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40 Matching Annotations

Mar 2025
www.cell.com www.cell.com

Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression

1
1. scibot 23 Mar 2025
  
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  RRID:AB_2134736
  
  DOI: 10.1016/j.immuni.2025.02.023
  
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cell.com/immunity/fulltext/S1074-7613(25)00090-1
Dec 2024
www.nature.com www.nature.com

Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

1
1. scibot 21 Dec 2024
  
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  RRID:AB_2134736
  
  DOI: 10.1038/s41586-024-08348-2
  
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nature.com/articles/s41586-024-08348-2
www.sciencedirect.com www.sciencedirect.com

The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation

1
1. scibot 21 Dec 2024
  
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  RRID:AB_2134736
  
  DOI: 10.1016/j.celrep.2024.115101
  
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sciencedirect.com/science/article/pii/S2211124724014529
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The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance

1
1. scibot 17 Dec 2024
  
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  AB_2134736
  
  DOI: 10.1016/j.immuni.2024.11.017
  
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sciencedirect.com/science/article/pii/S1074761324005326
Oct 2024
link.springer.com link.springer.com

High-confidence and high-throughput quantification of synapse engulfment by oligodendrocyte precursor cells

1
1. scibot 08 Oct 2024
  
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  AB_2134736
  
  DOI: 10.1038/s41596-024-01048-1
  
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link.springer.com/article/10.1038/s41596-024-01048-1
Sep 2024
www.sciencedirect.com www.sciencedirect.com

Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

1
1. scibot 25 Sep 2024
  
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  RRID:AB_369111
  
  DOI: 10.1016/j.cmet.2019.05.018
  
  Resource: (GeneTex Cat# GTX13524, RRID:AB_369111)
  
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sciencedirect.com/science/article/pii/S155041311930258X
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Nephron specific ATP6AP2 knockout increases urinary excretion of fatty acids and decreases renal cortical megalin expression

1
1. scibot 22 Aug 2024
  
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  RRID:AB_2134736
  
  DOI: 10.1038/s41598-024-69749-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11319469/
Jul 2024
www.biorxiv.org www.biorxiv.org

Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and Parkinsonian motor deficits

1
1. scibot 23 Jul 2024
  
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  RRID:AB_2134736
  
  DOI: 10.1101/2024.07.09.602700
  
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biorxiv.org/content/10.1101/2024.07.09.602700v1
May 2024
www.biorxiv.org www.biorxiv.org

Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities

2
1. scibot 10 May 2024
  
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  ab13524; Abcam
  
  DOI: 10.1101/2024.01.25.577280
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
  Curator: @abever99
  
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2. scibot 10 May 2024
  
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  ab13524; Abcam
  
  DOI: 10.1101/2024.01.25.577280
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
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biorxiv.org/content/10.1101/2024.01.25.577280v1
Oct 2023
www.science.org www.science.org

Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance

1
1. scibot 17 Oct 2023
  
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  AB_2134736
  
  DOI: 10.1126/sciadv.abo3610
  
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science.org/doi/10.1126/sciadv.abo3610
Aug 2023
52.53.155.43 52.53.155.43

PIIS2211124723009543-html.html

1
1. scibot 12 Aug 2023
  
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  RRID:AB_2134736
  
  DOI: 10.1016/j.celrep.2023.112943
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
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52.53.155.43/7a7cd2b37d518c0daab3f29f5b28b810c1030ef5/PIIS2211124723009543-html.html
Sep 2022
www.sciencedirect.com www.sciencedirect.com

Ral GTPases are critical regulators of spinal cord myelination and homeostasis

1
1. scibot 29 Sep 2022
  
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  RRID:AB_2134736
  
  DOI: 10.1016/j.celrep.2022.111413
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
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sciencedirect.com/science/article/pii/S2211124722012542
Aug 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance

2
1. scibot 13 Aug 2022
  
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  AB_2134736
  
  DOI: 10.1126/sciadv.abo3610
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
  Curator: @scibot
  
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  RRID:AB_2134736
2. scibot 13 Aug 2022
  
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  AB_2134736
  
  DOI: 10.1126/sciadv.abo3610
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9299535/
Apr 2022
www.sciencedirect.com www.sciencedirect.com

KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion

1
1. scibot 07 Apr 2022
  
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  RRID:AB_2134736
  
  DOI: 10.1016/j.ebiom.2022.103980
  
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sciencedirect.com/science/article/pii/S2352396422001645
Feb 2022
www.embopress.org www.embopress.org

LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function

1
1. scibot 12 Feb 2022
  
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  RRID:AB_2134736
  
  DOI: 10.15252/embj.2021108119
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
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embopress.org/doi/abs/10.15252/embj.2021108119
Nov 2021
www.sciencedirect.com www.sciencedirect.com

Structural mechanism for regulation of Rab7 by site-specific monoubiquitination

1
1. scibot 19 Nov 2021
  
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  ab13524
  
  DOI: 10.1016/j.ijbiomac.2021.11.074
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2134736
  
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  RRIDCUR:Missing RRID:AB_2134736
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sciencedirect.com/science/article/pii/S0141813021024715
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic

1
1. scibot 27 Aug 2021
  
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  RRID:AB_2134736
  
  DOI: 10.1016/j.cell.2021.08.002
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S0092867421009442
academic.oup.com academic.oup.com

