107 Matching Annotations
  1. Oct 2026
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    Increased extracellular fluid viscosity drives M2-like macrophage polarization to promote breast cancer progression and immunotherapy resistance
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    sciencedirect.com/science/article/pii/S221112472601123X
  3. Sep 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lactobacillus acidophilus CICC 22162 alleviates sleep deprivation-induced cognitive impairment by remodeling gut microbiota and enhancing S-adenosylmethionine-mediated neuroimmune regulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13536946/
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    Cyclin E-CDK2 regulates cancer cell transcriptional program and response to immunotherapy through BRD4
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    sciencedirect.com/science/article/pii/S109727652600554X
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    Benzyl isothiocyanate alleviates endotoxin-induced uveitis in association with LOX-1 downregulation to modulate JAK2-STAT3 signaling, endoplasmic reticulum stress and apoptosis
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    sciencedirect.com/science/article/pii/S1567576926011719
  7. Aug 2026
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    JI017 Sensitizes EGFR-T790M NSCLC to Erlotinib by Extinguishing the STAT3–Survivin Axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13438235/
  9. Jun 2026
  10. www.sciencedirect.com www.sciencedirect.com
    RNF138 promotes cisplatin resistance and PD-L1-mediated immune evasion via JAK2/STAT3 activation in nasopharyngeal carcinoma
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    sciencedirect.com/science/article/pii/S221112472600625X
  11. May 2026
  12. www.nature.com www.nature.com
    Cannabinoid CB2 receptor drives trastuzumab resistance and predicts durable anti-HER2 response
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    nature.com/articles/s41388-026-03814-9
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    A peritumoral microenvironment engaged by Reg-EXTL3 axis fosters nerve-cancer interactions in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S0896627326002692
  14. Feb 2026
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    BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes
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    sciencedirect.com/science/article/pii/S1097276526000328
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    Hepatocyte PLAGL2 deficiency alleviates MASH through MYD88-licensed inactivation of inflammasome
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    sciencedirect.com/science/article/pii/S2211124726000203
  17. Jan 2026
  18. www.sciencedirect.com www.sciencedirect.com
    CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance
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    sciencedirect.com/science/article/pii/S266637912500638X
  19. Dec 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    STAT-independent functions of Janus kinases 1 and 2 are obligatory for the postnatal development of mammary epithelial ducts
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    pmc.ncbi.nlm.nih.gov/articles/PMC12990061/
  21. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Tumor-initiating stem cells fine-tune the plasticity of neutrophils to sculpt a protective niche
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    sciencedirect.com:5037/science/article/pii/S1535610825004945
  22. Nov 2025
  23. www.biorxiv.org www.biorxiv.org
    Lymphotoxin-driven cancer cell eradication by tumoricidal CD8+ TIL
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    biorxiv.org/content/10.1101/2025.11.19.689204v2
  24. www.sciencedirect.com www.sciencedirect.com
    Blocking glycogen synthase 1 in white adipose tissue alleviates hypermetabolism following severe burn injury through inhibition of JAK2 by UDPG
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    sciencedirect.com/science/article/pii/S221112472501349X
  25. www.sciencedirect.com www.sciencedirect.com
    Therapeutic stress triggers tumor STAT1 acetylation to disarm immunotherapy
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    sciencedirect.com/science/article/pii/S266637912500521X
  26. www.sciencedirect.com www.sciencedirect.com
    Mesothelin as a biomarker and potential therapeutic target in rheumatoid arthritis bone destruction
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    sciencedirect.com/science/article/pii/S2666379125005038
  27. Oct 2025
  28. link.springer.com link.springer.com
    SOCS2 alleviates traumatic brain injury-induced mitochondrial damage and parthanatos in endothelial cells by inhibiting the JAK2/STAT3 signaling pathway
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    link.springer.com/article/10.1007/s11011-025-01724-5
  29. www.sciencedirect.com www.sciencedirect.com
    Inter- and intra-tumoral ALDH1 heterogeneity in breast cancer identifies therapeutic opportunities for ALDH1A-specific inhibitors
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    sciencedirect.com/science/article/pii/S2451945625002685
  30. Aug 2025
  31. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225016840-main-html.html
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  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Aberrantly Expressed Mitochondrial Lipid Kinase, AGK Activates JAK2-Histone H3 Axis and BCR Signal: A Mechanistic Study with Implication in CLL Therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11790368/
  33. May 2025
  34. www.sciencedirect.com www.sciencedirect.com
    Novel evidence in vivo: Berberine ameliorated glucocorticoid-induced post-natal growth retardation by regulating the GH/IGF-1 axis through KMT1A downregulation
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    sciencedirect.com/science/article/pii/S0041008X25001383
  35. www.sciencedirect.com www.sciencedirect.com
    A Novel Compound DBZ Alleviates Chronic Inflammatory Pain and Anxiety-Like Behaviors by Targeting the JAK2-STAT3 Signaling Pathway
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    sciencedirect.com/science/article/pii/S0021925825020733
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GuBenPeiYuan Formula Inhibits Lung Cancer Metastasis by Suppressing Myeloid-Derived Suppressor Cells and Related Immune Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12035261/
  37. Mar 2025
  38. www.sciencedirect.com www.sciencedirect.com
    The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis
