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Mutant p53 gains RNA-binding activity to reprogram translation and mitochondrial function

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Dietary soy fiber limits Salmonella infection by disrupting the self-reinforcing loop between pathogen virulence and host inflammation

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Aug 2026
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L1CAM signaling through planar cell polarity drives SOX2 expression and lung adenocarcinoma metastasis

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Jul 2026
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SWI/SNF Functions as a Gatekeeper of Enhancer Chromatin Access to Control Progression of Mesenchymal Triple-Negative Breast Cancer

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aacrjournals.org/cancerres/article/85/23/4648/767290/SWI-SNF-Functions-as-a-Gatekeeper-of-Enhancer
Jun 2026
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Noncanonical IRF3 function mediates STING-dependent pro-inflammatory cytokine production in macrophages

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A cell-intrinsic glucocorticoid biosynthesis and sensing circuit maintains a homeostatic Th17 cell state

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May 2026
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In vivo single-cell ribosome profiling reveals cell-type-specific translational programs during aging

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Loss-of-Function (G603R) Lrp10 Fails to Downregulate mRNA of Pathologic α-Synuclein and Causes Neurodegeneration of Substantia Nigra Dopaminergic Cells in Parkinson’s Disease Knockin Mice

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link.springer.com/article/10.1007/s11064-026-04762-2
Apr 2026
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Mechanical activation of PIEZO1 drives AP-1–dependent PTGS2/PGE2 signaling and corneal inflammation

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RHOV is a Detachment-Responsive Rho GTPase Necessary for Ovarian Cancer Peritoneal Metastasis

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Proteasome Inhibitor–Induced Cytotoxic Mechanisms in Canine Pulmonary Adenocarcinoma Cell Lines

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An interactome-based framework for DDB1- and CUL4-associated factor prioritization in targeted protein degradation

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Metabolic stress sensing by epithelial RXRα links westernization of diet with Crohn’s disease

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Mar 2026
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Decoding the spatiotemporal development of the blood-brain barrier in human cortex

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1-s2.0-S2589004226008114-main-html.html

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Panx1 deficiency exacerbates GAN diet-induced obesity by destabilizing β-catenin via GSK3β

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pmc.ncbi.nlm.nih.gov/articles/PMC12999355/
Feb 2026
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Intratumoral bacterium Enterocloster bolteae promotes hepatocellular carcinoma progression by directly binding tumor cells

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Targeted inhibition of M2 macrophages polarization via a PDC attenuates chronic pancreatitis through the PPARα pathway

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Netrin-1 Promotes Pancreatic Tumorigenesis and Innervation through NEO1

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Epigenetic and Transcriptional Programs Define Osteosarcoma Subtypes and Establish Targetable Vulnerabilities

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LRRC8A-containing anion channels promote glioblastoma proliferation via a WNK1/mTORC2-dependent mechanism

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Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer’s disease risk factors

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Stepwise epigenetic signal integration drives adaptive programming of cytotoxic lymphocytes

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NAD+ sensing by PARP7 regulates the C/EBPβ-dependent transcription program during adipogenesis

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Jan 2026
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Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections

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Dec 2025
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Targeted protein O-GlcNAc reveals transcriptional functions for O-GlcNAc

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Nov 2025
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kato-et-al-2025-effects-of-repetition-duration-on-skeletal-muscle-hypertrophy-in-a-rat-model-of-resistance-exercise-html.html

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2025.11.06.686987v1.full-html.html

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Oct 2025
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Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas

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A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function

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Inter- and intra-tumoral ALDH1 heterogeneity in breast cancer identifies therapeutic opportunities for ALDH1A-specific inhibitors

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Sep 2025
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Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response

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  DOI: 10.7554/eLife.106901
  
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Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state

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Aug 2025
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L1CAM signaling through planar cell polarity generates SOX2+ metastatic progenitors in lung adenocarcinoma

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  DOI: 10.1101/2025.08.22.671773
  
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Alternatively spliced isoforms of IRF7 differentially regulate interferon expression to tune response to viral infection

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Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control

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Single-cell image-based screens identify host regulators of Ebola virus infection dynamics

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β-catenin functions as a molecular adapter for disordered cBAF interactions

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Asthma and inflammation transcriptionally up-regulate the aryl hydrocarbon receptor in airway smooth muscle via p38/JNK-AP1 signalling

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Plinabulin following radiation enhances dendritic cell maturation and checkpoint inhibitor retreatment of relapsed/refractory cancers

