125 Matching Annotations
  1. Jul 2026
  2. www.sciencedirect.com www.sciencedirect.com
    Nilotinib induces immunogenic cuproptosis to potentiate cancer immunotherapy
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    sciencedirect.com/science/article/pii/S2666379126003459
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    MEK-dependent bioenergetic demand drives terminal CD8+ T cell exhaustion
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    sciencedirect.com/science/article/pii/S1074761326002633
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    Erk inhibitors intercept Erk-mediated negative feedback while imposing cell-cycle arrest and activating p38
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    sciencedirect.com/science/article/pii/S2589004226020055
  5. Jun 2026
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13131504/
  7. May 2026
  8. link.springer.com link.springer.com
    Renal denervation in experimental autoimmune myocarditis: association with cardiac function and changes in calcium and MAPK/ERK signaling
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    link.springer.com/article/10.1007/s00395-026-01183-8
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combined Inhibition of HRAS and MEK Induces Tumor Regression and Restores Myogenic Differentiation in HRAS-Mutant Rhabdomyosarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13176821/
  10. www.sciencedirect.com www.sciencedirect.com
    Disrupted molecular glue complex drives RAS inhibitor resistance
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    sciencedirect.com/science/article/pii/S0092867426003326
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13131504/
  12. Apr 2026
  13. www.sciencedirect.com www.sciencedirect.com
    ErbB family receptor dimerization dynamics and dysregulation via long-term single-molecule imaging
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    sciencedirect.com/science/article/pii/S0092867426003995
  14. www.jci.org www.jci.org
    Combinatorial therapy regimens targeting preclinical models of melanoma resistant to immune checkpoint blockade
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    jci.org/articles/view/185220
  15. aacrjournals.org aacrjournals.org
    Functional analysis of rare RAS variants of unknown significance
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    aacrjournals.org/cancerrescommun/article/5/10/1747/766027/Functional-Analysis-of-Rare-RAS-Variants-of
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutant and Wild-type RAS Crosstalk and Stoichiometric Deficiencies are Determinants of Sensitivity to Targeted Therapies in KRASG12R Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13080315/
  17. Mar 2026
  18. www.sciencedirect.com www.sciencedirect.com
    Targeting the noncanonical function of metabolic enzyme PHGDH in driving PD-L1 expression and cancer immune evasion
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    sciencedirect.com/science/article/pii/S2666379126001217
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Wild-type RAS signaling is an essential therapeutic target in RAS-mutated cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC12983336/
  20. www.sciencedirect.com www.sciencedirect.com
    Functionally distinct ALK and ROS1 fusions detected in infant-type hemispheric gliomas converge on STAT3 and SHP2 activation
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    sciencedirect.com/science/article/pii/S2211124726001245
  21. Jan 2026
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    USP10-mediated deubiquitination and activation of KRAS mutants promotes colorectal cancer via a novel USP10/KRAS positive feedback circuit
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    pmc.ncbi.nlm.nih.gov/articles/PMC12827889/
  23. www.sciencedirect.com www.sciencedirect.com
    Mechanisms of Clinical Resistance to Selective FGFR2 Inhibition by Lirafugratinib
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    sciencedirect.com/science/article/pii/S092375342600013X
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sevabertinib, a Reversible HER2 Inhibitor with Activity in Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12793832/
  25. Dec 2025
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RAS mutation–specific responses to paralog- and state-selective RAS inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12710464/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KSR1 mediates small-cell lung carcinoma tumor initiation and cisplatin resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12133430/
  28. Nov 2025
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    USP10-mediated deubiquitination and activation of KRAS mutants promotes colorectal cancer via a novel USP10/KRAS positive feedback circuit
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    pmc.ncbi.nlm.nih.gov/articles/PMC12827889/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12614194/
  31. www.sciencedirect.com www.sciencedirect.com
    Paneth-like transition drives resistance to dual targeting of KRAS and EGFR in colorectal cancer
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    sciencedirect.com/science/article/pii/S1535610825004519
  32. Oct 2025
  33. www.sciencedirect.com www.sciencedirect.com
    TAOK2 controls synaptic plasticity and anxiety via ERK and calcium signaling
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    sciencedirect.com/science/article/pii/S258900422501973X
  34. Sep 2025
  35. www.biorxiv.org www.biorxiv.org
    Cooperativity between Ras pathway mutations in colonic tumorigenesis
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    biorxiv.org/content/10.1101/2025.09.05.673994v1
  36. Jul 2025
  37. www.sciencedirect.com www.sciencedirect.com
    Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers
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    sciencedirect.com/science/article/pii/S266637912500326X
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695159/
  39. Jun 2025
  40. www.sciencedirect.com www.sciencedirect.com
    EGFR TKIs suppress MUC1 glycosylation through the PI3K/AKT/SP1/C1GALT1 pathway to enhance TnMUC1 CAR-T efficacy in EGFR-mutant NSCLC
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    sciencedirect.com/science/article/pii/S2666379125002721
  41. May 2025
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046322/
  43. 52.53.155.43 52.53.155.43
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  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel TRKB-activating internal tandem duplication characterizes a new mechanism of receptor tyrosine kinase activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12065843/
  45. Feb 2025
  46. www.sciencedirect.com www.sciencedirect.com
    FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma
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    sciencedirect.com/science/article/pii/S1535610825000534
  47. www.sciencedirect.com www.sciencedirect.com
    Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP
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    sciencedirect.com/science/article/pii/S2211124725001111
  48. academic.oup.com academic.oup.com
    Overexpression of NR1D1 portends disease recurrence in thyroid cancer
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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgae687/7808457
  49. aacrjournals.org aacrjournals.org
    ASCL1 restrains ERK1/2 to promote survival of a subset of neuroendocrine lung cancers
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    aacrjournals.org/mct/article/23/12/1789/750248/ASCL1-Restrains-ERK1-2-to-Promote-Survival-of-a
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases
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    pmc.ncbi.nlm.nih.gov/articles/PMC11866499/
  51. Sep 2024
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription
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    ncbi.nlm.nih.gov/pmc/articles/PMC11387499/
  53. Aug 2024
  54. www.sciencedirect.com www.sciencedirect.com
    In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S266637912400377X
  55. Jul 2024
  56. www.cell.com www.cell.com
    Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK
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    cell.com/cell-host-microbe/fulltext/S1931-3128(24)00254-3
  57. 52.53.155.43 52.53.155.43
    Cancer-associated endocrine cells participate in pancreatic carcinogenesis
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    52.53.155.43/00ed7388bef43fd34d4811e77f0e00ce1748f907/1-s2.0-S0016508524052259-main-html.html
  58. www.cell.com www.cell.com
    TSPAN4 influences glioblastoma progression through regulating EGFR stability
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    cell.com/iscience/fulltext/S2589-0042(24)01642-0
  59. May 2024
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11030525/
  61. Mar 2024
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
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    ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
  63. Feb 2024
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10851855/
  65. Jan 2024
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Landscape of Clinical Resistance Mechanisms to FGFR Inhibitors in FGFR2-Altered Cholangiocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10767308/
  67. Dec 2023
  68. www.sciencedirect.com www.sciencedirect.com
    Wildtype C-Raf gene dosage and dimerization drive prostate cancer metastasis
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    sciencedirect.com/science/article/pii/S2589004223025579
  69. 52.53.155.43 52.53.155.43
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  70. Nov 2023
  71. www.sciencedirect.com www.sciencedirect.com
    Repositioning of Montelukast to inhibit proliferation of mutated KRAS pancreatic cancer through a novel mechanism that interfere the binding between KRAS and GTP/GDP
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    sciencedirect.com/science/article/pii/S0014299923006714
  72. Oct 2023
  73. www.sciencedirect.com www.sciencedirect.com
    High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma
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    sciencedirect.com/science/article/pii/S2666379123004214
  74. Aug 2023
  75. www.sciencedirect.com www.sciencedirect.com
    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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    sciencedirect.com/science/article/pii/S1535610823002453
  76. Jul 2023
  77. www.sciencedirect.com www.sciencedirect.com
    Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia
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    sciencedirect.com/science/article/pii/S221112472300880X
  78. Jun 2023
  79. www.sciencedirect.com www.sciencedirect.com
    Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
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    sciencedirect.com/science/article/pii/S2211124723007076
  80. www.sciencedirect.com www.sciencedirect.com
    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
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    sciencedirect.com/science/article/pii/S030438352300215X
  81. www.sciencedirect.com www.sciencedirect.com
    KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2
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    sciencedirect.com/science/article/pii/S2589004223009914
  82. May 2023
  83. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo
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    onlinelibrary.wiley.com/doi/full/10.1002/mc.23284
