125 Matching Annotations
  1. Last 7 days
  2. www.biorxiv.org www.biorxiv.org
    Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities
    1
    1. scibot 10 May 2024
      3868; Cell Signaling Technology

      DOI: 10.1101/2024.01.25.577280

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    biorxiv.org/content/10.1101/2024.01.25.577280v1
  3. Apr 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
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    1. scibot 30 Apr 2024
      RRID:AB_2137707

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    sciencedirect.com/science/article/pii/S2211124724004777
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    Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy
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    sciencedirect.com/science/article/pii/S2589004224008022
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    An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade
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    1. scibot 02 Apr 2024
      RRID:AB_2137707

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    sciencedirect.com/science/article/pii/S2211124724003486
  7. Feb 2024
  8. aacrjournals.org aacrjournals.org
    Phospholipase PLCE1 promotes transcription and phosphorylation of MCM7 to drive tumor progression in esophageal cancer
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    1. scibot 23 Feb 2024
      RRID:AB_2137707

      DOI: 10.1158/0008-5472.CAN-23-1633

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    aacrjournals.org/cancerres/article/84/4/560/734132/Phospholipase-PLCE1-Promotes-Transcription-and
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    The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs
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    1. scibot 08 Feb 2024
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    sciencedirect.com/science/article/pii/S1097276524000480
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    OVOL2 induces autophagy-mediated epithelial-mesenchymal transition by the ERK1/2 MAPK signaling in lung adenocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10838806/
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EBAG9-deficient mice display decreased bone mineral density with suppressed autophagy
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    1. scibot 06 Feb 2024
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      DOI: 10.1016/j.isci.2024.108871

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    ncbi.nlm.nih.gov/pmc/articles/PMC10835455/
  12. Jan 2024
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRIP1 involves the pathogenesis of multiple myeloma via dual-regulation of proteasome and autophagy
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    1. scibot 11 Jan 2024
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      DOI: 10.1016/j.ebiom.2023.104961

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    ncbi.nlm.nih.gov/pmc/articles/PMC10825369/
  14. Nov 2023
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    Enniatin A inhibits the chaperone Hsp90 and unleashes the immune system against triple-negative breast cancer
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    1. scibot 18 Nov 2023
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    sciencedirect.com/science/article/pii/S2589004223023854
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    ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress
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    1. scibot 17 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113402

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    sciencedirect.com/science/article/pii/S2211124723014146
  17. Oct 2023
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modification of Lysine-260 2-hydroxyisobutyrylation destabilizes ALDH1A1 expression to regulate bladder cancer progression
    1
    1. scibot 21 Oct 2023
      RRID:AB_2137707

      DOI: 10.1016/j.isci.2023.108142

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    ncbi.nlm.nih.gov/pmc/articles/PMC10585400/
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells
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    1. scibot 06 Oct 2023
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      DOI: 10.1016/j.celrep.2023.112790

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    ncbi.nlm.nih.gov/pmc/articles/PMC10528745/
  20. 52.53.155.43 52.53.155.43
    s41586-023-06657-6_reference-html.html
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    1. scibot 06 Oct 2023
      AB_2137707

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  21. Sep 2023
  22. www.sciencedirect.com www.sciencedirect.com
    PARP1 inhibition protects mice against Japanese encephalitis virus infection
    1
    1. scibot 08 Sep 2023
      RRID:AB_2137707

      DOI: 10.1016/j.celrep.2023.113103

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    sciencedirect.com/science/article/pii/S2211124723011142
  23. Jul 2023
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rapamycin reverses ferroptosis by increasing autophagy in MPTP/MPP+-induced models of Parkinson’s disease
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    1. scibot 25 Jul 2023
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      DOI: 10.4103/1673-5374.371381

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    ncbi.nlm.nih.gov/pmc/articles/PMC10360095/
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bexarotene improves motor function after spinal cord injury in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10358692/
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    Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machinery
    1
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      DOI: 10.1016/j.celrep.2023.112807

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    sciencedirect.com/science/article/pii/S2211124723008185
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Caffeine supplementation and FOXM1 inhibition enhance the antitumor effect of statins in neuroblastoma
    1
    1. scibot 08 Jul 2023
      RRID:AB_2137707

      DOI: 10.1158/0008-5472.CAN-22-3450

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    ncbi.nlm.nih.gov/pmc/articles/PMC10320471/
  28. Jun 2023
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    Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2
    1
    1. scibot 28 Jun 2023
      RRID:AB_2137707

      DOI: 10.1016/j.celrep.2023.112693

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    sciencedirect.com/science/article/pii/S2211124723007040
  30. 52.53.155.43 52.53.155.43
    can-22-3450-html.html
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    52.53.155.43/d74c78a2e62f04f8ffa00018470c131fb0d65945/can-22-3450-html.html
  31. May 2023
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    DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons
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      DOI: 10.1016/j.celrep.2023.112575

