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SOCS1-based therapeutic peptides improve liver disease and metabolic dysfunction in obesity and diabetes

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nature.com/articles/s41598-026-46312-4
Jun 2026
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Prevention of Myc-Driven Prostate Cancer in Mice by Oral Administration of Sulforaphane

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1. scibot 25 Jun 2026
  
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  DOI: 10.1002/mc.70139
  
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onlinelibrary.wiley.com/doi/10.1002/mc.70139
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Reductive death is averted by a conserved de novo lipogenic switch

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  DOI: 10.1016/j.molcel.2026.05.011
  
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sciencedirect.com/science/article/pii/S1097276526003175
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Therapeutic effects of chitooligosaccharide-epigallocatechin gallate conjugate on NAFLD: impact on gut-liver axis, lipid metabolism, and inflammation in rats fed a high-fat diet

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1. scibot 04 Jun 2026
  
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link.springer.com/article/10.1007/s13105-026-01193-z
Mar 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

FASN Inhibition Enhances the Efficacy of Chemotherapy in Colorectal Cancer by Inhibiting the DNA Damage Response

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  DOI: 10.1158/0008-5472.CAN-25-1917
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13007557/
Jan 2026
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SREBP-1 upregulates SOAT1 to promote tumor growth by preventing lipotoxicity

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1. scibot 27 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116896
  
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sciencedirect.com/science/article/pii/S2211124725016687
Dec 2025
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Enhanced non-enzymatic H2S generation extends lifespan and healthspan in male mice

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1. scibot 20 Dec 2025
  
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sciencedirect.com:5037/science/article/pii/S1550413125005261
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Bile acids regulate lipid metabolism through selective actions on fatty acid absorption

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1. scibot 14 Dec 2025
  
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sciencedirect.com:5037/science/article/pii/S1550413125004942
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The exit of naive pluripotency contains a metabolism-induced checkpoint for telomere homeostasis

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1. scibot 13 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116654
  
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sciencedirect.com:5037/science/article/pii/S2211124725014263
Jul 2025
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Targeting PGM3 abolishes SREBP-1 activation-hexosamine synthesis feedback regulation to effectively suppress brain tumor growth

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1. scibot 25 Jul 2025
  
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  DOI: 10.1126/sciadv.adq0334
  
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science.org/doi/10.1126/sciadv.adq0334
Jun 2025
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PRPS activity tunes redox homeostasis in Myc-driven lymphoma

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.redox.2025.103649
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12166406/
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Cancer-associated fibroblasts promote drug resistance in ALK-driven lung adenocarcinoma cells by upregulating lipid biosynthesis

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1. scibot 17 Jun 2025
  
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  DOI: 10.1186/s40170-025-00400-7
  
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link.springer.com/article/10.1186/s40170-025-00400-7
May 2025
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KMT2C deficiency drives transdifferentiation of double-negative prostate cancer and confer resistance to AR-targeted therapy

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.ccell.2025.04.002
  
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sciencedirect.com/science/article/pii/S1535610825001394
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Targeting PGM3 abolishes SREBP-1 activation-hexosamine synthesis feedback regulation to effectively suppress brain tumor growth

1
1. scibot 24 Apr 2025
  
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  DOI: 10.1126/sciadv.adq0334
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12007565/
Mar 2025
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Lipid-metabolism-focused CRISPR screens identify enzymes of the mevalonate pathway as essential for prostate cancer growth

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1. scibot 28 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115470
  
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sciencedirect.com/science/article/pii/S2211124725002414
Feb 2025
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Identification of Meibomian gland stem cell populations and mechanisms of aging

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1. scibot 20 Feb 2025
  
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  DOI: 10.1038/s41467-025-56907-6
  
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link.springer.com/article/10.1038/s41467-025-56907-6
52.53.155.43 52.53.155.43

The propensity of fructose to induce metabolic dysfunction is dependent on the baseline diet, length of the dietary exposure, and sex of the mice

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1. scibot 07 Feb 2025
  
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  DOI: 10.1101/2024.11.26.625441
  
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52.53.155.43/0ad10a4b143da766a0796a5cae53ba79e7ffc8ca/2024.11.26.625441.full-html.html
Dec 2024
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FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology

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1. scibot 19 Dec 2024
  
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  DOI: 10.1016/j.cmet.2024.11.001
  
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sciencedirect.com/science/article/pii/S1550413124004479
Nov 2024
www.cell.com www.cell.com

Formate promotes invasion and metastasis in reliance on lipid metabolism

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  DOI: 10.1016/j.celrep.2023.113034
  
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cell.com/cell-reports/abstract/S2211-1247(23)01045-8
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High fat diet induced hepatic insulin resistance per se attenuates murine de novo lipogenesis

