186 Matching Annotations
  1. Sep 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anabolic deficits and divergent unfolded protein response underlie skeletal and cardiac muscle growth impairments in the Yoshida hepatoma tumor model of cancer cachexia
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    1. scibot 25 Sep 2024
      RRID:AB_2097841

      DOI: 10.14814/phy2.70044

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    ncbi.nlm.nih.gov/pmc/articles/PMC11410559/
  3. www.sciencedirect.com www.sciencedirect.com
    A TBK1-independent primordial function of STING in lysosomal biogenesis
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    sciencedirect.com/science/article/pii/S1097276524007032
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice
    1
    1. scibot 06 Sep 2024
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      DOI: 10.1210/endocr/bqad133

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    ncbi.nlm.nih.gov/pmc/articles/PMC10502789/
  5. Aug 2024
  6. www.sciencedirect.com www.sciencedirect.com
    Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions
    1
    1. scibot 22 Aug 2024
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      DOI: 10.1016/j.celrep.2024.114663

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    sciencedirect.com/science/article/pii/S2211124724010143
  7. www.cell.com www.cell.com
    RIPK1 Promotes Energy Sensing by the mTORC1 Pathway
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    1. scibot 02 Aug 2024
      4E-BP1

      DOI: 10.1016/j.molcel.2020.11.008

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    cell.com/molecular-cell/fulltext/S1097-2765(20)30786-3
  8. Jul 2024
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging
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    1. scibot 25 Jul 2024
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      DOI: 10.1080/15548627.2024.2333717

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    ncbi.nlm.nih.gov/pmc/articles/PMC11262205/
  10. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004224017851-main-html.html
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    1. scibot 25 Jul 2024
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      DOI: 10.1016/j.isci.2024.110560

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    52.53.155.43/28f1f0cd51770599356cfb72d036c0e468b38b34/1-s2.0-S2589004224017851-main-html.html
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dystrophin S3059 phosphorylation partially attenuates denervation atrophy in mouse tibialis anterior muscles
    1
    1. scibot 17 Jul 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11245571/
  12. www.sciencedirect.com www.sciencedirect.com
    Multi-step regulation of microRNA expression and secretion into small extracellular vesicles by insulin
    1
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      AB_2097841

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    sciencedirect.com/science/article/pii/S2211124724008209
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells
    1
    1. scibot 03 Jul 2024
      RRID:AB_2097841

      DOI: 10.3389/fonc.2024.1394653

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    ncbi.nlm.nih.gov/pmc/articles/PMC11199525/
  14. Jun 2024
  15. www.sciencedirect.com www.sciencedirect.com
    Electron transport chain inhibition increases cellular dependence on purine transport and salvage
    1
    1. scibot 21 Jun 2024
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    sciencedirect.com/science/article/pii/S1550413124001906
  16. May 2024
  17. www.sciencedirect.com www.sciencedirect.com
    mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
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    1. scibot 24 May 2024
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      DOI: 10.1016/j.molcel.2024.04.026

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    sciencedirect.com/science/article/pii/S1097276524003939
  18. 52.53.155.43 52.53.155.43
    Everolimus exerts anticancer effects through inhibiting the interaction of matrix metalloproteinase-7 with syndecan-2 in colon cancer cells
    2
    1. scibot 24 May 2024
      RRID:AB_209784

      DOI: 10.1152/ajpcell.00669.2023

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    2. scibot 24 May 2024
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      RRIDCUR:Unresolved RRID:AB_2097841 DOI:10.1152/ajpcell.00669.2023
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    52.53.155.43/76598b44d554c4165a9f84a25bc34c671709ff41/lee-et-al-2024-everolimus-exerts-anticancer-effects-through-inhibiting-the-interaction-of-matrix-metalloproteinase-7-html.html
  19. www.biorxiv.org www.biorxiv.org
    Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells
    1
    1. scibot 23 May 2024
      RRID:AB_2097841