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    sciencedirect.com/science/article/pii/S2211124725001743
  39. Feb 2025
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance
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    pmc.ncbi.nlm.nih.gov/articles/PMC11338319/
  41. Dec 2024
  42. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    Chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice
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    bmcbiol.biomedcentral.com/articles/10.1186/s12915-024-02097-4
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    Campylobacter jejuni-derived cytolethal distending toxin promotes colorectal cancer metastasis
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    sciencedirect.com/science/article/pii/S1931312824004372
  44. Nov 2024
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Deciphering the composition and key driver genes of breast invasive micropapillary carcinoma by multi-omics analysis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11549989/
  46. Sep 2024
  47. www.sciencedirect.com www.sciencedirect.com
    CXCR4 orchestrates the TOX-programmed exhausted phenotype of CD8+ T cells via JAK2/STAT3 pathway
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    sciencedirect.com/science/article/pii/S2666979X24002702
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function
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    pmc.ncbi.nlm.nih.gov/articles/PMC7398039/
  49. www.sciencedirect.com www.sciencedirect.com
    H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response
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    sciencedirect.com/science/article/pii/S2211124724010374
  50. Aug 2024
  51. www.sciencedirect.com www.sciencedirect.com
    Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression
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    sciencedirect.com/science/article/pii/S1534580724004866
  52. jbiomedsci.biomedcentral.com jbiomedsci.biomedcentral.com
    Proteasome inhibitors restore the STAT1 pathway and enhance the expression of MHC class I on human colon cancer cells
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    jbiomedsci.biomedcentral.com/articles/10.1186/s12929-021-00769-9
  53. Jul 2024
  54. www.sciencedirect.com www.sciencedirect.com
    Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity
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    sciencedirect.com/science/article/pii/S1074761324002796
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Influenza A virus infection activates STAT3 to enhance SREBP2 expression, cholesterol biosynthesis, and virus replication
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    ncbi.nlm.nih.gov/pmc/articles/PMC11301072/
  56. May 2024
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PABPC1L induces IDO1 to promote tryptophan metabolism and immune suppression in renal cell carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11094425/
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ruxolitinib improves the inflammatory microenvironment, restores glutamate homeostasis, and promotes functional recovery after spinal cord injury
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    ncbi.nlm.nih.gov/pmc/articles/PMC11090442/
  59. www.sciencedirect.com www.sciencedirect.com
    Active substances and molecular mechanisms of Astragali Radix and Angelicae Sinensis Radix against idiopathic pulmonary fibrosis effects by network pharmacology and in vitro experiments
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    sciencedirect.com/science/article/pii/S1872204024000422
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Janus kinase 1 is critical for pancreatic cancer initiation and progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11194014/
  61. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16393
  62. Apr 2024
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anorexia-Induced Hypoleptinemia Drives Adaptations in the JAK2/STAT3 Pathway in the Ventral and Dorsal Hippocampus of Female Rats
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    ncbi.nlm.nih.gov/pmc/articles/PMC11054075/
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    Oncostatin M signaling drives cancer-associated skeletal muscle wasting
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    sciencedirect.com/science/article/pii/S2666379124001666
  65. Mar 2024
  66. www.sciencedirect.com www.sciencedirect.com
    Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon
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    sciencedirect.com/science/article/pii/S1534580724000765
  67. Feb 2024
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Schisandrin B promotes hepatic differentiation from human umbilical cord mesenchymal stem cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10844828/
  69. Nov 2023
  70. www.sciencedirect.com www.sciencedirect.com
    Exosomes derived from platelet-rich plasma promote diabetic wound healing via the JAK2/STAT3 pathway
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    sciencedirect.com/science/article/pii/S2589004223023131
  71. Oct 2023
  72. www.sciencedirect.com www.sciencedirect.com
    Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria
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    sciencedirect.com/science/article/pii/S0092867423010784
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma
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    pmc.ncbi.nlm.nih.gov/articles/PMC10591052/
  74. Sep 2023
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Crizotinib has Preclinical Efficacy in Philadelphia-negative Myeloproliferative Neoplasms
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    ncbi.nlm.nih.gov/pmc/articles/PMC9992133/
  76. Aug 2023
  77. 52.53.155.43 52.53.155.43
    British J Pharmacology - 2023 - Han-html.html
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    52.53.155.43/5e554e9cedd6e38ae632f7a8eb735fb3080af333/British J Pharmacology - 2023 - Han-html.html
  78. 52.53.155.43 52.53.155.43
    BPS Publications
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    52.53.155.43/d8c850c315bd1ef9a1794152cac296a4123affe5/British J Pharmacology - 2023 - Wang - Sanguinarine induces apoptosis in osteosarcoma by attenuating the binding of STAT3-html.html
  79. Jul 2023
  80. www.sciencedirect.com www.sciencedirect.com
    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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  81. Jun 2023
  82. www.sciencedirect.com www.sciencedirect.com
    New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