NHERF1 Is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland

1
1. scibot 05 Aug 2021
  
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  RRID:AB_2134736
  
  DOI: 10.1210/en.2019-00230
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
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academic.oup.com/endo/article/160/8/1797/5488072
www.sciencedirect.com www.sciencedirect.com

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis

1
1. scibot 01 Aug 2021
  
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  RRID:AB_2134736
  
  DOI: 10.1016/j.cell.2018.05.028
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
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sciencedirect.com/science/article/pii/S0092867418306408
Jul 2021
www.sciencedirect.com www.sciencedirect.com

Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells

1
1. scibot 02 Jul 2021
  
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  RRID:AB_2134736
  
  DOI: 10.1016/j.devcel.2021.06.011
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
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sciencedirect.com/science/article/pii/S1534580721005189
May 2021
www.sciencedirect.com www.sciencedirect.com

Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity

1
1. scibot 07 May 2021
  
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  RRID:AB_2134736
  
  DOI: 10.1016/j.molcel.2020.10.004
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
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sciencedirect.com/science/article/pii/S1097276520306870
www.sciencedirect.com www.sciencedirect.com

Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation

1
1. scibot 07 May 2021
  
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  RRID:AB_2134736
  
  DOI: 10.1016/j.molcel.2020.05.007
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1097276520303087
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer

1
1. scibot 27 Apr 2021
  
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  RRID:AB_2134736
  
  DOI: 10.1016/j.chembiol.2020.06.011
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
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sciencedirect.com/science/article/pii/S2451945620302348
Mar 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer’s disease

1
1. scibot 11 Mar 2021
  
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  RRID:AB_2134736
  
  DOI: 10.1186/s13024-021-00435-6
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2134736
  
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  RRIDCUR:Validated RRID:AB_2134736
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ncbi.nlm.nih.gov/pmc/articles/PMC7941983/
Feb 2021
elifesciences.org elifesciences.org

Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice

1
1. scibot 09 Feb 2021
  
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  RRID:AB_2134736
  
  DOI: 10.7554/eLife.62174
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2134736
  
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  RRID:AB_2134736 RRIDCUR:Validated
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elifesciences.org/articles/62174
Sep 2020
elifesciences.org elifesciences.org

Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model

1
1. scibot 10 Sep 2020
  
  in Public
  
  RRID:AB_2134736
  
  DOI: 10.7554/eLife.40316
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
  Curator: @evieth
  
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  RRIDCUR:Validated RRID:AB_2134736
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elifesciences.org/articles/40316
clincancerres.aacrjournals.org clincancerres.aacrjournals.org

Molecular imaging of extracellular tumor pH to reveal effects of loco-regional therapy on liver cancer microenvironment

1
1. scibot 07 Sep 2020
  
  in Public
  
  RRID:AB_2134736
  
  DOI: 10.1158/1078-0432.CCR-19-1702
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2134736
  
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  RRID:AB_2134736 RRIDCUR:Validated
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clincancerres.aacrjournals.org/content/26/2/428
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Essential Functions of Glycans in Human Epithelia Dissected by a CRISPR-Cas9-Engineered Human Organotypic Skin Model

1
1. scibot 03 Sep 2020
  
  in Public
  
  RRID:AB_2134736
  
  DOI: 10.1016/j.devcel.2020.06.039
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2134736
  
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  RRIDCUR:Validated RRID:AB_2134736
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pubmed.ncbi.nlm.nih.gov/32710848/
elifesciences.org elifesciences.org

UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity

1
1. scibot 03 Sep 2020
  
  in Public
  
  RRID:AB_2134736
  
  DOI: 10.7554/eLife.37993
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2134736
  
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  RRIDCUR:Validated RRID:AB_2134736
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elifesciences.org/articles/37993
Aug 2020
www.sciencedirect.com www.sciencedirect.com

ZIGIR, a Granule-Specific Zn2+ Indicator, Reveals Human Islet α Cell Heterogeneity

1
1. scibot 26 Aug 2020
  
  in Public
  
  RRID:AB_213473
  
  DOI: 10.1016/j.celrep.2020.107904
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2134736
  
  Curator comments: LAMP2 antibody [GL2A7] - Lysosome Marker Abcam Cat# ab13524
  
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  RRIDCUR:Incorrect RRID:AB_2134736 RRIDCUR:Unresolved
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sciencedirect.com/science/article/pii/S2211124720308858
Jan 2020
onlinelibrary.wiley.com onlinelibrary.wiley.com

Extracellular pH mapping of liver cancer on a clinical 3T MRI scanner

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2134736
  
  DOI: 10.1002/mrm.28035
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2134736
  
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  RRID:AB_2134736 RRIDCUR:Validated
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onlinelibrary.wiley.com/doi/10.1002/mrm.28035
www.sciencedirect.com www.sciencedirect.com

Lipocalin-2 Regulates Epidermal Growth Factor Receptor Intracellular Trafficking

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2134736
  
  DOI: 10.1016/j.celrep.2019.10.015
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2134736
  
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  RRID:AB_2134736 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124719313154
www.sciencedirect.com www.sciencedirect.com

Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2134736
  
  DOI: 10.1016/j.immuni.2019.12.004
  
  Resource: (Abcam Cat# ab13524, RRID:AB_2134736)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2134736
  
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  RRID:AB_2134736 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1074761319305230
www.sciencedirect.com www.sciencedirect.com

Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models

1
1. scibot 13 Jan 2020
  
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  DOI: 10.7554/eLife.40316
  
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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

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Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner

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