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    sciencedirect.com/science/article/pii/S2211124723005867
  33. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells
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      DOI: 10.1002/cac2.12332

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    onlinelibrary.wiley.com/doi/10.1002/cac2.12332
  34. pubs.acs.org pubs.acs.org
    The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules
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    1. scibot 05 May 2023
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      DOI: 10.1021/acsinfecdis.0c00349

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    pubs.acs.org/doi/full/10.1021/acsinfecdis.0c00349
  35. Apr 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation
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    1. scibot 19 Apr 2023
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      DOI: 10.1016/j.cmet.2023.03.019

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    sciencedirect.com/science/article/pii/S1550413123001249
  37. Feb 2023
  38. www.sciencedirect.com www.sciencedirect.com
    GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis
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      DOI: 10.1016/j.devcel.2023.01.006

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    sciencedirect.com/science/article/pii/S1534580723000370
  39. www.nature.com www.nature.com
    CTB-targeted protocells enhance ability of lanthionine ketenamine analogs to induce autophagy in motor neuron-like cells
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      DOI: 10.1038/s41598-023-29437-8

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    nature.com/articles/s41598-023-29437-8
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    Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix
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      DOI: 10.1016/j.isci.2023.105965

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    sciencedirect.com/science/article/pii/S2589004223000421
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    β-Hydroxybutyrate preferentially enhances neuron over astrocyte respiration while signaling cellular quiescence
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      DOI: 10.1016/j.mito.2022.12.004

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    sciencedirect.com/science/article/pii/S1567724922001088
  42. Dec 2022
  43. www.sciencedirect.com www.sciencedirect.com
    The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER
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      DOI: 10.1016/j.celrep.2022.111868

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    sciencedirect.com/science/article/pii/S2211124722017648
  44. Nov 2022
  45. www.sciencedirect.com www.sciencedirect.com
    Autophagy promotes cell survival by maintaining NAD levels
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    sciencedirect.com/science/article/pii/S1534580722007602
  46. Oct 2022
  47. www.nature.com www.nature.com
    The Cancermuts software package for the prioritization of missense cancer variants: a case study of AMBRA1 in melanoma
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      DOI: 10.1038/s41419-022-05318-2

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    nature.com/articles/s41419-022-05318-2
  48. Sep 2022
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins
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      DOI: 10.1158/2159-8290.CD-22-0043

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    ncbi.nlm.nih.gov/pmc/articles/PMC9437572/
  50. Aug 2022
  51. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial double-stranded RNAs govern the stress response in chondrocytes to promote osteoarthritis development
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      DOI: 10.1016/j.celrep.2022.111178

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    sciencedirect.com/science/article/pii/S2211124722009913
  52. Jul 2022
  53. www.sciencedirect.com www.sciencedirect.com
    Phloretin enhances autophagy by impairing AKT activation and inducing JNK-Beclin-1 pathway activation
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      DOI: 10.1016/j.yexmp.2022.104814

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    sciencedirect.com/science/article/pii/S0014480022000776
  54. Jun 2022
  55. www.sciencedirect.com www.sciencedirect.com
    The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity
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      DOI: 10.1016/j.isci.2022.104561

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    sciencedirect.com/science/article/pii/S2589004222008331
  56. www.imrpress.com www.imrpress.com
    miR-4463 Regulates Hypoxia-Induced Autophagy and Apoptosis by Targeting ULK1 in Endothelial Cells
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      DOI: 10.31083/j.fbl2706175

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    imrpress.com/journal/FBL/27/6/10.31083/j.fbl2706175
  57. May 2022
  58. www.sciencedirect.com www.sciencedirect.com
    MiR-25 blunts autophagy and promotes the survival of Mycobacterium tuberculosis by regulating NPC1
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      DOI: 10.1016/j.isci.2022.104279

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    sciencedirect.com/science/article/pii/S2589004222005491
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    Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy
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      DOI: 10.1016/j.celrep.2022.110796

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  60. Apr 2022
  61. www.sciencedirect.com www.sciencedirect.com
    VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites
    1
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  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control
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  63. Mar 2022
  64. www.sciencedirect.com www.sciencedirect.com
    A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis
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  65. Jan 2022
  66. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    C10orf10/DEPP activates mitochondrial autophagy and maintains chondrocyte viability in the pathogenesis of osteoarthritis
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      DOI: 10.1096/fj.202100896R

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  67. Dec 2021
  68. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel live-cell imaging assay reveals regulation of endosome maturation
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  71. Oct 2021
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    Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy
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    Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension
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  74. Sep 2021
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Treatment of acromegaly by rosiglitazone via upregulating 15-PGDH in both pituitary adenoma and liver
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  76. Aug 2021
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells
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  78. www.cell.com www.cell.com
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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  84. Jul 2021
  85. www.sciencedirect.com www.sciencedirect.com
    SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance
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  86. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Activation of spinal PDGFRβ in microglia promotes neuronal autophagy via p38 MAPK pathway in morphine-tolerant rats
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  87. academic.oup.com academic.oup.com
    Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment
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    1. scibot 31 Jul 2021
      rabbit polyclonal anti-LC3B