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    sciencedirect.com/science/article/pii/S2451945623001502
  83. May 2023
  84. www.sciencedirect.com www.sciencedirect.com
    Targeting of Annexin A1 in Tumor-associated Macrophages as a Therapeutic Strategy for Hepatocellular Carcinoma
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    sciencedirect.com/science/article/pii/S0006295223002034
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    Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation
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    sciencedirect.com/science/article/pii/S2211124723005016
  86. www.sciencedirect.com www.sciencedirect.com
    DUSP4 promotes esophageal squamous cell carcinoma progression by dephosphorylating HSP90β
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    sciencedirect.com/science/article/pii/S2211124723004564
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    Exercise-derived peptide protects against pathological cardiac remodeling
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    sciencedirect.com/science/article/pii/S2352396422003450
  88. Apr 2023
  89. www.sciencedirect.com www.sciencedirect.com
    MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer
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    sciencedirect.com/science/article/pii/S2666379123001167
  90. Mar 2023
  91. 52.53.155.43 52.53.155.43
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  92. Jan 2023
  93. www.nature.com www.nature.com
    Pacritinib inhibits glucose consumption in squamous cell lung cancer cells by targeting FLT3
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    nature.com/articles/s41598-023-28576-2
  94. Dec 2022
  95. link.springer.com link.springer.com
    RAGE deficiency ameliorates autoimmune hepatitis involving inhibition of IL-6 production via suppressing protein Arid5a in mice
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    link.springer.com/article/10.1007/s10238-022-00960-8
  96. Nov 2022
  97. www.sciencedirect.com www.sciencedirect.com
    The target antigen determines the mechanism of acquired resistance to T cell-based therapies
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    sciencedirect.com/science/article/pii/S2211124722012712
  98. Jun 2022
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Circulating Protein Disulfide Isomerase is associated with increased risk of Thrombosis in JAK2-mutated Myeloproliferative Neoplasms
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    ncbi.nlm.nih.gov/pmc/articles/PMC9170286/
  100. May 2022
  101. pubs.acs.org pubs.acs.org
    Simultaneous Delivery of Doxorubicin and Protease Inhibitor Derivative to Solid Tumors via Star-Shaped Polymer Nanomedicines Overcomes P-gp- and STAT3-Mediated Chemoresistance
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    pubs.acs.org/doi/full/10.1021/acs.biomac.2c00256
  102. Apr 2022
  103. academic.oup.com academic.oup.com
    GH action in prostate cancer cells promotes proliferation limits apoptosis and regulates cancer-related gene expression
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    academic.oup.com/endo/article/163/5/bqac031/6564019
  104. www.nature.com www.nature.com
    Identifying a confused cell identity for esophageal squamous cell carcinoma
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    nature.com/articles/s41392-022-00946-8
  105. Mar 2022
  106. www.sciencedirect.com www.sciencedirect.com
    Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells
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    sciencedirect.com/science/article/pii/S1097276522002076
  107. journals.lww.com journals.lww.com
    Ruxolitinib attenuates secondary injury after traumatic spinal cord injury
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    journals.lww.com/nrronline/Fulltext/2022/17090/Ruxolitinib_attenuates_secondary_injury_after.35.aspx
  108. academic.oup.com academic.oup.com
    Interleukin-6 trans-signaling promotes progesterone production in human granulosa-lutein cells
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    academic.oup.com/biolreprod/advance-article/doi/10.1093/biolre/ioac020/6517230
  109. Feb 2022
  110. www.nature.com www.nature.com
    Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo
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    nature.com/articles/s41375-020-01077-1
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The SH2 domain and kinase activity of JAK2 target JAK2 to centrosome and regulate cell growth and centrosome amplification
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    ncbi.nlm.nih.gov/pmc/articles/PMC8797172/
  112. Jan 2022
  113. www.sciencedirect.com www.sciencedirect.com
    Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses
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    sciencedirect.com/science/article/pii/S1097276521010686
  114. Nov 2021
  115. www.sciencedirect.com www.sciencedirect.com
    Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring
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  116. Oct 2021
  117. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15652
  118. Aug 2021
  119. www.sciencedirect.com www.sciencedirect.com
    ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis
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    sciencedirect.com/science/article/pii/S2211124721010408
  120. academic.oup.com academic.oup.com
    IL6/sIL-6Rα trans-signaling increases PGE2 production in human granulosa cells
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    academic.oup.com/biolreprod/advance-article/doi/10.1093/biolre/ioab128/6312586
  121. www.nature.com www.nature.com
    Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
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    nature.com/articles/s41467-021-24687-4
  122. Jul 2021
  123. academic.oup.com academic.oup.com
    ATM Is Required for the Prolactin-Induced HSP90-Mediated Increase in Cellular Viability and Clonogenic Growth After DNA Damage
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    academic.oup.com/endo/article/159/2/907/4657271
  124. europepmc.org europepmc.org
    Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth.
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    europepmc.org/articles/PMC5736349/
  125. Jun 2021
  126. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatment.
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    clincancerres.aacrjournals.org/content/27/12/3432
  127. www.hindawi.com www.hindawi.com
    Table 2 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition
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