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Cingulin is an RNA-binding protein promoting pancreatic cancer through enhancing importin 7-mediated phospho-ERK nuclear translocation

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Lipocalin-2 regulates astrocyte-oligodendrocyte interaction to drive post-stroke secondary demyelination

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PTEN neddylation aggravates CDK4/6 inhibitor resistance in breast cancer

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An integrated proteomic portrait of prostate cancer progression

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Aged and BRCA-Mutated Stromal Cells Drive Epithelial Cell Transformation

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Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis

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An integrated proteomics approach identifies phosphorylation sites on viral and host proteins that regulate West Nile virus infection

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Integrator loss leads to dsRNA formation that triggers the integrated stress response

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PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma

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Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma

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Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration

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TFEB/3 govern repair Schwann cell generation and function following peripheral nerve injury

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Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy

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SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis

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OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth

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MFGE8 induces anti-PD-1 therapy resistance by promoting extracellular vesicle sorting of PD-L1

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Shifting GnRH Neuron Ensembles Underlie Successive Preovulatory Luteinizing Hormone Surges

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MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics

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Pancreatic β cell interleukin-22 receptor subunit alpha 1 deficiency impairs β cell function in type 2 diabetes via cytochrome b5 reductase 3

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IL-17A/CEBPβ/OPN/LYVE-1 axis inhibits anti-tumor immunity by promoting tumor-associated tissue-resident macrophages

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EWS-FLI1 and Activator Protein-1 (AP-1) Reciprocally Regulate Extracellular-Matrix Proteins in Ewing sarcoma Cells

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FRA1 controls acinar cell plasticity during murine KrasG12D-induced pancreatic acinar to ductal metaplasia

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Dynamic regulation of tissue fluidity controls skin repair during wound healing

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Nuclear NME1 enhances the malignant behavior of A549 cells and impacts lung adenocarcinoma patient prognosis

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A transient transcriptional activation governs unpolarized-to-polarized morphogenesis during embryo implantation

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Comparative transcriptomic profiling reveals a role for Olig1 in promoting axon regeneration

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The roles of nuclear orphan receptor NR2F6 in anti-viral innate immunity

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Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress

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Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation

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Ganoderma lucidum extract attenuates corticotropin-releasing hormone induced cellular senescence in human hair follicle cells

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Positive and negative feedback regulation of the TGF-β1 explains two equilibrium states in skin aging

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Hypomethylation-enhanced CRTC2 expression drives malignant phenotypes and primary resistance to immunotherapy in hepatocellular carcinoma

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PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer

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A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function

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WW domains form a folded type of nuclear localization signal to guide YAP1 nuclear import

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The MYCN 5′ UTR as a therapeutic target in neuroblastoma

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HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression

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Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics

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CircTMEM165 facilitates endothelial repair by modulating mitochondrial fission via miR-192/SCP2 in vitro and in vivo

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TEAD1 is crucial for developmental myelination, Remak bundles, and functional regeneration of peripheral nerves

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Regional modulation of toll-like receptor signaling pathway genes in acute epididymitis in mice

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A unique chaperoning mechanism in class A JDPs recognizes and stabilizes mutant p53

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Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis

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Engagement of CD99 activates distinct programs in Ewing sarcoma and macrophages

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Axon-derived PACSIN1 binds to the Schwann cell survival receptor, LRP1, and transactivates TrkC to promote gliatrophic activities

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HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance

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Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice

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SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion

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cwad087-html.html

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Quantitative proteomics and RNA-sequencing of mouse liver endothelial cells identify novel regulators of BMP6 by iron

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Bisphenol S induces brown adipose tissue whitening and aggravates diet-induced obesity in an estrogen-dependent manner

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Cooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer

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cwad087-html.html

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TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

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PIIS0092867423009650-html.html

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Review Commons Transfer: Schwann cells are axo-protective after injury irrespective of myelination status in mouse Schwann cell–neuron cocultures

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Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation

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Activator protein-1 (AP-1) signaling inhibits the growth of Ewing sarcoma cells in response to DNA replication stress

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crc-23-0268-html.html

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Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting

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Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation

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ATF3 stimulates FSHβ expression in vitro, but is dispensable for FSH production in murine gonadotropes in vivo

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Distinct axo-protective and axo-destructive roles for Schwann cells after injury in a novel compartmentalised mouse myelinating coculture system

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Impact of supraphysiologic MDM2 expression on chromatin networks and therapeutic responses in sarcoma

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BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

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IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma

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SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice