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1. scibot 14 Nov 2024
  
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  DOI: 10.1016/j.isci.2024.111175
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11550620/
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Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment

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1. scibot 14 Nov 2024
  
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  DOI: 10.1016/j.celrep.2024.114972
  
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sciencedirect.com/science/article/pii/S2211124724013238
Sep 2024
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Myeloid beta-arrestin 2 depletion attenuates metabolic dysfunction-associated steatohepatitis via the metabolic reprogramming of macrophages

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1. scibot 26 Sep 2024
  
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sciencedirect.com/science/article/pii/S1550413124003620
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Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCε-insulin receptorT1150 phosphorylation pathway

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.celrep.2024.114746
  
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sciencedirect.com/science/article/pii/S2211124724010970
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Intravenous lipid emulsions designed to meet preterm infant requirements increase plasma and tissue levels of docosahexaenoic acid and arachidonic acid in mice

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1. scibot 13 Sep 2024
  
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sciencedirect.com/science/article/pii/S0261561424002966
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Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma

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  DOI: 10.1016/j.xcrm.2024.101706
  
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sciencedirect.com/science/article/pii/S2666379124004270
Aug 2024
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Immune suppression by human thymus-derived effector Tregs relies on glucose/lactate-fueled fatty acid synthesis

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1. scibot 27 Aug 2024
  
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sciencedirect.com/science/article/pii/S2211124724010325
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Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11

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1. scibot 21 Aug 2024
  
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cell.com/cell-metabolism/fulltext/S1550-4131(24)00285-7
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

KLF4 promotes milk fat synthesis by regulating the PI3K-AKT-mTOR pathway and targeting FASN activation in bovine mammary epithelial cells

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1. scibot 24 May 2024
  
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  DOI: 10.1016/j.isci.2024.109850
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11108978/
Apr 2024
www.nature.com www.nature.com

Limitations in metabolic plasticity after traumatic injury are only moderately exacerbated by physical activity restriction

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1. scibot 10 Apr 2024
  
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  DOI: 10.1038/s44324-024-00006-5
  
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nature.com/articles/s44324-024-00006-5
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Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation

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  DOI: 10.1016/j.xcrm.2024.101477
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10983109/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Semaglutide Improves Liver Steatosis and De Novo Lipogenesis Markers in Obese and Type-2-Diabetic Mice with Metabolic-Dysfunction-Associated Steatotic Liver Disease

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1. scibot 17 Mar 2024
  
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  DOI: 10.3390/ijms25052961
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10932050/
Feb 2024
aacrjournals.org aacrjournals.org

FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-Genomic Features of Prostate Cancer

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1. scibot 27 Feb 2024
  
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  DOI: 10.1158/2767-9764.CRC-23-0248
  
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aacrjournals.org/cancerrescommun/article/4/1/152/733383/FASN-Gene-Methylation-is-Associated-with-Fatty
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Exercise training adaptations in liver glycogen and glycerolipids require hepatic AMP-activated protein kinase in mice

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1. scibot 22 Feb 2024
  
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  DOI: 10.1101/2023.09.01.555935
  
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  DOI: 10.1101/2023.09.01.555935
  
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52.53.155.43/fd6bbeebd50ae2c0912f6e8604e8bc905b0c2518/2023.09.01.555935v1.full-html.html
Jan 2024
aacrjournals.org aacrjournals.org

FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-Genomic Features of Prostate Cancer

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1. scibot 20 Jan 2024
  
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aacrjournals.org/cancerrescommun/article/4/1/152/733383/FASN-Gene-Methylation-is-Associated-with-Fatty
Dec 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures

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Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice

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Dominant-negative HNF1α mutant promotes liver steatosis and inflammation by regulating hepatic complement factor D

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SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells

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Porcine reproductive and respiratory syndrome virus upregulates SMPDL3B to promote viral replication by modulating lipid metabolism

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FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1

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Modulation of cellular metabolism by protein crotonylation regulates pancreatic cancer progression

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Peroxisome proliferator activated receptor-γ in osteoblasts controls bone formation and fat mass by regulating sclerostin expression

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Pregnancy-associated steroid effects on insulin sensitivity, adipogenesis and lipogenesis: Role of Wnt/β-catenin pathway

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The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-κB

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Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program

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Metformin mitigates renal dysfunction in obese insulin-resistant rats via activation of the AMPK/PPARα pathway

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Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness

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Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET

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Pleiotropic effects of Syntaxin16 identified by gene editing in cultured adipocytes

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Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes

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Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesis

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Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation

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Deficiency of peroxisomal NUDT7 stimulates de novo lipogenesis in hepatocytes

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PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis

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Cardiac ultrastructure inspired matrix induces advanced metabolic and functional maturation of differentiated human cardiomyocytes

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T cells mediate kidney tubular injury via impaired PDHA1 and Autophagy in type 1 diabetes