  84. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells
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    onlinelibrary.wiley.com/doi/10.1002/cac2.12332
  85. Apr 2023
  86. www.embopress.org www.embopress.org
    RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis
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    embopress.org/doi/10.15252/emmm.202217078
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities
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    ncbi.nlm.nih.gov/pmc/articles/PMC10069870/
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
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    ncbi.nlm.nih.gov/pmc/articles/PMC10069867/
  89. Mar 2023
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC10035898/
  91. Feb 2023
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Scaffold coupling: ERK activation by trans-phosphorylation across different scaffold protein species
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    ncbi.nlm.nih.gov/pmc/articles/PMC9931222/
  93. www.nature.com www.nature.com
    Repositioning Lomitapide to block ZDHHC5-dependant palmitoylation on SSTR5 leads to anti-proliferation effect in preclinical pancreatic cancer models
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    nature.com/articles/s41420-023-01359-4
  94. Jan 2023
  95. www.sciencedirect.com www.sciencedirect.com
    Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling
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    sciencedirect.com/science/article/pii/S2211124723000426
  96. journals.lww.com journals.lww.com
    Oncogenic BRAFV600E induces microglial proliferation... : Neural Regeneration Research
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    journals.lww.com/nrronline/Fulltext/2023/07000/Oncogenic_BRAFV600E_induces_microglial.38.aspx
  97. Nov 2022
  98. www.sciencedirect.com www.sciencedirect.com
    Systematic analysis of the MAPK signaling network reveals MAP3K-driven control of cell fate
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    sciencedirect.com/science/article/pii/S2405471222004306
  99. Oct 2022
  100. www.nature.com www.nature.com
    Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy
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    nature.com/articles/s41418-022-01072-2
  101. Sep 2022
  102. journals.plos.org journals.plos.org
    CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells
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    journals.plos.org/plosone/article
  103. May 2022
  104. www.sciencedirect.com www.sciencedirect.com
    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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    sciencedirect.com/science/article/pii/S1097276522004348
  105. aacrjournals.org aacrjournals.org
    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
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    aacrjournals.org/cancerdiscovery/article/12/5/1378/694560/EGFR-Inhibition-Potentiates-FGFR-Inhibitor-Therapy
  106. elifesciences.org elifesciences.org
    Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs
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    elifesciences.org/articles/76495
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translational Strategies for Repotrectinib in Neuroblastoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC8571000/
  108. Apr 2022
  109. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Downregulation of microRNA-124-3p promotes subventricular zone neural stem cell activation by enhancing the function of BDNF downstream pathways after traumatic brain injury in adult rats
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    onlinelibrary.wiley.com/doi/10.1111/cns.13845
  110. www.sciencedirect.com www.sciencedirect.com
    Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation
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    sciencedirect.com/science/article/pii/S1097276522002647
  111. Mar 2022
  112. www.sciencedirect.com www.sciencedirect.com
    Regulation of GTPase function by autophosphorylation
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    sciencedirect.com/science/article/pii/S1097276522001162
  113. Feb 2022
  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8807877/
  115. Jan 2022
  116. www.sciencedirect.com www.sciencedirect.com
    Acetylation-dependent regulation of BRAF oncogenic function
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    sciencedirect.com/science/article/pii/S2211124721017629
  117. Dec 2021
  118. elifesciences.org elifesciences.org
    Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology
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    elifesciences.org/articles/73430
  119. www.nature.com www.nature.com
    Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
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    nature.com/articles/s42003-021-02842-3
  120. Oct 2021
  121. www.sciencedirect.com www.sciencedirect.com
    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
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    sciencedirect.com/science/article/pii/S2211124721013371
  122. Aug 2021
  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8370767/
  124. www.sciencedirect.com www.sciencedirect.com
    A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies
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    sciencedirect.com/science/article/pii/S1097276521005906
  125. www.sciencedirect.com www.sciencedirect.com
    Selective activation of PFKL suppresses the phagocytic oxidative burst
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    sciencedirect.com/science/article/pii/S0092867421008308
  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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