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Aug 2025
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The transcription factor BATF pioneers the differentiation program of effector CD8+ T cells through the interaction with IRF4

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Multi-dimensional metabolomic remodeling under diverse muscle atrophic stimuli in vivo

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Jul 2025
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RUNX2 inhibition disrupts a PAX3::FOXO1-RUNX2 feed-forward loop and dismantles oncogenic gene programs in fusion-positive rhabdomyosarcoma

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Highly quantitative measurement of differential protein-genome binding with PerCell chromatin sequencing

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The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells

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Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo

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Jun 2025
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Potential Probiotic Lacticaseibacillus rhamnosus NKU FL1-11 Prevents Aging-Related Oxidative Stress and Inflammation via mTOR and FoxO Signaling Pathways in Zebrafish

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May 2025
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The interplay between FOXO1 and glucocorticoid signaling in promoting the terminal differentiation of somatotropes

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Apr 2025
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Combined inhibition of de novo glutathione and nucleotide biosynthesis is synthetically lethal in glioblastoma

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1. scibot 24 Apr 2025
  
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Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling

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Mar 2025
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1-s2.0-S2589004225004043-main-html.html

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Jan 2025
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Non-cell-autonomous regulation of mTORC2 by Hedgehog signaling maintains lipid homeostasis

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Dec 2024
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Hypoxia-inducible factor 2α promotes pathogenic polarization of stem-like Th2 cells via modulation of phospholipid metabolism

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Nov 2024
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Aberrant zonal recycling of germinal center B cells impairs appropriate selection in lupus

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Decoding transcriptional identity in developing human sensory neurons and organoid modeling

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Sep 2024
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A TBK1-independent primordial function of STING in lysosomal biogenesis

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New dual inducible cellular model to investigate temporal control of oncogenic cooperating genes

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Aug 2024
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CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response

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Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis

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Activated dormant stem cells recover spermatogenesis in chemoradiotherapy-induced infertility

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cell.com/cell-reports/fulltext/S2211-1247(24)00911-2
May 2024
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Regulation of Foxo1 expression is critical for central B cell tolerance and allelic exclusion

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Deficiency of UCHL1 results in insufficient decidualization accompanied by impaired dNK modulation and eventually miscarriage

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Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by miR-128

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The Long Non-Coding RNA Gene AC027288.3 Plays a Role in Human Endometrial Stromal Fibroblast Decidualization

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IL17A Suppresses IGFBP1 in Human Endometrial Stromal Cells

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Apr 2024
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Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner

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hnRNPU is required for spermatogonial stem cell pool establishment in mice

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Mutant FOXO1 controls an oncogenic network via enhancer accessibility

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Mar 2024
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Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats

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FOXO1 stimulates tip cell-enriched gene expression in endothelial cells

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ncbi.nlm.nih.gov/pmc/articles/PMC10914484/
Feb 2024
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Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models

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  DOI: 10.1158/2767-9764.CRC-23-0308
  
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aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
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Stromal-derived MAOB promotes prostate cancer growth and progression

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Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas

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  DOI: 10.1158/2159-8290.CD-22-1401
  
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Jan 2024
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Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models

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aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
Nov 2023
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MiR-337-3p improves metabolic-associated fatty liver disease through regulation of glycolipid metabolism

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PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors

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Piperacetazine directly binds to the PAX3::FOXO1 fusion protein and inhibits its transcriptional activity.

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Hepatocyte FoxO1 deficiency protects from liver fibrosis via reducing inflammation and TGF-β1 mediated HSC activation

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Paternal obesity impairs hepatic gluconeogenesis of offspring by altering Igf2/H19 DNA methylation

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PARP1 inhibition protects mice against Japanese encephalitis virus infection

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GM-CSF receptor/SYK/JNK/FOXO1/CD11c signaling promotes atherosclerosis

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GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells

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Inhibition of AXL receptor tyrosine kinase enhances brown adipose tissue functionality in mice

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Exogenous hydrogen sulfide alleviates hepatic endoplasmic reticulum stress via SIRT1/FoxO1/PCSK9 pathway in NAFLD

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Detection of spermatogonial stem cells in testicular tissue of dogs with chronic asymptomatic orchitis

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Identification of XAF1 as an endogenous AKT inhibitor

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PAC1 deficiency protects obese male mice from immobilization-induced muscle atrophy by suppressing FoxO-atrogene axis

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Asymmetric cell division safeguards memory CD8 T cell development

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Uterine epithelial progesterone receptor governs uterine receptivity through epithelial cell differentiation

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CD36 regulates diurnal glucose metabolism and hepatic clock to maintain glucose homeostasis in mice

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Metformin Prevents Endothelial Oxidative Stress and Microvascular Insulin Resistance during Obesity Development in Male Rats

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Glucagon receptor blockage inhibits β-cell dedifferentiation through FoxO1

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Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis

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Activation of Wnt/β-catenin signaling by Zeb1 in endothelial progenitors induces vascular quiescence entry

