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CDK12/13 inhibition overcomes platinum resistance by impairing RNA metabolism

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pmc.ncbi.nlm.nih.gov/articles/PMC13538385/
Sep 2026
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Programmable protein degraders enable selective knockdown of pathogenic β-catenin subpopulations in vitro and in vivo

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  DOI: 10.1126/sciadv.aec8271
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13524019/
Aug 2026
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Upadacitinib effectively suppresses IL13RA2 expression in primary human intestinal fibroblasts derived from Crohn’s disease tissue

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Dynamic characterization of pathological and functional deterioration in a mouse model of optic neuritis related to neuromyelitis optica spectrum disorder

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pmc.ncbi.nlm.nih.gov/articles/PMC13452670/
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Identification and functional validation of EPS15L1 as a key driver of triple-negative breast cancer

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Jun 2026
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Effects of Lysine Deacetylation Inhibition Alone or in Combination With Arimoclomol on TDP-43 Proteinopathy

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onlinelibrary.wiley.com/doi/10.1111/jnc.70493
May 2026
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Pharmacological Rescue of Follicle-Stimulating Hormone Receptor Mutants. In vitro and In silico Studies

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54.241.53.176 54.241.53.176

Kinetochore proteins control microtubule dynamics in postmitotic neurons to regulate the formation of dendritic spines

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54.241.53.176/03151d48a7c4fa531de4290e9ed1e3530686fc72/PMID_42044343-html.html
Feb 2026
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Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis

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Dec 2025
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1-s2.0-S2589004225027622-main-html.html

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54.241.53.176/2b06d68b56fd35648bb8c883fa5f10d713483e37/1-s2.0-S2589004225027622-main-html.html
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2025.12.02.691883.full-html.html

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1-s2.0-S2589004225025519-main-html.html

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54.241.53.176/8c76358cffbdca3590659296903fbb7ba84db3c2/1-s2.0-S2589004225025519-main-html.html
Nov 2025
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Phospho-proteome profiling in human neurons reveals targets of TBK1 in ALS/FTD-associated autophagy networks

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sciencedirect.com/science/article/pii/S2211124725012653
Oct 2025
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The CGG triplet repeat binding protein 1 counteracts R-loop induced transcription-replication stress

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pmc.ncbi.nlm.nih.gov/articles/PMC12508481/
Sep 2025
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The kinesin motor Kif9 regulates centriolar satellite positioning during interphase

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sciencedirect.com/science/article/pii/S0960982225011303
Aug 2025
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Alpha-synuclein abundance and localization are regulated by the RNA-binding protein PUMILIO1

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sciencedirect.com/science/article/pii/S2211124725009167
May 2025
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Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation

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  DOI: 10.3389/fnagi.2025.1549770
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12069431/
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RNA splicing modulator for Huntington’s disease treatment induces peripheral neuropathy

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Mar 2025
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SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair

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sciencedirect.com/science/article/pii/S1097276525001091
Jan 2025
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1-s2.0-S2212877824002229-main-html.html

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52.53.155.43/ff53ca808409e557edfcd52846690258be8d728c/1-s2.0-S2212877824002229-main-html.html
Oct 2024
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Dysregulation of miRNA expression and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids

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  DOI: 10.1038/s41380-024-02761-9
  
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nature.com/articles/s41380-024-02761-9
Jun 2024
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SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA

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  DOI: 10.7554/eLife.74940
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11149935/
May 2024
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Nuclear aggregates of NONO/SFPQ and A-to-I-edited RNA in Parkinson’s disease and dementia with Lewy bodies

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Mar 2024
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IQGAP1 and NWASP promote human cancer cell dissemination and metastasis by regulating β1-integrin via FAK and MRTF/SRF

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ER-stress response in retinal Müller glia occurs significantly earlier than amyloid pathology in the Alzheimer's mouse brain and retina

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  DOI: 10.1002/glia.24514
  
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onlinelibrary.wiley.com/doi/10.1002/glia.24514
Feb 2024
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TOP1 and R-loops facilitate transcriptional DSBs at hypertranscribed cancer driver genes

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ncbi.nlm.nih.gov/pmc/articles/PMC10875566/
Nov 2023
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The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection

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sciencedirect.com/science/article/pii/S1097276523008420
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Generation of four gene-edited human induced pluripotent stem cell lines with mutations in the ATM gene to model Ataxia-Telangiectasia

