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IGF2BP2 stabilized by USP7 promotes cancer-associated fibroblast activation and attenuates gemcitabine sensitivity in PDAC

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  DOI: 10.1016/j.celrep.2025.116476
  
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Oct 2025
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TOM1 G307D variant impairs interaction with TOLLIP, autophagosome-lysosome fusion and regulation of innate immunity

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1. scibot 16 Oct 2025
  
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  DOI: 10.1242/dmm.052140
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12519566/
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CRISPR-Cas9 screening reveals G2E3 as a novel ubiquitin-linked factor controlling autophagosome-lysosome fusion and cancer cell progression

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1. scibot 14 Oct 2025
  
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  DOI: 10.1038/s41420-025-02717-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12511632/
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AMPKα2 signals amino acid insufficiency to inhibit protein synthesis

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1. scibot 08 Oct 2025
  
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  DOI: 10.1016/j.cmet.2025.09.004
  
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Sep 2025
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ADSL deficiency is a secondary mitochondrial disease affecting organelle homeostasis and ERK2/AKT signaling in a linear genotype-phenotype relation

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  DOI: 10.1016/j.celrep.2025.116230
  
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Aug 2025
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A lipid transfer-dependent feedback loop activates ATG9A compartments in autophagy initiation

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1. scibot 22 Aug 2025
  
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  DOI: 10.1101/2025.08.16.670665
  
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52.53.155.43/d4ad68e14ea5acb61caf80d1a118f583c2293300/2025.08.16.670665v1.full-html.html
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Ridaifen derivatives function as potent lysosomotropic agents, depending on their basic side chains.

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  DOI: 10.1016/j.ejphar.2025.178082
  
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Jul 2025
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RFX2-BNIP3 axis-driven adaptive mitophagy promotes resistance to ACK1-targeted therapy in non-small cell lung cancer

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1. scibot 29 Jul 2025
  
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  DOI: 10.1038/s41388-025-03502-0
  
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nature.com/articles/s41388-025-03502-0
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NEDD4 Promotes Sertoli Cell Proliferation and Adult Leydig Cell Differentiation in the Murine Testis

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1. scibot 25 Jul 2025
  
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  DOI: 10.1210/endocr/bqaf115
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12280327/
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Flufenamic acid inhibits pyroptosis in ischemic flaps via the AMPK-TRPML1-Calcineurin signaling pathway

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1. scibot 15 Jul 2025
  
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  DOI: 10.1093/burnst/tkaf007
  
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Human umbilical cord mesenchymal stem cell-derived exosomes repair raloxifene-induced damage in endometrial stromal cells via autophagy activation

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016/j.reprotox.2025.108997
  
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Jun 2025
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Heat-shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via restoration of autophagic flux

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1. scibot 28 Jun 2025
  
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  DOI: 10.1080/15548627.2025.2466144
  
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tandfonline.com/doi/abs/10.1080/15548627.2025.2466144
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DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation

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1. scibot 18 Jun 2025
  
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  DOI: 10.1038/s41594-025-01581-x
  
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nature.com/articles/s41594-025-01581-x
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Rapid hepatitis C virus replication machinery removal after antiviral treatment with DAA monitored by multimodal imaging

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.str.2025.05.015
  
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PDF-html.html

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1. scibot 12 Jun 2025
  
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  DOI: 10.1158/0008-5472.can-24-3785
  
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52.53.155.43/6d05284590fa38103d7fbc1633c815ab1c347fcd/PDF-html.html
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Mitochondrial fumarate inhibits Parkin-mediated mitophagy

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.molcel.2025.05.021
  
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The lysosomal membrane protein LAMP2B mediates microlipophagy to target obesity-related disorders

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115829
  
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May 2025
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Macrophage extracellular traps as key mediators of scleral remodeling in myopia induced by hypoxia and activated platelets

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115771
  
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Dysregulation of Labile Iron Predisposes Chemotherapy Resistant Cancer Cells to Ferroptosis

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1. scibot 21 May 2025
  
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  DOI: 10.3390/ijms26094193
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12072162/
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Inhibition of histone deacetylase 6 activity mitigates neurological impairment and post-hemorrhagic hydrocephalus after intraventricular hemorrhage by modulating pyroptosis and autophagy pathways

