reduces its transcription and attenuates erythrogenesis in Tibetans

1
1. scibot 06 Mar 2025
  
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  RRID:AB_2097841
  
  DOI: 10.1016/j.xgen.2025.100782
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11960549/
52.53.155.43 52.53.155.43

1-s2.0-S2589004225004043-main-html.html

1
1. scibot 06 Mar 2025
  
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  AB_2097841
  
  DOI: 10.1016/j.isci.2025.112144
  
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52.53.155.43/a54d23b2534862197be3e5d5ad98a8cc187610fd/1-s2.0-S2589004225004043-main-html.html
Feb 2025
aacrjournals.org aacrjournals.org

GDF-15 predicts epithelioid hemangioendothelioma aggressiveness and is down-regulated by sirolimus through ATF4/ATF5 suppression

1
1. scibot 13 Feb 2025
  
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  RRID:AB_2097841
  
  DOI: 10.1158/1078-0432.CCR-23-3991
  
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aacrjournals.org/clincancerres/article/30/22/5122/749578/GDF-15-Predicts-Epithelioid-Hemangioendothelioma
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation

1
1. scibot 08 Feb 2025
  
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  RRID:AB_2097841
  
  DOI: 10.1038/s41467-025-56564-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11791202/
www.nature.com www.nature.com

The coagulation and tumor system are directly linked through the proteolysis and activation of epidermal growth factor receptor by thrombin

2
1. scibot 07 Feb 2025
  
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  AB_2097841
  
  DOI: 10.1038/s41388-025-03296-1
  
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2. scibot 06 Feb 2025
  
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  AB_2097841
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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nature.com/articles/s41388-025-03296-1
Jan 2025
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Mitochondrial uncouplers inhibit oncogenic E2F1 activity and prostate cancer growth

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1. scibot 14 Jan 2025
  
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  RRID:AB_2097841
  
  DOI: 10.1016/j.xcrm.2024.101890
  
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sciencedirect.com/science/article/pii/S266637912400661X
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mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase

1
1. scibot 14 Jan 2025
  
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  RRID:AB_2097841
  
  DOI: 10.1016/j.celrep.2024.115179
  
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sciencedirect.com/science/article/pii/S2211124724015304
www.jidonline.org www.jidonline.org

5’-cap-dependent translation as a potent therapeutic target for lethal human squamous cell carcinoma

1
1. scibot 10 Jan 2025
  
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  4E-BP-1
  
  DOI: 10.1016/j.jid.2020.08.021
  
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jidonline.org/article/S0022-202X(20)32066-2/fulltext
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Non-cell-autonomous regulation of mTORC2 by Hedgehog signaling maintains lipid homeostasis

1
1. scibot 09 Jan 2025
  
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  RRID:AB_2097841
  
  DOI: 10.1016/j.celrep.2024.115191
  
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sciencedirect.com/science/article/pii/S2211124724015420
Dec 2024
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The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation

1
1. scibot 21 Dec 2024
  
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  RRID:AB_2097841
  
  DOI: 10.1016/j.celrep.2024.115101
  
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sciencedirect.com/science/article/pii/S2211124724014529
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A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor

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1. scibot 10 Dec 2024
  
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  RRID:AB_2097841
  
  DOI: 10.1016/j.cell.2024.11.009
  
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sciencedirect.com/science/article/pii/S0092867424013266
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Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma

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1. scibot 05 Dec 2024
  
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  RRID:AB_2097841
  
  DOI: 10.1016/j.celrep.2024.115026
  
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sciencedirect.com/science/article/pii/S2211124724013779
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Anabolic deficits and divergent unfolded protein response underlie skeletal and cardiac muscle growth impairments in the Yoshida hepatoma tumor model of cancer cachexia

1
1. scibot 25 Sep 2024
  
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  RRID:AB_2097841
  
  DOI: 10.14814/phy2.70044
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11410559/
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A TBK1-independent primordial function of STING in lysosomal biogenesis

1
1. scibot 25 Sep 2024
  
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  AB_2097841
  
  DOI: 10.1016/j.molcel.2024.08.026
  
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sciencedirect.com/science/article/pii/S1097276524007032
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice

1
1. scibot 06 Sep 2024
  
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  RRID:AB_2097841
  
  DOI: 10.1210/endocr/bqad133
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10502789/
Aug 2024
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Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions

1
1. scibot 22 Aug 2024
  
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  RRID:AB_2097841
  
  DOI: 10.1016/j.celrep.2024.114663
  
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sciencedirect.com/science/article/pii/S2211124724010143
www.cell.com www.cell.com

RIPK1 Promotes Energy Sensing by the mTORC1 Pathway

1
1. scibot 02 Aug 2024
  
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  4E-BP1
  
  DOI: 10.1016/j.molcel.2020.11.008
  
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cell.com/molecular-cell/fulltext/S1097-2765(20)30786-3
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging

1
1. scibot 25 Jul 2024
  
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  RRID:AB_2097841
  
  DOI: 10.1080/15548627.2024.2333717
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11262205/
52.53.155.43 52.53.155.43

1-s2.0-S2589004224017851-main-html.html

1
1. scibot 25 Jul 2024
  
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  RRID:AB_2097841
  
  DOI: 10.1016/j.isci.2024.110560
  
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52.53.155.43/28f1f0cd51770599356cfb72d036c0e468b38b34/1-s2.0-S2589004224017851-main-html.html
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Dystrophin S3059 phosphorylation partially attenuates denervation atrophy in mouse tibialis anterior muscles

1
1. scibot 17 Jul 2024
  
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Multi-step regulation of microRNA expression and secretion into small extracellular vesicles by insulin