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  DOI: 10.1016/j.scr.2023.103247
  
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sciencedirect.com/science/article/pii/S1873506123002337
Oct 2023
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β1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4

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  DOI: 10.1016/j.celrep.2023.113322
  
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sciencedirect.com/science/article/pii/S2211124723013347
Jul 2023
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Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis

1
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  DOI: 10.1016/j.celrep.2023.112801
  
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sciencedirect.com/science/article/pii/S2211124723008124
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Reduced intestinal lipid absorption improves glucose metabolism in aged G2-Terc knockout mice

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  DOI: 10.1186/s12915-023-01629-8
  
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link.springer.com/article/10.1186/s12915-023-01629-8
Mar 2023
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Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration

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  DOI: 10.1016/j.neuron.2023.02.019
  
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Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination

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  DOI: 10.7554/eLife.77441
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9946447/
Jan 2023
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Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1

1
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  DOI: 10.1016/j.neuron.2022.11.016
  
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GSNOR deficiency promotes tumor growth via FAK1 S-nitrosylation

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GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer

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Functional properties of the spike glycoprotein of the emerging SARS-CoV-2 variant B.1.1.529

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Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria

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Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy

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A Novel Mutation in the FSH Receptor (I423T) Affecting Receptor Activation and Leading to Primary Ovarian Failure

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Interleukin-17 affects synaptic plasticity and cognition in an experimental model of multiple sclerosis

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Rescue of α-synuclein aggregation in Parkinson’s patient neurons by synergistic enhancement of ER proteostasis and protein trafficking

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Functional differences among the spike glycoproteins of multiple emerging severe acute respiratory syndrome coronavirus 2 variants of concern

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Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway

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Oligodendrocytes enhance axonal energy metabolism by deacetylation of mitochondrial proteins through transcellular delivery of SIRT2

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Stress-Induced Suppression of Milk Protein Is Involved in a Noradrenergic Mechanism in the Mammary Gland

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Untitled document

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Untitled document

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Predicted Benign and Synonymous Variants in CYP11A1 Cause Primary Adrenal Insufficiency Through Missplicing

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Untitled document

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Sema3a-Nrp1 Signaling Mediates Fast-Twitch Myofiber Specificity of Tw2+ Cells

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Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply and facilitates neuron survival and regeneration after injury and ischemia

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Functional connexin35 increased in the myopic chicken retina

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Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3

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Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability

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A Quantitative Proteome Map of the Human Body

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Cardiovascular disease risk factors induce mesenchymal features and senescence in mouse cardiac endothelial cells

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Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C

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Distinct circuits in rat central amygdala for defensive behaviors evoked by socially signaled imminent versus remote danger

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Evaluation of UBE3A antibodies in mice and human cerebral organoids

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Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer’s Disease

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Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG

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DDX56 Binds to Chikungunya Virus RNA To Control Infection

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Tead transcription factors differentially regulate cortical development

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IQGAP1 Negatively Regulates HIV-1 Gag Trafficking and Virion Production

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In vitro impact of FSH glycosylation variants on FSH receptor-stimulated signal transduction and functional selectivity

1
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  DOI: 10.1210/jendso/bvaa019
  
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Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and WNT

1
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  anti-GAPDH
  
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Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

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Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21

1
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  DOI: 10.1016/j.celrep.2019.08.036
  
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Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer

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  DOI: 10.1016/j.ccell.2019.09.004
  
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Predicted Benign and Synonymous Variants in CYP11A1 Cause Primary Adrenal Insufficiency Through Missplicing

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  RRID:AB_2107426
  
  DOI: 10.1210/js.2018-00130
  
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A Mild PUM1 Mutation Is Associated with Adult-Onset Ataxia, whereas Haploinsufficiency Causes Developmental Delay and Seizures

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Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells

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Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide

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Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy

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Impaired axonal retrograde trafficking of the retromer complex augments lysosomal deficits in Alzheimer’s disease neurons

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Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition

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Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions

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The Role of Calcium‐Sensing Receptors in Endothelin‐1‐Dependent Effects on Adult Rat Ventricular Cardiomyocytes: Possible Contribution to Adaptive Myocardial Hypertrophy

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Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease

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A Rapid Induction Mechanism for Lin28a in Trophic Responses

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1. scibot 08 Nov 2017
  
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