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1. scibot 21 May 2025
  
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  DOI: 10.1186/s12987-025-00658-5
  
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link.springer.com/article/10.1186/s12987-025-00658-5
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Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.cell.2025.04.025
  
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sciencedirect.com/science/article/pii/S0092867425004581
Apr 2025
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Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib

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  DOI: 10.1016/j.isci.2025.112283
  
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Mar 2025
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Screening of patient-derived organoids identifies mitophagy as a cell-intrinsic vulnerability in colorectal cancer during statin treatment

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1. scibot 28 Mar 2025
  
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  DOI: 10.1016/j.xcrm.2025.102039
  
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Feb 2025
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1-s2.0-S2589004225003785-main-html.html

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1. scibot 28 Feb 2025
  
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Jan 2025
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GDF15 inhibits early-stage adipocyte differentiation by enhancing HOP2 expression and suppressing C/EBPα expression

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1. scibot 14 Jan 2025
  
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  DOI: 10.1016/j.mce.2025.112461
  
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BPS Publications

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1. scibot 05 Jan 2025
  
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  DOI: 10.1111/bph.17425
  
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Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator

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  DOI: 10.1016/j.chembiol.2024.12.002
  
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sciencedirect.com/science/article/pii/S2451945624004914
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Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes

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  DOI: 10.1016/j.chembiol.2024.10.005
  
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Circular RNAs trigger nonsense-mediated mRNA decay

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  DOI: 10.1016/j.molcel.2024.11.022
  
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The ATAC complex represses the transcriptional program of the autophagy-lysosome pathway via its E3 ubiquitin ligase activity

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  DOI: 10.1016/j.celrep.2024.115033
  
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sciencedirect.com/science/article/pii/S2211124724013846
Oct 2024
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Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux

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1. scibot 05 Oct 2024
  
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  DOI: 10.1016/j.chembiol.2023.06.016
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11426993/
Sep 2024
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IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1

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1. scibot 26 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110693
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11387596/
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ZIKV Induces P62-Mediated Autophagic Degradation of TRAF6 through TRAF6-NS1 Interaction

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110757
  
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  DOI: 10.1016/j.isci.2024.110757
  
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sciencedirect.com/science/article/pii/S2589004224019825
Aug 2024
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Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread

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1. scibot 21 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114484
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11316253/
Jul 2024
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Targeting type I DED interactions at the DED filament serves as a sensitive switch for cell fate decisions

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1. scibot 25 Jul 2024
  
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Novel autophagy inducers by accelerating lysosomal clustering against Parkinson’s disease

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Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule

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ATG16L1 induces the formation of phagophore-like membrane cups

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Oncogenic fatty acid oxidation senses circadian disruption in sleep-deficiency-enhanced tumorigenesis

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Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities

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Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner

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Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy

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An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade

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Phospholipase PLCE1 promotes transcription and phosphorylation of MCM7 to drive tumor progression in esophageal cancer

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The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs

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OVOL2 induces autophagy-mediated epithelial-mesenchymal transition by the ERK1/2 MAPK signaling in lung adenocarcinoma

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EBAG9-deficient mice display decreased bone mineral density with suppressed autophagy

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CRIP1 involves the pathogenesis of multiple myeloma via dual-regulation of proteasome and autophagy

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Enniatin A inhibits the chaperone Hsp90 and unleashes the immune system against triple-negative breast cancer

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ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress

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Modification of Lysine-260 2-hydroxyisobutyrylation destabilizes ALDH1A1 expression to regulate bladder cancer progression

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SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells

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s41586-023-06657-6_reference-html.html

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PARP1 inhibition protects mice against Japanese encephalitis virus infection

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Rapamycin reverses ferroptosis by increasing autophagy in MPTP/MPP+-induced models of Parkinson’s disease

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Bexarotene improves motor function after spinal cord injury in mice

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Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machinery

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Caffeine supplementation and FOXM1 inhibition enhance the antitumor effect of statins in neuroblastoma

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Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2