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Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells

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Electron transport chain inhibition increases cellular dependence on purine transport and salvage

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mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway

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Everolimus exerts anticancer effects through inhibiting the interaction of matrix metalloproteinase-7 with syndecan-2 in colon cancer cells

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Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells

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A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1

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Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner

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The MYCN 5′ UTR as a therapeutic target in neuroblastoma

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The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle

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Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats

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MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors

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CREB3L4 promotes hepatocellular carcinoma progression and decreases sorafenib chemosensitivity by promoting RHEB-mTORC1 signaling pathway

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β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models

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Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model

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MORG1 limits mTORC1 signaling by inhibiting Rag GTPases

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Metastatic or xenograft colorectal cancer induce divergent anabolic deficits and pro-inflammatory effectors of muscle wasting in a tumor-type dependent manner

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LP07 and LLC pre-clinical models of lung cancer induce divergent anabolic deficits and expression of pro-inflammatory effectors of muscle wasting

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Nutrient-regulated control of lysosome function by signaling lipid conversion

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The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency

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Breast adipose tissue-derived extracellular vesicles from obese women alter tumor cell metabolism

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CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions

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CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline

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Spatiotemporal Regulation of De Novo and Salvage Purine Synthesis during Brain Development

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s41586-023-06657-6_reference-html.html

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CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling

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Protocol for high-sensitivity western blot on murine hematopoietic stem cells

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Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells

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WNK1 is required during male pachynema to sustain fertility.

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Insulin Signaling Is Preserved in Skeletal Muscle During Early Diabetic Ketoacidosis

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  DOI: 10.1210/clinem/dgad464
  
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A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection

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Short-term PI3K inhibition prevents breast cancer in preclinical models

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  DOI: 10.1158/1940-6207.CAPR-22-0275
  
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Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression

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mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching

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Phosphorylated S6K1 and 4E-BP1 play different roles in constitutively active Rheb-mediated retinal ganglion cell survival and axon regeneration after optic nerve injury

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Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells

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Development of small fluorescent probes for the analysis of autophagy kinetics

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Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors

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Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells

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N-myc mediated translation control is a therapeutic vulnerability in medulloblastoma

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mct-22-0224 (1)-html.html

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Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”

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Bursting translation on single mRNAs in live cells

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Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity

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PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway

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MicroRNA-31 induced by Fusobacterium nucleatum infection promotes colorectal cancer tumorigenesis

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Whole-body and forearm muscle protein metabolism in patients with acromegaly before and after treatment

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Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR

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Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression

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Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort

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CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth

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Large neutral amino acid levels tune perinatal neuronal excitability and survival

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Cytotoxic CD161−CD8+ TEMRA cells contribute to the pathogenesis of systemic lupus erythematosus

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Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity

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PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6

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Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix

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Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation

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Dec 2022
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can-22-0945-html.html

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Neuronal-epithelial cross-talk drives acinar specification via NRG1-ERBB3-mTORC2 signaling

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Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

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Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response

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Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein

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Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation

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Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival

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PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer

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DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting

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Context-dependent regulation of ferroptosis sensitivity

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Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis

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Neuron-specific translational control shift ensures proteostatic resilience during ER stress

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Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A

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Loss of 4E-BP converts cerebellar long-term depression to long-term potentiation

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Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry

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The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth

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PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson’s disease

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Transcription factors AP-2α and AP-2β regulate distinct segments of the distal nephron in the mammalian kidney

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Microbiota-mediated skewing of tryptophan catabolism modulates CD4+ T cells in lupus-prone mice

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The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets

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SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation

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Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication

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Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling

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japplphysiol.00536.2021-html.html

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DRAM-4 and DRAM-5 are compensatory regulators of autophagy and cell survival in nutrient-deprived conditions

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Creatine transport and creatine kinase activity is required for CD8+ T cell immunity

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A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring

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Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism

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Cytosolic adaptation to mitochondria-induced proteostatic stress causes progressive muscle wasting

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Translational and post-translational control of human naïve versus primed pluripotency

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TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models

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Protocol for the assessment of mTOR activity in mouse primary hepatocytes

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Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress

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Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase

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Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination

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Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression

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RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal

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Untitled document

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Untitled document

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Untitled document

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Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling

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mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability

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New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis

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An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress

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OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin

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MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages

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Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function

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Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility

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Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity

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NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

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AP-2β/KCTD1 Control Distal Nephron Differentiation and Protect against Renal Fibrosis

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HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis

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Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth

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4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors

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Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer

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Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer

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The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine

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The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

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Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis

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Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer

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Metabolic conditioning of CD8 + effector T cells for adoptive cell therapy

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  anti-4E-BP1
  
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Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation

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Comprehensive pharmacogenomic characterization of gastric cancer

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Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

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The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest

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The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis

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Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids

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UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity

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  DOI: 10.7554/eLife.37993
  
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Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module

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Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition

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Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR

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Kinetic Heterogeneity of Cancer Cell Fractional Killing

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Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1

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  4E‐BP1
  
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Vcp Overexpression and Leucine Supplementation Increase Protein Synthesis and Improve Fear Memory and Social Interaction of Nf1 Mutant Mice

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Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

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  DOI: 10.1016/j.celrep.2019.07.084
  
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Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α

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Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in the dsRNA Response

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  DOI: 10.1016/j.molcel.2019.07.027
  
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Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters

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  DOI: 10.1016/j.chembiol.2019.05.009
  
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p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

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Synergistic Highly Potent Targeted Drug Combinations in different Pheochromocytoma Models including Human Tumor Cultures

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NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression

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Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy

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mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux

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TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress

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p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

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Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer

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Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling

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Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides

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Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool

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