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RACK1 attenuates pancreatic tumorigenesis by suppressing acinar-to-ductal metaplasia through inflammatory signaling modulation

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1. scibot 06 Sep 2025
  
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  DOI: 10.1007/s13402-025-01084-3
  
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link.springer.com/article/10.1007/s13402-025-01084-3
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Tumors hijack macrophages for iron supply to promote bone metastasis and anemia

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1. scibot 04 Sep 2025
  
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  DOI: 10.1016/j.cell.2025.08.013
  
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sciencedirect.com/science/article/pii/S0092867425009274
Aug 2025
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HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes

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1. scibot 13 Aug 2025
  
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  DOI: 10.1016/j.cmet.2025.07.007
  
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cell.com/cell-metabolism/fulltext/S1550-4131(25)00334-1
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BPS Publications

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1. scibot 01 Aug 2025
  
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  RRID:AB_2133570
  
  DOI: 10.1111/bph.70137
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70137
Jul 2025
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Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer

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1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.ccell.2025.06.021
  
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sciencedirect.com/science/article/pii/S1535610825002715
www.biorxiv.org www.biorxiv.org

Targeting ZNRF3 and RNF43 to Restore Regeneration and Reverse Metabolic Dysfunction-Associated Steatotic Liver Disease

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1. scibot 01 Jul 2025
  
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  DOI: 10.1101/2025.06.19.660551
  
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biorxiv.org/content/10.1101/2025.06.19.660551v1
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Conserved signals control self-organization and symmetry breaking of murine bilayered epithelia during development and regeneration

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1. scibot 01 Jul 2025
  
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  DOI: 10.1016/j.devcel.2025.06.007
  
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sciencedirect.com/science/article/pii/S1534580725003624
Jun 2025
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HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury

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1. scibot 24 Jun 2025
  
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  DOI: 10.1016/j.stem.2025.04.010
  
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cell.com/cell-stem-cell/abstract/S1934-5909(25)00177-8
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Protocol for adeno-associated virus-mediated gene delivery to accelerate pancreatic carcinogenesis in mice

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1. scibot 21 Jun 2025
  
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  DOI: 10.1016/j.xpro.2025.103907
  
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sciencedirect.com/science/article/pii/S2666166725003132
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Dual Role of NRF2 in Pancreatic Precursor Lesions

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1. scibot 13 Jun 2025
  
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  DOI: 10.1158/2767-9764.CRC-25-0107
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12158068/
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Trametinib potentiates anti-PD-1 efficacy in tumors established from chemotherapy-primed pancreatic cancer cells

1
1. scibot 11 Jun 2025
  
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  DOI: 10.1158/1535-7163.MCT-23-0833
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11614707/
May 2025
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Single-cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.xgen.2025.100888
  
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sciencedirect.com/science/article/pii/S2666979X25001442
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Ductal or Ngn3+ cells do not contribute to adult pancreatic islet beta-cell neogenesis in homeostasis

1
1. scibot 20 May 2025
  
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  DOI: 10.1038/s44318-025-00434-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12084597/
Apr 2025
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Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis

1
1. scibot 16 Apr 2025
  
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  DOI: 10.7554/eLife.98023
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11978302/
www.embopress.org www.embopress.org

Ductal or Ngn3+ cells do not contribute to adult pancreatic islet beta-cell neogenesis in homeostasis

1
1. scibot 13 Apr 2025
  
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  DOI: 10.1038/s44318-025-00434-z
  
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embopress.org/doi/10.1038/s44318-025-00434-z
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A new effLuc/Kate dual reporter allele for tumor imaging in mice

1
1. scibot 18 Feb 2025
  
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  AB_2133570
  
  DOI: 10.1242/dmm.052130
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11789939/
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Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer

1
1. scibot 13 Feb 2025
  
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  RRID:AB_2133570
  
  DOI: 10.1126/scitranslmed.adj9366
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11811823/
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Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy

1
1. scibot 07 Feb 2025
  
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  AB_2133570
  
  DOI: 10.1016/j.xcrm.2024.101927
  
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sciencedirect.com/science/article/pii/S2666379124006980
Nov 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Jag1 insufficiency alters liver fibrosis via T cell and hepatocyte differentiation defects

1
1. scibot 14 Nov 2024
  
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  RRID:AB_2133570
  
  DOI: 10.1038/s44321-024-00145-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11554675/
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Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer

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1. scibot 08 Nov 2024
  
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  DOI: 10.1158/0008-5472.CAN-23-3574
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11532783/
Aug 2024
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FRA1 controls acinar cell plasticity during murine KrasG12D-induced pancreatic acinar to ductal metaplasia

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1. scibot 23 Aug 2024
  
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  DOI: 10.1016/j.devcel.2024.07.021
  
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sciencedirect.com/science/article/pii/S1534580724004830
May 2024
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The Janus kinase 1 is critical for pancreatic cancer initiation and progression

1
1. scibot 14 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114202
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11194014/
Apr 2024
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NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo

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1. scibot 05 Apr 2024
  
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  DOI: 10.1016/j.stem.2024.03.003
  
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sciencedirect.com/science/article/pii/S1934590924000845
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Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer

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1. scibot 05 Apr 2024
  
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  DOI: 10.1016/j.ccell.2024.03.005
  
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sciencedirect.com/science/article/pii/S1535610824000904
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Tracing the origin of alveolar stem cells in lung repair and regeneration

