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  1. Last 7 days
  2. www.cell.com www.cell.com
    TSPAN4 influences glioblastoma progression through regulating EGFR stability
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    1. scibot 16 Jul 2024
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      DOI: 10.1016/j.isci.2024.110417

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    cell.com/iscience/abstract/S2589-0042(24)01642-0
  3. May 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation
    1
    1. scibot 01 May 2024
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      DOI: 10.21203/rs.3.rs-4114038/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11030525/
  5. Mar 2024
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
    1
    1. scibot 27 Mar 2024
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      DOI: 10.1080/15384047.2024.2332000

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    ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
  7. Feb 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
    1
    1. scibot 11 Feb 2024
      RRID:AB_2138017

      DOI: 10.1158/2767-9764.CRC-23-0321

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    ncbi.nlm.nih.gov/pmc/articles/PMC10851855/
  9. Jan 2024
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Landscape of Clinical Resistance Mechanisms to FGFR Inhibitors in FGFR2-Altered Cholangiocarcinoma
    1
    1. scibot 10 Jan 2024
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      DOI: 10.1158/1078-0432.CCR-23-1317

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    ncbi.nlm.nih.gov/pmc/articles/PMC10767308/
  11. Dec 2023
  12. www.sciencedirect.com www.sciencedirect.com
    Wildtype C-Raf gene dosage and dimerization drive prostate cancer metastasis
    1
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      DOI: 10.1016/j.isci.2023.108480

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    sciencedirect.com/science/article/pii/S2589004223025579
  13. 52.53.155.43 52.53.155.43
    ccr-23-1317-html.html
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    1. scibot 01 Dec 2023
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  14. Nov 2023
  15. www.sciencedirect.com www.sciencedirect.com
    Repositioning of Montelukast to inhibit proliferation of mutated KRAS pancreatic cancer through a novel mechanism that interfere the binding between KRAS and GTP/GDP
    1
    1. scibot 17 Nov 2023
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      DOI: 10.1016/j.ejphar.2023.176157

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    sciencedirect.com/science/article/pii/S0014299923006714
  16. Oct 2023
  17. www.sciencedirect.com www.sciencedirect.com
    High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma
    1
    1. scibot 28 Oct 2023
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      DOI: 10.1016/j.xcrm.2023.101244

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    sciencedirect.com/science/article/pii/S2666379123004214
  18. Aug 2023
  19. www.sciencedirect.com www.sciencedirect.com
    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
    1
    1. scibot 04 Aug 2023
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    sciencedirect.com/science/article/pii/S1535610823002453
  20. Jul 2023
  21. www.sciencedirect.com www.sciencedirect.com
    Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia
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    1. scibot 27 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112869

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    sciencedirect.com/science/article/pii/S221112472300880X
  22. Jun 2023
  23. www.sciencedirect.com www.sciencedirect.com
    Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
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    1. scibot 30 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112696

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    sciencedirect.com/science/article/pii/S2211124723007076
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    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
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    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.canlet.2023.216264

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    sciencedirect.com/science/article/pii/S030438352300215X
  25. www.sciencedirect.com www.sciencedirect.com
    KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2
    1
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      DOI: 10.1016/j.isci.2023.106914

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    sciencedirect.com/science/article/pii/S2589004223009914
  26. May 2023
  27. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo
    1
    1. scibot 05 May 2023
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      DOI: 10.1002/mc.23284

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    onlinelibrary.wiley.com/doi/full/10.1002/mc.23284
  28. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells
    1
    1. scibot 05 May 2023
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      DOI: 10.1002/cac2.12332

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    onlinelibrary.wiley.com/doi/10.1002/cac2.12332
  29. Apr 2023
  30. www.embopress.org www.embopress.org
    RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis
    1
    1. scibot 18 Apr 2023
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      DOI: 10.15252/emmm.202217078

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    embopress.org/doi/10.15252/emmm.202217078
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities
    1
    1. scibot 09 Apr 2023
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      DOI: 10.7554/eLife.78629

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    ncbi.nlm.nih.gov/pmc/articles/PMC10069870/
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
    1
    1. scibot 08 Apr 2023
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      DOI: 10.7554/eLife.86971

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    ncbi.nlm.nih.gov/pmc/articles/PMC10069867/
  33. Mar 2023
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo
    1
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      DOI: 10.1371/journal.pone.0281063

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    ncbi.nlm.nih.gov/pmc/articles/PMC10035898/
  35. Feb 2023
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Scaffold coupling: ERK activation by trans-phosphorylation across different scaffold protein species
    1
    1. scibot 17 Feb 2023
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      DOI: 10.1126/sciadv.add7969

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    ncbi.nlm.nih.gov/pmc/articles/PMC9931222/
  37. www.nature.com www.nature.com
    Repositioning Lomitapide to block ZDHHC5-dependant palmitoylation on SSTR5 leads to anti-proliferation effect in preclinical pancreatic cancer models
    1
    1. scibot 15 Feb 2023
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      DOI: 10.1038/s41420-023-01359-4