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Ageing Impairs Adaptive Unfolded Protein Response and Drives Beta Cell Dedifferentiation in Human

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Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes

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Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation

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E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance

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The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/ insulin like growth factor receptor signaling

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The RNA helicase DDX5 cooperates with EHMT2 to sustain alveolar rhabdomyosarcoma growth

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PH domain-mediated autoinhibition and oncogenic activation of Akt

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Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia

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Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging

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British J Pharmacology - 2022 - Li - Maresin 1 intervention Reverses Experimental Pulmonary Arterial Hypertension in mice-html.html

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Gut microbe-derived metabolite trimethylamine N-oxide activates PERK to drive fibrogenic mesenchymal differentiation

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Upregulation of FOXO1 contributes to lipopolysaccharide-induced pulmonary endothelial injury by induction of autophagy

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Convergent somatic mutations in metabolism genes in chronic liver disease

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Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry

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FOXO transcription factors are required for normal somatotrope function and growth

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C10orf10/DEPP activates mitochondrial autophagy and maintains chondrocyte viability in the pathogenesis of osteoarthritis

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Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice

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TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver

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The role of epithelial progesterone receptor isoforms in embryo implantation

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Effect of miR-183-5p on Cholestatic Liver Fibrosis by Regulating Fork Head Box Protein O1 Expression

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FOXO1 represses lymphatic valve formation and maintenance via PRDM1

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TXNIP links anticipatory unfolded protein response to estrogen reprogramming glucose metabolism in breast cancer cells

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Transcriptional regulation of LGALS9 by HAND2 and FOXO1 in human endometrial stromal cells in women with regular cycles

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CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development

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TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states

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RNF8-mediated regulation of Akt promotes lung cancer cell survival and resistance to DNA damage

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BPS Publications

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PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory

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Akt regulates Sox10 expression to control oligodendrocyte differentiation via phosphorylating FoxO1

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Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis

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Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase

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Pericyte Insulin Receptors Modulate Retinal Vascular Remodeling and Endothelial Angiopoietin Signaling

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Delivery of membrane impermeable molecules to primary mouse T lymphocytes

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Evidence of pioneer factor activity of an oncogenic fusion transcription factor

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Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis

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Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis

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Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression

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Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis

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Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate

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Targeting Wnt/EZH2/microRNA-708 signaling pathway inhibits neuroendocrine differentiation in prostate cancer

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Premature Expression of FOXO1 in Developing Mouse Pituitary Results in Anterior Lobe Hypoplasia

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Protective role of GPR120 in the maintenance of pregnancy by promoting decidualization via regulation of glucose metabolism

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Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling

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Mechanical load regulates bone growth via periosteal Osteocrin

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Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression

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Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses

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Proper mTORC1 activity is required for glucose sensing and early adaptation in human pancreatic beta cell

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Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism

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Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis

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A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance

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Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer

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SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways

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Paternal obesity impairs hepatic gluconeogenesis of offspring by altering Igf2/H19 DNA methylation

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The kinase PDK1 is critical for promoting T follicular helper cell differentiation

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A FOXO-dependent replication checkpoint restricts proliferation of damaged cells

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Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division

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Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells

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Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor of Insulin Receptor and IGF-1 Receptor

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Molecular Fingerprint and Developmental Regulation of the Tegmental GABAergic and Glutamatergic Neurons Derived from the Anterior Hindbrain

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The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development

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Skeletal muscle IGF-1 is lower at rest and after resistance exercise in humans with obesity

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Control of Early B Cell Development by the RNA N6-Methyladenosine Methylation

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Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish

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BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells

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Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells

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Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells

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Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

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Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

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Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity

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CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways

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WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis

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Untitled document

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Reversal of angiotensin ll-induced β-cell dedifferentiation via inhibition of NF-κb signaling

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Endothelial Regeneration of Large Vessels Is a Biphasic Process Driven by Local Cells with Distinct Proliferative Capacities

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Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis

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Knockout of USP19 Deubiquitinating Enzyme Prevents Muscle Wasting by Modulating Insulin and Glucocorticoid Signaling

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In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver

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Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling

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B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells

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Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses

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Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells

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FoxO1 Is Required for Most of the Metabolic and Hormonal Perturbations Produced by Hepatic Insulin Receptor Deletion in Male Mice

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Glucocorticoid Receptor Signaling Impairs Protein Turnover Regulation in Hypoxia-Induced Muscle Atrophy in Male Mice

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CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response

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Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice

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Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response

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Nov 2017
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The Progestin Receptor Interactome in the Female Mouse Hypothalamus: Interactions with Synaptic Proteins Are Isoform Specific and Ligand Dependent

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Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy

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Effects of the Activation of Three Major Hepatic Akt Substrates on Glucose Metabolism in Male Mice

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Glucose Sensing by Skeletal Myocytes Couples Nutrient Signaling to Systemic Homeostasis

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Low-Dose Dihydrotestosterone Drives Metabolic Dysfunction via Cytosolic and Nuclear Hepatic Androgen Receptor Mechanisms

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Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2

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Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments

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Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

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