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can-22-3450-html.html

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DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons

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Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells

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The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules

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Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation

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GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis

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CTB-targeted protocells enhance ability of lanthionine ketenamine analogs to induce autophagy in motor neuron-like cells

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Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix

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β-Hydroxybutyrate preferentially enhances neuron over astrocyte respiration while signaling cellular quiescence

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The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER

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Nov 2022
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Autophagy promotes cell survival by maintaining NAD levels

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The Cancermuts software package for the prioritization of missense cancer variants: a case study of AMBRA1 in melanoma

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NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins

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Mitochondrial double-stranded RNAs govern the stress response in chondrocytes to promote osteoarthritis development

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Phloretin enhances autophagy by impairing AKT activation and inducing JNK-Beclin-1 pathway activation

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The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity

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miR-4463 Regulates Hypoxia-Induced Autophagy and Apoptosis by Targeting ULK1 in Endothelial Cells

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MiR-25 blunts autophagy and promotes the survival of Mycobacterium tuberculosis by regulating NPC1

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Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy

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VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites

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Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control

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A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis

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C10orf10/DEPP activates mitochondrial autophagy and maintains chondrocyte viability in the pathogenesis of osteoarthritis

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BPS Publications

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BPS Publications

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A novel live-cell imaging assay reveals regulation of endosome maturation

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Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy

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Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension

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Treatment of acromegaly by rosiglitazone via upregulating 15-PGDH in both pituitary adenoma and liver

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Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells

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Untitled document

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Untitled document

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SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance

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Activation of spinal PDGFRβ in microglia promotes neuronal autophagy via p38 MAPK pathway in morphine-tolerant rats

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Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment

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Autophagy inhibition as a promising therapeutic target for laryngeal cancer

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MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat

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A role for autophagy in long‐term spatial memory formation in male rodents

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Neuronal activity recruits the CRTC1/CREB axis to drive transcription-dependent autophagy for maintaining late-phase LTD

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NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism

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The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules

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LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes

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Oncogene-regulated release of extracellular vesicles

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TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology

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NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

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Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers

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Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells

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Coordinate regulation of the senescent state by selective autophagy

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Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth

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A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology

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S1PR3–G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation

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Autophagy blockade limits HER2+ breast cancer tumorigenesis by perturbing HER2 trafficking and promoting release via small extracellular vesicles

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Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption

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Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

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TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance

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  LC3B
  
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https://doi.org/10.1101/2020.05.16.091520

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Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery

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Auto-ubiquitination of NEDD4-1 Recruits USP13 to Facilitate Autophagy through Deubiquitinating VPS34

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H63D variant of the homeostatic iron regulator (HFE) gene alters α‐synuclein expression, aggregation, and toxicity

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Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis

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Autophagy Controls CSL/RBPJκ Stability through a p62/SQSTM1-Dependent Mechanism

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Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation

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Mitophagy, Autophagy and Cell Death: The novel cyclophilin-D-interacting protein FASTKD1 protects cells against oxidative stress-induced cell death

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Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors

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Alpha-lipoic acid protects against pressure overload-induced heart failure via ALDH2-dependent Nrf1-FUNDC1 signaling

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BPS Publications

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Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

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TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion

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Regulation of Autophagic Flux by the 20S Proteasome

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The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing

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LC3C-Mediated Autophagy Selectively Regulates the Met RTK and HGF-Stimulated Migration and Invasion

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Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

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KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis

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PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis

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  DOI: 10.1111/bph.14626
  
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The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

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  DOI: 10.1016/j.immuni.2018.12.018
  
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  DOI: 10.1016/j.celrep.2019.01.019
  
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Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway

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Curcumin Attenuates gp120-Induced Microglial Inflammation by Inhibiting Autophagy via the PI3K Pathway

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AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

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Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors

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Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer

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Complement C3 Drives Autophagy-Dependent Restriction of Cyto-invasive Bacteria

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Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1

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Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy

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Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance

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Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells

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CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

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MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma

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Modulation of Autophagy by BDNF Underlies Synaptic Plasticity

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A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability

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Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

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Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks

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Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy

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