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1. scibot 05 Apr 2024
  
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  DOI: 10.1016/j.cell.2024.03.010
  
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sciencedirect.com/science/article/pii/S0092867424003027
Mar 2024
52.53.155.43 52.53.155.43

Dual-color live imaging unveils stepwise organization of multiple basal body arrays by cytoskeletons

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1. scibot 21 Mar 2024
  
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  DOI: 10.1038/s44319-024-00066-0
  
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2. scibot 16 Mar 2024
  
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  DOI: 10.1038/s44319-024-00066-0
  
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52.53.155.43/4b57339fc132c33422f5acdf5e25f05236818ed2/shiratsuchi-et-al-2024-dual-color-live-imaging-unveils-stepwise-organization-of-multiple-basal-body-arrays-by-html.html
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PRMT1 promotes pancreatic cancer development and resistance to chemotherapy

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1. scibot 12 Mar 2024
  
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  DOI: 10.1016/j.xcrm.2024.101461
  
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2. scibot 12 Mar 2024
  
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  DOI: 10.1016/j.xcrm.2024.101461
  
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sciencedirect.com/science/article/pii/S2666379124001058
Feb 2024
www.biorxiv.org www.biorxiv.org

Loss of TIM4-Dependent Efferocytosis in Kupffer Cells Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

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1. scibot 15 Feb 2024
  
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  DOI: 10.1101/2024.01.30.578023
  
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biorxiv.org/content/10.1101/2024.01.30.578023v1
Oct 2023
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Spatial-temporal proliferation of hepatocytes during pregnancy revealed by genetic lineage tracing

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1. scibot 14 Oct 2023
  
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  DOI: 10.1016/j.stem.2023.09.002
  
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sciencedirect.com/science/article/pii/S1934590923003235
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development

1
1. scibot 12 Aug 2023
  
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  DOI: 10.1016/j.isci.2023.107368
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10407955/
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Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression

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1. scibot 10 Aug 2023
  
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  DOI: 10.1016/j.isci.2023.107408
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10405072/
Jun 2023
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Volume imaging to interrogate cancer cell-tumor microenvironment interactions in space and time

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1. scibot 01 Jun 2023
  
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  AB_2133570
  
  DOI: 10.3389/fimmu.2023.1176594
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10228654/
Apr 2023
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Matters arising: Insufficient evidence that pancreatic β cells are derived from adult ductal Neurog3-expressing progenitors

1
1. scibot 07 Apr 2023
  
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  DOI: 10.1016/j.stem.2023.03.003
  
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sciencedirect.com/science/article/pii/S1934590923000747
Mar 2023
www.embopress.org www.embopress.org

Two Hippo signaling modules orchestrate liver size and tumorigenesis

2
1. scibot 16 Mar 2023
  
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  RRID:AB_2133570
  
  DOI: 10.15252/embj.2022112126
  
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  DOI: 10.15252/embj.2022112126
  
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Pericyte stem cells induce Ly6G+ cell accumulation and immunotherapy resistance in pancreatic cancer

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Bone metastasis initiation is coupled with bone remodeling through osteogenic differentiation of NG2+ cells

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  DOI: 10.1158/2159-8290.CD-22-0220
  
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Dec 2022
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cd-22-0220-html.html

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Loss of Hepatic Lgr4 and Lgr5 Promotes Nonalcoholic Fatty Liver Disease

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Single-cell spatial transcriptomics reveals a dynamic control of metabolic zonation and liver regeneration by endothelial cell Wnt2 and Wnt9b

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Differentiation of beta-like cells from human induced pluripotent stem cell-derived pancreatic progenitor organoids

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Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma

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Rapid fluorescent vital imaging of olfactory epithelium

2
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Single-cell proteomics defines the cellular heterogeneity of localized prostate cancer

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WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy

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Mar 2022
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An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function

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Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin

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Dec 2021
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A mechanistic basis for the malignant progression of salivary gland tumors

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Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment

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Aug 2021
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Untitled document

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The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer

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Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation

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Untitled document

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Untitled document

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FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis

1
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A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice

1
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Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development

2
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A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling

1
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Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors

1
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Budding epithelial morphogenesis driven by cell-matrix versus cell-cell adhesion

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ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation

1
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May 2021
cancerdiscovery.aacrjournals.org cancerdiscovery.aacrjournals.org

Cell of Origin Influences Pancreatic Cancer Subtype

1
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Apr 2021
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The bone microenvironment invigorates metastatic seeds for further dissemination

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PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression

1
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Mar 2021
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DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome

1
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  DOI: 10.7554/eLife.60916
  
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Feb 2021
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Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS

1
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Sep 2020
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Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis

1
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Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

1
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  DOI: 10.1016/j.ccell.2020.02.008
  
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Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors

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Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism

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α-Ketoglutarate links p53 to cell fate during tumour suppression

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  DOI: 10.1038/s41586-019-1577-5
  
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A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas

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AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration

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Desmoplasia and oncogene driven acinar-to-ductal metaplasia are concurrent events during acinar cell-derived pancreatic cancer initiation in young adult mice

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Modeling Human Cancer-induced Cachexia

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Untitled document

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Untitled document

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Simultaneous Multiplexed Imaging of mRNA and Proteins with Subcellular Resolution in Breast Cancer Tissue Samples by Mass Cytometry

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A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer

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SOX2 regulates acinar cell development in the salivary gland

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Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS

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FGF21 Is an Exocrine Pancreas Secretagogue

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