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Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size

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1. scibot 01 Nov 2025
  
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  DOI: 10.1152/ajpcell.00602.2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12551769/
Oct 2025
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Discovery of a tau-aggregate clearing compound that covalently targets P4HB

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1. scibot 08 Oct 2025
  
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  DOI: 10.1016/j.chembiol.2025.09.006
  
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sciencedirect.com/science/article/pii/S2451945625003010
Aug 2025
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Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size

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1. scibot 01 Aug 2025
  
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  DOI: 10.1101/2025.07.23.666188
  
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biorxiv.org/content/10.1101/2025.07.23.666188v1
Jul 2025
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Intracrine VEGF Signaling Is Required for Adult Hippocampal Neural Stem Cell Maintenance and Vascular Proximity

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1. scibot 30 Jul 2025
  
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  DOI: 10.1007/s12035-025-04861-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12289830/
Jun 2025
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Pre-clinical characterization of novel multi-client inhibitors of Sec61 with broad anti-tumor activity

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.jpet.2025.103634
  
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sciencedirect.com/science/article/pii/S0022356525398472
Apr 2025
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Activity-dependent synthesis of Emerin gates neuronal plasticity by regulating proteostasis

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1. scibot 10 Apr 2025
  
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sciencedirect.com/science/article/pii/S2211124725002104
Jan 2025
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Effects of lysine and methionine on mRNA expression of candidate transcription factors by primary bovine mammary epithelial cells

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1. scibot 24 Jan 2025
  
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  DOI: 10.1371/journal.pone.0305440
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11661575/
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Targeting the mevalonate pathway potentiates NUAK1 inhibition-induced immunogenic cell death and antitumor immunity

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1. scibot 17 Jan 2025
  
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  DOI: 10.1016/j.xcrm.2024.101913
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11866496/
Aug 2024
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E3 Ubiquitin Ligase Nedd4-2 Exerts Neuroprotective Effects During Endoplasmic Reticulum Stress

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1. scibot 02 Aug 2024
  
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  DOI: 10.1111/jnc.15567
  
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onlinelibrary.wiley.com/doi/full/10.1111/jnc.15567
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Traumatic Optic Neuropathy Is Associated with Visual Impairment, Neurodegeneration, and Endoplasmic Reticulum Stress in Adolescent Mice

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1. scibot 02 Aug 2024
  
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  DOI: 10.3390/cells10050996
  
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mdpi.com/2073-4409/10/5/996
Jul 2024
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AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

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1. scibot 18 Jul 2024
  
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  DOI: 10.1038/s41422-024-00985-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11442470/
May 2024
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Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors

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1. scibot 24 May 2024
  
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  DOI: 10.1016/j.isci.2024.109860
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11108982/
Apr 2024
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Adipocyte-Released Adipomes in Chagas Cardiomyopathy: Impact on Cardiac Metabolic and Immune Regulation

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1. scibot 28 Apr 2024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11039351/
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Variant-specific effects of GBA1 mutations on dopaminergic neuron proteostasis

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1. scibot 25 Apr 2024
  
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  DOI: 10.1111/jnc.16114
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.16114
Dec 2023
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A forebrain-hypothalamic ER stress driven circuit mediates hepatic steatosis during obesity

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1. scibot 29 Dec 2023
  
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  DOI: 10.1016/j.molmet.2023.101858
  
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sciencedirect.com/science/article/pii/S2212877823001928
Jun 2023
www.pnas.org www.pnas.org

Redox states in the endoplasmic reticulum directly regulate the activity of calcium channel, inositol 1,4,5-trisphosphate receptors

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1. scibot 30 Jun 2023
  
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  DOI: 10.1073/pnas.2216857120
  
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pnas.org/doi/abs/10.1073/pnas.2216857120
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Restoration of mitochondrial function by Spirulina polysaccharide via upregulated SOD2 in aging fibroblasts

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1. scibot 29 Jun 2023
  
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  DOI: 10.1016/j.isci.2023.107113
  
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sciencedirect.com/science/article/pii/S2589004223011902
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Targeting extracellular CIRP with an X-aptamer shows therapeutic potential in acute pancreatitis

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1. scibot 23 Jun 2023
  
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  DOI: 10.1016/j.isci.2023.107043
  
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sciencedirect.com/science/article/pii/S2589004223011203
Apr 2023
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ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion

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1. scibot 13 Apr 2023
  
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  DOI: 10.1016/j.devcel.2023.03.014
  