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    nature.com/articles/s41420-023-01359-4
  38. Jan 2023
  39. www.sciencedirect.com www.sciencedirect.com
    Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling
    1
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      DOI: 10.1016/j.celrep.2023.112031

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    sciencedirect.com/science/article/pii/S2211124723000426
  40. journals.lww.com journals.lww.com
    Oncogenic BRAFV600E induces microglial proliferation... : Neural Regeneration Research
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      DOI: 10.4103/1673-5374.361516

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    journals.lww.com/nrronline/Fulltext/2023/07000/Oncogenic_BRAFV600E_induces_microglial.38.aspx
  41. Nov 2022
  42. www.sciencedirect.com www.sciencedirect.com
    Systematic analysis of the MAPK signaling network reveals MAP3K-driven control of cell fate
    1
    1. scibot 10 Nov 2022
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      DOI: 10.1016/j.cels.2022.10.003

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    sciencedirect.com/science/article/pii/S2405471222004306
  43. Oct 2022
  44. www.nature.com www.nature.com
    Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy
    1
    1. scibot 08 Oct 2022
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      DOI: 10.1038/s41418-022-01072-2

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    nature.com/articles/s41418-022-01072-2
  45. Sep 2022
  46. journals.plos.org journals.plos.org
    CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells
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    1. scibot 14 Sep 2022
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      DOI: 10.1371/journal.pone.0273711

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    journals.plos.org/plosone/article
  47. May 2022
  48. www.sciencedirect.com www.sciencedirect.com
    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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    1. scibot 26 May 2022
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      DOI: 10.1016/j.molcel.2022.04.034

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    sciencedirect.com/science/article/pii/S1097276522004348
  49. aacrjournals.org aacrjournals.org
    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
    1
    1. scibot 13 May 2022
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      DOI: 10.1158/2159-8290.CD-21-1168

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    aacrjournals.org/cancerdiscovery/article/12/5/1378/694560/EGFR-Inhibition-Potentiates-FGFR-Inhibitor-Therapy
  50. elifesciences.org elifesciences.org
    Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs
    1
    1. scibot 11 May 2022
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      DOI: 10.7554/eLife.76495

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    elifesciences.org/articles/76495
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translational Strategies for Repotrectinib in Neuroblastoma
    1
    1. scibot 05 May 2022
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      DOI: 10.1158/1535-7163.MCT-21-0126

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    ncbi.nlm.nih.gov/pmc/articles/PMC8571000/
  52. Apr 2022
  53. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Downregulation of microRNA-124-3p promotes subventricular zone neural stem cell activation by enhancing the function of BDNF downstream pathways after traumatic brain injury in adult rats
    1
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      DOI: 10.1111/cns.13845

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    onlinelibrary.wiley.com/doi/10.1111/cns.13845
  54. www.sciencedirect.com www.sciencedirect.com
    Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation
    1
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      DOI: 10.1016/j.molcel.2022.03.026

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    sciencedirect.com/science/article/pii/S1097276522002647
  55. Mar 2022
  56. www.sciencedirect.com www.sciencedirect.com
    Regulation of GTPase function by autophosphorylation
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      DOI: 10.1016/j.molcel.2022.02.011

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    sciencedirect.com/science/article/pii/S1097276522001162
  57. Feb 2022
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells
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      DOI: 10.26508/lsa.202101187

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    ncbi.nlm.nih.gov/pmc/articles/PMC8807877/
  59. Jan 2022
  60. www.sciencedirect.com www.sciencedirect.com
    Acetylation-dependent regulation of BRAF oncogenic function
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    1. scibot 19 Jan 2022
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      DOI: 10.1016/j.celrep.2021.110250

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    sciencedirect.com/science/article/pii/S2211124721017629
  61. Dec 2021
  62. elifesciences.org elifesciences.org
    Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology
    1
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      RRID:AB_2138017

      DOI: 10.7554/eLife.73430

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    elifesciences.org/articles/73430
  63. www.nature.com www.nature.com
    Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
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    1. scibot 03 Dec 2021
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      DOI: 10.1038/s42003-021-02842-3

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    nature.com/articles/s42003-021-02842-3
  64. Oct 2021
  65. www.sciencedirect.com www.sciencedirect.com
    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
    1
    1. scibot 21 Oct 2021
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      DOI: 10.1016/j.celrep.2021.109870

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    sciencedirect.com/science/article/pii/S2211124721013371
  66. Aug 2021
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2α-induced corpus luteum regression
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    Hotspots of Aberrant Enhancer Activity in Fibrolamellar Carcinoma Reveal Candidate Oncogenic Pathways and Therapeutic Vulnerabilities
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    Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors
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    A Loss of Epigenetic Control Can Promote Cell Death through Reversing the Balance of Pathways in a Signaling Network
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    The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells
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    c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling
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    KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS
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    Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C
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  116. academic.oup.com academic.oup.com
    Dual Role of Insulin in Spexin Regulation: Functional Link Between Food Intake and Spexin Expression in a Fish Model
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    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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  118. www.sciencedirect.com www.sciencedirect.com
    DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells
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      Curator: @gabimpine

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  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis
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