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Deficiency of C1QL1 reduced murine ovarian follicle reserve through intraovarian and endocrine control

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Tumor Microenvironment Acidity Triggers Lipid Accumulation in Liver Cancer via SCD1 Activation

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Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy

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Enhanced C/EBPβ function promotes hypertrophic versus hyperplastic fat tissue growth and prevents steatosis in response to high-fat diet feeding

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Meta-Inflammation and De Novo Lipogenesis Markers Are Involved in Metabolic Associated Fatty Liver Disease Progression in BTBR ob/ob Mice

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YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth

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Dysregulated lipid metabolism blunts the sensitivity of cancer cells to EZH2 inhibitor

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Lysophosphatidic acid shifts metabolic and transcriptional landscapes to induce a distinct cellular state in human pluripotent stem cells

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Diurnal regulation of oxidative phosphorylation restricts hepatocyte proliferation and inflammation

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Aug 2021
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Untitled document

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Systematic Functional Annotation of Somatic Mutations in Cancer

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Excess dietary carbohydrate affects mitochondrial integrity as observed in brown adipose tissue

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Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis

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Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis

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In vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate

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Fatty acid receptor GPR120 promotes breast cancer chemoresistance by upregulating ABC transporters expression and fatty acid synthesis

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Systematic Functional Annotation of Somatic Mutations in Cancer

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Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis

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1. scibot 14 Jul 2021
  
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SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice

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1. scibot 07 Jul 2021
  
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The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding

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Contrasting recruitment of skin-associated adipose depots during cold challenge of mouse and human

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1. scibot 20 May 2021
  
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  DOI: 10.1113/JP280922
  
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An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells

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sciencedirect.com/science/article/pii/S1074761320302715
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An isocaloric moderately high-fat diet extends lifespan in male rats and Drosophila

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sciencedirect.com/science/article/pii/S1550413120306720
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PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis

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1. scibot 25 Feb 2021
  
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Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor

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1. scibot 28 Jan 2021
  
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ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism

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1. scibot 07 Jan 2021
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7837265/
Nov 2020
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Gut Akkermansia muciniphila ameliorates non-alcoholic fatty liver disease by L-aspartate via interaction with liver

1
1. scibot 24 Nov 2020
  
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  RRID:AB_2100796
  
  DOI: 10.22541/au.160225760.01320126/v1
  
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authorea.com/users/314537/articles/485703-gut-akkermansia-muciniphila-ameliorates-non-alcoholic-fatty-liver-disease-by-l-aspartate-via-interaction-with-liver
Oct 2020
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The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development

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Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP

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  DOI: 10.1016/j.molcel.2020.04.013
  
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sciencedirect.com/science/article/pii/S1097276520302550
Jan 2020
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Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.molcel.2019.07.023
  
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Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.cmet.2019.07.010
  
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UCP2 Deficiency Increases Colon Tumorigenesis by Promoting Lipid Synthesis and Depleting NADPH for Antioxidant Defenses

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.07.097
  
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sciencedirect.com/science/article/pii/S2211124719310137
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BPS Publications

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  DOI: 10.1111/bph.14713
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14713
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Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids

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  DOI: 10.1016/j.molcel.2019.01.036
  
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sciencedirect.com/science/article/pii/S1097276519300565
Nov 2018
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Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

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sciencedirect.com/science/article/pii/S0092867418313047
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ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

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1. scibot 05 Nov 2018
  
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Regulation of hepatic lipid accumulation and distribution by Agouti-related protein in male mice

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academic.oup.com/endo/article/159/6/2408/4993922
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Very Long Chain Fatty Acids Are Functionally Involved in Necroptosis

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sciencedirect.com/science/article/pii/S2451945617303240
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Maternal exercise modifies body composition and energy substrates handling in high‐fat/high‐sucrose diet fed male offspring

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onlinelibrary.wiley.com/doi/10.1113/JP274739/full
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Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis

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sciencedirect.com/science/article/pii/S1550413117306204
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Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling

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sciencedirect.com/science/article/pii/S0092867417312631
Nov 2017
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TERT‐EZH2 network regulates lipid metabolism and DNA damage responses in glioblastoma

1
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onlinelibrary.wiley.com/doi/10.1111/jnc.14152/full
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A Cell-Autonomous Mammalian 12 hr Clock Coordinates Metabolic and Stress Rhythms

1
1. scibot 08 Nov 2017
  
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Liver NF-κB-Inducing Kinase Promotes Liver Steatosis and Glucose Counterregulation in Male Mice With Obesity

1
1. scibot 08 Nov 2017
  
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  AB_2100796
  
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academic.oup.com/endo/article/158/5/1207/3098658/Liver-NF-B-Inducing-Kinase-Promotes-Liver

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