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Pancreatic islet cell-type-specific transcriptomic changes during pregnancy and postpartum

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Histone H3 phospho-regulation by KimH3 in both interphase and mitosis

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Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies

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Integrator endonuclease drives promoter-proximal termination at all RNA polymerase II-transcribed loci

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Changes in nuclear pore numbers control nuclear import and stress response of mouse hearts

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Modulation of Specific Sphingosine-1-Phosphate Receptors Augments a Repair Mediating Schwann Cell Phenotype

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Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression

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AP-1 transcription factor network explains diverse patterns of cellular plasticity in melanoma cells

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Efficacy of Combined Use of Everolimus and Second-Generation Pan-EGRF Inhibitors in KRAS Mutant Non-Small Cell Lung Cancer Cell Lines

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Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma

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Phloretin enhances autophagy by impairing AKT activation and inducing JNK-Beclin-1 pathway activation

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The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity

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The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62

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Systematic discovery of mutation-directed neo-protein-protein interactions in cancer

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PTIP governs NAD+ metabolism by regulating CD38 expression to drive macrophage inflammation

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Notch-mediated lactate metabolism regulates MDSC development through the Hes1/MCT2/c-Jun axis

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Monosodium urate crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response

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Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-dependent Manner

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A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair

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Decoding the temporal and regional specification of microglia in the developing human brain

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Magnesium sensing via LFA-1 regulates CD8+ T cell effector function

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Myeloid Fbxw7 Prevents Pulmonary Fibrosis by Suppressing TGF-β Production

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Synergy of epidermal growth factor (EGFR) and angiotensin II (AT1R) receptor determines composition and temporal pattern of transcriptome variation

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Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome

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c-FOS drives reversible basal to squamous cell carcinoma transition

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Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination

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Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy

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Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression

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Establishment, maintenance, and recall of inflammatory memory

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RS9, a novel Nrf2 activator, attenuates light‐induced death of cells of photoreceptor cells and Müller glia cells

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Intron 1-Mediated Regulation of EGFR Expression In EGFR-Dependent Malignancies is Mediated by AP-1 and BET Proteins

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Curcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF‐κB signaling pathway

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Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication

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Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons

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An alternative splicing program promotes adipose tissue thermogenesis

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Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents

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Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development

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Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis

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T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1

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Table 2 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition

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MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway

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The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation

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CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance

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Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance

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Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities

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Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer

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MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer

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Deficiency of histone methyltransferase SETD2 in liver leads to abnormal lipid metabolism and hepatocarcinoma

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BPS Publications

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Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

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Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration

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1. scibot 25 Feb 2021
  
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Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

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1. scibot 28 Jan 2021
  
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Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism

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A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA

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Schistosoma mansoni eggs induce Wnt/β-catenin signaling and activate the protooncogene c-Jun in human and hamster colon

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ncbi.nlm.nih.gov/pmc/articles/PMC7758332/
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Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism

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1. scibot 12 Dec 2020
  
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  DOI: 10.7554/eLife.59258
  
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Nov 2020
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Distinct alpha‐Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH‐SY5Y cells

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  DOI: 10.1111/jnc.15174
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15174
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MicroRNAs of the miR-17~9 family maintain adipose tissue macrophage homeostasis by sustaining IL-10 expression

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  DOI: 10.7554/eLife.55676
  
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Oct 2020
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The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG

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Phosphorylation of eIF2α promotes Schwann cell differentiation and myelination in CMT1B mice with activated UPR

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  DOI: 10.1523/JNEUROSCI.0957-20.2020
  
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Sep 2020
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BPS Publications

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  DOI: 10.1111/bph.14981
  
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Glioblastoma Cell Resistance to EGFR and MET Inhibition Can Be Overcome via Blockade of FGFR-SPRY2 Bypass Signaling

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Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling

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Chromatin Priming Renders T Cell Tolerance-Associated Genes Sensitive to Activation below the Signaling Threshold for Immune Response Genes

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EDF1 coordinates cellular responses to ribosome collisions

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  DOI: 10.7554/eLife.58828
  
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Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration

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1. scibot 14 Sep 2020
  
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Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness

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Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53-Deficient Cells

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IL-13 as Target to Reduce Cholestasis and Dysbiosis in Abcb4 Knockout Mice

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JNK signalling regulates antioxidant responses in neurons

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DPP-4 inhibition with anagliptin reduces lipotoxicity-induced insulin resistance and steatohepatitis in male mice

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academic.oup.com/endo/article/161/10/bqaa139/5892311

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