      DOI: 10.1101/2024.05.13.593567

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    biorxiv.org/content/10.1101/2024.05.13.593567v1
  20. www.sciencedirect.com www.sciencedirect.com
    A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1
    1
    1. scibot 08 May 2024
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      DOI: 10.1016/j.cmet.2024.04.015

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    sciencedirect.com/science/article/pii/S1550413124001359
  21. Apr 2024
  22. www.sciencedirect.com www.sciencedirect.com
    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
    1
    1. scibot 30 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114149

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    sciencedirect.com/science/article/pii/S2211124724004777
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    The MYCN 5′ UTR as a therapeutic target in neuroblastoma
    1
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      DOI: 10.1016/j.celrep.2024.114134

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    sciencedirect.com/science/article/pii/S2211124724004625
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle
    1
    1. scibot 10 Apr 2024
      RRID:AB_2097841

      DOI: 10.1038/s41598-024-58716-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10998866/
  25. Mar 2024
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats
    1
    1. scibot 09 Mar 2024
      AB_2097841

      DOI: 10.14814/phy2.15969

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    ncbi.nlm.nih.gov/pmc/articles/PMC10920058/
  27. www.sciencedirect.com www.sciencedirect.com
    MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors
    2
    1. scibot 07 Mar 2024
      RRID:AB_2097841

      DOI: 10.1016/j.isci.2024.109188

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      RRID:AB_2097841

      DOI: 10.1016/j.isci.2024.109188

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    sciencedirect.com/science/article/pii/S2589004224004097
  28. Feb 2024
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CREB3L4 promotes hepatocellular carcinoma progression and decreases sorafenib chemosensitivity by promoting RHEB-mTORC1 signaling pathway
    1
    1. scibot 03 Feb 2024
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      DOI: 10.1016/j.isci.2024.108843

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    ncbi.nlm.nih.gov/pmc/articles/PMC10831937/
  30. www.sciencedirect.com www.sciencedirect.com
    β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models
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      DOI: 10.1016/j.biopha.2024.116217

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    sciencedirect.com/science/article/pii/S0753332224000982
  31. Jan 2024
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
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      DOI: 10.1016/j.jbc.2023.105619

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    pmc.ncbi.nlm.nih.gov/articles/PMC10839450/
  33. Dec 2023
  34. www.sciencedirect.com www.sciencedirect.com
    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
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    1. scibot 16 Dec 2023
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      DOI: 10.1016/j.molcel.2023.11.023

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    sciencedirect.com/science/article/pii/S1097276523009681
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metastatic or xenograft colorectal cancer induce divergent anabolic deficits and pro-inflammatory effectors of muscle wasting in a tumor-type dependent manner
    1
    1. scibot 02 Dec 2023
      AB_2097841

      DOI: 10.1152/japplphysiol.00247.2022

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    ncbi.nlm.nih.gov/pmc/articles/PMC9678410/
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LP07 and LLC pre-clinical models of lung cancer induce divergent anabolic deficits and expression of pro-inflammatory effectors of muscle wasting
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    1. scibot 02 Dec 2023
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      DOI: 10.1152/japplphysiol.00246.2022

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    ncbi.nlm.nih.gov/pmc/articles/PMC9678411/
  37. www.sciencedirect.com www.sciencedirect.com
    Nutrient-regulated control of lysosome function by signaling lipid conversion
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      DOI: 10.1016/j.cell.2023.09.027

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    sciencedirect.com/science/article/pii/S0092867423010814
  38. Nov 2023
  39. www.sciencedirect.com www.sciencedirect.com
    The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency
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    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.cmet.2023.10.016

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    sciencedirect.com/science/article/abs/pii/S1550413123003856
  40. www.embopress.org www.embopress.org
    Breast adipose tissue-derived extracellular vesicles from obese women alter tumor cell metabolism
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      DOI: 10.15252/embr.202357339

