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TAOK2 controls synaptic plasticity and anxiety via ERK and calcium signaling

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1. scibot 22 Oct 2025
  
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  DOI: 10.1016/j.isci.2025.113712
  
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sciencedirect.com/science/article/pii/S258900422501973X
Sep 2025
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Cooperativity between Ras pathway mutations in colonic tumorigenesis

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1. scibot 10 Sep 2025
  
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  DOI: 10.1101/2025.09.05.673994
  
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biorxiv.org/content/10.1101/2025.09.05.673994v1
Jul 2025
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Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102253
  
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sciencedirect.com/science/article/pii/S266637912500326X
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SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

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1. scibot 04 Jul 2025
  
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  DOI: 10.1158/0008-5472.CAN-23-3256
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11695159/
Jun 2025
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EGFR TKIs suppress MUC1 glycosylation through the PI3K/AKT/SP1/C1GALT1 pathway to enhance TnMUC1 CAR-T efficacy in EGFR-mutant NSCLC

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1. scibot 25 Jun 2025
  
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  DOI: 10.1016/j.xcrm.2025.102199
  
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sciencedirect.com/science/article/pii/S2666379125002721
May 2025
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Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration

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1. scibot 20 May 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-2220
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12046322/
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PDF-html.html

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1. scibot 20 May 2025
  
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  DOI: 10.1101/2025.04.30.651453
  
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52.53.155.43/dd3c8f74e9cdc1e420d33be7f8443dfa69ebea7a/PDF-html.html
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A novel TRKB-activating internal tandem duplication characterizes a new mechanism of receptor tyrosine kinase activation

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1. scibot 19 May 2025
  
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  DOI: 10.1038/s41698-025-00928-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12065843/
Feb 2025
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FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma

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1. scibot 28 Feb 2025
  
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sciencedirect.com/science/article/pii/S1535610825000534
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Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP

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1. scibot 25 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115340
  
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sciencedirect.com/science/article/pii/S2211124725001111
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Overexpression of NR1D1 portends disease recurrence in thyroid cancer

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1. scibot 20 Feb 2025
  
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  RRID:AB_2138017
  
  DOI: 10.1210/clinem/dgae687
  
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academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgae687/7808457
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ASCL1 restrains ERK1/2 to promote survival of a subset of neuroendocrine lung cancers

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1. scibot 13 Feb 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0355
  
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aacrjournals.org/mct/article/23/12/1789/750248/ASCL1-Restrains-ERK1-2-to-Promote-Survival-of-a
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Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases

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1. scibot 11 Feb 2025
  
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  DOI: 10.1016/j.xcrm.2025.101943
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11866499/
Sep 2024
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Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription

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1. scibot 25 Sep 2024
  
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  DOI: 10.1038/s44319-024-00217-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11387499/
Aug 2024
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In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma

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1. scibot 18 Aug 2024
  
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  DOI: 10.1016/j.xcrm.2024.101663
  
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sciencedirect.com/science/article/pii/S266637912400377X
Jul 2024
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Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK

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1. scibot 30 Jul 2024
  
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  DOI: 10.1016/j.chom.2024.07.001
  
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cell.com/cell-host-microbe/fulltext/S1931-3128(24)00254-3
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Cancer-associated endocrine cells participate in pancreatic carcinogenesis

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1. scibot 25 Jul 2024
  
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  DOI: 10.1053/j.gastro.2024.07.016
  
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52.53.155.43/00ed7388bef43fd34d4811e77f0e00ce1748f907/1-s2.0-S0016508524052259-main-html.html
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TSPAN4 influences glioblastoma progression through regulating EGFR stability

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1. scibot 16 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110417
  
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cell.com/iscience/fulltext/S2589-0042(24)01642-0
May 2024
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Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation

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1. scibot 01 May 2024
  
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  DOI: 10.21203/rs.3.rs-4114038/v1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11030525/
Mar 2024
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The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies

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1. scibot 27 Mar 2024
  
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  DOI: 10.1080/15384047.2024.2332000
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
Feb 2024
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Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer

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1. scibot 11 Feb 2024
  
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  DOI: 10.1158/2767-9764.CRC-23-0321
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10851855/
Jan 2024
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Landscape of Clinical Resistance Mechanisms to FGFR Inhibitors in FGFR2-Altered Cholangiocarcinoma

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1. scibot 10 Jan 2024
  
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  DOI: 10.1158/1078-0432.CCR-23-1317
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10767308/
Dec 2023
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Wildtype C-Raf gene dosage and dimerization drive prostate cancer metastasis

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1. scibot 02 Dec 2023
  
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  DOI: 10.1016/j.isci.2023.108480
  
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ccr-23-1317-html.html

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1. scibot 01 Dec 2023
  
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  DOI: 10.1158/1078-0432.ccr-23-1317
  