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sciencedirect.com/science/article/pii/S1534580723001302
Feb 2023
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Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix

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1. scibot 11 Feb 2023
  
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  DOI: 10.1016/j.isci.2023.105965
  
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sciencedirect.com/science/article/pii/S2589004223000421
Jan 2023
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Bile acids target mitofusin 2 to differentially regulate innate immunity in physiological versus cholestatic conditions

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1. scibot 19 Jan 2023
  
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  DOI: 10.1016/j.celrep.2023.112011
  
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sciencedirect.com/science/article/pii/S2211124723000220
Dec 2022
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A discovery-based proteomics approach identifies protein disulphide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes

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  DOI: 10.1016/j.ebiom.2022.104379
  
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sciencedirect.com/science/article/pii/S2352396422005618
Sep 2022
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De novo sphingolipid biosynthesis necessitates detoxification in cancer cells

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  DOI: 10.1016/j.celrep.2022.111415
  
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sciencedirect.com/science/article/pii/S2211124722012566
Aug 2022
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PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis

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sciencedirect.com/science/article/pii/S1550413122003485
Apr 2022
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Amniogenesis occurs in two independent waves in primates

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  DOI: 10.1016/j.stem.2022.03.014
  
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sciencedirect.com/science/article/pii/S1934590922001126
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Protein disulfide isomerase modulation of TRPV1 controls heat hyperalgesia in chronic pain

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  DOI: 10.1016/j.celrep.2022.110625
  
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sciencedirect.com/science/article/pii/S2211124722003734
Dec 2021
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Methods to separate nuclear soluble fractions reflecting localizations in living cells

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  DOI: 10.1016/j.isci.2021.103503
  
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sciencedirect.com/science/article/pii/S2589004221014747
Oct 2021
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Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance via protein cysteine-homocysteinylation

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1. scibot 13 Oct 2021
  
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  DOI: 10.1016/j.celrep.2021.109821
  
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sciencedirect.com/science/article/pii/S2211124721012857
Sep 2021
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Roles of autophagy in relation to mitochondrial stress responses of HeLa cells to lamellarin cytotoxicity

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1. scibot 28 Sep 2021
  
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  3501
  
  DOI: 10.1016/j.tox.2021.152963
  
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sciencedirect.com/science/article/pii/S0300483X21002857
Jul 2021
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McCarthy_Trehalose manuscript-table 1 (AJP Heart & Circ)

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  DOI: 10.6084/m9.figshare.8323301.v4
  
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  DOI: 10.6084/m9.figshare.8323301.v4
  
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figshare.com/articles/McCarthy_Trehalose_manuscript-table_1_AJP_Heart_Circ_docx/8323301
May 2021
www.tandfonline.com www.tandfonline.com

CREG1 promotes lysosomal biogenesis and function

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1. scibot 14 May 2021
  
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  DOI: 10.1080/15548627.2021.1909997
  
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tandfonline.com/doi/abs/10.1080/15548627.2021.1909997
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Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress

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1. scibot 08 May 2021
  
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  DOI: 10.1016/j.neuron.2021.02.023
  
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sciencedirect.com/science/article/pii/S0896627321001239
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NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

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1. scibot 06 May 2021
  
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  DOI: 10.1016/j.devcel.2020.11.016
  
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sciencedirect.com/science/article/pii/S1534580720309254
Mar 2021
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Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis

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1. scibot 10 Mar 2021
  
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  DOI: 10.1016/j.celrep.2021.108826
  
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sciencedirect.com/science/article/pii/S2211124721001406
Feb 2021
www.cell.com www.cell.com

Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1

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1. scibot 25 Feb 2021
  
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Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

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Morphology, localization, and postnatal development of dural macrophages

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Spatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics

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Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

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TBC1D5-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry

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Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex

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Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells

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Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss

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Lipocalin-2 Regulates Epidermal Growth Factor Receptor Intracellular Trafficking

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Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

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The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1

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The Translational Landscape of the Human Heart

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Profile of the Unfolded Protein Response in Rat Cerebellar Cortical Development

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PKR Senses Nuclear and Mitochondrial Signals by Interacting with Endogenous Double-Stranded RNAs

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Systematic Characterization of Stress-Induced RNA Granulation

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CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

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NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis

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The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation

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Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies

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Heterozygous Loss-of-Function SEC61A1 Mutations Cause Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney Disease with Anemia

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