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    embopress.org/doi/full/10.15252/embr.202357339
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    CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions
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      DOI: 10.1016/j.celrep.2023.113306

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    sciencedirect.com/science/article/pii/S2211124723013189
  42. www.sciencedirect.com www.sciencedirect.com
    CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline
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      DOI: 10.1016/j.celrep.2023.113269

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    sciencedirect.com/science/article/pii/S2211124723012810
  43. Oct 2023
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Spatiotemporal Regulation of De Novo and Salvage Purine Synthesis during Brain Development
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      DOI: 10.1523/ENEURO.0159-23.2023

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    ncbi.nlm.nih.gov/pmc/articles/PMC10566546/
  45. 52.53.155.43 52.53.155.43
    s41586-023-06657-6_reference-html.html
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      DOI: 10.1038/s41586-023-06657-6

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    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
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      DOI: 10.1016/j.celrep.2023.113202

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    sciencedirect.com/science/article/pii/S2211124723012147
  47. Sep 2023
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for high-sensitivity western blot on murine hematopoietic stem cells
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      DOI: 10.1016/j.xpro.2023.102578

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    ncbi.nlm.nih.gov/pmc/articles/PMC10519847/
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    Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells
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      DOI: 10.1016/j.molcel.2023.08.032

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    sciencedirect.com/science/article/pii/S1097276523006950
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    WNK1 is required during male pachynema to sustain fertility.
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      DOI: 10.1016/j.isci.2023.107616

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  52. Aug 2023
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    A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection
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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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    Phosphorylated S6K1 and 4E-BP1 play different roles in constitutively active Rheb-mediated retinal ganglion cell survival and axon regeneration after optic nerve injury
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    Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
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    Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells
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    Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”
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    Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity
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    PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway
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    Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR
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  105. Jun 2022
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    Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
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    Creatine transport and creatine kinase activity is required for CD8+ T cell immunity
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  125. Jan 2022
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    Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism
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  128. Dec 2021
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    TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models
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  137. Aug 2021
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    Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling
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  146. Jul 2021
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    mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
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    New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis
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  150. Jun 2021
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    OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin
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    MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages
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  153. May 2021
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    Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility
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    Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity
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    NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C
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    HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis
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    Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth
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  161. Apr 2021
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    4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors
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    Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer
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    The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine
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  166. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
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  167. Mar 2021
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    Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis
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    Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer
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      Anti-4EBP1 rabbit monoclonal

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  170. Feb 2021
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    Metabolic conditioning of CD8 + effector T cells for adoptive cell therapy
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  172. www.cell.com www.cell.com
    Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation
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  174. Dec 2020
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    Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2
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  176. Nov 2020
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    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
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  178. Oct 2020
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    The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest
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  180. Sep 2020
  181. elifesciences.org elifesciences.org
    The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis
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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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  183. elifesciences.org elifesciences.org
    UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity
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    Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module
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    Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition
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    Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR
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    Kinetic Heterogeneity of Cancer Cell Fractional Killing
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  188. www.embopress.org www.embopress.org
    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
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    Vcp Overexpression and Leucine Supplementation Increase Protein Synthesis and Improve Fear Memory and Social Interaction of Nf1 Mutant Mice
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  190. Jan 2020
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    Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming
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    Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α
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    Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in the dsRNA Response
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    Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters
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    p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas
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    Synergistic Highly Potent Targeted Drug Combinations in different Pheochromocytoma Models including Human Tumor Cultures
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      RRID:AB_2097841

      DOI: 10.1210/en.2019-00410

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    NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression
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    Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy
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    mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux
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    TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress
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    p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
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    Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer
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  203. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling
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  214. Nov 2018
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    Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides
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    Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool
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    Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance
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    Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells
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    Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
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    mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma
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  224. Nov 2017
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    Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
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    Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
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    mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
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    L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
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    Genetic Removal of Matrix Metalloproteinase 9 Rescues the Symptoms of Fragile X Syndrome in a Mouse Model
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