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52.53.155.43/eb06d63ced7d6b4d34065d25e0eab223f52bfb41/ccr-23-1317-html.html
Nov 2023
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Repositioning of Montelukast to inhibit proliferation of mutated KRAS pancreatic cancer through a novel mechanism that interfere the binding between KRAS and GTP/GDP

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1. scibot 17 Nov 2023
  
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  DOI: 10.1016/j.ejphar.2023.176157
  
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sciencedirect.com/science/article/pii/S0014299923006714
Oct 2023
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High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma

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1. scibot 28 Oct 2023
  
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  DOI: 10.1016/j.xcrm.2023.101244
  
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Aug 2023
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Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer

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1. scibot 04 Aug 2023
  
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  DOI: 10.1016/j.ccell.2023.07.005
  
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sciencedirect.com/science/article/pii/S1535610823002453
Jul 2023
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Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia

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1. scibot 27 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112869
  
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sciencedirect.com/science/article/pii/S221112472300880X
Jun 2023
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Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response

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  DOI: 10.1016/j.celrep.2023.112696
  
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sciencedirect.com/science/article/pii/S2211124723007076
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MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells

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1. scibot 21 Jun 2023
  
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  DOI: 10.1016/j.canlet.2023.216264
  
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sciencedirect.com/science/article/pii/S030438352300215X
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KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2

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  DOI: 10.1016/j.isci.2023.106914
  
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sciencedirect.com/science/article/pii/S2589004223009914
May 2023
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Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo

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1. scibot 05 May 2023
  
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  DOI: 10.1002/mc.23284
  
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onlinelibrary.wiley.com/doi/full/10.1002/mc.23284
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Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells

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1. scibot 05 May 2023
  
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  DOI: 10.1002/cac2.12332
  
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onlinelibrary.wiley.com/doi/10.1002/cac2.12332
Apr 2023
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RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis

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1. scibot 18 Apr 2023
  
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  DOI: 10.15252/emmm.202217078
  
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embopress.org/doi/10.15252/emmm.202217078
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Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities

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1. scibot 09 Apr 2023
  
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  DOI: 10.7554/eLife.78629
  
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Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion

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Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo

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Scaffold coupling: ERK activation by trans-phosphorylation across different scaffold protein species

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Repositioning Lomitapide to block ZDHHC5-dependant palmitoylation on SSTR5 leads to anti-proliferation effect in preclinical pancreatic cancer models

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Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling

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Oncogenic BRAFV600E induces microglial proliferation... : Neural Regeneration Research

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Systematic analysis of the MAPK signaling network reveals MAP3K-driven control of cell fate

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Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy

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CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells

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ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1

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EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma

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Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

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Translational Strategies for Repotrectinib in Neuroblastoma

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Downregulation of microRNA-124-3p promotes subventricular zone neural stem cell activation by enhancing the function of BDNF downstream pathways after traumatic brain injury in adult rats

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Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation

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Regulation of GTPase function by autophosphorylation

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Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells

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Acetylation-dependent regulation of BRAF oncogenic function

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Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology

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Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer

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Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis

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NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

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A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies

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Selective activation of PFKL suppresses the phagocytic oxidative burst

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Untitled document

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Untitled document

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KRAS activation in gastric adenocarcinoma stimulates epithelial-to-mesenchymal transition to cancer stem-like cells and promotes metastasis

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The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression

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Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

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Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling

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Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma

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A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2α-induced corpus luteum regression

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Induction of cyclophilin A by influenza A virus infection facilitates group A Streptococcus coinfection

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Activation of Neuronal Ras‐Related C3 Botulinum Toxin Substrate 1 (Rac1) Improves Post‐Stroke Recovery and Axonal Plasticity in Mice

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Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation

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Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis

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Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress

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Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells

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Hotspots of Aberrant Enhancer Activity in Fibrolamellar Carcinoma Reveal Candidate Oncogenic Pathways and Therapeutic Vulnerabilities

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Prolactin enhances the proliferation of proliferative endometrial glandular cells and endometrial cancer cells

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Certain ortho-hydroxylated brominated ethers are promiscuous kinase inhibitors that impair neuronal signaling and neurodevelopmental processes

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BPS Publications

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Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

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YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression

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A Loss of Epigenetic Control Can Promote Cell Death through Reversing the Balance of Pathways in a Signaling Network

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MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation

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The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells

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An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential

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Systematic Functional Annotation of Somatic Mutations in Cancer

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c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling

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KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS

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IL-1β Inhibits Connexin 43 and Disrupts Decidualization of Human Endometrial Stromal Cells Through ERK1/2 and p38 MAP Kinase

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Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex.

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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C

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Dual Role of Insulin in Spexin Regulation: Functional Link Between Food Intake and Spexin Expression in a Fish Model

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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells

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Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis

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