      DOI: 10.1093/hmg/ddz255

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  88. academic.oup.com academic.oup.com
    Autophagy inhibition as a promising therapeutic target for laryngeal cancer
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      Anti-LC3B

      DOI: 10.1093/carcin/bgz080

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    academic.oup.com/carcin/advance-article/doi/10.1093/carcin/bgz080/5485218
  89. www.nature.com www.nature.com
    MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat
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      anti-LC3B

      DOI: 10.1038/s41467-019-11568-0

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  90. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A role for autophagy in long‐term spatial memory formation in male rodents
    2
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      DOI: 10.1002/jnr.24121

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  91. www.sciencedirect.com www.sciencedirect.com
    Neuronal activity recruits the CRTC1/CREB axis to drive transcription-dependent autophagy for maintaining late-phase LTD
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    NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism
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      DOI: 10.1016/j.cell.2021.06.022

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  93. pubs.acs.org pubs.acs.org
    The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules
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      RRID:AB_2137707

      DOI: 10.1021/acsinfecdis.0c00349

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  94. Jun 2021
  95. www.sciencedirect.com www.sciencedirect.com
    LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes
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      DOI: 10.1016/j.cub.2021.05.052

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    sciencedirect.com/science/article/pii/S0960982221007508
  96. www.sciencedirect.com www.sciencedirect.com
    Oncogene-regulated release of extracellular vesicles
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      RRID:AB_2137707

      DOI: 10.1016/j.devcel.2021.05.014

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  97. May 2021
  98. www.sciencedirect.com www.sciencedirect.com
    TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology
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      DOI: 10.1016/j.molcel.2020.10.018

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    NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C
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    Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers
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  101. Apr 2021
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    Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells
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      DOI: 10.1016/j.cmet.2020.10.017

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    Coordinate regulation of the senescent state by selective autophagy
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    Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth
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      DOI: 10.1016/j.celrep.2021.109024

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    A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology
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      rabbit anti‐LC3

      DOI: 10.1016/j.ebiom.2021.103314

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  106. Mar 2021
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    S1PR3–G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation
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    Autophagy blockade limits HER2+ breast cancer tumorigenesis by perturbing HER2 trafficking and promoting release via small extracellular vesicles
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  109. Feb 2021
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    Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption
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      RRID:AB_2137707

      DOI: 10.1016/j.cub.2021.01.028

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  111. Dec 2020
  112. www.sciencedirect.com www.sciencedirect.com
    Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q
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      RRID:AB_2137707

      DOI: 10.1016/j.celrep.2020.108493

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  116. Sep 2020
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    Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery
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    PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis
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    The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages
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    Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway
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    Curcumin Attenuates gp120-Induced Microglial Inflammation by Inhibiting Autophagy via the PI3K Pathway
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    AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity
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    Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors
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    Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer
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    Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1
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    Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy
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    Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells
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    CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis
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    MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma
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      RRID:AB_2137707 RRIDCUR:Validated
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    europepmc.org/articles/PMC5734934/
  157. Nov 2017
  158. www.sciencedirect.com www.sciencedirect.com
    Modulation of Autophagy by BDNF Underlies Synaptic Plasticity
    1
    1. scibot 08 Nov 2017
      AB_2137707

      Curator: @chewbeccax

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      (Cell Signaling Technology Cat# 3868, RRID:AB_2137707)

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      RRID:AB_2137707 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1550413117303479
  159. www.sciencedirect.com www.sciencedirect.com
    A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability
    1
    1. scibot 08 Nov 2017
      AB_2137707

      Curator: @Zeljana_Babic

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      (Cell Signaling Technology Cat# 3868, RRID:AB_2137707)

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      RRID:AB_2137707 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0092867417305378
  160. www.sciencedirect.com www.sciencedirect.com
    Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
    1
    1. scibot 08 Nov 2017
      AB_2137707

      Curator: @Zeljana_Babic

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      (Cell Signaling Technology Cat# 3868, RRID:AB_2137707)

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      RRID:AB_2137707 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S109727651730312X
  161. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks
    1
    1. scibot 08 Nov 2017
      AB_2137707

      Curator: @kaitlinsung

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      (Cell Signaling Technology Cat# 3868, RRID:AB_2137707)

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      RRID:AB_2137707 RRIDCUR:Validated
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    ncbi.nlm.nih.gov/pmc/articles/PMC5376188/
  162. www.sciencedirect.com www.sciencedirect.com
    Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy
    1
    1. scibot 08 Nov 2017
      AB_2137707

      Curator: @chewbeccax

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      (Cell Signaling Technology Cat# 3868, RRID:AB_2137707)

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      RRID:AB_2137707 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276517300539